Search Results (63)

Activating mutations in the epidermal growth factor receptor (EGFR) are key oncogenic drivers across multiple cancers, yet the structural mechanisms by which these mutations promote persistent receptor activation remain elusive. Here, we investigate how three clinically relevant mutations—T790M, L858R, and the T790M_L858R double mutant—reshape EGFR’s conformational ensemble and regulatory network architecture. Using multiscale molecular simulations and kinetic modeling, we show that these mutations, particularly in combination, enhance flexibility in the αC-helix and A-loop, favoring activation-competent states. Markov state modeling reveals a shift in equilibrium toward active macrostates and accelerated transitions between metastable conformations. To resolve the underlying coordination mechanism, we apply neural relational inference to reconstruct time-dependent interaction networks, uncovering the mutation-induced rewiring of allosteric pathways linking distant regulatory regions. This coupling of conformational redistribution with network remodeling provides a mechanistic rationale for sustained EGFR activation and suggests new opportunities for targeting dynamically organized allosteric circuits in therapeutic design. Full article

The sustainable development of autonomous vehicles (AVs) depends on effective collaboration among the government–industry–academia (GIA). Drawing on the Triple Helix theory, this study examines how the GIA interacts within emerging AV ecosystems at the local level. A qualitative research design was employed, including policy reviews and in-depth semi-structured interviews with key stakeholders in Suzhou’s AV ecosystem, to gain a detailed understanding of the collaborations. Our findings revealed three bottlenecks: (1) fragmented governance across administrative districts, which blurs responsibility for infrastructure investment and policy alignment; (2) short-term, project-based industry partnerships that limit knowledge spillovers and marginalize smaller local firms; and (3) limited academic engagement in R&D, despite a strong output in basic research. These factors lock the AV ecosystem into a hybrid configuration between government-led (Triple Helix I) and industry-driven (Triple Helix II) models, constraining sustained innovation. The study argues that to strengthen the AV ecosystem, it is essential to establish a cohesive policy framework, promote cross-sector collaboration, and involve academia more deeply in addressing social, ethical, and regulatory concerns. This paper contributes to the GIA and Triple Helix literature by offering insights into the complexity of collaboration within a rapidly developing AV sector and providing recommendations for enhancing the effectiveness of GIA collaborations to foster sustainable AV development. Full article

Environmental degradation remains an increasingly urgent challenge, leading to focused debates at the Rio+20 conference (2012) on how to operationalise sustainability. This conference’s central theme was the green economy and the role of institutions in driving the transition to a more sustainable model. Today, concepts such as the green economy, circular economy, bioeconomy, and circular bioeconomy (CBE) are integral to institutional efforts towards sustainable development. The CBE has significant potential as a driver of sustainability. This article examines the challenges, opportunities, and governance structures that the Andalusian (Southern Spain) public administration is implementing in the context of the CBE. The findings are based on qualitative methods, with a comprehensive literature review, semi-structured interviews, and workshops with different stakeholders from the quadruple helix model, conducted as part of the ROBIN project and other related projects. The results systematises the main weaknesses and strengths collected during the fieldwork in terms of the tools of governance. The conclusions highlight the need to develop this model and outline the actions needed to develop the CBE further. Full article

The lack of access to centralized technologies and economic resources in rural communities makes wastewater management a critical challenge. Decentralized systems such as constructed wetlands offer sustainable solutions by leveraging natural processes for effluent treatment. However, their success and sustainability require active community participation. Currently, there is little evidence of community involvement in the implementation, maintenance, and management of constructed wetlands. Existing strategies for community collaboration in environmental and sanitation projects were analyzed through a literature review covering research conducted in the last 20 years. Only peer-reviewed research in English and Spanish was considered. Based on the findings, a triple helix model integrating academia, government, and society is proposed, compiling the most functional strategies from initial awareness raising to maintenance and dissemination. A case study of community participation is presented under this approach in the Salvador Díaz Mirón rural community, Veracruz, Mexico. The results of this study provide key information for effective strategies designed to manage constructed wetlands, emphasizing that their success depends on both the technology and the genuine commitment of communities to their operation and long-term sustainability. Furthermore, these findings can serve as a reference for decision-makers and project planners seeking to integrate participatory models into decentralized sanitation and water resource conservation. Full article

