Search Results (785)

Microwave imaging is a promising non-ionizing technique for bedside follow-up of intracranial hemorrhage, but dynamic monitoring remains challenging under limited multistatic sampling because weak inter-frame changes can be obscured by measurement variability, model mismatch, and the high cost of frame-by-frame nonlinear inversion. To address this problem, this paper proposes a state-referenced truncated singular-value decomposition (SR-TSVD) framework for dynamic microwave monitoring of hemorrhagic evolution. The method maintains an internal gate state and reconstructs only the state-referenced increment at each monitoring instant. A row-whitened TSVD inversion is introduced to reduce channel dominance effects and improve robustness to route-dependent imbalance, while a residual-driven gate-refresh mechanism updates the internal state only when the current linearization background becomes insufficiently accurate. The proposed method was validated through two-dimensional numerical experiments and hardware phantom measurements. The numerical study examined different lesion evolution scenarios and analyzed the effects of antenna count, frequency diversity, and measurement noise. The hardware study showed that the method preserves the main dynamic evolution in a real measurement system and remains more stable than baseline linear methods under sparse array conditions. These results indicate that SR-TSVD provides an effective and computationally practical framework for repeated bedside microwave monitoring of intracranial hemorrhage. Full article

Large-scale engineering of the 3D scenes used in BIM, GIS, digital twins, and geospatial web delivery frequently suffer from significant geometric redundancy after export to mesh-based delivery formats, arising in part from the inconsistent reuse of geometry, where many repetitive components are stored as independent meshes rather than being fully instantiated. This paper proposes an affine–covariant mesh instancing framework designed to achieve a lightweight representation of watertight triangular solids. The core of the method lies in a canonicalization pipeline: each mesh is normalized via volume-centroid translation, principal-axis alignment derived from volume covariance, and anisotropic covariance whitening. This process effectively decouples the influence of translation, rotation, and non-uniform scaling, projecting diverse geometries into a unified canonical space. Within this space, geometric similarity is quantified by evaluating compact descriptors against user-defined tolerances. A greedy clustering strategy is then employed to group affine–similar models based on these descriptors. Finally, the scene is efficiently reconstructed by applying inverse affine transformations to the representative instance of each cluster. The output stores one shared geometry per cluster alongside per-instance $4\times 4$ transform matrices, preserving the original spatial layout while reducing redundant geometry storage. Experiments on four real-world engineering scenes demonstrate varying compression benefits. The results prove particularly effective for scenes containing unlinked repetitive parts and affine–similar parametric components, while also revealing a controllable trade-off between fidelity and compression rate. The method is therefore suitable as a post-export geometry-lightweighting step in mesh-based BIM/GIS integration, infrastructure digital twins, and large-scale 3D mapping workflows. Full article

Constant light (LL) exposure is an established environmental risk factor for metabolic diseases, in which the whitening of brown adipose tissue (BAT) plays a critical role. This study aimed to elucidate the molecular mechanisms through which cordycepin counteracts LL-induced BAT whitening and improves metabolic function. We established an LL-exposed mouse model and employed an integrative approach combining pharmacological, metabolic, molecular, and computational (docking) assays to define cordycepin’s effects and targets. Cordycepin treatment significantly improved cold tolerance and attenuated BAT whitening in LL mice. Mechanistically, cordycepin directly bound to and enhanced the activity of the NAD⁺-dependent deacetylase SIRT1. This activation mitigated LL-induced impairments in mitochondrial biogenesis, dynamics, and autophagy. Furthermore, SIRT1 activation rebalanced fatty acid metabolism by downregulating CD36 and upregulating CPT1, thereby restoring the coupling of fatty acid uptake to oxidation. All beneficial effects of cordycepin were abolished by the selective SIRT1 inhibitor EX-527. In summary, our work provides strong evidence that cordycepin directly interacts with SIRT1 and enhances its deacetylase activity, thereby restoring mitochondrial function and fatty acid oxidative homeostasis in BAT to counteract constant LL-induced metabolic dysfunction. These findings position cordycepin as a promising natural compound targeting the SIRT1 pathway for metabolic disorders. Full article

