Next Article in Journal
Characterization and Quantification of Polyphenols in Amazon Grape (Pourouma cecropiifolia Martius)
Next Article in Special Issue
Fully Automated Spectrometric Protocols for Determination of Antioxidant Activity: Advantages and Disadvantages
Previous Article in Journal
Characterization of Phosphate Solubilizing Bacteria in Sediments from a Shallow Eutrophic Lake and a Wetland: Isolation, Molecular Identification and Phosphorus Release Ability Determination
Previous Article in Special Issue
Effects of Different Maturity Stages on Antioxidant Content of Ivorian Gnagnan (Solanum indicum L.) Berries
Open AccessArticle

Antiproliferative Activity, Antioxidant Capacity and Tannin Content in Plants of Semi-Arid Northeastern Brazil

Biology Department, Pernambuco Federal University, Rua Dom Manoel de Medeiros, s/n, Recife, PE, Brazil
Department of Pharmaceutical Sciences, Health Sciences Center, Pernambuco Federal University, Av., Prof. Arthur de Sá, s/n, 50740-521, Recife, PE, Brazil
Department of Antibiotics, Pernambuco Federal University, Av. Prof. Arthur de Sá, s/n, 50740-521, Recife, PE, Brazil
Author to whom correspondence should be addressed.
Molecules 2010, 15(12), 8534-8542;
Received: 29 October 2010 / Accepted: 22 November 2010 / Published: 24 November 2010
(This article belongs to the Special Issue Antioxidants)
The objective of this study was to evaluate antiproliferative activity, antioxidant capacity and tannin content in plants from semi-arid northeastern Brazil (Caatinga). For this study, we selected 14 species and we assayed the methanol extracts for antiproliferative activity against the HEp-2 (laryngeal cancer) and NCI-H292 (lung cancer) cell lines using the (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazole) (MTT) method. In addition, the antioxidant activity was evaluated with the DPPH (2,2-diphenyl-2-picrylhydrazyl) assay, and the tannin content was determined by the radial diffusion method. Plants with better antioxidant activity (expressed in a dose able to decrease the initial DPPH concentration by 50%, or IC50) and with higher levels of tannins were: Poincianella pyramidalis (42.95 ± 1.77 µg/mL IC50 and 8.17 ± 0.64 tannin content), Jatropha mollissima (54.09 ± 4.36µg/mL IC50 and 2.35 ± 0.08 tannin content) and Anadenanthera colubrina (73.24 ± 1.47 µg/mL IC50 and 4.41 ± 0.47 tannin content). Plants with enhanced antiproliferative activity (% living cells) were Annona muricata (24.94 ± 0.74 in NCI-H292), Lantana camara (25.8 ± 0.19 in NCI-H292), Handroanthus impetiginosus (41.8 ± 0.47 in NCI-H292) and Mentzelia aspera (45.61 ± 1.94 in HEp-2). For species with better antioxidant and antiproliferative activities, we suggest future in vitro and in vivo comparative studies with other pharmacological models, and to start a process of purification and identification of the possible molecule(s) responsible for the observed pharmacological activity. We believe that the flora of Brazilian semi-arid areas can be a valuable source of plants rich in tannins, cytotoxic compounds and antioxidant agents. View Full-Text
Keywords: Caatinga; antiproliferative; antioxidant; tannin Caatinga; antiproliferative; antioxidant; tannin
MDPI and ACS Style

Gomes de Melo, J.; De Sousa Araújo, T.A.; Thijan Nobre de Almeida e Castro, V.; Lyra de Vasconcelos Cabral, D.; Do Desterro Rodrigues, M.; Carneiro do Nascimento, S.; Cavalcanti de Amorim, E.L.; De Albuquerque, U.P. Antiproliferative Activity, Antioxidant Capacity and Tannin Content in Plants of Semi-Arid Northeastern Brazil . Molecules 2010, 15, 8534-8542.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop