Search Results (21)

This study dives into what drives people to use AR filters in the catering industry, focusing on the Hong Kong market. The main idea is to determine how “perceived value” shapes users’ intentions to engage with these filters. To do this, the research combines concepts from two popular models—the extended Technology Acceptance Model (TAM) and the Satisfaction–Loyalty Model (SLM)—to understand what influences perceived value. The survey data were then analyzed with Structural Equation Modeling (SEM) to see how perceived usefulness, enjoyment, satisfaction, and value connect to users’ intentions. The results showed that “perceived value” is a big deal—the main factor driving whether people want to use AR filters. Things like how useful or enjoyable the filters are and how satisfied users feel all play a role in shaping this perceived value. These findings are gold for marketing teams and AR developers, especially in the catering world. Combining TAM and the Satisfaction–Loyalty Model offers a fresh perspective on how AR technology influences consumer behavior. On top of that, it gives practical advice for businesses looking to make the most of AR filters in their marketing and customer experience strategies. Full article

Background/Objectives: Many deprived communities in the UK have low fruit and vegetable (FV) intake, leading to poor health outcomes. Fresh Street is a place-based voucher approach that enables households to buy FV from local independent suppliers. Fresh Street Community embeds this approach within community hubs, thus enabling households to use vouchers to purchase FV from community centres. This paper explores the enablers and barriers influencing the uptake of Fresh Street Community in two UK urban areas of high deprivation. Methods: This three-phase exploratory qualitative study was informed by ‘co-production’ with community researchers at both sites: (1) literature review and observations identifying enablers and barriers in FV voucher schemes; (2) semi-structured interviews and focus groups with the research team and community food researchers to ‘validate’ the factors identified in phase 1 and to develop explanatory narratives for these factors; and (3) participatory and thematic analysis of the enablers and barriers to finalise the identified factors. Results: A total of ten enablers and sixteen barriers were validated across both sites. However, differences in local contexts and operational procedures impacted future FV voucher scheme implementation. The important role of community food researchers to engage participants and support the synthesis of findings is also presented. Conclusions: This study offers practical and critical insights for researchers, community food researchers, and practitioners on factors that influence a community centre-based FV voucher scheme to address nutritional inequalities. Full article

The tightening of sanitary and phytosanitary (SPS) regulations, along with stringent private standards in international fresh produce trade, requires citrus producers, especially in developing regions, to adopt robust compliance mechanisms. This study examines the integration of a Risk Management System (RMS) into the existing Quality Management System (QMS) of citrus producers in the Western Cape (WC), South Africa, aimed at improving adherence to European Union (EU) market requirements. Through a comprehensive survey of citrus producers, the research identifies the primary barriers to effective risk management integration, such as financial constraints, limited human resources, and the prevalent non-compliance in the export chain, including pest infestations and exceeding Maximum Residue Limits (MRLs). The results highlight the fact that producers of varying scales face substantial challenges in resource allocation for RMS implementation. The study advocates for a strategic, top-down integration approach, which includes targeted financial support, the establishment of dedicated teams, and well-structured implementation plans. Additionally, the role of both governmental and private sector support is emphasised, particularly in providing training, technical assistance, and infrastructure investments to strengthen compliance efforts. These actions are crucial for ensuring sustained market access, enhancing the competitiveness of citrus producers, and promoting sustainable agricultural practices in the global market. Full article