The increasing demand for better dental aesthetics has driven the development of tooth-whitening techniques that are effective while reducing invasiveness. Hydrogen peroxide (HP) and carbamide peroxide (CP) continue to be the most common active ingredients in bleaching products. Various types of light and laser activation have been introduced to speed up the bleaching process and decrease clinical application time. However, published results regarding their effectiveness and biological safety are inconsistent and sometimes contradictory. Aim: The objective of this study was to identify irradiation conditions that optimise the whitening performance of peroxide-based bleaching agents while ensuring safety for dental hard tissues and ocular structures. This objective was achieved through a systematic synthesis and meta-analyses of both experimental and clinical evidence on bleaching techniques, light or laser activation, and related treatment outcomes. Additionally, the study aimed to provide an integrated overview of currently used irradiation technologies, bleaching agents, treatment protocols, and relevant safety considerations. Methods: A multi-stage analytical approach was employed. Evidence was collected from systematic reviews, randomised and non-randomised clinical trials, and laboratory-based in vitro investigations. The studies assessed differences in bleaching agents (HP and CP), their concentrations, and application protocols, as well as various activation systems, including halogen lamps, conventional LEDs, violet LEDs, metal–halide lamps, and laser wavelengths such as visible blue (~440 nm), red or near-infrared (~1.7 µm), and other spectral ranges. Extracted outcome measures included tooth colour improvement (ΔSGU, ΔE), incidence of tooth sensitivity, changes in enamel surface morphology, temperature increases in the pulp chamber, and the bond strength of restorative or orthodontic materials. When methodological compatibility permitted, quantitative synthesis and meta-analysis were conducted to estimate the effects of activation modalities and irradiation parameters. Results: Analysis of data from 28 systematic reviews and numerous clinical and laboratory studies showed that the degree of colour improvement did not consistently rely on peroxide concentration or on whether bleaching was performed in-office or through home-based protocols. In most studies, adding light activation did not produce a clearly superior whitening effect compared to chemically driven bleaching alone. However, certain laser-assisted methods—especially those using blue diode lasers around 440 nm or near-infrared diode lasers near 1.7 µm—were linked with faster whitening responses and, in several in vitro experiments, fewer enamel surface irregularities. Increases in pulp temperature remained below the generally accepted safety threshold of 5.5 °C in the reported experimental conditions. While laser activation reduced treatment time, some studies observed a temporary decrease in the bond strength of orthodontic brackets following bleaching. Photobiomodulation techniques seem promising for reducing post-treatment sensitivity, although more robust clinical evidence is still needed. Conclusions: Targeted activation with diode lasers, especially within the blue and near-infrared spectral ranges, may speed up the whitening process and potentially minimise structural changes to enamel when irradiation parameters are carefully managed. Despite these positive findings, current clinical evidence remains limited. Well-designed randomised controlled trials with standardised treatment protocols are essential to determine the best wavelengths, energy delivery settings, and safety limits for laser-assisted dental bleaching. Full article

Background/Objectives: To explore the mechanisms of Hydrangea macrophylla adapting to low light-induced ornamental whitening, this study established treatments involving normal light (CK, 200 μmol·m⁻²·s⁻¹), moderate low light (L1, 100 μmol·m⁻²·s⁻¹), and severe low light (L2, 20 μmol·m⁻²·s⁻¹). Methods: Meanwhile, physiological indicators, including growth, photosynthesis, and antioxidant activity, were assessed, alongside transcriptomic and metabolomic analyses. Results: Results indicate that L1 increased the proportion of leaf whitening area while maintaining plant growth (crown width, biomass), photosynthetic efficiency comparable to CK, and superior to L2. Concurrently, L1 activated a coordinated antioxidant defence system, namely by increasing the activity of key enzymes (e.g., SOD, GR) and the accumulation of protective metabolites (e.g., soluble proteins, total phenolics and total flavonoids), thereby minimising oxidative damage (low MDA). Multi-omics analyses revealed that L1 specifically activated these networks associated with carbon assimilation, energy metabolism, secondary metabolite synthesis, and hormone signalling, indicating a systemic molecular mechanism towards enhanced defence. Conclusions: In summary, moderate low light triggers a synergistic molecular network involving enhanced antioxidant defences and secondary metabolism, enabling H. macrophylla to maintain overall physiological homeostasis and healthy growth while exhibiting ornamental whitening phenotypes, thereby revealing a unique aesthetic adaptation mechanism to environmental stress. Full article

