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Search Results (16,855)

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16 pages, 5272 KB  
Article
Metagenomics Analysis of Viruses Associated with Cassava Brown Streak Disease in Kenya
by Florence M. Munguti, Katherine LaTourrette, Gonçalo Silva, Solomon Maina, Dora C. Kilalo, Isaac Macharia, Agnes W. Mwango’mbe, Evans N. Nyaboga and Hernan Garcia-Ruiz
Viruses 2026, 18(3), 395; https://doi.org/10.3390/v18030395 (registering DOI) - 21 Mar 2026
Abstract
Cassava brown streak disease (CBSD), caused by cassava brown streak virus (CBSV; Ipomovirus brunusmanihotis) and Ugandan cassava brown streak virus (UCBSV; Ipomovirus manihotis) (family Potyviridae, genus Ipomovirus), is increasingly becoming a threat to cassava production in several parts of [...] Read more.
Cassava brown streak disease (CBSD), caused by cassava brown streak virus (CBSV; Ipomovirus brunusmanihotis) and Ugandan cassava brown streak virus (UCBSV; Ipomovirus manihotis) (family Potyviridae, genus Ipomovirus), is increasingly becoming a threat to cassava production in several parts of Africa, especially in Eastern, Central and Southern Africa. In Kenya, the disease continues to wreak havoc on cassava production leading to a significant reduction in crop yields and economic losses of up to USD 1 billion. Variation in virus populations make the control of CBSD challenging as virus genomic variation can affect the accuracy of diagnostic tests, lead to resistance breaking isolates and jeopardize strategies of breeding for resistance. CBSV and UCBSV populations obtained from cassava fields in Kenya were characterized. In total, 44 new complete sequences of CBSV and UCBSV were assembled and 40 sequences successfully submitted to GenBank. Single Nucleotide Polymorphism (SNP) analysis revealed that the cylindrical inclusion protein (CI) is the most stable region across the genome of CBSV and UCBSV. In contrast, protein 1 (PI) and the coat protein (CP) were the most hypervariable regions. Phylogenetic analysis showed three major geographical groupings for both UCBSV and CBSV isolates, suggesting a continued spread of the viruses through human-mediated movement of infected planting materials. The data obtained in this study can support the development of disease management strategies through improved molecular diagnostic tests and targets for breeding for resistance against CBSD. Full article
(This article belongs to the Special Issue Viroinformatics and Viral Diseases)
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44 pages, 4688 KB  
Review
Research Status on Metal Surface Wear and Protection of Grain Combine Harvesters: A Review
by Yuting Dong, Yuxi Gao, Yuyuan Qiao, Qi He and Zhong Tang
Lubricants 2026, 14(3), 136; https://doi.org/10.3390/lubricants14030136 (registering DOI) - 21 Mar 2026
Abstract
Combine harvesters are core modern grain production equipment with high reliability, critical for food security. Yet their metal parts suffer severe grain-induced wear during operation, directly reducing efficiency, increasing grain loss, and raising maintenance costs and environmental burdens. This paper clarifies the grain-induced [...] Read more.
