Search Results (52)

Extracorporeal membrane oxygenation (ECMO) is increasingly used to support critically ill adults with severe cardiac or respiratory failure, but ECMO circuits and the physiological disturbances of critical illness significantly alter drug pharmacokinetics (PK) and pharmacodynamics (PD), complicating dosing and monitoring. This narrative review synthesizes current clinical evidence on ECMO-related PK/PD alterations and provides practical guidance for optimizing pharmacotherapy in adult intensive care. A structured literature search (January–May 2025) was conducted across PubMed/MEDLINE, EMBASE, Scopus, Cochrane Library, Sage Journals, ScienceDirect, Taylor & Francis Online, SpringerLink, and specialized databases, focusing on seven therapeutic classes commonly used in ECMO patients. Eligible studies included clinical trials, observational studies, systematic reviews, and practice guidelines in adults, while pediatric and preclinical data were excluded. Evidence quality varied substantially across drug classes. Hydrophilic, low-protein-bound agents such as β-lactams, aminoglycosides, fluconazole, and caspofungin generally showed minimal ECMO-specific PK alterations, with dose adjustment mainly driven by renal function. Conversely, lipophilic and highly protein-bound drugs including fentanyl, midazolam, propofol, voriconazole, and liposomal amphotericin B exhibited substantial circuit adsorption and variability, often requiring higher loading doses, prolonged infusions, and rigorous therapeutic drug monitoring. No ECMO-specific data were identified for certain neuromuscular blockers, antivirals, and electrolytes. Overall, individualized dosing guided by therapeutic drug monitoring (TDM), organ function, and validated PK principles remains essential to optimize therapy in this complex population. Full article

Energy conservation, rooted in the time invariance of physical laws and formalized by Noether’s theorem, requires that systems with space-time translational symmetry conserve momentum and energy. This work examines how this principle applies to a charged retarded field engine, where the rate of change of total energy—mechanical plus field energy—is balanced by the energy flux through the system’s boundary. Using electric and magnetic field expressions from a Taylor expansion to incorporate retardation effects, we analyze the energy equation order by order for two arbitrary charged bodies. Our results show that total energy is conserved up to the fourth order, with mechanical and field energy changes exactly offset by boundary energy flux. Consequently, the work done by the internal electromagnetic field precisely equals the engine’s gained mechanical kinetic energy, addressing the central focus of this study. Full article

Melt electrowriting (MEW) is an advanced additive manufacturing technology that can produce micro- or nano-scale fibres, achieving accurate fibre deposition, and is suitable for manufacturing high-precision, miniature products. This review introduces the key principles and parameters that influence the performance of melt electrowriting and explores the current mathematical modelling under four stages: (1) heating and extrusion system, (2) formation of the Taylor cone, (3) formation and injection of the melt jet, and (4) deposition of the melt jet. In addition, current applications of melt electrowriting in emerging areas, such as tissue engineering, energy, filtration, and bioengineering, are introduced while discussing its combination with other additive manufacturing technologies. Finally, recent challenges, including production time, cost, and precision are covered, while the future research directions are to improve technology and introduce new materials. Full article

The point-kernel (PK) technique has a long history in applied radiation shielding, originating from the early days of digital computers. The PK technique applied to gamma-ray attenuation is one of many successful applications, based on the linear superposition principle applied to distributed radiation sources. Mathematically speaking, the distributed source will produce a detector response equivalent to the numerical integration of the radiation received from an equivalent number of point sources. In this treatment, there is no interference between individual point sources, while inherent limitations of the PK method are its inability to simulate gamma scattering in shields and the usage of simple boundary conditions. The PK method generally works for gamma-ray shielding with corrective B-factor for scattering and only specifically for fast neutron attenuation in a hydrogenous medium with the definition of cross section removal. This paper presents theoretical and programming aspects of the PK program developed for a distributed source of photons (line, disc, plane, sphere, slab volume, etc.) and slab shields. The derived flux solutions go beyond classical textbooks as they include the analytical integration of Taylor B-factor, obtaining a closed form readily suitable for programming. The specific computational modules are unified with a graphical user interface (GUI), assisting users with input/output data and visualization, developed for the fast radiological characterization of simple shielding problems. Numerical results of the selected PK test cases are presented and verified with the CADIS hybrid shielding methodology of the MAVRIC/SCALE6.1.3 code package from the ORNL. Full article