Background: The aim of this study was to evaluate the whitening efficacy and long-term stability of different in-office bleaching agents containing high concentrations of hydrogen peroxide (HP). Methods: Records of 50 patients who underwent in-office bleaching treatment at the Department of Restorative Dentistry, Ege University, were retrospectively analyzed. Five bleaching agents were evaluated: Opalescence (40%HP), FGM Whiteness HP (35%HP), FGM Whiteness HP Blue (35%HP), Biowhiten (40%HP) and Powerbright (35%HP). Color measurements were obtained using a spectrophotometer (VITA Easyshade V, VITA Zahnfabrik, Bad Säckingen, Germany) and standardized intraoral photographs at baseline, immediately after treatment, at 1 week, 6 months, 12 months, and 18 months. Color change (ΔE₀₀) was calculated using the CIEDE2000 formula, and shade differences were assessed using ΔSGU values. Statistical analyses were performed using repeated-measures ANOVA and Kruskal–Wallis tests, followed by post hoc comparisons where appropriate (p < 0.05). Results: Baseline age distribution, initial color parameters, and patient-related behavioral factors were comparable among the groups, with no statistically significant differences observed. All bleaching agents resulted in significant color improvement at the 1-week evaluation (ΔE₀₀ range: 3.67–6.34; p < 0.05), exceeding clinically acceptable thresholds. At 6 months, slight, non-significant reductions in ΔE₀₀ values were observed in the Powerbright, FGM Whiteness HP Blue, and FGM Whiteness HP groups (p > 0.05). At 18 months, ΔE₀₀ values remained within a clinically acceptable range (3.56–4.74), with no significant color regression in most groups (p > 0.05), except for a significant decrease in the FGM Whiteness HP group (p < 0.05). Conclusions: High-concentration (35–40%) in-office bleaching agents demonstrated effective short-term whitening and maintained clinically acceptable and stable color outcomes over 18 months. Although material-dependent differences were observed, bleaching efficacy and long-term color stability appear to be influenced by multiple factors beyond hydrogen peroxide concentration alone. These findings support the clinical reliability of in-office bleaching procedures and highlight the importance of long-term follow-up. Full article

Elaeocarpus sylvestris (Lour.) Poir., an evergreen tree native to East and Southeast Asia, has gained increasing scientific attention owing to its broad pharmacological properties. Traditionally used in East Asian medicine to treat inflammation, fever, and infectious diseases, modern research has revealed diverse bioactivities, including potent antioxidant, anti-inflammatory, antiviral, anticancer, antidiabetic, and immunomodulatory effects. This therapeutic potential is primarily attributed to its rich phytochemical composition, particularly polyphenols such as geraniin, 1,2,3,4,6-penta-O-galloyl-β-D-glucose and quercetin. This review particularly focuses on the chemistry of E. sylvestris, summarizing structurally elucidated compounds, including hydrolysable tannins, flavonoids, and triterpenoids, along with recent insights into the structure–activity relationships that underpin these antiviral, antioxidant, and anticancer activities. Recent studies have demonstrated substantial antiviral efficacy of E. sylvestris extracts and isolated compounds against major human pathogens, including herpesviruses, influenza A virus, and SARS-CoV-2, supported by in silico, in vitro, in vivo, and early-phase clinical evaluations. Its cosmeceutical applications, including antioxidant, skin-whitening, and blue-light protective effects, further highlight its multifunctional potential. To our knowledge, this is the first comprehensive review summarizing the phytochemistry, pharmacological activities, therapeutic potential, and cosmeceutical applications of E. sylvestris. Despite these promising findings, challenges remain in elucidating precise molecular mechanisms, pharmacokinetics, and clinical validation. This review identifies current research gaps and future directions necessary to advance E. sylvestris as a scientifically validated natural therapeutic resource. Full article

