Microalgal Biosynthetic Pathways and Their Modulation: From Basic Knowledge to Biotechnological Applications

A special issue of Phycology (ISSN 2673-9410).

Deadline for manuscript submissions: 31 May 2026 | Viewed by 698

Special Issue Editors


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Guest Editor
Consiglio Nazionale delle Ricerche, Istituto di Scienze Applicate e Sistemi Intelligenti (ISASI), Pozzuoli, Italy
Interests: molecular biology; marine biology; genetic engeeniring; biotechnology

Special Issue Information

Dear Colleagues,

Microalgae represent a renewable source of valued and specialized metabolites, including polyphenols, terpenoids, polyketides and other functionalized fatty acid-derived lipids, which are of great interest for their functional role and potential biotechnological applications. However, our knowledge of the biosynthetic routes underlying their production remains in some cases quite limited. Cultivation conditions can significantly influence the level of these compounds, modulating gene expression and cellular metabolism; in fact, the modification of physical parameters such as nutrient availability, light intensity, temperature, and salinity has been used as a tool to explore and tune secondary metabolite biosynthesis, particularly in a biotechnological application perspective.

This Special Issue welcomes original contributions and review papers focusing on studies that investigate (1) the effect of cultivation parameters on the biosynthesis and accumulation of specific secondary metabolites and (2) the characterization of biosynthetic pathways involved in their production. By integrating chemical, biochemical, and molecular approaches, it aims to collect recent insights into the regulation and roles of secondary metabolites in microalgae, contributing to the advancement of basic and applied research in this field.

Dr. Adele Cutignano
Dr. Martina Blasio
Guest Editors

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Keywords

  • microalgae
  • secondary metabolites
  • biosynthesis
  • functional lipids
  • biotechnological applications

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Published Papers (1 paper)

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Research

13 pages, 4496 KB  
Article
Further Insights into Influence of Light Intensities on the Production of Long-Chain Hydroxy Fatty Acids, Fatty Diols and Fatty Alcohols in Nannochloropsis oceanica
by Martina Blasio, Adele Cutignano, Angela Sardo, Stefan Schouten and Sergio Balzano
Phycology 2026, 6(1), 11; https://doi.org/10.3390/phycology6010011 - 8 Jan 2026
Viewed by 141
Abstract
Microalgae can modify their metabolic pathways as a response to environmental stimuli such as light, temperature, salinity, and nutrient availability, which critically influence the synthesis of lipids and other biomolecules. While extensive studies have focused on the impact of these environmental variables on [...] Read more.
Microalgae can modify their metabolic pathways as a response to environmental stimuli such as light, temperature, salinity, and nutrient availability, which critically influence the synthesis of lipids and other biomolecules. While extensive studies have focused on the impact of these environmental variables on the accumulation of valuable compounds such as polyunsaturated fatty acids (PUFAs) and triacylglycerols (TAGs), information on the biosynthesis of specialized metabolites, including long-chain hydroxy fatty acids (LCHFAs), long-chain diols (LCDs), and long-chain alkenols (LCAs) is scarce. These metabolites are thought to contribute to the structural integrity of cell walls in certain microalgae, such as Nannochloropsis spp. (Eustigmatophyceae), where they make up a biopolymer known as algaenan. This study investigates how varying light intensities affect the production of LCHFAs, LCDs, and LCAs in Nannochloropsis oceanica over a 12 h light/dark cycle. Our findings provide insights into the lipid biosynthetic pathways in microalgae, revealing that light strongly drives the production of LCHFAs, whereas LCDs and LCAs are less light-dependent and show more variable responses to different light intensities. Full article
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