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Phycology
Special Issues
Seaweed Metabolites
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Seaweed Metabolites

A special issue of Phycology (ISSN 2673-9410).

Deadline for manuscript submissions: 30 April 2026 | Viewed by 2070

Special Issue Editor

Dr. Yan Li

E-Mail Website
Guest Editor
College of Science and Engineering, Flinders University, Bedford Park, SA, Australia
Interests: innovative applied biotechnologies; algal value-added bioproducts across different industries

Special Issue Information

Dear Colleagues,

Seaweed represents a prolific source of biologically active and structurally diverse metabolites. As well as playing crucial ecological roles in the marine environment, these natural compounds show immense potential for different applications in the areas of pharmaceuticals, nutraceuticals, cosmetics, agriculture, and environmental technologies.

For this Special Issue, we welcome original research articles, reviews, and short communications showcasing (1) novel insights into seaweed metabolomics and chemical ecology, (2) advances in bioprospecting and sustainable aquaculture, and (3) innovative approaches to valorizing seaweed metabolites in industry. This Special Issue will improve our understanding of the scientific discovery, industrial characterization, ecological functions, and biotechnological and functional applications of primary and secondary metabolites derived from red, green, and brown macroalgae. Meanwhile, we aim to foster interdisciplinary collaboration among marine biologists, chemists, biotechnologists, and industry stakeholders, promoting the sustainable use of seaweed metabolites.

Dr. Yan Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Phycology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • macroalgal bioactive compounds
  • phycochemistry
  • seaweed biotechnology
  • metabolomics
  • marine drug discovery
  • algal chemical ecology
  • sustainable bioprospecting

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Published Papers (2 papers)

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Research

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11 pages, 1088 KB  
Communication
2-Bromo-5-Hydroxy-4-Methoxybenzaldehyde Exhibits Anti-Inflammatory Effects Through the Inactivation of ERK, JNK, and NF-kB Pathways in RAW 264.7 Cells
by Junseong Kim, Seong-Yeong Heo, Eun-A Kim, Nalae Kang and Soo-Jin Heo
Phycology 2026, 6(1), 10; https://doi.org/10.3390/phycology6010010 - 7 Jan 2026
Viewed by 163
Abstract
Inflammation plays a central role in the pathogenesis of numerous diseases through the excessive production of nitric oxide (NO), prostaglandins, and pro-inflammatory cytokines. Although bromophenols from marine algae and various phenolic compounds exhibit strong anti-inflammatory activity, the biological properties of brominated vanillin derivatives [...] Read more.
Inflammation plays a central role in the pathogenesis of numerous diseases through the excessive production of nitric oxide (NO), prostaglandins, and pro-inflammatory cytokines. Although bromophenols from marine algae and various phenolic compounds exhibit strong anti-inflammatory activity, the biological properties of brominated vanillin derivatives remain largely unexplored. This study aimed to investigate the anti-inflammatory effects of 2-bromo-5-hydroxy-4-methoxybenzaldehyde (2B5H4M), a brominated vanillin derivative structurally similar to marine bromophenols, in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. 2B5H4M significantly reduced LPS-induced NO and PGE2 production by suppressing the protein and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). It also downregulated the expression of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6. Mechanistically, 2B5H4M inhibited the phosphorylation and degradation of IκB-α, thereby preventing NF-κB nuclear translocation, and reduced the phosphorylation of ERK and JNK. These findings demonstrate that 2B5H4M exerts potent anti-inflammatory effects by simultaneously blocking NF-κB and MAPK signaling pathways. Although not algae-derived, the structural resemblance of 2B5H4M to marine bromophenols highlights its potential as a marine-inspired reference compound. This work suggests that 2B5H4M may serve as a promising lead scaffold for developing new phenolic anti-inflammatory agents and provides a foundation for future mechanistic and in vivo studies. Full article
(This article belongs to the Special Issue Seaweed Metabolites)
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Review

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33 pages, 2550 KB  
Review
Comprehensive Review on the Biomedical Applications of Marine Algal Polysaccharides
by Ashwini A. Waoo, Sukhendra Singh, Neha Chandra, Shaily Mishra, Manish Pratap Singh, Joyabrata Mal, Abhimanyu Kumar Jha, Jeong Chan Joo and Ashutosh Pandey
Phycology 2025, 5(4), 80; https://doi.org/10.3390/phycology5040080 - 1 Dec 2025
Viewed by 1371
Abstract
Marine algal polysaccharides (MAPs) are multifunctional biopolymers with significant potential in biomedical applications. Derived from brown, red, and green algae, key examples include alginate, agar, carrageenan, fucoidan, ulvan, and laminarin. Their structural diversity underlies a broad range of biological activities, particularly among sulfated [...] Read more.
Marine algal polysaccharides (MAPs) are multifunctional biopolymers with significant potential in biomedical applications. Derived from brown, red, and green algae, key examples include alginate, agar, carrageenan, fucoidan, ulvan, and laminarin. Their structural diversity underlies a broad range of biological activities, particularly among sulfated polysaccharides, which exhibit antiviral, anticancer, anticoagulant, immunomodulatory, and antioxidant effects. Owing to their biocompatibility and tunable physicochemical properties, MAPs are also valuable in wound healing, tissue regeneration, and drug delivery. Advances in ultrasound-, microwave-, and enzyme-assisted extraction methods have enhanced yield and functionality. This review combines structural, extraction, and biomedical views on MAPs, with a focus on how molecular characteristics relate to their potential as drugs. Future work should focus on scalable green extraction, molecular-level characterization, and clinical validation to develop MAPs-based biomaterials for next-generation drug delivery, wound healing, and tissue engineering. Full article
(This article belongs to the Special Issue Seaweed Metabolites)
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