Search Results (119)

In Ivy Road’s new game Wanderstop (March 2025), the player character is so burned out from their lifetime as a workaholic warrior that they find themselves trapped and forced to serve tea in a charming, purgatorial teashop until they finally learn how to rest and recover. This article analyzes the game through its two core verbs—wander and stop—both of which the player first resists and then eventually accepts. With wander, the game forces the player into a jarring experience of presence, using a defamiliarization technique I term ‘confrontational coziness’—an experience of safety, abundance, and softness taken to such an extreme it becomes uncomfortable. With stop, the game uses ideas from the anti-capitalist philosophy of degrowth to engage the player in the challenge of not doing rather than doing. Full article

Nonalcoholic fatty liver disease (NAFLD) is a major public health concern with a global prevalence of approximately 32%. This study examined the association between the “weekend warrior”, other leisure-time physical activity patterns, and NAFLD in Korean adults. We included 44,264 individuals from the Korea National Health and Nutrition Examination Survey (2014–2023). Physical activity was measured using the Global Physical Activity Questionnaire (GPAQ), a self-reported instrument, and physical activity patterns were classified as inactive, weekend warrior (≥150 min/week of moderate-to-vigorous physical activity [MVPA] performed in 1–2 days), and regularly active. NAFLD was identified using the Hepatic Steatosis Index with a cutoff of >36. Weighted logistic regression was used to examine the association between physical activity patterns and NAFLD. The prevalence of NAFLD was 24%. After adjustment for sociodemographic and metabolic factors, both the weekend warrior (odds ratio [OR] = 0.80, 95% confidence interval [CI]: 0.64–0.99) and regularly active (OR = 0.83, 95% CI: 0.77–0.89) groups had significantly lower odds of NAFLD compared to the inactive group. When stratified by total MVPA level, both the weekend warrior and regularly active patterns with >300 min/week of MVPA showed even lower odds of NAFLD, compared to those with 150–300 min/week of MVPA. Both regularly active and weekend warrior patterns were associated with a lower prevalence of NAFLD, suggesting that the weekend warrior pattern may represent a feasible behavioral pattern associated with lower NAFLD prevalence for individuals with time constraints. Full article

Amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease is a progressive neurodegenerative disease that attacks and kills motor neurons in the brain and spinal cord, leading to muscle weakness and atrophy, eventually causing respiratory failure and death within 2–5 years after diagnosis. By 2040, the global population of individuals living with ALS is projected to approach 400,000. Since ALS was discovered by Charcot 150 years ago, only two drugs (Edaravone and Riluzole) have been available, offering modest clinical benefits in slowing disease progression. The increasing number of cases, along with the high costs of treatment and care, creates a growing burden on communities and the healthcare system. However, despite this rising burden and the failure of most clinical trials, the ALS community remains hopeful because of the patients themselves. ALS patients are the beating heart of the ALS community. They engage in efforts to improve lives for others, raising awareness through their real-life experiences, participating in research activities, fundraising, providing samples for research, and advocating strongly in front of communities and governments to raise funds. Their engagement is highly valuable, and collaboration with the research community is essential to understanding the disease process and developing effective disease-modifying therapies. Here, we share the story of Mrs. Sherry Wityshyn, an ALS patient and a true ALS warrior from Winnipeg, Manitoba, Canada. We believe her story will inspire and motivate the entire community to learn more about ALS. Furthermore, her story gives hope to everyone impacted. In this manuscript, we also emphasize the different stages of Sherry’s journey from weakness to diagnosis and our efforts to share her enduring words with policymakers in the government. Full article

Five centuries ago, the Gibraltar Strait was emerging as the border zone between the core and the periphery of the modern/colonial world-system—a liminal position it continues to occupy today. During this period, Muslims on the southern shore of the Strait resisted the Portuguese and Spanish imperialism which was supported by several other Western European powers as well as the Catholic Papacy. This paper examines the life of Sayyida al-Ḥurra (c. 1491–c. 1552), who played an active role in this resistance, as Governor of the city-state of Tétouan and eventually Queen of Morocco. It summarizes years of transdisciplinary research about her life, which draws upon historical sources and popular narratives, as well as fieldwork in Northern Morocco and Southern Spain. The main finding of this research is that Sayyida al-Ḥurra is an early modern Muslim decolonial exemplar who remains significant today. She embodied an alternate way of being a ruler, a warrior, a woman, and a Muslim. Remembering her life can inspire contemporary decolonial thought, since the very fact of her existence unsettles modern colonial formations of race, ethnicity, governance, war, gender, and religion. Full article

