Next Article in Journal
Inhibitory Effect of Three C-glycosylflavonoids from Cymbopogon citratus (Lemongrass) on Human Low Density Lipoprotein Oxidation
Next Article in Special Issue
Antifungal Activity of Eugenol Analogues. Influence of Different Substituents and Studies on Mechanism of Action
Previous Article in Journal
A New Look at the Most Successful Prodrugs for Active Vitamin D (D Hormone): Alfacalcidol and Doxercalciferol
Previous Article in Special Issue
The Effect of Dye Density on the Efficiency of Photosensitization of TiO2 Films: Light-Harvesting by Phenothiazine-Labelled Dendritic Ruthenium Complexes
Open AccessArticle

Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers

Institute of Organic Chemistry PAS, Kasprzaka Str. 44/52 01-224 Warsaw, Poland
National Institute of Public Health – PZH, Chocimska Str. 24, 00-791 Warsaw, Poland
Author to whom correspondence should be addressed.
Molecules 2009, 14(10), 3881-3905;
Received: 31 August 2009 / Revised: 22 September 2009 / Accepted: 27 September 2009 / Published: 29 September 2009
(This article belongs to the Special Issue Dendrimers - from Synthesis to Applications)
Novel polyfunctional small amphiphilic peptide dendrimers characterized by incorporation of a new core compounds – tris-amino acids or tetrakis-amino alcohols that originated from a series of basic amino acids – were efficiently synthesized. These new core elements yielded molecules with multiple branching and (+5)/(+6) charge at the 1-st dendrimer generation. Dendrimers exhibited significant antimicrobial potency against Gram(+) and Gram(-) strains involving also multiresistant reference strains (S. aureus ATCC 43300 and E. coli ATCC BAA-198). In addition, high activity against fungi from the Candida genus was detected. More charged and more hydrophobic peptide dendrimers expressed hemolytic properties. View Full-Text
Keywords: dendrimeric peptides; antimicrobial; antibiotic resistance dendrimeric peptides; antimicrobial; antibiotic resistance
Show Figures

Figure 1

MDPI and ACS Style

Polcyn, P.; Jurczak, M.; Rajnisz, A.; Solecka, J.; Urbanczyk-Lipkowska, Z. Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers. Molecules 2009, 14, 3881-3905.

AMA Style

Polcyn P, Jurczak M, Rajnisz A, Solecka J, Urbanczyk-Lipkowska Z. Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers. Molecules. 2009; 14(10):3881-3905.

Chicago/Turabian Style

Polcyn, Piotr; Jurczak, Margarita; Rajnisz, Aleksandra; Solecka, Jolanta; Urbanczyk-Lipkowska, Zofia. 2009. "Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers" Molecules 14, no. 10: 3881-3905.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop