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Locked and Unlocked Nucleosides in Functional Nucleic Acids

Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly

School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK
National Centre for Advanced Tribology, School of Engineering Sciences, University of Southampton, Highfield, Southampton, SO17 1BJ, UK
Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, UK
Author to whom correspondence should be addressed.
Molecules 2011, 16(6), 4912-4922;
Received: 4 May 2011 / Revised: 31 May 2011 / Accepted: 10 June 2011 / Published: 15 June 2011
(This article belongs to the Special Issue Nucleoside Analogues)
We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers. View Full-Text
Keywords: terpy-DNA; AFM; TEM; DNA nanotubes terpy-DNA; AFM; TEM; DNA nanotubes
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MDPI and ACS Style

Burns, J.R.; Zekonyte, J.; Siligardi, G.; Hussain, R.; Stulz, E. Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly. Molecules 2011, 16, 4912-4922.

AMA Style

Burns JR, Zekonyte J, Siligardi G, Hussain R, Stulz E. Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly. Molecules. 2011; 16(6):4912-4922.

Chicago/Turabian Style

Burns, Jonathan R., Jurgita Zekonyte, Giuliano Siligardi, Rohanah Hussain, and Eugen Stulz. 2011. "Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly" Molecules 16, no. 6: 4912-4922.

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