An efficient numerical approach utilizing a variational weak form, grounded in 2D elastic theory and variational principles, is proposed for analyzing the in-plane vibrational behavior of rectangular plates resting on elastically restrained boundaries. The differential and integral operators can be discretized into matrix representations employing the differential quadrature method (DQM) and Taylor series expansion techniques. The discretization of dynamics equations stems directly from a weak formulation that circumvents the need for any transformation or discretization of higher-order derivatives encountered in the corresponding strong equations. Utilizing the matrix elementary transformation technique, the displacements of boundary and internal nodes are segregated, subsequently leading to the derivation of the generalized eigenvalue problem pertaining to the free vibration analysis of the Functionally Graded Material (FGM) rectangular plate. Furthermore, the study examines the impact of the gradient parameter, aspect ratio, and elastic constraints on the dimensionless frequency characteristics of the FGM rectangular plate. Ultimately, the modal properties of an in-plane FGM rectangular plate are investigated. Full article

Accurate measurement of pipeline flow is of great significance for industrial and environmental monitoring. Traditional intrusive methods have the disadvantages of high cost and damage to pipeline structure, while non-intrusive techniques can circumvent such issues. Although Taylor’s frozen hypothesis has a theoretical advantage in non-intrusive velocity detection, current research focuses on planar flow fields, and its applicability in turbulent circular pipes remains controversial. Moreover, there is no precedent for combining it with distributed acoustic sensing (DAS) technology. This paper constructs a circular pipe turbulence model through large eddy simulation (LES), revealing the spatiotemporal distribution characteristics of turbulent kinetic energy and the energy propagation rules of FK spectra. It proposes a dispersion feature enhancement algorithm based on cross-correlation, which combines a rotatable elliptical template with normalized cross-correlation coefficients to suppress interference from non-target directions. An experimental circulating pipeline DAS measurement system was set up to complete signal denoising and compare two principles of flow velocity verification. The results show that the vortex structure of turbulent flow in circular pipes remains stable in the convection direction, conforming to theoretical premises; the relative error of average flow velocity by this method is ≤3%, with significant improvements in accuracy and stability in high-flow zones. This study provides innovative methods and experimental basis for non-intrusive flow detection using DAS. Full article

This article explores the role of religion in nation-building by examining its public dimensions within the evolving context of secularism in Québec. By examining the shift from open secularism, recommended by the Bouchard–Taylor Commission report of Building the Future, a Time for Reconciliation (2008), to a more rigid form under Bill 21, the study critiques Bill 21’s marginalization of religious minorities and explores the broader tension between state neutrality and religious participation in public life. Drawing on Rajeev Bhargava’s concept of “principled distance”, the author advocates for a flexible secular framework that balances institutional neutrality with ethical commitments to equity and justice. Through case studies, including the accommodation of Sikh turbans in the RCMP and the United Church of Canada’s support for same-sex marriage, the article illustrates how religious engagement fosters bridging social capital and enacts public religion, thereby enriching democratic discourse. This article insists on the limitations of rigid secularism in its dealings with pluralism and proposes that principled distance offers a more inclusive approach, allowing constructive religious contributions to civic life without undermining secular governance. Ultimately, the study promotes a vision of secularism that honors differences and encourages religious participation in nation-building. Full article