Fully polarimetric SAR provides richer scattering information than single-polarisation imaging, but multichannel sparse image formation can be computationally and memory demanding, especially when channels are processed jointly. In our previous work, we introduced Orthogonal Matching Pursuit 2D Fully Polarimetric (OMP2D-FP), a greedy reconstruction algorithm that enforces a shared spatial support across polarimetric channels while exploiting a separable 2D formulation to avoid vectorisation and reduce computational burden and memory footprint relative to vectorised OMP-based formulations. In this paper, we extend its validation to real measurements and further develop its theoretical foundations by recasting the atom-selection step as a detection–estimation problem, thereby defining a cumulative objective function (COF) design space that enables the incorporation of disturbance statistics and prior knowledge into sparse recovery. Experiments on fully polarimetric SAR data of a T-72 tank over a wide range of aspect angles, SNR levels, and measurement percentages show that joint support selection improves reconstruction fidelity and polarimetric information preservation over independent per-channel processing, with particularly clear gains under challenging conditions. Preliminary applications of the COF framework (a whitening COF incorporating polarimetric clutter statistics and a mask-based COF incorporating spatial prior knowledge) yield encouraging results, motivating further systematic investigation of adaptive COF designs. Full article

In this paper, an improved state-space method (SSM) is proposed for gait feature extraction. By introducing zero-phase component analysis Whitening (ZCA Whitening) and an algorithm to search estimated echo as the preprocessing method, pedestrian echoes are divided into three groups according to the frequency probability density: torso, feet, and other segments. Two channels of echoes are selected as inputs to the SSM, which is employed to identify the corresponding micro-Doppler trajectory. On this basis, five gait features of torso amplitude, stride length, walking cycle, torso maximum speed, and feet maximum speed are extracted. Simulation based on the Boulic model, compared with the traditional SSM, demonstrated that there is no need to estimate the model order and that a more accurate torso micro-Doppler trajectory and effective micro-motion features of the feet can be obtained by the proposed method. Finally, 77 GHz FMCW radar was used to collect the echoes of four pedestrians. The classifier was designed based on a support vector machine (SVM), and the classification experiment verified the effectiveness of the extracted gait features. Full article

Distillation time (DT) is a key parameter influencing yield and chemical composition, and its optimisation is crucial for production. This study is the first laboratory-scale investigation of the effect of distillation time (DT) on the leaf essential oils of Abies koreana, aiming to maximise oil yield and target bioactive components for cosmetic applications. Essential oils were obtained by hydrodistillation at 14 DTs (1, 3, 5, 10, 20, 40, 80, 120, 160, 200, 240, 280, 360, and 480 min), and the yields, chemical profiles, and fragrance characteristics were comparatively analysed. The control (exhaustive hydrodistillation: 20 h) yielded 2.82% and was dominated by D-limonene, bornyl acetate, and camphene. The contents of bioactive compounds associated with whitening and anti-wrinkle activities (α-pinene, D-limonene, borneol, and bornyl acetate) varied markedly with DT. The highest oil yield was obtained at 80 min (0.30 ± 0.01%), while the targeted components were achieved at 80–160 min. Heatmap-based multivariate analysis revealed distinct compositional differences between oils distilled at 80 min and 160 min, with DT shifting fragrance profiles from fresh, monoterpene-rich notes (linalyl acetate, camphor, and fenchol) to longer-lasting, sesquiterpene-dominated aromas (α-bisabolol and β-eudesmol). Therefore, distillation time significantly influenced A. koreana oil, with shorter distillation (80 min) maximising yield and longer distillation (80–160 min) enriching bioactive components for cosmetic applications. Full article