Canada is a leading producer of wild lowbush blueberries, most of which are mechanically harvested, washed, individually quick frozen (IQF), and bulk packaged. Still, some berries are harvested by more gentle methods and sold as fresh-packed products. These berries do not undergo a wash step, nor are subjected to antimicrobial treatments. The purpose of this study was to conduct a microbiological survey of berries harvested in the province of Nova Scotia to assess their potential for harborage of bacterial foodborne pathogens. A combination of standardized plate count methods and 3M-Petrifilm protocols were used to enumerate total aerobic mesophilic bacteria (APC), yeasts and molds (YMC), coliforms, and generic E. coli, the latter being an indicator of fecal contamination. Overall, APC and YMC levels were 1.2 and 0.5 log greater, respectively, for berries collected early in the harvest season versus those acquired late season and varied significantly (p < 0.05) between farm (location) and harvest practices used. Berries harvested by our team using sanitized hand rakes (SH) had consistently lower APC and YMC levels than those harvested by farm crews. Yet, when gentle harvesting (GH) methods (hand-raking, walk-behind or modified mechanical harvesters) were employed on farms, lower numbers were generally observed compared to berries harvested by traditional tractor-mounted mechanized harvesters (MH). The presence of coliforms (and their levels) was also impacted by the harvest method, with detection rates of ~29%, 73%, and 92% in SH, GH, and MH samples, respectively. Mean counts were < 2.5 log₁₀ CFU/g for both SH and GH berries, but significantly higher (p < 0.05) on MH berries (3.6 log₁₀ CFU/g). Although ~56% of all berry samples collected (n = 350) contained coliforms, only 12 were positive for E. coli, 9 of which were MH samples. Only the latter had numbers > 2 log₁₀ CFU/g, but none tested positive for Shiga toxin-producing serotype O157 (STEC O157) or Salmonella spp. when using internationally recognized selective enrichment and plating methods. ATP luminescence was used to assess the general hygiene of processing lines, whereby “hot spots” for microbial activity were identified, even after cleaning., Standard selective enrichment and plating methods were used for the detection of Listeria monocytogenes on 61 swab samples taken from berry totes or conveyor belts at different times during processing; 4 swabs tested positive for L. monocytogenes. However, the pathogen could not be detected by direct plating on selective agar without prior enrichment; this indicated its numbers were low. The results from this work demonstrated that alternative gentle harvest methods can reduce microbial numbers on wild blueberries. Although the frequency of fecal contamination in berry samples appeared to be low and targeted human pathogens were not detected; this represents a single study conducted over one harvest season. Therefore, it would be prudent for processors to seek effective antimicrobial technologies prior to packaging, while consumers should use caution and thoroughly wash produce before consumption. Where sporadic detection of L. monocytogenes was observed on environmental samples from the processing line, processors must ensure that effective sanitation programs are implemented to avoid potential food safety risks. Full article

During the COVID-19 pandemic, scientific collaboration has profoundly influenced the sustainability of human science. The pandemic has exposed the fragility of the global health system, forcing various research institutions to cooperate more actively and giving rise to a pressing inquiry regarding its implications on the patterns of scientific institution collaboration. With this in mind, we investigate 2,252,016 scientific papers between 2019 and 2020 to study this issue from an institution cooperation view. Specifically, by proposing a novel weighted cooperation network and utilizing institution cooperation freshness, we investigate different collaboration patterns and strategies when institutions respond to the pandemic. The results show that the crisis generally promotes both fresh and stable cooperation relationships among institutions, and different fields (e.g., STEM and Humanities) demonstrate different collaboration patterns. During the pandemic, institutions with a strong influence have a variety of cooperation strategies, while institutions with a low influence prefer a conservative strategy. Moreover, institutions participating in COVID-19 research are very cautious in choosing partners, which may originate from the risk of cooperation, e.g., the fluctuation of influence, and the causal inference results also verify this conclusion. Overall, our study reveals the impact of the COVID-19 pandemic on scientific research work, which may pave the way for designing policy when other global crises occur again. Full article

