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Open AccessArticle

Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids

College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, P.R. China
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Molecules 2007, 12(3), 543-551; https://doi.org/10.3390/12030543
Received: 13 December 2006 / Revised: 11 February 2007 / Accepted: 17 February 2007 / Published: 19 March 2007
A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation. View Full-Text
Keywords: Modified nucleoside analogues; microwave irradiation; peptide nucleic acids Modified nucleoside analogues; microwave irradiation; peptide nucleic acids
MDPI and ACS Style

Qu, G.; Zhang, Z.; Guo, H.; Geng, M.; Xia, R. Microwave-promoted Facile and Efficient Preparation of N-(alkoxycarbonylmethyl) Nucleobases − Building Blocks for Peptide Nucleic Acids. Molecules 2007, 12, 543-551.

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