Search Results (101)

Cervical cancer (CC) remains a common malignant tumor that seriously threatens women’s health globally. Gramine (GR), a natural alkaloid derived from plants such as Arundo donax L., exhibits anti-tumor activities, yet its mechanistic actions in CC are still unclear. Here, we integrated cell-based assays, network pharmacology, and multi-omics analysis to systematically investigate the molecular mechanisms underlying GR’s anti-CC effects. In vitro experiments showed that GR significantly inhibited proliferation and migration, induced apoptosis, and triggered G₀/G₁ phase cell cycle arrest in HeLa cells. Integrated multi-omics analysis identified CDK2 as a critical target of GR, with both mRNA and protein levels markedly reduced following treatment. Mechanistically, GR likely suppresses CC progression by modulating the “CYP4A22-AS1/LINC00958–hsa-miR-133b–CDK2” competitive endogenous RNA (ceRNA) axis. Immune analysis indicated positive correlations of CDK2, CYP4A22-AS1, and LINC00958 with the immune checkpoint molecule CD47. Collectively, our findings demonstrate that GR inhibits CC through a ncRNA-mediated suppression of CDK2, leading to reduced HeLa cell proliferation and migration and enhanced apoptosis. These results provide a mechanistic rationale for developing GR as a candidate agent for targeted therapy and immuno-combination strategies in CC. Full article

The present study explores the role of food as a symbolic, material, and relational device in identity construction and community processes. This study draws on a qualitative case study of a community-based social restaurant located in a mid-sized city in central-northern Italy. The initiative’s objective is to promote the social and labor inclusion of migrant women through training and experiential programs. The research, conducted over a period of nine months from October 2024 to June 2025, was based on a participatory qualitative design, which integrated semi-structured interviews, ecological maps, photointervention, world café, and affective cartography, involving 35 participants including operators, trainees, local community members, and politicians. The results demonstrate the multifaceted role of food practices at the restaurant, which serve to strengthen internal relationships, regulate community life, construct intercultural narratives, and establish spaces of recognition and agency for the women involved. Moreover, the restaurant has been shown to have the capacity to influence the broader social representations of migration in the urban context, thereby promoting processes of cohesion and belonging. It is evident that food-related activities manifest as quotidian micro-political practices, which have the capacity to subvert stereotypes, recognize frequently unseen abilities, and generate new forms of inclusive citizenship. The present study underscores the transformative capacity of initiatives that employ food practices as innovative instruments for fostering empowerment; well-being; and social participation; through the third element of food. The limitations and future prospects of the present situation are discussed; with particular reference to the need to ensure continuity and institutional sustainability for similar experiences. Full article

The migration of Ethiopian women to the Middle East has primarily been studied in connection with domestic labour and the related vulnerabilities. Due to assumptions about the low educational levels of women entering this sector, as well as the precarity and temporality the sector entails, opportunities for social mobility have been largely overlooked. This article examines changes in Ethiopian women’s labour market participation in the United Arab Emirates (UAE). It demonstrates that, over time, women who enter the workforce as maids may transition into better-paid work or establish their own business ventures. It further depicts an evolving pattern of well-educated Ethiopian women entering the skilled labour market. Based on ethnographic findings from the UAE, the article offers a critical re-engagement with prevailing narratives of victimhood and severely restricted social mobility opportunities. Drawing on recent conceptualisations of mobilities, trajectories, and temporalities, the article critiques the tendency to portray Ethiopian female migrants as a homogeneous group with similar paths, thereby concealing the diversity of their experiences. Second, it questions the essentialization of women migrant workers as passive victims. By highlighting developments in women’s aspirations and agency over time, the article contributes new knowledge on the potential for social mobility within transnational labour markets. Full article

