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Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway

1
China Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing 100039, China
2
Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
3
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
4
Research and Technology Service Center, 302 Military Hospital of China, Beijing 100039, China
5
Department of Integrative Medical Center, 302 Military Hospital of China, Beijing 100039, China
*
Author to whom correspondence should be addressed.
Molecules 2014, 19(11), 18767-18780; https://doi.org/10.3390/molecules191118767
Received: 4 September 2014 / Revised: 21 October 2014 / Accepted: 27 October 2014 / Published: 17 November 2014
(This article belongs to the Special Issue Curcumin, Inflammation, and Chronic Diseases: How are They Linked?)
The ERK/HIF-1α signaling pathway is believed to play an important role in the genesis of progressive fibrosis. An increasing expression of HIF-1α and ERK accompanies CCl4-induced liver fibrosis in rats. Curcumin is verified to have antifibrotic effects in several kinds of liver fibrosis models. There is no specific evidence illustrating a connection between curcumin and the HIF-1α/ERK pathway in rat liver fibrosis induced by CCl4. In this study, liver fibrosis was induced by CCl4 in treated rats. The data demonstrated that curcumin was able to attenuate liver fibrosis and inhibit the proliferation of HSC. Moreover, curcumin could remarkably elevate the hepatic function by decreasing serum levels of ALT, AST and ALP, and increasing levels of ALB, TP and α-SMA, Col III mRNA expression. Meanwhile, ECM status could also be reflected by curcumin treatment. The alleviation with curcumin treatment was associated with inhibition of HIF-1α and phosphor-ERK. This study indicates that curcumin alleviates fibrosis by reducing the expression of HIF-1α partly through the ERK pathway. View Full-Text
Keywords: curcumin; carbon tetrachloride; liver fibrosis; hypoxia inducible factor curcumin; carbon tetrachloride; liver fibrosis; hypoxia inducible factor
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Zhao, Y.; Ma, X.; Wang, J.; He, X.; Hu, Y.; Zhang, P.; Wang, R.; Li, R.; Gong, M.; Luo, S.; Xiao, X. Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway. Molecules 2014, 19, 18767-18780.

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