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Molecules 2014, 19(9), 13577-13586;

Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one

Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 70000, Vietnam
Department of Chemistry, Vinh University, Vinh 42000, Vietnam
Department of Biotechnology, National Formosa University, Yunlin 63201, Taiwan
Authors to whom correspondence should be addressed.
Received: 30 June 2014 / Revised: 26 August 2014 / Accepted: 27 August 2014 / Published: 1 September 2014
(This article belongs to the Section Medicinal Chemistry)
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In an effort to develop new antimicrobial agents, 3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazolidin-4-one (4) was synthesized by reaction of thiocarbonylbisthioglycolic acid with ethyl (4-methyl-2-oxo-2H-chromen-7-yloxy)aceto- hydrazide (3), which was prepared in turn from 7-hydroxy-4-methylcoumarin (1). The condensation of compound 4 with different aromatic aldehydes afforded a series of 5-(arylidene)-3-(4-methylcoumarin-7-yloxyacetyl-amino)-2-thioxo-1,3-thiozolidin-4-one analogs 5ah. The structures of these synthetic compounds were elucidated on the basis of IR, 1H-NMR and 13C-NMR spectral data and ESI-MS spectrometric analysis. Compounds 5ah were examined for their antibacterial activity against several strains of Gram-positive and Gram-negative bacteria. View Full-Text
Keywords: coumarin; 2-thioxo-1,3-thiazolidin-4-one; spectral elucidation; antibacterial activity coumarin; 2-thioxo-1,3-thiazolidin-4-one; spectral elucidation; antibacterial activity

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Cong, N.T.; Nhan, H.T.; Van Hung, L.; Thang, T.D.; Kuo, P.-C. Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one. Molecules 2014, 19, 13577-13586.

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