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Molecules 2015, 20(1), 1626-1642;

Inhibition of Urinary Macromolecule Heparin on Aggregation of Nano-COM and Nano-COD Crystals

Department of Nephrology, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China
Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China
Authors to whom correspondence should be addressed.
Academic Editor: Vito Ferro
Received: 28 November 2014 / Accepted: 29 December 2014 / Published: 19 January 2015
(This article belongs to the Special Issue Glycosaminoglycans and Their Mimetics)
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Purpose: This research aims to study the influences of heparin (HP) on the aggregation of nano calcium oxalate monohydrate (COM) and nano calcium oxalate dihydrate (COD) with mean diameter of about 50 nm. Method: The influences of different concentrations of HP on the mean diameter and Zeta potential of nano COM and nano COD were investigated using a nanoparticle size Zeta potential analyzer. Results: HP could be adsorbed on the surface of nano COM and nano COD crystals, leading to an increase in the absolute value of Zeta potential on the crystals and an increase in the electrostatic repulsion force between crystals. Consequently, the aggregation of the crystals is reduced and the stability of the system is improved. The strong adsorption ability of HP was closely related to the -OSO3 and -COO groups contained in the HP molecules. X-ray photoelectron spectroscopy confirmed the coordination of HP with Ca2+ ions of COM and COD crystals. Conclusion: HP could inhibit the aggregation of nano COM and nano COD crystals and increase their stability in aqueous solution, which is conducive in inhibiting the formation of calcium oxalate stones. View Full-Text
Keywords: nanocrystal; calcium oxalate; heparin; aggregation; XPS; TEM nanocrystal; calcium oxalate; heparin; aggregation; XPS; TEM

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Ou, Y.; Xue, J.-F.; Tan, C.-Y.; Gui, B.-S.; Sun, X.-Y.; Ouyang, J.-M. Inhibition of Urinary Macromolecule Heparin on Aggregation of Nano-COM and Nano-COD Crystals. Molecules 2015, 20, 1626-1642.

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