Industry 4.0 (I4.0) and Industry 5.0 (I5.0) represent important changes in industrial paradigms. I4.0 is centered on efficiency and competitiveness, and I5.0 adds sustainability, human-centricity, and resilience to the framework. Despite their growing relevance, much of the existing research remains techno-centric, neglecting the sociocultural and institutional forces shaping them. This study investigates how the transition from I4.0 to I5.0 is occurring using an institutional perspective. A qualitative methodology was employed, combining theoretical synthesis and secondary data analysis to develop an integrative model. The proposed model draws on insights from Institutional Theory, Scandinavian Institutionalism, Management Fashion, and Quintuple Helix, emphasizing the role of translation and diffusion in institutionalizing these paradigms. We maintain that both of them are fundamentally discursive, shaped by institutional pressures, shared meanings, and stakeholder interactions. I4.0 already allows for a heterogeneous vision adjusted to different perspectives and stakeholders. I5.0 goes further by responding to criticism about social and environmental issues and introducing resilience, especially after the COVID-19 pandemic and the ongoing climate crisis. As a result, I5.0 aligns with a broader range of actors and interests, increasing its potential for widespread acceptance and long-term impact. This research challenges deterministic views of technology, arguing that this new industrial revolution is not eminently technology-driven but instead emphasizes the central role of discourse and institutional processes in shaping its development. Full article

The Circular Economy (CE) has become an essential management model to address the environmental challenges of the traditional linear model employed by companies, protecting society and ecosystems from resource depletion and intensified ecological emissions. Thus, this study proposes a framework with recommendations for CE implementation, structured around the Triple Helix (TH) model and designed to be government-led in guiding joint actions among government, organizations, and academia. The framework comprises 21 recommendations distributed across six interconnected stages: (1) Policy Generation from Academic Inputs, (2) Development of Pilot Projects with Industry, (3) Analysis and Academic Validation of Results, (4) Policy Improvement and Scaling, (5) Promotion of Innovation and Technology Transfer, and (6) Global Connection and Replicability. These stages collectively enhance policies and practices, accelerating the transition to a CE. This framework underscores the importance of regionally adapted public policies, technological innovations to extend material lifespans, and the promotion of conscious consumption. It also emphasizes the need for intersectoral collaboration to foster sustainability and efficiency in resource management. Methodologically, this study employs an integrative review to map technical and scientific CE practices in the United Kingdom, China, and the United States. The theoretical contribution validates the TH model as a strategic tool for developing the CE. Furthermore, the practical contribution is the structured pathway to implementing the CE, detailing the main phases of collaboration among TH actors to ensure the effective operationalization of circular strategies. Full article

Quadruple Helix open innovation ecosystems are gaining relevance as they incorporate different actors with different perspectives, contributing significantly to the development of social innovation communities that are more responsive to today’s social and environmental challenges. The Horizon Europe INTEGER project aims to better understand how social and economic innovation actors can be effectively integrated into European innovation ecosystems to address critical sustainability challenges. An exploratory and qualitative study was conducted, using three different focus groups (partners, stakeholders, and driving group) and analysing the intra- and inter-regional health and wellbeing ecosystems of three European regions (Krakow, Hamburg, and Catalonia). The results propose a systemic model based on a new generation of Living Labs, called Collaboratories, that involves the actors of social and economic innovation and facilitates a holistic understanding of the interconnected dimensions of the ecosystem, where all the dimensions interact to drive sustainable impact. In addition, this study highlights the key role of the facilitator who guides the group process from the beginning to the achievement of the objective, as well as the adaptation when it comes to scaling and replication, as each ecosystem has a particular level of maturity. Full article

Background: The hypoglycemic activity of mulberry leaf polyphenols has been widely studied, while its mechanism of action needs further elucidation. Methods: The inhibitory activity mechanism of astragalin on α-glucosidase was investigated with a combination of multispectroscopic techniques and molecular docking. The hypoglycemic pathway was further revealed with a high-glucose human hepatocellular carcinomas (HepG2) cell model. Results: The results indicated that astragalin inhibited α-glucosidase with IC₅₀ of 154.5 µM, which was the highest in potency among the main polyphenols from mulberry leaves. Astragalin could bind to α-glucosidase with a single inhibition site and quench its endofluorescence with a static quenching mechanism. Astragalin changed the secondary structure of α-glucosidase, and the decreased α-helix content, representing the un-folding conformation, resulted in the decreased activity. The molecular docking further indicated that two sustainable hydrogen bonds were generated between astragalin and α-glucosidase residue Ser-88 and Tyr-133. The main driving forces to form the astragalin-α-glucosidase complex were the van der Waals force and hydrogen bond. Astragalin at a concentration of 80 µg/mL obtained the best hypoglycemic effect by activating the Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway. Conclusions: This study provides new insights into the potential utilization of astragalin-rich foods in the improvement of diabetes mellitus. Full article

