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Molecules 2015, 20(2), 2165-2175;

New Lignans and Iridoid Glycosides from Dipsacus asper Wall

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
State Nationalities Affairs Commission and Department of Educational Key Lab of Minority Traditional Medicine, MINZU University of China, Beijing 10081, China
Beijing Institute of Microchemistry, Beijing 100091, China
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 7 January 2015 / Revised: 20 January 2015 / Accepted: 22 January 2015 / Published: 28 January 2015
(This article belongs to the Section Natural Products Chemistry)
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Six new compounds, including four new lignans, dipsalignan A (1), B–D (35), and two new bis-iridoid glycoside dimmers, dipsanosides M (7) and N (8), together with two known compounds (2) and (6), have been isolated from the roots of Dipsacus asper Wall. Their structures were established on the basis of spectroscopic data (MS, 1D, 2D NMR, and CD) and chemical methods. All the isolated compounds were tested against human immunodeficiency virus-1 (HIV-1) integrase inhibition activities, and only compounds 1, 2, 7, and 8 displayed weak activities. View Full-Text
Keywords: Dipsacus asper Wall; lignans; bis-iridoid glycoside Dipsacus asper Wall; lignans; bis-iridoid glycoside

Figure 1

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Sun, X.; Ma, G.; Zhang, D.; Huang, W.; Ding, G.; Hu, H.; Tu, G.; Guo, B. New Lignans and Iridoid Glycosides from Dipsacus asper Wall. Molecules 2015, 20, 2165-2175.

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