The objective of this study was to explore the potential enhancement of response within GP medical centres in New Zealand when facing heightened healthcare demand during a pandemic. This investigation sheds light on effective crisis management and leadership. By elucidating the contributions of this research, we gain a deeper appreciation of its importance in advancing our understanding of pandemic management. This study has yielded fresh insights and knowledge, beneficial to both academic and real-world applications, particularly concerning the adoption and effects of leadership and management within the healthcare domain amidst crisis situations. Using a multiple case study design, we conducted 86 in-depth interviews with staff from 16 General Practice centres in New Zealand. The critical activities delivered during the first six months of the COVID pandemic to keep New Zealand communities safe during the initial COVID-19 outbreak were (a) leadership in health service planning, including workforce planning, new operational processes, and expansion in the use of Information Communication Technology systems by the GP medical centres; (b) environment disinfection using national guidelines, education and establishment of respiratory clinics and expanding testing sites in GP medical centres; and (c) education and outreach to the patients including the protection of Māori, Pasifika, and remote communities. The decision to adopt a localised response to the pandemic, centralise testing, and better understand local-level needs prompted GP medical centres to communicate and engage early and effectively with patients. This enabled centres to lead and manage the COVID-19 pandemic with greater efficiency in the first six months of the outbreak. The New Zealand government’s “team of 5 million” COVID-compliance campaign program provided clear and persistent communication by the Ministry of Health. This campaign assisted in a better national understanding and compliance with the regulation of the COVID-19 pandemic. The dedication of medical centre managers to forward planning using contingency and accrued funding and setting up Community-Based Assessment Centres and respiratory clinics, including walk-in and outreach services, proved to be highly effective. GP centres led the way in COVID-19 pandemic planning, response, and management. Full article

The Chatbot Generative Pre-Trained Transformer (ChatGPT) has garnered great attention from the public, academicians and science communities. It responds with appropriate and articulate answers and explanations across various disciplines. For the use of ChatGPT in education, research and healthcare, different perspectives exist with some level of ambiguity around its acceptability and ideal uses. However, the literature is acutely lacking in establishing a link to assess the intellectual levels of ChatGPT in the medical sciences. Therefore, the present study aimed to investigate the knowledge level of ChatGPT in medical education both in basic and clinical medical sciences, multiple-choice question (MCQs) examination-based performance and its impact on the medical examination system. In this study, initially, a subject-wise question bank was established with a pool of multiple-choice questions (MCQs) from various medical textbooks and university examination pools. The research team members carefully reviewed the MCQ contents and ensured that the MCQs were relevant to the subject’s contents. Each question was scenario-based with four sub-stems and had a single correct answer. In this study, 100 MCQs in various disciplines, including basic medical sciences (50 MCQs) and clinical medical sciences (50 MCQs), were randomly selected from the MCQ bank. The MCQs were manually entered one by one, and a fresh ChatGPT session was started for each entry to avoid memory retention bias. The task was given to ChatGPT to assess the response and knowledge level of ChatGPT. The first response obtained was taken as the final response. Based on a pre-determined answer key, scoring was made on a scale of 0 to 1, with zero representing incorrect and one representing the correct answer. The results revealed that out of 100 MCQs in various disciplines of basic and clinical medical sciences, ChatGPT attempted all the MCQs and obtained 37/50 (74%) marks in basic medical sciences and 35/50 (70%) marks in clinical medical sciences, with an overall score of 72/100 (72%) in both basic and clinical medical sciences. It is concluded that ChatGPT obtained a satisfactory score in both basic and clinical medical sciences subjects and demonstrated a degree of understanding and explanation. This study’s findings suggest that ChatGPT may be able to assist medical students and faculty in medical education settings since it has potential as an innovation in the framework of medical sciences and education. Full article

Animal models have been utilized for decades to investigate the causes of human diseases and provide platforms for testing novel therapies. Indeed, breakthrough advances in genetically engineered mouse (GEM) models and xenograft transplantation technologies have dramatically benefited in elucidating the mechanisms underlying the pathogenesis of multiple diseases, including cancer. The currently available GEM models have been employed to assess specific genetic changes that underlay many features of carcinogenesis, including variations in tumor cell proliferation, apoptosis, invasion, metastasis, angiogenesis, and drug resistance. In addition, mice models render it easier to locate tumor biomarkers for the recognition, prognosis, and surveillance of cancer progression and recurrence. Furthermore, the patient-derived xenograft (PDX) model, which involves the direct surgical transfer of fresh human tumor samples to immunodeficient mice, has contributed significantly to advancing the field of drug discovery and therapeutics. Here, we provide a synopsis of mouse and zebrafish models used in cancer research as well as an interdisciplinary ‘Team Medicine’ approach that has not only accelerated our understanding of varied aspects of carcinogenesis but has also been instrumental in developing novel therapeutic strategies. Full article