Robotaxi services represent a major step in the commercialization of autonomous driving, offering efficiency, consistency, and safety benefits. However, despite technological advances, their large-scale adoption is far from guaranteed. Most urban users already rely on mature ride-hailing platforms such as Didi and Uber, making the real behavioral question not whether to adopt Robotaxi, but whether to migrate from existing services. Prior studies based on TAM, UTAUT, or trust models have primarily examined users’ initial adoption decisions, overlooking the substitution behavior that better captures how people shift between competing mobility services in real contexts. This study addresses this gap by applying the Push–Pull–Mooring (PPM) framework to examine users’ migration from ride-hailing to Robotaxi services, based on survey data collected from 1206 respondents across four Chinese cities (Beijing, Shanghai, Guangzhou, and Wuhan). The model was tested using structural equation modeling and multi-group analysis (SEM–MGA). Push factors reflect negative experiences with ride-hailing, including social anxiety and insecurity caused by drivers’ behaviors; pull factors emphasize Robotaxi’ autonomy and service reliability; while mooring factors capture habitual ride-hailing use and perceived Robotaxi risk. Findings indicate that push and pull factors significantly promote migration intentions, whereas mooring factors hinder them. Among all factors, perceived risk exerted the strongest negative effect (β = −0.36), underscoring its critical role as a barrier to Robotaxi migration. Gender differences are also evident, with women more sensitive to risks and men more influenced by reliability. By situating adoption within a migration context, this study enriches high-risk innovation theory and offers practical guidance for designing gender-sensitive and user-specific promotion strategies. Full article

Triple-negative breast cancer (TNBC) remains a leading cause of cancer-related mortality in women, characterized by its aggressive nature and limited therapeutic options. TNBC is defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression, which excludes patients from targeted endocrine and HER2-directed therapies, contributing to poor prognosis. This study investigates BKS-112, a potent histone deacetylase 6 (HDAC6) inhibitor, for its anticancer activity against TNBC using MDA-MB-231 cells. We assessed HDAC protein expression and their prognostic implications, alongside in vitro experiments analyzing cell viability, apoptosis, autophagy, and colony formation. BKS-112 exhibited dose- and time-dependent reductions in cell viability, significant morphological alterations, and decreased colony formation. The compound increased the acetylation of histones H3, H4, and α-tubulin while downregulating HDAC6 expression and activity. Additionally, BKS-112 reduced cell migration, demonstrating anti-metastatic potential. It induced G1 phase cell cycle arrest and modulated key regulators, including cyclins and cyclin-dependent kinases (CDKs). Apoptosis was promoted through mitochondrial pathways, evidenced by changes in Bcl-2, Bax, and caspase activation. BKS-112 also elevated reactive oxygen species (ROS) levels, affecting apoptosis-related PI3K/AKT signaling. Autophagy was triggered by upregulating LC3 and Atg-7 expression. Collectively, these findings suggest that BKS-112 exerts robust anticancer effects by inducing cell cycle arrest, apoptosis, and autophagy, highlighting its therapeutic promise for TNBC treatment. Full article

Background/Objectives: Involuntary migration exposes individuals to multiple losses and ruptures that profoundly affect their physical, emotional, and social well-being. This study aimed to explore the vital losses experienced by Latin American women seeking international protection, identifying key dimensions of these losses and the coping strategies they employ to support their health and well-being. Methods: The study employed a qualitative phenomenological approach, with 17 international migrant women comprising the study subjects. Data were analysed using an inductive approach and interpretative phenomenological analysis, facilitated by Atlas.ti 23.0 software. The COREQ criteria were followed. Results: The analysis revealed two central themes: the multiplicity of losses associated with migration, including loss of identity, emotional deterioration, disruption of family and community ties, economic instability, and loss of sense of belonging; and hidden gains, encompassing processes of gratitude, spiritual strength, and personal transformation. Conclusions: The findings highlight the complexity of both the losses and the hidden gains associated with the migration experience, underscoring the need for compassionate and culturally competent healthcare. This study provides relevant evidence to improve professional support strategies for refugee women from a comprehensive and humanised perspective. Full article