In the past decade, research on recombinant oncolytic viral agents in the treatment of solid tumors has evolved from the initial stage of simple genetic engineering to the current stage of multiple pipelines of parallel clinical application and combination therapy. Compared with T-VEC, the classical therapeutic agent that only expresses GM-CSF, which was approved in 2015, most new oncolytic virus designs include diverse gene constructs to reduce toxic effects, enhance multiple antitumor immunity, avoid immune clearance, or enhance tumor targeting. The single route of administration that activates the inflammatory tumor immune microenvironment by intratumoral injection is no longer sufficient to meet the treatment needs of refractory solid tumors. In this review, we illustrated the construction patterns of typical recombinant oncolytic viral agents and their latest clinical trial progress. Secondly, we summarized the underlying mechanisms of the combined application of antiviral and antitumor immunity in the field of solid tumor immunotherapy. Finally, we explored the feasibility of the intravenous application of oncolytic viruses and their future development directions. We believe that the diversified treatment design of oncolytic viruses will bring more surprises to the immunotherapy of refractory tumors. Full article

Understanding streamflow dynamics in watersheds affected by human activity and climate variability is important for sustainable water and environmental resource management. This study evaluates the vulnerability of Alabama watersheds to anthropogenic and climatic changes using an integrated framework combining GIS, remote sensing, hydrological modeling, and machine learning (ML). Three Soil and Water Assessment Tool (SWAT) models, differing in spatial resolution and soil inputs, were developed to simulate streamflow under baseline and land-use/land cover (LULC) scenarios from 1990 to 2023. The model, built with consistent 100 × 100 m rasters and fine-resolution SSURGO (Soil Survey Geographic Database) soil data, achieved the best calibration and was selected for detailed analysis. Streamflow trends were assessed over two periods (1993–2009 and 2010–2023) to help isolate climate variability (from LULC effects), while LULC changes were evaluated using 1992, 2011, and 2021 maps. A Long Short-Term Memory (LSTM) model further enhanced simulation accuracy by integrating partially calibrated SWAT outputs. Watershed vulnerability was ranked using a multi-criteria framework. Two watersheds were classified as highly vulnerable, nine as moderately vulnerable, and three as having low vulnerability. Basin-level contrasts revealed moderate climate impacts in the Tombigbee Basin, greater climate sensitivity in the Black Warrior Basin, and LULC-dominated impacts in the Alabama Basin. Overall, LULC change exerted stronger and more spatially variable effects on streamflow than climate variability. This study introduces a transferable SWAT–ML vulnerability ranking framework to guide watershed and environmental management in data-scarce, human-modified regions. Full article

Background: General aviation pilots are, anecdotally, referred to as “weekend warriors” due to their flying infrequency. Considering that flight skills erode with irregular practice/reinforcement, we determined whether private pilots (PPLs) fly/train sufficiently to operate safely in the context of slow flight, a skill critical for safe operations and which rapidly atrophies with <~51 h flight time/8 months per prior research. Method: Slow-flight-related aviation accidents (2008–2019) were per the NTSB Access^R database, and fatal mishap rates were calculated using general aviation fleet times. Eight-month flight histories of airplanes in single PPL ownership were captured retrospectively using FlightAware^R. PPL survey responses were collected between January and March 2025. Statistical tests employed proportion/Independent-Samples Median Tests and a Poisson Distribution. Results: The slow-flight-related fatal accident rate (2017–2019) trended downwards (p = 0.077). In-flight tracking of 90 airplanes revealed an 8-month median flight time of 6 h, which is well below the aforementioned 51 h requisite for safe operations. Of the aircraft flown < 51 h, only 9% engaged in slow-flight practice. In the online survey, only the upper quartile of 126 PPLs achieved the aforementioned time requisite for preserving slow-flight skills, but nevertheless, 89% of respondents attested to being flight-proficient. Conclusions: Persistence in slow-flight-related fatal accidents likely partly reflects PPLs’ deficiency in in-flight time/slow-flight practice. Full article

As sustainable tourism practices gain traction globally, immersive technologies such as augmented reality (AR) and virtual reality (VR) have emerged as effective tools to enrich visitor experiences while supporting heritage site preservation. Particularly within built cultural environments, these technologies facilitate non-invasive interpretation of architectural spaces, enabling sustainable interaction with fragile historical structures. Despite growing scholarly attention, existing research has primarily focused on the pre-adoption phase or the technical affordances of AR/VR, with limited understanding of user behavior in the post-adoption phase. To address this gap, this study integrates the Expectation Confirmation Model (ECM) with the experiential attributes of AR/VR-enabled heritage applications, proposing an integrated theoretical model to identify key determinants of tourists’ continuance intention. Based on 434 valid survey responses collected at the Terracotta Warriors Museum, a UNESCO World Heritage Site, and analyzed using structural equation modeling (SEM), the results reveal that perceived usefulness, perceived ease of use, satisfaction, and confirmation directly influence continuance intention, while visual appeal, entertainment, enjoyment, interactivity and confirmation exert indirect effects through mediating mechanisms. The findings contribute theoretically by extending ECM to the heritage tourism domain and empirically by providing robust evidence from a high-profile non-Western site. Practically, this study offers actionable implications for designing immersive experiences that enhance post-visit continuance intention and align with broader sustainability objectives. Full article