Recent studies indicate that food demand will increase by 35–56% over the period 2010–2050 due to population increase, economic development, and urbanization. Greenhouse systems allow for the sustainable intensification of food production with demonstrated high crop production per cultivation area. Breakthroughs in resource-efficient fresh food production merging horticultural and AI expertise take place with the international competition “Autonomous Greenhouse Challenge”. This paper describes and analyzes the results of the third edition of this competition. The competition’s goal is the realization of the highest net profit in fully autonomous lettuce production. Two cultivation cycles were conducted in six high-tech greenhouse compartments with operational greenhouse decision-making realized at a distance and individually by algorithms of international participating teams. Algorithms were developed based on time series sensor data of the greenhouse climate and crop images. High crop yield and quality, short growing cycles, and low use of resources such as energy for heating, electricity for artificial light, and CO₂ were decisive in realizing the competition’s goal. The results highlight the importance of plant spacing and the moment of harvest decisions in promoting high crop growth rates while optimizing greenhouse occupation and resource use. In this paper, images taken with depth cameras (RealSense) for each greenhouse were used by computer vision algorithms (Deepabv3+ implemented in detectron2 v0.6) in deciding optimum plant spacing and the moment of harvest. The resulting plant height and coverage could be accurately estimated with an R² of 0.976, and a mIoU of 98.2, respectively. These two traits were used to develop a light loss and harvest indicator to support remote decision-making. The light loss indicator could be used as a decision tool for timely spacing. Several traits were combined for the harvest indicator, ultimately resulting in a fresh weight estimation with a mean absolute error of 22 g. The proposed non-invasively estimated indicators presented in this article are promising traits to be used towards full autonomation of a dynamic commercial lettuce growing environment. Computer vision algorithms act as a catalyst in remote and non-invasive sensing of crop parameters, decisive for automated, objective, standardized, and data-driven decision making. However, spectral indexes describing lettuces growth and larger datasets than the currently accessible are crucial to address existing shortcomings between academic and industrial production systems that have been encountered in this work. Full article

Amyloidosis refers to a clinically heterogeneous group of disorders characterized by the extracellular deposition of amyloid proteins in various tissues of the body. To date, 42 different amyloid proteins that originate from normal precursor proteins and are associated with distinct clinical forms of amyloidosis have been described. Identification of the amyloid type is essential in clinical practice, since prognosis and treatment regimens both vary according to the particular amyloid disease. However, typing of amyloid protein is often challenging, especially in the two most common forms of amyloidosis, i.e., the immunoglobulin light chain amyloidosis and transthyretin amyloidosis. Diagnostic methodology is based on tissue examinations as well as on noninvasive techniques including serological and imaging studies. Tissue examinations vary depending on the tissue preparation mode, i.e., whether it is fresh-frozen or fixed, and they can be carried out by ample methodologies including immunohistochemistry, immunofluorescence, immunoelectron microscopy, Western blotting, and proteomic analysis. In this review, we summarize current methodological approaches used for the diagnosis of amyloidosis and discusses their utility, advantages, and limitations. Special attention is paid to the simplicity of the procedures and their availability in clinical diagnostic laboratories. Finally, we describe new methods recently developed by our team to overcome limitations existing in the standard assays used in common practice. Full article

