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Proanthocyanidins from Grape Seeds Modulate the NF-κB Signal Transduction Pathways in Rats with TNBS-Induced Ulcerative Colitis

1
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Department of College of Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
2
People’s Hospital of Gansu Province, Lanzhou 730000, China
3
Department of Pharmacology, College of Medicine, The Third Military Medical University, Chongqing 400038, China
4
Department of Pharmacy, Southwestern Hospital, The Third Military Medical University, Chongqing 400038, China
*
Author to whom correspondence should be addressed.
Molecules 2011, 16(8), 6721-6731; https://doi.org/10.3390/molecules16086721
Received: 5 July 2011 / Revised: 29 July 2011 / Accepted: 3 August 2011 / Published: 8 August 2011
To elucidate the molecular mechanisms involved in the therapeutic effects of proanthocyanidins from grape seeds (GSPE), we explore whether GSPE regulates the inflammatory response of TNBS-induced colitis in rats at the levels of NF-κB signal transduction pathway. Rats were intragastrically administered of different doses of GSPE (100, 200 and 400 mg·kg−1) per day for seven days after ulcerative colitis (UC) was induced by intracolonic injection of 2,4,6-trinitrobenzenesulfonic acid (TNBS) dissolved in 50% ethanol. Sulfasalazine (SASP) at 400 mg/kg was used as a positive control drug. The expression of nuclear factor-kappa B (NF-κB), phospho-I kappaB-alpha (pIκBα), inhibitor kappa B kinase (IκK) in the colon tissues were all measured by enzyme-linked immunosorbent assay (ELISA) methods. Treatment with GSPE reduced the expression of NF-κB, pIκBα and IκK in the colon. The results of this study show that GSPE exerts beneficial effects in inflammatory bowel disease by inhibition of NF-κB signal transduction pathways. View Full-Text
Keywords: proanthocyanidins from grape seeds; ulcerative colitis; nuclear factor-kappa B proanthocyanidins from grape seeds; ulcerative colitis; nuclear factor-kappa B
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Li, X.; Yang, X.; Cai, Y.; Qin, H.; Wang, L.; Wang, Y.; Huang, Y.; Wang, X.; Yan, S.; Wang, L.; Zhao, X.; Li, W.; Li, S.; Chen, J.; Wu, Y. Proanthocyanidins from Grape Seeds Modulate the NF-κB Signal Transduction Pathways in Rats with TNBS-Induced Ulcerative Colitis. Molecules 2011, 16, 6721-6731.

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