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Molecules 2014, 19(6), 8544-8555;

Loddigesiinols G–J: α-Glucosidase Inhibitors from Dendrobium loddigesii

1,* , 3
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
Guangdong Pharmaceutical University, Guangzhou 510006, China
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 10 May 2014 / Revised: 10 June 2014 / Accepted: 13 June 2014 / Published: 23 June 2014
(This article belongs to the Section Natural Products Chemistry)
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Four new polyphenols, loddigesiinols G–J (compounds 14) and a known compound, crepidatuol B (5), were isolated from the stems of Dendrobium loddigesii that have long been used in Traditional Chinese Medicine and have recently been used to treat type 2 diabetes. Compounds 15 structures were elucidated based on spectroscopic analysis. The absolute configurations of compounds 14 were determined using theoretical calculations of electronic circular dichroism (ECD), and the absolute configuration of compound 5 was determined by a comparison of the experimental ECD spectra and the literature data. Compounds 15 are strong inhibitors of α-glucosidase, with IC50 values of 16.7, 10.9, 2.7, 3.2, and 18.9 μM, respectively. Their activities were significantly stronger than trans-resveratrol as a positive control (IC50 values of 27.9 μM). View Full-Text
Keywords: Dendrobium loddigesii; α-glucosidase inhibitory activity; polyphenols Dendrobium loddigesii; α-glucosidase inhibitory activity; polyphenols

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Lu, Y.; Kuang, M.; Hu, G.-P.; Wu, R.-B.; Wang, J.; Liu, L.; Lin, Y.-C. Loddigesiinols G–J: α-Glucosidase Inhibitors from Dendrobium loddigesii. Molecules 2014, 19, 8544-8555.

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