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Open AccessArticle

Pd0-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer

1
Institut des Sciences Moléculaires, Université de Bordeaux, UMR5255, 351 Cours de la Libération, Talence 33405, France
2
Laboratoire de Synthèse et Physicochimie- de Molécules d'Intérêt Biologique, Université Paul Sabatier, UMR5068, 118 route de Narbonne, Toulouse 31062, France
*
Authors to whom correspondence should be addressed.
Molecules 2013, 18(11), 13654-13665; https://doi.org/10.3390/molecules181113654
Received: 26 August 2013 / Revised: 14 October 2013 / Accepted: 23 October 2013 / Published: 5 November 2013
(This article belongs to the Special Issue Synthesis of Nucleosides, Nucleotides and Their Derivatives)
The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under “ligandless” conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in a few minutes and quantitative yield, even under dilute conditions, thus affording a rapid and efficient new method for oligonucleotide labelling with carbon-11. View Full-Text
Keywords: Stille coupling; nucleosides; oligonucleotides; methyl transfer; Positron Emission Tomography Stille coupling; nucleosides; oligonucleotides; methyl transfer; Positron Emission Tomography
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James, D.; Escudier, J.-M.; Szlosek-Pinaud, M.; Fouquet, E. Pd0-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer. Molecules 2013, 18, 13654-13665.

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