Where we find and form identity and belonging, meaning and purpose, is often entangled in the dynamics that play out between people and place, and for Aboriginal and Torres Strait Islander Peoples, the legacy and ongoing experience of invasion and colonisation. Place-based understandings of identity and its importance in shaping young people’s experience of what is possible and probable in their futures might be critical to framing cross-cultural work with young people impacted by violence and trauma. This paper draws on practitioner reflections of work with young Aboriginal women both on, and off Country, highlighting common and distinct themes related to identity formation and migration in navigating new futures. These include connection to Country and spiritual connection, family and kinship relationships, Women’s Business and felt cultural safety. The findings illustrate a meaningful parallel instructive to practice; for both young women and practitioners, access to cultural knowledge and connection is strengthened by endorsement and in turn strengthens understanding and experienced safety. This work emphasises the importance of creating culturally connected opportunities, sensitive to dynamics of place, to support positive identity expression and wellbeing. Full article

Background/Objectives: Despite legal frameworks acknowledging the need to protect the rights of female prisoners, penitentiary systems often neglect gender-specific needs, particularly for foreign women. Among them, Muslim women face distinct challenges linked to cultural and religious practices, which are frequently unmet in prison contexts. This review aims to explore the academic literature on the experiences of Muslim women in detention. Methods: A systematic review was conducted using three major bibliographic databases—Scopus, PubMed, and Web of Science—covering the period from 2010 to 2024. Inclusion criteria focused on peer-reviewed studies examining the condition of Muslim women in prison. Of the initial pool, only four articles met the criteria and were included in the final analysis. Results: The review reveals a marked scarcity of research on Muslim women in prison at both national and international levels. This gap may be due to their limited representation or cultural factors that hinder open discourse. The selected studies highlight key issues, including restricted access to services, limited ability to practice religion, and language and cultural barriers. These challenges contribute to increased psychological vulnerability, which is often underestimated in prison settings. Conclusions: There is an urgent need for targeted research and culturally competent training for prison staff to adequately support Muslim women in detention. Greater academic and institutional attention is essential to develop inclusive policies that consider the intersection of gender, religion, and migration, particularly in the post-release reintegration process. Full article

Return migration is frequently associated with failure, particularly in the context of women returnees from the global south. This research challenges this notion, focusing on women returnees from Italy to North Africa. It aims to analyze return migration by focusing on women who returned to Morocco and Tunisia in the last 15 years, and the aftermath of the Arab uprisings, emphasizing the transformative potential of migration experiences for themselves and the local community. Women returnees not only redefine their roles in society but also foster socio-economic development, community building, and political changes in the countries of return. The study employs thematic analysis to examine 25 semi-structured interviews conducted with returnees aged 25–60, where women shared insights into their migration, re-adaptation experiences, and challenges upon return. Returnees utilized skills gained abroad to achieve economic empowerment, often starting businesses or finding new jobs. However, they faced cultural challenges, particularly societal expectations of traditional gender roles. Nonetheless, migration empowered many returnees to question these policies and norms, and contribute to societal change. Full article

This study examines Lombardy’s response to the Ukrainian migration crisis which was triggered by the conflict between Russia and Ukraine. It focuses on the on the innovative experience of refugee reception that emerged as the traditional system became overwhelmed. It analyzes which aspects proved effective and which did not in the development of this alternative approach and the collaboration among various actors. Qualitative data were collected through semi-structured interviews with 28 participants, including professionals from both traditional reception systems and new collaborative actors and entities. Results highlight four specificities of the Ukrainian migration: geographic and cultural proximity, the demographic composition (predominantly women and children), positive media portrayal, and the activation of new actors. The study delves into six motivations driving this collaborative effort, ranging from historical ties, and pre-existing communities to emotional involvement and a perceived urgency for support. The challenges in coordinating between traditional systems and new collaborative entities are also examined, including communication barriers, the need for flexibility, and the lack of clear guidelines. This study recommends establishing a steering committee for enhanced collaboration and emphasizes the importance of long-term sustainability of these collaborative efforts. The findings offer valuable considerations for managing migration emergencies and fostering collaboration between different organizations and stakeholders. Full article