Extensive use of chemical herbicides has raised serious concerns regarding agricultural sustainability and ecological safety, highlighting the need for environment friendly bioherbicides. In this study, activity-guided fractionation led to the identification of xanthoxylin and α-santonin from the ethanol extract of a dominant desert plant, Seriphidium transiliense, with the phytotoxicity of xanthoxylin being reported for the first time. Petri dish bioassay revealed that both compounds significantly suppressed seedling growth of tested plants in a dose-dependent manner; at 1000 μg/mL, α-santonin inhibited root growth of Amaranthus retroflexus, Setaria viridis, Medicago sativa, and Oxybasis glauca by 98.25%, 79.75%, 71.40%, and 62.75%, respectively, whereas the corresponding inhibition rates for xanthoxylin were 59.15%, 89.71%, 38.80%, and 62.90%. Following pot experiments revealed that both compounds significantly increased MDA content and altered the activities of SOD, CAT, and POD of A. retroflexus seedlings, indicating the induction of oxidative stress. Treated plants also displayed chlorosis and leaf whitening, suggesting possible disturbance of photosynthetic pigment-related processes; subsequent molecular docking further implied that both compounds may interact with protoporphyrinogen IX oxidase (PPO), a key enzyme associated with tetrapyrrole metabolism and chlorophyll biosynthesis. Our results suggests that α-santonin and xanthoxylin have the potential to be developed as bio-herbicides. Full article

This study evaluates the feasibility of using two affordable thermal cameras (UNI-T UTi260M and UTi260T), which are not designed as automotive sensors, for observing pedestrians and warm objects during night-time driving under low-illumination conditions. The experimental setup includes mounting the camera on the vehicle body (e.g., side mirror area/roof), recording road scenes in urban and rural environments, and selecting representative frames for qualitative and quantitative analysis. The study assesses: (i) observable pedestrian detectability in unlit road sections and under oncoming headlight glare, where visible cameras often lose contrast; (ii) the influence of low ambient temperature and strong cold wind on image appearance (including “whitening”/contrast shifts); and (iii) workflow differences, where UTi260M relies on a smartphone application for streaming/recording, while UTi260T supports PC-based image analysis and temperature-profile visualization. In addition, a calibration-based geometric method is proposed for approximate pedestrian distance estimation from single frames using silhouette pixel height and a regression model based on 1$/h_{px}$, valid for a specific mounting configuration and a known subject height. Results indicate that both cameras can highlight warm objects relative to the background and support visual pedestrian identification at low illumination, including in the presence of oncoming headlights, with UTi260M showing more stable behavior in parts of the tests. This work is a feasibility study and does not claim Advanced Driver Assist Systems (ADAS) functionality; it outlines limitations, repeatability considerations, and a minimal set of metrics and procedures for future extension. All quantitative indicators derived from exported frames are explicitly treated as image-level proxy metrics, not as physical sensor characteristics. Full article

Skin-whitening products (SWPs) are widely used, yet many contain prohibited or misdeclared depigmenting agents posing safety concerns. This study developed and validated a sensitive and reliable HPLC-DAD method for the simultaneous determination of hydroquinone (HQ), salicylic acid (SAL), and niacinamide (NIC) in commercial and homemade SWPs. Validation followed ICH Q2(R1), demonstrating good specificity, linearity (R² > 0.9999), method precision (%RSD < 2%), and LOD/LOQ values of 0.2 and 0.7 µg/mL for all analytes. Recoveries of 97.48–99.83% for HQ, 99.37–101.26% for NIC, and 83.04–95.38% for SAL were also obtained. Analysis of 51 products revealed major discrepancies between declared and measured contents. HQ was detected in 18.60% of commercial samples despite its prohibition in OTC cosmetic formulations; none of the SAL-containing products matched their labels, and NIC appeared in 25.58% of samples, with only one sample compliant with its declared content. Homemade products showed undeclared HQ in 62.50% of samples, 25% of samples exceeded the 2% permitted SAL limit, and unregulated multi-ingredient combinations. Risk assessment showed all HQ-containing commercial products and several homemade formulations posed unacceptable systemic exposure risks (MoS < 100). Overall, the proposed method provides a practical and accessible approach for routine quality control and market surveillance of cosmetic products. Full article