Background: The KSA government has envisioned a national transformation plan via Vision 2030. The purpose of this plan is liberalization which provides an opportunity for the private sector to increase its share in the healthcare system. Evaluating the entrepreneurial potential of healthcare students is essential due to their future role in the healthcare environment. Thus, the goal of the current study is to measure entrepreneurial intentions and identify the characteristics and personality dimensions among junior healthcare students and fresh graduates in Saudi Arabia. Materials and methods: A cross-sectional study design was utilized to survey healthcare students in their final years of study and fresh graduates at King Faisal University (KFU), Saudi Arabia. The research team identified six as the most common entrepreneurial intention traits. Entrepreneurial traits included internal locus of control, innovativeness, risk-taking, proactiveness, autonomy, and problem-solving. A previously recognized and validated questionnaire was distributed through social media platforms and formal university emails. PLS-SEM was employed for the examination of both the measurement and structural models. Results: Internal locus of control was found to have a positive impact on entrepreneurial intention, so H1 was supported. Likewise, innovativeness showed a positive impact on entrepreneurial intention among healthcare students, which confirmed H2. The results also showed that autonomy substantially impacted entrepreneurial intention, so H3 was supported. Similarly, proactiveness has a direct influence on entrepreneurial intention; thus, H5 was supported. Furthermore, problem-solving personality dimensions also had a positive impact on entrepreneurial intention, so H5 and H6 were supported. Conversely, risk-taking propensity exhibited a negative insignificant effect on entrepreneurial intention. Thus, H4 was not supported. Conclusions: Saudi healthcare students revealed their intention towards entrepreneurship and were quite positive about becoming entrepreneurs. Furthermore, students’ entrepreneurial intention was affected by their quality of proactiveness, innovativeness, internal locus of control, problem-solving, and autonomy but not risk-taking propensity. Full article

Graphic designers play an important role in producing various types of designs to meet the promotional needs of a business, especially in today’s digital media industry. This is closely related to marketing at Kumparan which requires design execution through the visual marketing team. Kumparan is an Indonesia’s leading digital news media platform, leveraging data and innovation to deliver fresh content to millions of readers daily through world-class storytelling and journalism. This paper shows the role of a graphic designer carrying out creative execution on the Kumparan visual marketing team in meeting the needs of KumparanPLUS premium content that tries to keep up with the times and the transformation of the new media industry with an interactive communication approach. The focus of KumparanPLUS is the provision of premium content to meet the information needs of the various types of Indonesian people with attractive visual presentations in the form of cover collections, cover stories, social media content, and infographics. This research is observational research conducted at Kumparan. The data were obtained from interviews, observations, assessments, and applications of graphic design practices. The contribution of a graphic designer will be seen through the results of creative execution to produce content with high engagement and achievements on the social media platform Instagram which has experienced a drastic increase from the number of followers of 11,000 within 4 months, as well as the interaction of each audience from each post. With the activities of the visual marketing team itself, it is expected to be able to achieve the main goal of premium content, namely brand loyalty. Full article

Improving hygiene practices is considered to be the single most cost-effective means of reducing the global health burden of infectious diseases. Hygiene promotion and disease prevention interventions often portray and promote “hygiene” from a biomedical perspective, which may not be optimally effective for achieving their goal of changing people’s behaviors. This study aimed to educe the meaning of hygiene for the residents of a low-income community in Bangladesh and how that meaning shapes their personal hygiene practices. We conducted this study in the Tongi township in Dhaka, Bangladesh, from September 2014 to June 2016. The research team purposively selected 24 households. The team conducted day-long observations using the participant observation approach and in-depth interviews with specific members of the 24 households. The concept of “hygiene” had two separate meanings to the study participants: cleanliness and holiness. The participants reported that cleanliness was required to remove odors, grease, hot spices and dirt. The motivation for cleanliness was to feel fresh, avoid heavy feelings, feel light and feel comfortable. To maintain the holiness of the body, bathing and ablution needed to be performed following particular religious rules/rituals. The motivation of holiness was derived from their accountability to God. The participants also reported that the cleansing processes and methods for the body and the home for cleanliness reasons were also different from those for holiness reasons. The notion of “hygiene” was multidimensional for the residents of the low-income urban community in Bangladesh. Our study participants did not explicitly conceptualize a notion of hygiene that was based on the germ theory of diseases but rather a notion that was based on individual physical comfort and cultural belief systems. Future studies on the prevention of hygiene-related diseases should combine and link the biomedical aspect to religious and cultural rituals to promote improved hygiene practices. Full article

