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Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery

by Yuhua Bai 1,2, Ping Lu 2,†, Chenghua Han 2, Chunyue Yu 2, Minggang Chen 2, 2, Dan Yi 2,† and Lijun Wu 1,*
1
College of Pharmacy, Harbin Medical University, Harbin 150081, Heilongjiang, China
2
College of Pharmacy, Harbin Medical University-Daqing, Daqing 163319, Heilongjiang, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2012, 17(12), 14918-14927; https://doi.org/10.3390/molecules171214918
Received: 22 October 2012 / Revised: 19 November 2012 / Accepted: 7 December 2012 / Published: 13 December 2012
(This article belongs to the Section Natural Products Chemistry)
Flowers of Carthamus tinctorius L. are traditionally used in China to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of Carthamus tinctorius L. flowers, is known for its multiple biological activities. In the present study, HSYA was isolated from Carthamus tinctorius L. flowers by a macroporous resin adsorption chromatography method coupled with a Waters high-throughput auto-purification system and it's vasodilatation effects on pulmonary artery (PA) were explored by an assay of tension study on rat pulmonary artery (PA) rings. Results suggest that HSYA possesses vascular relaxation effects on rat PA by activating the KV channel in pulmonary vascular smooth muscle cells (PVSMCs). View Full-Text
Keywords: HSYA; Carthamus tinctorius L.; pulmonary arteries; vasodilatation HSYA; Carthamus tinctorius L.; pulmonary arteries; vasodilatation
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MDPI and ACS Style

Bai, Y.; Lu, P.; Han, C.; Yu, C.; Chen, M.; He, F.; Yi, D.; Wu, L. Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery. Molecules 2012, 17, 14918-14927.

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