Objective: The aim of this study is to examine the effect of social support on the mental state of cancer patients using a phenomenological approach. Materials–Methods: In this study, a phenomenological research orientation was used, and semi-structured in-depth interviews were conducted with 14 people diagnosed with cancer living in a province in central Turkey. The criterion sampling method, one of the purposeful sampling methods, was used for the sample group. The interviews continued until data saturation was achieved, and all interviews were recorded and later transcribed verbatim. The data were analyzed using thematic analysis, and the study was conducted and reported according to the COREQ checklist. Results: Two categories (effects of cancer and needs of the cancer patient (invisible components)) and five themes (psychological effects, social effects, physical effects, social support, and spiritual care) were identified in the analysis of the data. Conclusions: It has been determined that individuals are affected by cancer mentally, physically, and socially, and have difficulty coping. In particular, it has been found that social support and thinking about the purpose of life, supporting hope, and self-acceptance are quite important in increasing individuals’ spirituality. Full article

Purpose: Following George Floyd’s death, the push for law enforcement accountability policies has intensified. Despite robust legislative action, challenges in enacting and implementing meaningful reforms persist. This study analyzes police accountability policies (PAP) in the U.S. from 2020 to 2022, identifying barriers and facilitators through expert perspectives in enforcement oversight, policy advocacy, and community engagement. Methods: The study used a dual approach: analyzing 226 police accountability bills from all 50 U.S. states, D.C., and Puerto Rico via the National Conference of State Legislatures database, and categorizing them into six key areas such as training, technology use, and certification. Additionally, a survey was conducted among experts to identify the challenges and drivers in passing police accountability legislation. Findings: A legislative analysis showed that although 35 states passed police accountability laws, California, New Jersey, Oklahoma, and Colorado have made significant strides by passing multiple pieces of legislation aimed at enhancing law enforcement accountability and ensuring better policing practices. The most common policies focused on training and technology, enacted by 16 and 12 states, respectively. However, crucial certification and decertification policies were adopted in just 13 states, highlighting the inconsistent implementation of measures critical for police accountability and transparency. The survey identified several barriers to passing PAP, including inadequate support from local governments (72.7%). Structural exclusion of poor and minority communities from policing resources was also a significant barrier (54.5%). Facilitators included community support (81.8%) and a cultural shift in policing towards viewing officers as “guardians” rather than “warriors” (63.6%). Conclusions: While some progress has been made in passing PAP, considerable gaps remain, particularly in enforcement and comprehensive reform. Resistance from law enforcement institutions, lack of community support, and structural inequalities continue to impede the adoption of effective PAP. Full article

This essay defies the literary ghettoization of Asian-authored narratives and interrogates the space delineated as mainstream American feminist literature by placing Ng’s Everything in dialogue with Kate Chopin’s The Awakening and Kingston’s Woman Warrior (focusing on the first chapter, “No Name Woman”). It proposes a dialectical reading of Ng’s contemporary novel as a synthesis of Chopin’s and Kingston’s works and shows how Ng accounts for the reality and complexity of our intersectional identities—mixed racial parentage, nonbinary sex, or gender. Ng underscores the urgency of considering intersectional bodies and communities, especially relevant to our current times. It calls for a reading that accounts for both White people and people of color, both men and women, and both straight and queer. It reevaluates the thorny questions of the ethics of motherhood and intergenerational trauma that Chopin’s and Kingston’s narratives explore. This article encourages ongoing conversations about interethnic and intersectional fissures and affinities. Full article

Background/Objectives: Since the emergence of the COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the discovery of compounds with antiviral potential from medicinal plants has been extensively researched. This study aimed to investigate plant metabolites with in vitro inhibitory potential against SARS-CoV-2 targets, including 3CL_pro, PL_pro, Spike protein, and RdRp. Methods: A systematic review was conducted following PRISMA guidelines, with literature searches performed in six electronic databases (Scielo, ScienceDirect, Scopus, Springer, Web of Science, and PubMed) from January 2020 to February 2024. Computational analyses using SwissADME, pkCSM, ADMETlab, ProTox3, Toxtree, and DataWarrior were performed to predict the absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles as well as other medicinal chemistry parameters of these compounds. Results: A total of 330 plant-derived compounds with inhibitory activities against the proposed targets were identified, with compounds showing IC₅₀ values as low as 0.01 μM. Our findings suggest that several plant metabolites exhibit significant in vitro inhibition of SARS-CoV-2 targets; however, few molecules exhibit drug development viability without further adjustments. Additionally, after these evaluations, two phenolic acids, salvianic acid A and protocatechuic acid methyl ester, stood out for their potential as candidates for developing antiviral therapies, with IC₅₀ values of 2.15 μM against 3CL_pro and 3.76 μM against PL_pro; respectively; and satisfactory in silico drug-likeness and ADMET profiles. Conclusions: These results reinforce the importance of plant metabolites as potential targets for antiviral drug discovery. Full article

