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Four New Furostanol Saponins from the Rhizomes and Roots of Smilax scobinicaulis and Their Cytotoxicity

College of Life Science, Northwest A&F University, Yangling 712100, Shaanxi, China
Key Laboratory of Southern Subtropical Plant Diversity, Shenzhen Fairy Lake Botanical Garden, Chinese Academy of Sciences, 160 Xianhu Road, Liantang, Shenzhen 518004, China
Shenzhen Boton Flavors & Fragrances Co., Ltd., 19 Daxin Road, Nanshan, Shenzhen 518051, China
Author to whom correspondence should be addressed.
Molecules 2014, 19(12), 20975-20987;
Received: 15 September 2014 / Revised: 21 November 2014 / Accepted: 2 December 2014 / Published: 15 December 2014
(This article belongs to the Section Natural Products Chemistry)
Four new furostanol saponins 14, along with two known furostanol saponins 5 and 6 and one known spirostanol saponin 7 were isolated from the rhizomes and roots of Smilax scobinicaulis. The structures of the new saponins were elucidated as 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one-3-O-α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside (1), 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one (2), 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-20(22)-en-6-one (3), 26-O-β-D-glucopyranoside-3β,23,26-trihydroxy-(23R, 25R)-5α-furostan-20(22)-en-6-one (4) on the basis of spectroscopic analysis. The isolated saponins were evaluated for cytotoxic activity against two human cancer cell lines including Hela (cervical carcinoma) and SMMC-7221 (hepatocellular carcinoma). Compounds 1 and 7 demonstrated cytotoxicity against the tested cell lines. View Full-Text
Keywords: Smilax scobinicaulis; furostanol saponins; cytotoxic activity Smilax scobinicaulis; furostanol saponins; cytotoxic activity
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Xu, J.; Feng, S.; Wang, Q.; Cao, Y.; Sun, M.; Zhang, C. Four New Furostanol Saponins from the Rhizomes and Roots of Smilax scobinicaulis and Their Cytotoxicity. Molecules 2014, 19, 20975-20987.

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