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Keywords = tetrasubstituted imidazoles

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28 pages, 12285 KiB  
Article
A Novel Recyclable Magnetic Nano-Catalyst for Fenton-Photodegradation of Methyl Orange and Imidazole Derivatives Catalytic Synthesis
by Marzough A. Albalawi, Amira K. Hajri, Bassem Jamoussi and Omnia A. Albalawi
Polymers 2024, 16(1), 140; https://doi.org/10.3390/polym16010140 - 1 Jan 2024
Cited by 6 | Viewed by 2251
Abstract
A magnetite chlorodeoxycellulose/ferroferric oxide (CDC@Fe3O4) heterogeneous photocatalyst was synthesised via treated and modified cotton in two steps. The designed nanocomposites were characterised by FTIR, TGA, XRD, SEM, and VSM analyses. The Fenton-photocatalytic decomposition efficiency of the synthesised magnetic catalyst [...] Read more.
A magnetite chlorodeoxycellulose/ferroferric oxide (CDC@Fe3O4) heterogeneous photocatalyst was synthesised via treated and modified cotton in two steps. The designed nanocomposites were characterised by FTIR, TGA, XRD, SEM, and VSM analyses. The Fenton-photocatalytic decomposition efficiency of the synthesised magnetic catalyst was evaluated under visible sunlight using Methyl Orange (MO) as a model organic pollutant. The impacts of several degradation parameters, including the light source, catalyst load, irradiation temperature, oxidant dose, and pH of the dye aqueous solution and its corresponding concentration on the Fenton photodegradation performance, were methodically investigated. The (CDC@Fe3O4) heterogeneous catalyst showed a remarkable MO removal rate of 97.9% at 10 min under visible-light irradiation. (CDC@Fe3O4) nanomaterials were also used in a heterogeneous catalytic optimised protocol for a multicomponent reaction procedure to obtain nine tetra-substituted imidazole derivatives. The green protocol afforded imidazole derivatives in 30 min with good yields (91–97%) at room temperature and under ultrasound irradiation. Generally, a synthesised recyclable heterogeneous nano-catalyst is a good example and is suitable for wastewater treatment and organic synthesis. Full article
(This article belongs to the Special Issue Advanced Composite Materials for Water Contaminant Removal)
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14 pages, 2643 KiB  
Article
Poly(tetrasubstituted-aryl imidazole)s: A Way to Obtain Multi-Chromophore Materials with a Tunable Absorption/Emission Wavelength
by Edouard Chauveau, Lara Perrin, Catherine Marestin and Régis Mercier
Processes 2023, 11(10), 2959; https://doi.org/10.3390/pr11102959 - 12 Oct 2023
Viewed by 1475
Abstract
Some original poly(tetrasubstituted imidazole)s incorporating different units were synthesized and characterized. These materials were obtained via a cascade polycondensation process assisted by microwave irradiation that was developed by our team. This time, we integrated two well-known chromophore structures into the macromolecular backbone, which [...] Read more.
Some original poly(tetrasubstituted imidazole)s incorporating different units were synthesized and characterized. These materials were obtained via a cascade polycondensation process assisted by microwave irradiation that was developed by our team. This time, we integrated two well-known chromophore structures into the macromolecular backbone, which were benzothiadiazole (BTD) and diketopyrrolopyrrole (DKPP). These new polymers were fully characterized: their chemical structures were confirmed using NMR spectroscopy and their thermal, optical and electrochemical properties were investigated and compared with a reference polymer containing a phenyl spacer instead of the mentioned chromophore units. These materials were found to exhibit a large Stokes shift of up to 350 nm. Furthermore, a polymer presenting large absorption on the UV–visible range and an emission close to the near-infrared region was obtained by coupling the mentioned moieties. According to the established properties of this latter polymer, it presents a potential for applications in biological imaging or optoelectronic devices. Full article
(This article belongs to the Special Issue New Technologies and Processing of Photoelectric Functional Materials and Devices)
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19 pages, 2951 KiB  
Article
A Diverse and Versatile Regiospecific Synthesis of Tetrasubstituted Alkylsulfanylimidazoles as p38α Mitogen-Activated Protein Kinase Inhibitors
by Francesco Ansideri, Stanislav Andreev, Annette Kuhn, Wolfgang Albrecht, Stefan A. Laufer and Pierre Koch
Molecules 2018, 23(1), 221; https://doi.org/10.3390/molecules23010221 - 20 Jan 2018
Cited by 6 | Viewed by 5654
Abstract
An alternative strategy for the synthesis of 1-aryl- and 1-alkyl-2-methylsulfanyl-4-(4-fluorophenyl)-5-(pyridin-4-yl)imidazoles as potential p38α mitogen-activated protein kinase inhibitors is reported. The regioselective N-substitution of the imidazole ring was achieved by treatment of α-aminoketones with different aryl or alkyl isothiocyanates. In contrast to previously [...] Read more.
An alternative strategy for the synthesis of 1-aryl- and 1-alkyl-2-methylsulfanyl-4-(4-fluorophenyl)-5-(pyridin-4-yl)imidazoles as potential p38α mitogen-activated protein kinase inhibitors is reported. The regioselective N-substitution of the imidazole ring was achieved by treatment of α-aminoketones with different aryl or alkyl isothiocyanates. In contrast to previously published synthesis routes starting from 2-amino-4-methylpyridine, the presented route is characterized by a higher flexibility and a lower number of steps. This strategy was also applied to access 1-alkyl-2-methylsulfanyl-5-(4-fluorophenyl)-4-(pyridin-4-yl)imidazoles in six steps starting from 2-chloro-4-methylpyridine. Full article
(This article belongs to the Section Organic Chemistry)
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11 pages, 2349 KiB  
Article
β–Cyclodextrin–Propyl Sulfonic Acid Catalysed One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles as Local Anesthetic Agents
by Yan Ran, Ming Li and Zong-Ze Zhang
Molecules 2015, 20(11), 20286-20296; https://doi.org/10.3390/molecules201119696 - 12 Nov 2015
Cited by 17 | Viewed by 7146
Abstract
Some functionalized 1,2,4,5-tetrasubstituted imidazole derivatives were synthesized using a one-pot, four component reaction involving 1,2-diketones, aryl aldehydes, ammonium acetate and substituted aromatic amines. The synthesis has been efficiently carried out in a solvent free medium using β-cyclodextrin-propyl sulfonic acid as a catalyst to [...] Read more.
Some functionalized 1,2,4,5-tetrasubstituted imidazole derivatives were synthesized using a one-pot, four component reaction involving 1,2-diketones, aryl aldehydes, ammonium acetate and substituted aromatic amines. The synthesis has been efficiently carried out in a solvent free medium using β-cyclodextrin-propyl sulfonic acid as a catalyst to afford the target compounds in excellent yields. The local anesthetic effect of these derivatives was assessed in comparison to lidocaine as a standard using a rabbit corneal and mouse tail anesthesia model. The three most potent promising compounds were subjected to a rat sciatic nerve block assay where they showed considerable local anesthetic activity, along with minimal toxicity. Among the tested analogues, 4-(1-benzyl-4,5-diphenyl-1H-imidazol-2-yl)-N,N-dimethylaniline (5g) was identified as most potent analogue with minimal toxicity. It was further characterized by a more favourable therapeutic index than the standard. Full article
(This article belongs to the Section Medicinal Chemistry)
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