In separate traditions in the HB, the Rephaim are presented either as a living group of gigantic warriors or as shadowy figures of the underworld of Sheol. They are referred to as the rp’um in earlier Amorite Ugaritic texts, in which their role and status are much debated. This paper offers a hypothesis that, first, tracks rp’um/Rephaim antecedent traditions from the Sumerian heroic and funerary practices adopted by the Amorites to the tradition of the rp’um of the Ugaritic literature, and then tracks them on to the HB, through the Amorite connection to Mlk/Molech, in two different regional traditions found in the HB. Literary analysis and cross-cultural evidence regarding the Amorites are used to demonstrate the plausibility of this hypothesis. This paper also puts forth that: the name Hammurapi is a reference to a funerary practice and is a titular name; rpi is employed in its more basic sense of meaning “to restore/mend”; rp’um, following Good, is the passive participle, “restored/healed ones”; and Deut 2:10–11 and the biblical King Og texts do not support the Israelites having encountered living Rephaim warriors. Tracking the heroic and death-culture traditions shows that the antecedents to the biblical Rephaim were likely originally heroic-age warriors who, upon death, were cared for and were appealed to through funerary rituals for some benefit. However, these Amorite traditions were not fully understood by the Israelites when they encountered them and appropriated aspects in their representation of the Rephaim. Full article

Curcumin (CUR), a bioactive compound found in turmeric, has garnered attention for its potential anti-inflammatory properties and impact on liver health. Numerous studies suggest that CUR may be crucial in mitigating liver inflammation. The compound’s anti-inflammatory effects are believed to be attributed to its ability to modulate various molecular pathways involved in the inflammatory response. Research indicates that CUR may suppress the activation of inflammatory cells and the production of pro-inflammatory cytokines in the liver. Additionally, it has been observed to inhibit the activity of transcription factors that play a key role in inflammation. By targeting these molecular mechanisms, CUR may help alleviate the inflammatory burden on the liver. Moreover, CUR’s antioxidant properties are thought to contribute to its protective effects on the liver. Oxidative stress is closely linked to inflammation, and CUR’s ability to neutralize free radicals may further support its anti-inflammatory action. While the evidence is promising, it is essential to note that more research is needed to fully understand the precise mechanisms through which CUR influences liver inflammation. Nevertheless, these findings suggest that CUR could be a potential therapeutic agent in managing liver inflammatory conditions. In this review, we explore the potential impact of CUR on inflammation, highlighting the key mechanisms involved, as reported in the literature. Full article

Bemisia tabaci is a major agricultural pest that affects both greenhouse and field crops by feeding on plant sap, which impairs plant growth, and by secreting honeydew, promotes sooty mold growth that further reduces photosynthesis. Additionally, these insects are vectors for viruses such as the cucurbit chlorotic yellows virus (CCYV), which causes significant damage to cucurbit crops. Traditional chemical pesticide treatments have limitations, including the development of resistance, harm to non-target organisms, and environmental contamination. Traditional chemical pesticides have limitations when it comes to controlling plants infested by CCYV and whitefly. However, the underlying reasons for these limitations remain unclear, as does the impact of entomopathogenic fungi on whitefly responses. This study explores the potential of using biological control agents, specifically Beauveria bassiana and Purpureocillium lilacinum, to manage whitefly populations and control CCYV transmission. Laboratory experiments were conducted to evaluate the pathogenicity of these fungi on non/viruliferous whitefly. The results indicated that both fungi effectively reduced whitefly populations, with B. bassiana showing particularly strong adverse effects. Whiteflies infected with CCYV exhibited a higher LC₅₀ to B. bassiana and P. lilacinum. Furthermore, bio-pesticides significantly altered the bacterial microbiome dynamics of the whitefly. Interestingly, CCYV increased the susceptibility of whiteflies to entomopathogenic fungus. The findings suggest that these biocontrol agents offer a sustainable alternative to chemical pesticides. Our study unraveled a new horizon for the multiple interaction theories among bio-pesticides–insects–symbionts–viruses. Full article