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Molecules 2014, 19(5), 6080-6105;

Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids

Institute for Systems Biology, Seattle, WA 98109, USA
Institute of Medical Systems Biology, Guangdong Medical College, Dongguan, Guangdong 523808, China
Laboratory of the Biology of Addictive Diseases, Rockefeller University, New York, NY 10065, USA
Authors to whom correspondence should be addressed.
Received: 17 March 2014 / Revised: 7 May 2014 / Accepted: 12 May 2014 / Published: 14 May 2014
(This article belongs to the Special Issue miRNAs as Probes to Monitor Cancer and Neurodegenerative Disorders)
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Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker candidates for various physiopathological conditions, including cancer, neurodegeneration, diabetes and other diseases. Since their discovery in 2008 as blood biomarkers, the field has expanded rapidly with a number of important findings. Despite the initial optimistic views of their potential for clinical application, there are currently no circulating miRNA-based diagnostics in use. In this article, we review the status of circulating miRNAs, examine different analytical approaches, and address some of the challenges and opportunities. View Full-Text
Keywords: diagnostic; exosomes; microvesicles; quantitative methods diagnostic; exosomes; microvesicles; quantitative methods
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chevillet, J.R.; Lee, I.; Briggs, H.A.; He, Y.; Wang, K. Issues and Prospects of microRNA-Based Biomarkers in Blood and Other Body Fluids. Molecules 2014, 19, 6080-6105.

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