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Open AccessArticle

Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media

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School of Safety Engineering, China University of Mining & Technology, Xuzhou 221116, China
2
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
3
Hainan Chuntch Pharmaceutical Company Limited, Hainan Province Seaport Bonded Area 6th Workshop, Haikou 570216, China
*
Authors to whom correspondence should be addressed.
Molecules 2013, 18(11), 13645-13653; https://doi.org/10.3390/molecules181113645
Received: 5 August 2013 / Revised: 22 October 2013 / Accepted: 31 October 2013 / Published: 5 November 2013
(This article belongs to the Section Organic Chemistry)
A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure. View Full-Text
Keywords: 5-arylisoxazole; without catalyst; aqueous media; synthesis 5-arylisoxazole; without catalyst; aqueous media; synthesis
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MDPI and ACS Style

Dou, G.; Xu, P.; Li, Q.; Xi, Y.; Huang, Z.; Shi, D. Clean and Efficient Synthesis of Isoxazole Derivatives in Aqueous Media. Molecules 2013, 18, 13645-13653.

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