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Isolation and Bioactivities of the Flavonoids Morin and Morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis—A Wild Arabian Medicinal Plant

1
Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Oman
2
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Oman
3
School of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Korea
*
Authors to whom correspondence should be addressed.
Molecules 2014, 19(11), 17763-17772; https://doi.org/10.3390/molecules191117763
Received: 10 July 2014 / Revised: 20 October 2014 / Accepted: 21 October 2014 / Published: 31 October 2014
(This article belongs to the Section Medicinal Chemistry)
Acridocarpus orientalis is an important medicinal plant for some of the locals of Arabian region. Very little is known about its phytochemical constituents. In the present study, we aimed to isolate bioactive chemicals from the crude methanolic extract of the aerial parts of A. orientalis. The extraction and isolation resulted in the purification of two flavonoids: morin (1) and morin-3-O-β-D-glucopyranoside (2). The structure elucidation was carried out by extensive analysis of spectroscopic data and comparison with the reported data for the known constituents. The pure isolates were subjected to various biological assays for their bioactivities. The compounds 1 and 2 were significantly active against the growth of various pathogenic fungi and phytotoxic against lettuce seed at higher concentrations. Furthermore, the free radical scavenging activities, anti-lipid peroxidation, and cytotoxic effects against HepG2, HT29, and HCT116 cancer cell lines were also assayed and the results are presented in this paper. View Full-Text
Keywords: flavonoid; morin; Acridocarpus orientalis; Malpighiaceae; antioxidant; lipid peroxidation; cytotoxicity flavonoid; morin; Acridocarpus orientalis; Malpighiaceae; antioxidant; lipid peroxidation; cytotoxicity
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Hussain, J.; Ali, L.; Khan, A.L.; Rehman, N.U.; Jabeen, F.; Kim, J.-S.; Al-Harrasi, A. Isolation and Bioactivities of the Flavonoids Morin and Morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis—A Wild Arabian Medicinal Plant. Molecules 2014, 19, 17763-17772.

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