Background: Preeclampsia (PE) is a deadly obstetric complication in pregnant women leading to escalated rates of maternal and fetal mortality. Current research indicates that inadequate invasion of extravillous trophoblasts (EVTs) is a primary factor associated with the pathogenesis of PE. Insulin-like growth factor binding protein 2 (IGFBP2) plays a significant role in promoting cell migration, invasion, and angiogenesis. Researchers aim to investigate the clinical significance and elucidate the molecular mechanisms of IGFBP2 in the pathogenesis of preeclampsia. Methods: This study included 40 pregnant women categorized into 20 PE patients and 20 healthy controls. Expression levels of the mRNA were quantified using real-time quantitative polymerase chain reaction (qRT-PCR), and protein levels were assessed through Western blotting and immunofluorescence techniques. Moreover, the gain- and loss-of-function assays were conducted in human trophoblast cell line HTR-8/SVneo, and cellular models exhibiting overexpression and the knockdown of IGFBP2 were established. The proliferation, migration, and invasion of HTR-8/Svneo cells were determined using CCK8, wound-healing, and transwell assays, respectively. Results: The IGFBP2 was significantly downregulated, and the EMT was suppressed in the placental tissues of the PE patients. Functional experiments demonstrated that IGFBP2 enhanced the proliferation, invasion, and EMT of trophoblast cells activated through the PI3K/AKT signaling pathway. Conclusion: Our findings indicated that IGFBP2 enhances the proliferation, invasion, and EMT of trophoblast cells by activating the PI3K/AKT signaling pathway, serving as a potential therapeutic target in PE patients. Full article

This study aimed to uncover how harm is normalised in migrant communities using rationalisations, power imbalances, and emotional distancing. This research counters the dominant discourse that migrant communities are cohesive, altruistic, and protective by critically analysing the psychological and moral mechanisms of intra-community harm. Migration scholarship has long extolled the contribution of migrant networks to settlement, employment, and integration. Using a qualitative ethnographic approach, data were gathered using participant observation and semi-structured interviews with twelve purposively sampled migrants. The aim of applying a primary qualitative study was to capture a detailed, first-hand understanding of participants’ lived experiences and social relations. It permitted the in-depth examination of how people rationalise and navigate intra-community harm in the actual contexts of their lives. Thematic analysis yielded four significant findings: one, injustices in the community are frequently met with silence and inaction due to fear and moral disengagement; two, assistance is extraordinarily situational and gendered, often falling disproportionately on women or being mediated by institutions; three, internal exploitation—like rent gouging and manipulation of aid—is justified through community narratives; and four, people increasingly feel isolation, emotional burnout, and only symbolic unity at communal events. The research suggests that, although migrant networks can offer critical resources, they are not invulnerable to internal hierarchies and moral collapses. To create effectively inclusive and nurturing settings, future interventions must account for more than mere structural barriers, intra-group processes, and psychological rationalisations allowing intra-community injury. Full article