Combine harvesters are core modern grain production equipment with high reliability, critical for food security. Yet their metal parts suffer severe grain-induced wear during operation, directly reducing efficiency, increasing grain loss, and raising maintenance costs and environmental burdens. This paper clarifies the grain-induced wear source characteristics and the dominant mechanisms and hazards for combine harvester metal surfaces, as well as summarizes the research progress of four key protection strategies: wear-resistant materials, surface engineering, structural and parameter optimization, and maintenance and remanufacturing. Based on the latest research data, the working principles, performance advantages and application scenarios of various protective technologies were analyzed. Current research faces several challenges: insufficient systematic wear data for multiple crops, unclear multi-factor coupled wear mechanisms, limited low-cost and long-lasting protective technologies, and the absence of online wear monitoring techniques. Finally, the directions for future research focus, such as the systematic research on the wear characteristics of multiple crops, the deepening of the wear mechanism of multi-factor coupling, the development of green, low-cost and long-term protection technologies, and the development of online wear monitoring and active control systems, are explored, providing theoretical support and technical reference for the transformation of wear control in combine harvesters, from passive maintenance to active protection throughout the entire life cycle. Such future work supports the high-quality development of agricultural mechanization and ensures food security. Full article
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25 pages, 57148 KB  
Article
Unraveling Hydrogeochemical Fingerprints, Formation Mechanisms and Quality Suitability of Groundwater Resource in the Eastern Qaidam Basin on the Tibetan Plateau
by Shaokang Yang, Zhen Zhao, Jiahao Liu, Lipeng Hou, Xu Guo, Guangbin Zhu, Zhihong Zhang, Liwei Wang, Mengyun Wang, Jie Wang and Yong Xiao
Appl. Sci. 2026, 16(6), 3043; https://doi.org/10.3390/app16063043 (registering DOI) - 21 Mar 2026
Abstract
Groundwater is a strategic resource for maintaining ecological balance and supporting human development in arid inland basins. However, under the dual pressures of climate change and human activities, it faces threats in both quantity and quality. This study selects the Chahan Usu River [...] Read more.
Groundwater is a strategic resource for maintaining ecological balance and supporting human development in arid inland basins. However, under the dual pressures of climate change and human activities, it faces threats in both quantity and quality. This study selects the Chahan Usu River watershed in the eastern Qaidam Basin, a typical arid inland basin on the Tibetan Plateau, to assess the current quality of groundwater resources and reveal the formation mechanisms and material sources of its hydrochemistry. The results show that the groundwater in the watershed is generally weakly alkaline, with some areas exhibiting high salinity. The dominant cations and anions are Na+ and Cl, respectively. The hydrochemical type is mainly Cl-Na, with a minority being mixed Cl-Mg·Ca. Overall, the groundwater in the watershed is suitable for domestic use. However, in the middle and lower reaches of the Chahan Usu River, nitrate and ammonia nitrogen contamination reduce its suitability. Meanwhile, although long-term use of this groundwater would not lead to soil degradation, its widespread high salinity and high sodium content make it unsuitable for irrigation. Water–rock interactions with evaporites and silicate rocks are the main mechanisms controlling groundwater chemistry in the watershed. Among them, halite minerals contribute most of the Na+ and Cl, while sulfate minerals provide Ca2+ and SO42−. In addition, cation exchange is widespread. This study provides a reference for ensuring the security and sustainable development of groundwater resources on the plateau. Full article
33 pages, 6038 KB  
Article
Phenotypic and Agronomic Evaluation of a Winter Barley Genotype Panel for Breeding Programs
by Liliana Vasilescu, Eugen-Iulian Petcu, Vasile Silviu Vasilescu, Alexandrina Sîrbu, Leon Muntean and Andreea D. Ona
Agronomy 2026, 16(6), 667; https://doi.org/10.3390/agronomy16060667 (registering DOI) - 21 Mar 2026
Abstract
Barley remains the fourth most cultivated cereal crop worldwide and is valued for its versatility in malting and brewing, animal feed, human nutrition, and dietary supplements. The identification of genotypes suitable for breeding or specific end-use applications requires multi-environment testing to evaluate agronomic [...] Read more.