Malaria elimination urgently needs novel antimalarial therapies that transcend resistance, toxicity, and high costs. Our multicentric international collaborative team focuses on developing multistage antimalarials that exhibit novel mechanisms of action. Here, we describe the design, synthesis, and evaluation of a novel multistage antimalarial compound, ‘Calxinin’. A compound that consists of hydroxyethylamine (HEA) and trifluoromethyl-benzyl-piperazine. Calxinin exhibits potent inhibitory activity in the nanomolar range against the asexual blood stages of drug-sensitive (3D7), multidrug-resistant (Dd2), artemisinin-resistant (IPC4912), and fresh Kenyan field isolated Plasmodium falciparum strains. Calxinin treatment resulted in diminished maturation of parasite sexual precursor cells (gametocytes) accompanied by distorted parasite morphology. Further, in vitro liver-stage testing with a mouse model showed reduced parasite load at an IC₅₀ of 79 nM. A single dose (10 mg/kg) of Calxinin resulted in a 30% reduction in parasitemia in mice infected with a chloroquine-resistant strain of the rodent parasite P. berghei. The ex vivo ookinete inhibitory concentration within mosquito gut IC₅₀ was 150 nM. Cellular in vitro toxicity assays in the primary and immortalized human cell lines did not show cytotoxicity. A computational protein target identification pipeline identified a putative P. falciparum membrane protein (Pf3D7_1313500) involved in parasite calcium (Ca²⁺) homeostasis as a potential Calxinin target. This highly conserved protein is related to the family of transient receptor potential cation channels (TRP-ML). Target validation experiments showed that exposure of parasitized RBCs (pRBCs) to Calxinin induces a rapid release of intracellular Ca²⁺ from pRBCs; leaving de-calcinated parasites trapped in RBCs. Overall, we demonstrated that Calxinin is a promising antimalarial lead compound with a novel mechanism of action and with potential therapeutic, prophylactic, and transmission-blocking properties against parasites resistant to current antimalarials. Full article

Background: Many countries rely upon subdural grid electroencephalography in the planning of epilepsy surgeries. However, craniotomy for subdural grid implantation is known to result in a variety of complications and requires diligence from the surgical team. We describe a minimally invasive method of subdural grid insertion, termed the linear oblique craniectomy, designed to mitigate complications and increase ease of subdural grid insertion. Objective: To demonstrate feasibility of minimally invasive subdural grid insertion utilizing skull anatomy. Methods: Three fresh frozen and embalmed human cadavers underwent surface landmarking and craniectomy to introduce a 4 × 5 cm² subdural grid over the Sylvian fissure. Anteroposterior lens-shaped craniectomy measured 5 cm in length with 1 cm maximal width. The dura mater was longitudinally incised, and subdural grids were introduced over the Sylvian fissure. Results: The total area of the craniectomy created by the linear oblique approach consists of only approximately 20% of the total area removed by the traditional approach to access the Sylvian fissure for mesial temporal epilepsy monitoring/preoperative planning. The locations of the grids were evaluated by MRI and computed tomography scans postoperatively to ensure accurate alignment with the Sylvian fissure. Conclusion: In this cadaveric study, we demonstrate the linear oblique craniectomy procedure that provides an alternative approach to subdural grid implantation with significantly decreased invasiveness. This surgical approach has the potential of reducing complication rates of subdural grid insertion for surface monitoring of the brain activity and/or neuromachine interface analysis and is associated with significant reduction of surgical time. Full article