Blue Biotechnology (BBt) is a young and promising sector in the Mediterranean region with the potential to drive innovation and strengthen the Blue Economy (BE). However, its progress is constrained by fragmented coordination among stakeholders, impeding policy development and efficient resource management. Under this context, this study investigates the role of networks of diverse stakeholders, particularly the Spanish Blue Biotechnology Hub (BBHub) and a digital tool, ICT Matchmaking Tool (which connects network actors), in addressing these challenges by fostering collaboration, enhancing governance and supporting sustainable innovation. Building on this, the research employed the quadruple helix model (administrations, academia and research, industry and society), engaging 214 individuals from 130 organizations in the BBHub network. A survey assessed participants’ involvement and influence perceptions, followed by the formation of a discussion group “called sherpa group” of 10 key stakeholders for in-depth discussions through semi-structured interviews and meetings. Through this approach, key barriers to BBt and potential solutions for BE sustainable growth in Spain were identified, including regulatory obstacles, limited funding or weak public-private collaboration. Among the solutions proposed were the simplification of administrative processes to create new business, the creation of specific funding opportunities or the implementation of labelling policies to promote BBt products and value chains. Considering these findings, the study demonstrates that the BBHub network and ICT Matchmaking Tool could enhance stakeholder coordination, governance and decision-making processes in Spain. By addressing these gaps, these tools enable collaboration and better coordination among actors, contributing to sustainable marine resource use and innovation in the BBt and BE sector. However, sustained progress requires stable funding and stronger stakeholder commitments. In turn, as a broader implication, this research provides a replicable model for leveraging open innovation and multi-stakeholder frameworks to promote coordination, policy development and sustainable growth in the BBt and BE sectors. Thus, it offers insights into addressing governance challenges in Spain and the Mediterranean, advancing the use of marine bioresources through collaborative approaches. Full article

There have been many discussions about the business ecosystem in order to promote the sustainable growth of firms recently. Business ecosystems have developed independently from three perspectives: business, innovation, and the platform ecosystem. However, considering the emergence of advanced technology and social values, there is a growing need to look at business ecosystems from an integrated point of view. Based on a new win–win platform combining these discussions, we have designed and demonstrated a sustainable business innovation ecosystem (SBIE) framework. Using the triple helix model, data were collected from 290 experts—industry (95), government (100), and university (95)—in Korea. Results show that firms should consider social values as well as economic values when building a SBIE. The findings also emphasize that performances are more effective when core agents of ecosystem build a win–win platform using the fourth industrial revolution (FIR) technology. Full article

Heritage has increasingly emerged as a pivotal medium for driving and adapting to change, and as an integral component of innovation ecosystems. In the ongoing participatory turn in governance, the management of collective heritage resources reflects a broader paradigm shift aimed at fostering sustainable socio-technical transformations. Far from being static relics of the past, heritage assets function as dynamic agents of innovation, thus influencing various dimensions of contemporary life. This research sheds light on heritage as a vibrant force for transformation and adjustment, showcasing its ability to position itself as a crucial component that both enables and guides broader processes of innovation. It emphasises how heritage sites, characterised by their transitional nature and ‘ex’ and ‘post’ identities, have become arenas for creative regeneration and socio-cultural, technical, territorial, and knowledge-based innovation. By utilising helical models and Schumpeter’s theory of creative destruction, this article underscores the transformative power of heritage to address global disruptions through heritage-driven innovations, drawing on three heritage and creative destruction categorizations. This highlights how heritage actively shapes innovative knowledge spaces while fostering urban and social regeneration, positioning it as a vital tool for rebuilding and reimagining sustainable futures. By exploring diverse local heritage transformation initiatives across different regions, this research unveils three heritage helix models that showcase the dynamic process of change management through heritage. These models offer a framework for guiding future heritage projects, fostering innovative knowledge spaces and inspiring sustainable transformations. Full article

