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Open AccessArticle

New Furanones from the Plant Endophytic Fungus Pestalotiopsis besseyi

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
Graduate School of Chinese Academy of Sciences, Beijing 100086, China
Institute of Microbiology, Beijing 100086, China
Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, Shandong, China
College of Life Science, Shaanxi Normal University, Xi'an 710062, Shaanxi, China
Author to whom correspondence should be addressed.
Molecules 2012, 17(12), 14015-14021;
Received: 24 October 2012 / Revised: 22 November 2012 / Accepted: 23 November 2012 / Published: 27 November 2012
(This article belongs to the Section Natural Products Chemistry)
Pestalafuranones A–E (compounds 15), five new 2(5H)-furanones, have been isolated from cultures of an isolate of Pestalotiopsis besseyi. The structures of these compounds were elucidated mainly by analysis of their NMR spectroscopic data and HRESIMS experiments. Pestalafuranones A–C (compounds 13) displayed weak inhibitory effects against HIV-1 replication in C8166 cells, whereas pestalafuranones D (4) and E (5) showed moderate antifungal activity against the plant pathogens Verticillium dahiae and Alternaria longipes. View Full-Text
Keywords: pestalafuranones A–E; endophytes; Pestalotiopsis besseyi; bioactivity pestalafuranones A–E; endophytes; Pestalotiopsis besseyi; bioactivity
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Liu, H.; Liu, S.; Guo, L.; Zhang, Y.; Cui, L.; Ding, G. New Furanones from the Plant Endophytic Fungus Pestalotiopsis besseyi. Molecules 2012, 17, 14015-14021.

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