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Molecules 2011, 16(8), 7097-7104;

Alkaloids from Hippeastrum papilio

Departament de Products Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, E-08028 Barcelona, Spain
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, RS, Brazil
AgroBioInstitute, 8 Dragan Tzankov Blvd., 1164 Sofia, Bulgaria
Author to whom correspondence should be addressed.
Received: 9 June 2011 / Revised: 20 July 2011 / Accepted: 26 July 2011 / Published: 18 August 2011
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
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Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer’s disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine. View Full-Text
Keywords: 11β-hydroxygalanthamine; Hippeastrum papilio; 2D NMR 11β-hydroxygalanthamine; Hippeastrum papilio; 2D NMR

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Andrade, J.P.; Berkov, S.; Viladomat, F.; Codina, C.; Zuanazzi, J.A.S.; Bastida, J. Alkaloids from Hippeastrum papilio. Molecules 2011, 16, 7097-7104.

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