Molecules 2015, 20(1), 929-950; https://doi.org/10.3390/molecules20010929
Activity of Alkaloids on Peptic Ulcer: What’s New?
Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil
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Academic Editor: Patricia Valentao
Received: 31 October 2014 / Accepted: 18 December 2014 / Published: 8 January 2015
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
Abstract
Peptic ulcer is a common disease characterized by lesions that affect the mucosa of the esophagus, stomach and/or duodenum, and may extend into the muscular layer of the mucosa. Natural products have played an important role in the process of development and discovery of new drugs, due to their wide structural diversity and present, mostly specific and selective biological activities. Among natural products the alkaloids, biologically active secondary metabolites, that can be found in plants, animals or microorganisms stand out. The alkaloids are compounds consisting of a basic nitrogen atom that may or may not be part of a heterocyclic ring. This review will describe 15 alkaloids with antiulcer activity in animal models and in vitro studies. View Full-TextKeywords:
alkaloids; gastroprotective; peptic ulcer; natural products; review
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Do Nascimento, R.F.; De Sales, I.R.P.; De Oliveira Formiga, R.; Barbosa-Filho, J.M.; Sobral, M.V.; Tavares, J.F.; Diniz, M.D.F.F.M.; Batista, L.M. Activity of Alkaloids on Peptic Ulcer: What’s New? Molecules 2015, 20, 929-950.
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