As primary producers in aquatic ecosystems, microalgae function not only as a natural source of nourishment for several economically important aquatic species but also as reservoirs of bioactive molecules. Microalgae can secrete exosome-like nanoparticles that transport functional biomolecules, such as proteins and nucleic acids, into the extracellular milieu, thereby mediating intercellular signaling and eliciting ecological or biomedical responses. Although plant-derived exosome-like nanoparticles have attracted attention for their utility in drug delivery and dermatology, the functional properties of microalgae-derived nanoparticles—particularly from species extensively applied in aquaculture—remain inadequately characterized. In this study, exosome-like nanovesicles were isolated from Nannochloropsis oculata (N-ELNs), a microalgal species widely used in aquaculture, and their skin-whitening potential was evaluated using the B16-F10 mouse melanoma cell model. The highest N-ELN yield was observed during the adaptation, exponential, and stationary growth phases. Uptake analyses confirmed the efficient internalization of N-ELNs by B16-F10 cells. Cell counting kit-8 assays indicated that N-ELNs exhibited no cytotoxic effects on melanoma cells or normal human dermal fibroblasts (HFF-1). Scratch wound healing assays revealed that N-ELNs exerted no significant effect on cellular migration. In B16-F10 cells, N-ELNs suppressed tyrosinase activity by downregulating Mitf and its downstream genes Tyr and Tyrp1, resulting in a substantial reduction in melanin synthesis (p < 0.05). The inhibitory effects of N-ELNs on melanin production, tyrosinase activity, and gene expression of Tyr, Tyrp1, and Mitf were comparable to those of the positive control, arbutin. Collectively, these findings suggest that N. oculata exhibits promising skin-whitening properties, providing a novel perspective for clinical applications and supporting the high-value utilization of the microalgae aquaculture industry. Full article

The edible tree peony (Paeonia suffruticosa Andrews) flowers are rich in bioactive components with potential health benefits, but the skin-health-promoting effects of their protein hydrolysates remain understudied. The present research sought to evaluate the antioxidant, anti-wrinkle, moisturizing, and whitening properties of tree peony flower protein hydrolysate (TPFP). TPFP was prepared via enzymatic hydrolysis and ultrafiltration, and its peptide sequences were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS), revealing 54 unique small-molecule peptides with an average amino acid length of 8.2 residues and a molecular weight of 914.51 Da. In vitro safety evaluation using CCK-8 assay showed TPFP (20–100 μM) did not induce substantial cytotoxic effects in either HaCaT keratinocytes or B16F10 melanoma cell lines. Functional assays demonstrated that TPFP dose-dependently inhibited UVB-induced reactive oxygen species (ROS) overproduction and restored superoxide dismutase (SOD) and catalase (CAT) activities in HaCaT cells, exerting antioxidant effects. Additionally, TPFP protected pro-collagen I from UVB-induced loss, suppressed the expression of matrix metalloproteinase 1 (MMP-1), and restored hyaluronic acid (HA) content, showing anti-wrinkle and moisturizing potentials. In α-MSH-stimulated B16F10 cells, TPFP suppressed melanin synthesis by downregulating the protein expression of tyrosinase (TYR), tyrosinase-related protein 1 (TRP-1), and TRP-2, achieving a whitening effect. These findings indicate that TPFP possesses comprehensive skin-health-promoting activities with good biocompatibility, highlighting its potential as a natural functional ingredient in cosmetics and functional foods. Full article