Over the last 25 years, research on geoparks has moved from basic research to comprehensive multidisciplinary studies related to the creation and development of geoparks, integrating the principle of sustainability. This research focuses on exploring geoparks as the core subject. The aim of this study is to synthesize the heterogeneous body of knowledge about geoparks in an exhaustive way by leveraging a multi-database bibliometric approach. The methodology applied is based on quantitative bibliometric analysis using R, including its application for non-coders and ensuring reliability with the PRISMA Statement framework. Ten databases were taken as the sources of research papers: Web of Science, Scopus, PubMed, Nature Journals, SpringerLink, Taylor & Francis, Wiley Journals, IEEE Xplore, and CABI. The method we used has limitations, providing a restricted number of trends aligned and scaled to the database boundary conditions used in analysis. The main goals of quantitative bibliometric analysis are as follows: (1) The impact of data integration—Evaluating how merging the data from the ten databases improves research coverage. (2) Global research trends—Identifying the evolution of geopark-related studies over time. (3) Three-year forecast—Predicting the upcoming research directions using a polynomial regression model. (4) Academic performance—Assessing geographical distribution, citation impact, and productivity using bibliometric laws. (5) Conceptual contribution—Identifying the key research themes that drive future studies and potential areas for exploration. Among these, we highlighted the key elements. The integration of the ten databases provides 63% greater insight into scientific research compared to that of the Web of Science (WoS) database. Geographically, the scientific output spans 102 countries, with China leading in production over the last two decades. The most impactful paper has accumulated 768 citations, while Ruben D.A. and Wu Fandong emerge as the most prolific authors. According to the bibliometric law, the core source of scientific output is Geoheritage. The future research directions are expected to address global challenges, particularly natural disasters in alignment with the Sustainable Development Goals (SDGs). Additionally, GIS-based subtopics leveraging advanced technologies for analyzing, mapping, and promoting geological resources represent a promising area for further exploration. The projections indicate that by the end of 2026, scientific production in this field could reach 5226 published papers, underscoring the growing significance of geopark research and interdisciplinary advancements. Full article

The Taylor–Quinney coefficient (TQC) is a critical parameter quantifying the thermal conversion of plastic work during deformation in metallic crystals. This review provides a comprehensive summary of recent advances in TQC research, spanning experimental, theoretical, and computational perspectives. The fundamental principles of the TQC are introduced, emphasizing its thermodynamic background and dependence on microstructural features. Experimental studies demonstrate how the strain rate, temperature, and microstructure influence the TQC, with advanced techniques such as infrared thermography and high-speed imaging enabling precise measurements under dynamic conditions. Theoretical models, including internal variable frameworks and nonequilibrium thermodynamics, offer insights into the energy distribution mechanisms and provide predictive capabilities across diverse loading scenarios. Computational simulations, using methods like finite element analysis and molecular dynamics, reveal multiscale thermal conversion mechanisms and the role of dislocation motion and localized heat accumulation in governing TQC values. Challenges and opportunities for TQC research are highlighted, including the need for multiscale modeling, the exploration of complex stress states, and applications under extreme environments. Future directions should focus on integrating advanced experimental techniques and computational models to optimize material design and performance. This review aims to deepen the understanding of the TQC and its implications for energy dissipation and material reliability in high-performance applications. Full article

The Lucas balancing polynomial is linked to a family of bi-starlike functions denoted as ${\mathcal{S}}_{sc}^c(\vartheta ,\Xi \left(x\right))$, which we present and examine in this work. These functions are defined with respect to symmetric conjugate points. Coefficient estimates are obtained for functions in this family. The classical Fekete–Szegö inequality of functions in this family is also obtained. Full article

