Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery
Abstract
:1. Introduction
2. Results and Discussion
2.1. HPLC Chromatography of F2 from Carthamus tinctorius L. Crude Extract and Separated HSYA
2.2. Effects on PA Rings
2.2.1. Effect of HSYA (10−9–10−5 M) on PE-Induced Vascular Constriction
2.2.2. Effect on Endothelium-Intact PA Rings
2.2.3. Effect on Endothelium-Denuded PA Rings
2.2.4. Effect on PA Rings after Blocking K+ Channels of PVSMCs
3. Experimental
3.1. Apparatus
3.2. Reagents and Materials
3.3. Plant Extract Preparation and Isolation of HSYA
3.4. Animals
3.5. Tension Studies of Pulmonary Arterial (PA) Rings
3.6. Statistical Analysis
4. Conclusions
Acknowledgments
References
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Sample Availability: Samples of the HSYA are available from the authors. |
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Bai, Y.; Lu, P.; Han, C.; Yu, C.; Chen, M.; He, F.; Yi, D.; Wu, L. Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery. Molecules 2012, 17, 14918-14927. https://doi.org/10.3390/molecules171214918
Bai Y, Lu P, Han C, Yu C, Chen M, He F, Yi D, Wu L. Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery. Molecules. 2012; 17(12):14918-14927. https://doi.org/10.3390/molecules171214918
Chicago/Turabian StyleBai, Yuhua, Ping Lu, Chenghua Han, Chunyue Yu, Minggang Chen, Fa He, Dan Yi, and Lijun Wu. 2012. "Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery" Molecules 17, no. 12: 14918-14927. https://doi.org/10.3390/molecules171214918