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Open AccessArticle

New Constituents from the Rhizomes of Egyptian Iris germanica L.

1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
2
Department of Natural products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 211589, Saudi Arabia
3
Department of Pharmacognosy, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
*
Author to whom correspondence should be addressed.
Permanent address: Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt
Molecules 2012, 17(3), 2587-2598; https://doi.org/10.3390/molecules17032587
Received: 5 February 2012 / Revised: 23 February 2012 / Accepted: 28 February 2012 / Published: 2 March 2012
(This article belongs to the Section Natural Products Chemistry)
Chemical investigation of the methanolic extract of the rhizomes of Iris germanica L. (Iridaceae) afforded two new compounds; irigenin S (7) and iriside A (12), together with ten known compounds: stigmasterol (1), a-irone (2), γ-irone (3), 3-hydroxy-5-methoxyacetophenone (4), irilone (5), irisolidone (6), irigenin (8), stigmasterol-3-O-β-D-glucopyranoside (9), irilone 4'-O-b-D-glucopyranoside (10) and iridin (11). Their structures were established by UV, IR, 1D (1H and 13C) and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to mass spectroscopic data and comparison with literature data. The methanolic extract was evaluated for its antimicrobial activity. Both the methanolic extract and the isolated flavonoids were tested for their anti-inflammatory activity. View Full-Text
Keywords: Iris germanica L.; Iridaceae; irigenin S; iriside A; antimicrobial; anti-inflammatory Iris germanica L.; Iridaceae; irigenin S; iriside A; antimicrobial; anti-inflammatory
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Ibrahim, S.R.M.; Mohamed, G.A.; Al-Musayeib, N.M. New Constituents from the Rhizomes of Egyptian Iris germanica L.. Molecules 2012, 17, 2587-2598.

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