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Molecules 2015, 20(5), 8816-8822;

Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network

Department of Human Pathology, Policlinico Universitario, Via C. Valeria, Messina 98125, Italy
Department of Biological and Environmental Science, University of Messina, Sal. Sperone 31, Messina 98100, Italy
Department of Drug Science and Products for Health, Vill. SS. Annunziata, Messina 98100, Italy
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 13 February 2015 / Revised: 9 May 2015 / Accepted: 11 May 2015 / Published: 15 May 2015
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [692 KB, uploaded 15 May 2015]   |  


We have investigated the effect of almond skin extracts on the production of pro-inflammatory and anti-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs). PBMCs were either infected or not by herpes simplex virus type 2 (HSV-2), with and without prior treatment with almond skin extracts. Production of IL-17 induced by HSV-2 was inhibited by natural skins (NS) treatment. NS triggered PBMC in releasing IFN-α, IFN-γ and IL-4 in cellular supernatants. These results may explain the antiviral potential of almond skins. View Full-Text
Keywords: HSV-2; cytokines; IL-17; almond skins HSV-2; cytokines; IL-17; almond skins

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Arena, A.; Bisignano, C.; Stassi, G.; Filocamo, A.; Mandalari, G. Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network. Molecules 2015, 20, 8816-8822.

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