Cervical cancer ranks as the fourth most prevalent cancer and cause of cancer-related mortality among women globally. It exhibits a recurrence/metastasis rate of approximately 30% and a dismal 5-year survival of only 17% in metastatic cases. Despite significant advancements in surgical techniques, chemoradiotherapy, and targeted therapies, effective treatment options for metastatic cervical cancer remain limited. This study explored Polyphyllin I (PPI), which is a monomeric compound derived from the Rhizoma of Paris Polyphyllin, as a potential inhibitor of cervical cancer metastasis. Mechanistically, PPI directly interacted with β-catenin at the Ser552 site, inhibiting its phosphorylation and subsequent nuclear translocation, thereby suppressing TCF/LEF transcriptional activity and downstream EMT transcription factors (ZEB1, Slug, Snail, and Twist). Notably, PPI promoted β-catenin degradation via the autophagy–lysosomal pathway, as confirmed by CHX chase assays and the detection of the p62 and LC3 proteins, without altering the mRNA levels of β-catenin. In vitro experiments demonstrated that PPI effectively suppressed the migration and invasion of HO-8910PM cells by reversing the process of EMT. Additionally, PPI effectively inhibited TCF/LEF signaling, leading to a reduction in the transcription levels of EMT-associated transcription factors (EMT-TFs), which was mediated by the TCF/LEF family downstream of β-catenin. Furthermore, PPI exhibited inhibitory effects on proliferation, migration, and invasion in both HPV-positive (SiHa) and HPV-negative (C33A) cervical cancer cells. In vivo, PPI significantly suppressed peritoneal metastasis in a luciferase-labeled HO-8910PM xenograft mouse model. These findings reveal the dual role of PPI in blocking β-catenin signaling and inducing β-catenin depletion, thereby effectively restraining metastatic progression. This study underscores the potential of PPI as a promising therapeutic candidate for targeting cervical cancer metastasis through autophagy-mediated β-catenin regulation, offering a novel strategy to address current treatment limitations. Full article

This article focuses on the health impacts of the gender-based violence (GBV) experienced by migrant and refugee women (MRW) survivors in their migration/settlement journeys in Canada, and their challenges in accessing healthcare. Adopting a feminist and intersectional lens, I draw upon qualitative in-depth interviews with 48 migrant women conducted between 2020 and 2022. GBV is a frequent experience in the migration and (re)settlement journey and has wide-ranging and cross-secting emotional-psychological, socio-economic, physical, as well as sexual and reproductive health consequences which, in turn, impact settlement and integration and may increase vulnerability to further GBV as a result. Drawing upon a “social determinants of health” approach, I aim to understand the workings of barriers to healthcare access and help seeking for MRW survivors of GBV in Canada. The social determinants of health involve structural (e.g., legal, financial, linguistic, knowledge, healthcare access) barriers, mediated by gender, intersecting with various positionalities and identities. GBV unambiguously impacts on the health and well-being of all survivors, but the extent of harm varies significantly depending on the intersections of positions and identities of survivors. The migration context entails unique barriers to MRW help seeking and healthcare access as well as aggravates the impacts of other barriers on MRW. My objective is to show how GBV affects the health status of MRW survivors in Canada in the specific context of healthcare access and help-seeking barriers MRW face, conceptualized as risk factors for reproducing GBV. Full article

Migration generates changes in the quality of life (QoL) of immigrants. One of the difficulties that the process of migrating can entail is discrimination, which is the set of negative attitudes towards a person, in this case, because of their nationality. Objective: To analyze the effect that the sense of coherence (SOC) has on the relationship that discrimination by national origin has on quality of life. Method: The WHOQOL-BREF questionnaire was used to assess QoL, and Krieger’s Perceived Discrimination Experiences scale and Antonovsky’s SOC-13 scale were applied to 2144 participants (49.9% women), aged between 18 and 82 years, from Venezuela, Colombia and Peru, all of them being first generation migrants living in Chile. Results: In all the national groups evaluated, discrimination has an inverse relationship with both QoL and SOC, while the latter has a positive relationship with QoL. The direct effect of discrimination on QoL life is found to be smaller when this relationship is mediated by the presence of the SOC. This proposed model has good goodness-of-fit indicators in the three national groups evaluated. Conclusions: A strong and well-defined life purpose, a perception of greater control over surrounding events and situations, and perceiving life events as understandable and consistent can be an effective tools to diminish the effect of discrimination on quality of life in the migrant population. Full article