It has been propagated by scholars and practitioners that entrepreneurship and innovation are potent tools that can be harnessed to transform rural areas, grow rural economies, create jobs, and enhance the prospects of attaining sustainable development goals (SDGs). Subsequently, these disciplines have garnered attention from researchers for virtually a century. Nonetheless, these researchers often focused on entrepreneurship and innovation activities in urban areas, thereby neglecting entrepreneurship and innovation activities in rural areas. Thus, there is a paucity of literature on rural entrepreneurship and innovation in the BRICS economies. Within the context of the agency theory and the Triple Helix Model of industrial policy, this study systematically reviews the literature on rural entrepreneurship and innovation in the Republic of South Africa. The study revealed that rural firms are risk-averse, which challenges the doctrine of rural transformation through rural entrepreneurship and innovation. Moreover, the ability to engage in entrepreneurship and innovation by rural firms is highly dependent on the availability of support from the government and actor networks. Subsequently, rural firms fail when support has been phased out. Thus, the government and actor networks should do things differently, with an emphasis on teaching rural firms to be independent and sustainable entrepreneurs and innovators. Full article

This article provides a comprehensive examination of sustainable 6G wireless communication systems, addressing the urgent need for environmentally friendly and energy-efficient networks. The background establishes the broader context and significance of the study, emphasizing the escalating concerns surrounding the environmental impact and energy consumption of wireless communication systems. The purpose of this study is to explore and propose sustainable solutions for 6G networks. The methods employed in this research encompass an analysis of various strategies and technologies, including energy-aware network design, dynamic power management, energy harvesting, and green infrastructure deployment. The main findings of this article highlight the effectiveness of these approaches in enhancing energy efficiency, reducing carbon footprint, and optimizing resource management in 6G networks. The conclusions drawn from this study emphasize the importance of sustainable 6G wireless communication systems in achieving a more eco-friendly and energy-efficient future. It is crucial to adopt these sustainable practices to minimize environmental impact and address the increasing energy demands of wireless communication networks. The article provides valuable insights to researchers, industry practitioners, and policymakers, aiding in the development and implementation of sustainable practices for 6G wireless communication systems. Full article

From the perspective of energy efficiency and environmental sustainability, the scheduling problem in a flexible workshop with the utilization of automated guided vehicles (AGVs) was investigated for material transportation. Addressing the dual-constrained integrated scheduling challenge involving machining machines and AGVs, a scheduling optimization model was established with makespan, workshop energy consumption, and processing quality as the optimization objectives. To effectively solve this model, an enhanced whale optimization algorithm (IWOA) was proposed. Specifically, nonlinear convergence factors, adaptive inertia weights, and improved helix positions were introduced into the standard whale optimization algorithm to update the model. Furthermore, a loss function was constructed based on fuzzy membership theory to obtain the optimal compromise solution of the multi-objective model. The research results indicate that: (1) The IWOA obtained the optimal solutions on benchmark instances MK01, MK02, MK04, MK07, and MK08; (2) The IWOA outperformed the WOA(1), WOA(2), WOA-LEDE, and NSGA-II algorithms in the two instances provided in this paper, demonstrating strong robustness of the model; (3) Although the multi-objective model constructed in this paper could not surpass the single-objective optimal solution in individual objectives, it achieved compensation in other objectives, effectively balancing the trade-offs among the makespan, workshop energy consumption, and processing quality of the three objectives. This research offers an effective practical approach to address green flexible workshop scheduling with AGV transportation. Full article

Industrial sectors’ innovative and sustainable development relies not only on solid government, society, academia, and industry but also on how they interact to set and implement strategic goals. In the fashion industry context, the new sociocultural scenario is increasingly driven by pressures from stakeholders to limit the impacts of industrial practices and to move toward new open ecosystems to create and maintain sustainable innovation. This article explores how such innovation can be enabled by design-driven actions in the context of the quadruple helix. Such a model aims to revitalize the areas of technological innovation and gradually advance the construction of the infrastructure needed for sustainable fashion growth, combining and integrating different knowledge. An initial literature review, complemented by case studies analysis, identifies the European fashion industry dynamics of innovation and the roles of industry, government, university, and society. In particular, the government is transforming from a mere controller to a facilitator of innovation synergies. Society relies on citizens revising their consumption habits by shifting toward a performative economy. Industry understands the need for collaboration and adopts new closed-loop supply chains to create and maintain its sustainable development. Universities enable new open system flows to make innovations concerning knowledge, technologies, and systems thrive, from technology transfer to knowledge co-creation. Based on the analysis, we propose a conceptual framework to understand the micro- and macro-dynamics of open innovation with a quadruple helix model to implement sustainability practices in the fashion sector through design-driven actions—reuse, repair, recycle, and refashion—that aim to eliminate the concept of waste to support local ecosystems toward establishing a closed-loop chain. Full article