This article examines whether Banco de la República (Banrep), Colombia’s central bank, has operated under a dual-regime policy framework—one for recessionary periods and another for periods of economic overheating—since adopting inflation targeting (IT) from Q4 2000 to Q4 2019. We modify the canonical New Keynesian inflation model to accommodate an optimal nonlinear monetary rule aligned with a two-regime policy framework. Using a LSTAR model estimated over the study period, with the output gap lagged by three periods as the transition variable, we identify two distinct monetary regimes. Our findings reveal that the smooth transitions between regimes were driven by shifts in Banrep’s preferences related to its loss function, alongside adjustments in the parameters of the aggregate demand and supply curves within the Colombian economy. Notably, we observe that a modified Taylor principle is not met in either identified monetary regime. This suggests that, in this context, IT has been a successful policy framework even without requiring the policy interest rate to respond aggressively to inflation gaps, as the Taylor principle would otherwise dictate. Full article

The contemporary American university largely operates as an agent of domestication, tasked more with enforcing the social and economic order than with expanding the horizons of possibility. The dawn of the Anthropocene, however, demands that we reconceive of the humanities not as self-sufficient, hierarchical, or divided away from other modes of seeking knowledge but as core to what human being and responsibility ought to mean in the more-than-human world. The present essay makes a case for reworking—and rethinking—the American university along the lines of Mark C. Taylor’s prompt to reconceive of the academy as a multidisciplinary forum for the “comparative analysis of common problems”. I suggest that religious teachings—and religious traditions themselves—can offer models for the intertwining of the humanities (literature, poetry, philosophy, the expressive and applied arts), the social sciences (the study of governance, political thought, the study and formulation of law), and the natural sciences as well as mathematics and engineering. Further, I argue that when faced with radical and unprecedented changes in technological, social, economic, and environmental structures, we must, I believe, engage with these traditional texts in order to enrich and critique the liberal mindset that has neither the values nor the vocabulary to deal with the climate crisis. We must begin to sow new and expansive ways of thinking, and I am calling this work the “rewilding” of our universities. Parallel to the three Cs of rewilding as a conservation paradigm, I suggest the following three core principles for the rewilding of higher education: creativity, curriculum, and collaboration. Though I focus on the interface of religion, ecology, and the study of the environmental, social, and moral challenges of climate change, I suggest that these categories of activity should impact all domains of inquiry to which a university is home. Full article

We present a novel application of transcendental equations for nonlinear distance optimization in hyperbolic space. Through asymptotic approximations using Fourier and Taylor series expansions, we obtain approximations for the transcendental equations with non-zero real values on the boundary λ. The series expansion of the logarithmic form of our equations around two arbitrary points P₁ and P₂ can be used to find values close to definite coordinates on λ. Applying principles from the Poincaré hyperbolic disk—a non-Euclidean space with constant negative curvature—we construct optimization methods following λ of our transcendental equations. Full article

A re-examination of some early classic turbulence literature, mainly of isotropic turbulence, is given in this selective review. Some early studies, including original concepts and points, are reviewed or highlighted. Two earliest studies and six major original concepts are found: (i) Lord Kelvin’s pioneering elementary studies of homogeneous, isotropic turbulence; (ii) Kelvin’s early introduction of Fourier Principles into turbulence studies; (iii) the Kelvin elementary concept of the direct energy cascade; (iv) the Kelvin early concept of the symmetry of turbulence; (v) the Taylor concept of the coefficient of eddy viscosity; (vi) the Taylor concept of the ‘age’ of the eddy; (vii) the Taylor–Fage–Townend concept of small eddies or microturbulence or small scale turbulence; and (viii) the Obukhov concept of a function of the inner Reynolds number (i.e., $Re$ dependent coefficient) in both the balance equation and the energy distribution equation (the two-thirds law). Both Kelvin and Taylor should be regarded as the co-founders of the statistical theory of homogeneous, isotropic turbulence. The notion, ‘the Maxwell–Reynolds decomposition of turbulent flow velocity’, should be used. The Kolmogorov–Obukhov scaling laws are reviewed in detail. Heisenberg’s inverse seventh power spectrum is briefly reviewed. The implications or significances of these early studies, original concepts and points are briefly discussed, with special reference to their possible links with modern approaches and theories. Full article