Barley remains the fourth most cultivated cereal crop worldwide and is valued for its versatility in malting and brewing, animal feed, human nutrition, and dietary supplements. The identification of genotypes suitable for breeding or specific end-use applications requires multi-environment testing to evaluate agronomic performance, grain quality, and trait stability. In this study, a panel of 50 winter barley genotypes (two-row and six-row) originating from diverse genetic backgrounds was evaluated over three growing seasons (2021–2023) under the environmental conditions of southeastern Romania. Seven traits were analyzed, including three phenological traits (heading time, flowering time and plant height), grain yield, and three quality parameters (thousand-grain weight, protein content, and starch content). Environmental conditions had a strong influence on phenological development and grain yield, whereas grain quality traits showed relatively greater stability, indicating a stronger genetic control. Multivariate analyses (Principal Component Analysis (PCA) and Genotype plus Genotype-by-Environment interaction biplot (GGE biplots)) revealed clear relationships among traits and highlighted contrasting adaptive strategies between the two barley types. In two-row barley, genotypes such as Idra and Sandra combined favorable yield performance with stable grain quality traits and therefore represent promising candidates for breeding programs and large-scale cultivation. In six-row barley, SU-Ellen and LG Zebra showed high productivity and strong starch accumulation, making them valuable genetic resources for yield-oriented breeding, although further improvement in nitrogen use efficiency may be beneficial. The 2022–2023 growing season represented the most restrictive environment, emphasizing the importance of stability under stress conditions. Genotypes located close to the Average Environment Coordination axis (AEC axis) during that season, such as Ametist (six-row) and Lardeya (two-row), may represent promising material for breeding programs targeting drought resilience. Overall, the results expand the phenotypic characterization of winter barley germplasm and identify valuable genetic resources that can support pre-breeding efforts and the development of climate-resilient barley cultivars. Full article
21 pages, 290 KB  
Article
Immigrant Status, Family Support, and Psychoactive Substance Use Among Adolescents: A Multilevel Analysis of the Cross-National HBSC Study Data
by Elitsa Dimitrova and Apolinaras Zaborskis
Societies 2026, 16(3), 100; https://doi.org/10.3390/soc16030100 (registering DOI) - 21 Mar 2026
Abstract
Background: Immigrant adolescents experience distinct risk and protective factors related to substance use; however, cross-national differences between immigrant and native-born youth remain insufficiently understood. This study examines differences in the prevalence of psychoactive substance use between immigrant and non-immigrant 15-year-old adolescents and assesses [...] Read more.
Background: Immigrant adolescents experience distinct risk and protective factors related to substance use; however, cross-national differences between immigrant and native-born youth remain insufficiently understood. This study examines differences in the prevalence of psychoactive substance use between immigrant and non-immigrant 15-year-old adolescents and assesses the protective role of family support across Europe, Central Asia, and North America. Materials and Methods: Data were drawn from nationally representative samples of the 2021/2022 WHO Health Behaviour in School-aged Children (HBSC) survey, including 15-year-olds from 32 countries, representing Belgium by two separate regions (n = 66,400). Outcomes included cigarette smoking, electronic cigarette use, alcohol consumption, drunkenness, and cannabis use in the past 30 days. Key predictors were immigrant status and family support. Multilevel analyses incorporated country-level indicators, including the proportion of immigrant youth and the Inclusiveness Index, and were adjusted for sex and family affluence. Results: Substantial cross-national variation in substance use prevalence was observed. Immigrant adolescents were more likely to smoke cigarettes, use electronic cigarettes, and use cannabis, whereas alcohol consumption was more common among non-immigrant adolescents. However, in countries with a low proportion of immigrant youth (<5%), immigrant adolescents showed an elevated likelihood of engaging in all forms of psychoactive substance use, including alcohol consumption. Low family support emerged as the strongest and most consistent predictor of substance use across all outcomes. Conclusions: Immigrant adolescents living in countries with low immigration rates constitute a particularly vulnerable group facing increased risk of substance use. Family support is protective against adolescent substance use for both immigrant and non-immigrant youth, with the strongest effect for alcohol use in low-immigration contexts. Full article
21 pages, 1821 KB  
Article
Thermal Ablation Versus Surgical Resection for Intermediate-Size (3–5 cm) Colorectal Liver Metastases: Results from the Amsterdam Colorectal Liver Met Registry (AmCORE)
by Madelon Dijkstra, Susan van der Lei, Hannah H. Schulz, Tineke E. Buffart, Rutger-Jan Swijnenburg and Martijn R. Meijerink
Cancers 2026, 18(6), 1017; https://doi.org/10.3390/cancers18061017 (registering DOI) - 21 Mar 2026
Abstract
Purpose: Surgical resection has been the gold standard for colorectal liver metastases (CRLM) for decades. In recent years, thermal ablation has emerged as a first-line treatment option for small-size CRLM, while for intermediate-size lesions (3–5 cm), it is reserved for patients with [...] Read more.
