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Molecules 2015, 20(12), 21658-21671;

Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins

Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche—Sezione di Chimica e Tecnologie Farmaceutiche—Università degli Studi di Palermo, Via Archirafi 32, Palermo 90123, Italy
IEMEST, Istituto Euromediterraneo di Scienza e Tecnologia, Via Emerico Amari, 123, Palermo 90139, Italy
Authors to whom correspondence should be addressed.
Academic Editor: Peter J. Rutledge
Received: 16 October 2015 / Revised: 19 November 2015 / Accepted: 24 November 2015 / Published: 4 December 2015
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The emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis. View Full-Text
Keywords: pyrrolomycins; antibiotic resistance; antibiofilm agents; pyoluteorin; pentabromopseudilin pyrrolomycins; antibiotic resistance; antibiofilm agents; pyoluteorin; pentabromopseudilin

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Cascioferro, S.; Raimondi, M.V.; Cusimano, M.G.; Raffa, D.; Maggio, B.; Daidone, G.; Schillaci, D. Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins. Molecules 2015, 20, 21658-21671.

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