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Molecules 2007, 12(3), 536-542;

New Cytotoxic Steroid from Stachyurus imalaicus var. himalaicus

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P.R. China
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.R. China
Author to whom correspondence should be addressed.
Received: 20 December 2006 / Revised: 11 February 2007 / Accepted: 17 February 2007 / Published: 17 March 2007
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A phytochemical study of the ethanolic extract of Stachyurus imalaicus var. himalaicus was undertaken and as a result a new polyoxygenated steroid, named stachsterol ((20S)-20, 25-dihydroxy-4-cholesten-3-one, 1) and three known ecdysteroids, 20-hydroxyecdysone (2), 20-hydroxyecdysone-20, 22-monoacetonide (3) and polypodine B-20,22-monoacetonide (4), were isolated. Their structures were elucidated by spectroscopic methods, including UV, NMR, MS and HR-MS. The purified product 1 was found to have in vitro cytotoxic activity against human Hela cell lines with an IC50 value of 2.5 μg/mL. This is the first time that phytoecdysteroids have been found in the genus Stachyurus. View Full-Text
Keywords: Steroids; Stachyurus himalaicus var. himalaicus; Stachyuraceae; Cytotoxity Steroids; Stachyurus himalaicus var. himalaicus; Stachyuraceae; Cytotoxity

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Wang, Y.-S.; Yang, J.-H.; Luo, S.-D.; Zhang, H.-B.; Li, L. New Cytotoxic Steroid from Stachyurus imalaicus var. himalaicus. Molecules 2007, 12, 536-542.

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