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Structure-Based Virtual Screening of Novel Natural Alkaloid Derivatives as Potential Binders of h-telo and c-myc DNA G-Quadruplex Conformations

Activity of Alkaloids on Peptic Ulcer: What’s New?

Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Patricia Valentao
Molecules 2015, 20(1), 929-950;
Received: 31 October 2014 / Accepted: 18 December 2014 / Published: 8 January 2015
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
Peptic ulcer is a common disease characterized by lesions that affect the mucosa of the esophagus, stomach and/or duodenum, and may extend into the muscular layer of the mucosa. Natural products have played an important role in the process of development and discovery of new drugs, due to their wide structural diversity and present, mostly specific and selective biological activities. Among natural products the alkaloids, biologically active secondary metabolites, that can be found in plants, animals or microorganisms stand out. The alkaloids are compounds consisting of a basic nitrogen atom that may or may not be part of a heterocyclic ring. This review will describe 15 alkaloids with antiulcer activity in animal models and in vitro studies. View Full-Text
Keywords: alkaloids; gastroprotective; peptic ulcer; natural products; review alkaloids; gastroprotective; peptic ulcer; natural products; review
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MDPI and ACS Style

Do Nascimento, R.F.; De Sales, I.R.P.; De Oliveira Formiga, R.; Barbosa-Filho, J.M.; Sobral, M.V.; Tavares, J.F.; Diniz, M.D.F.F.M.; Batista, L.M. Activity of Alkaloids on Peptic Ulcer: What’s New? Molecules 2015, 20, 929-950.

AMA Style

Do Nascimento RF, De Sales IRP, De Oliveira Formiga R, Barbosa-Filho JM, Sobral MV, Tavares JF, Diniz MDFFM, Batista LM. Activity of Alkaloids on Peptic Ulcer: What’s New? Molecules. 2015; 20(1):929-950.

Chicago/Turabian Style

Do Nascimento, Raphaela F., Igor R.P. De Sales, Rodrigo De Oliveira Formiga, José M. Barbosa-Filho, Marianna V. Sobral, Josean F. Tavares, Margareth D.F.F.M. Diniz, and Leônia M. Batista. 2015. "Activity of Alkaloids on Peptic Ulcer: What’s New?" Molecules 20, no. 1: 929-950.

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