Purpose: Surgical resection has been the gold standard for colorectal liver metastases (CRLM) for decades. In recent years, thermal ablation has emerged as a first-line treatment option for small-size CRLM, while for intermediate-size lesions (3–5 cm), it is reserved for patients with unresectable disease. In this setting, thermal ablation has proven safe and effective, achieving durable local control (LC) in the majority of patients. This retrospective study compares oncological outcomes of thermal ablation versus surgical resection of intermediate-size (3–5 cm) CRLM. Material and methods: Patients treated with thermal ablation or surgical resection for intermediate-size CRLM between 2000 and 2025 were included. Baseline per-patient and per-procedure characteristics were compared across three groups: thermal ablation, surgical resection, and combined treatment. Per tumor characteristics were compared between thermal ablation and surgical resection. Primary outcomes included local tumor progression-free survival (LTPFS) and complication rates. Secondary outcomes were OS, distant progression-free survival (DPFS), LC, and length of hospital stay. Survival outcomes were analyzed using the Kaplan–Meier method; additionally, LTPFS was assessed using Cox proportional hazards regression models, with multivariable analyses performed to adjust for potential confounders. Results: A total of 320 patients with 448 metastases were included: 135 patients underwent thermal ablation, 156 underwent surgical resection, and 29 received combined treatment. LTPFS per tumor was significantly higher in the surgical resection group (HR 1.86, 95% CI 1.24–2.81, p = 0.0025), however, LC per tumor did not significantly differ amongst groups (HR 1.48, 95% CI 0.70–3.11, p = 0.307). Complication rates were significantly higher after resection (p < 0.001). OS and DPFS did not differ significantly between the three groups (p = 0.08 and p = 0.084). OS comparing only thermal ablation and resection was significantly lower in the thermal ablation group. Median hospital stay was 3, 5, and 7 days for the ablation, resection, and combined groups, respectively (p < 0.001). Conclusions: Thermal ablation offers a safe alternative to surgical resection for selected patients with intermediate-size (3–5 cm) CRLM, with higher treatment-site recurrence rates. With the option of repeat ablation, comparable local tumor control can be achieved. Improvements in local control with both modalities over time support the need for a prospective clinical trial. Full article
(This article belongs to the Special Issue Image-Guided Treatment of Liver Tumors)
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14 pages, 1170 KB  
Article
Finite Element Analysis of Peri-Implant Stress in Maxillary All-on-Four Rehabilitation: Effects of Posterior Implant Angulation and Loading Protocol
by Juan Alberto Aristizábal-Hoyos, Leidy Katherine Gil-Tabares, Natalia Giraldo-Vélez, Martha Isabel Torres-Arteaga, Catalina Garces-Gonzalez, Olga Patricia López-Soto, Héctor Fuentes-Barría, Raúl Aguilera-Eguía and Lisse Angarita-Davila
Materials 2026, 19(6), 1239; https://doi.org/10.3390/ma19061239 (registering DOI) - 20 Mar 2026
Abstract
Objective: To evaluate the biomechanical effects of varying posterior implant inclinations and loading protocols on peri-implant stress distribution in full-arch maxillary rehabilitations using the All-on-Four concept. Methodology: A three-dimensional finite element model of an edentulous atrophic maxilla was developed from a digital point [...] Read more.
Objective: To evaluate the biomechanical effects of varying posterior implant inclinations and loading protocols on peri-implant stress distribution in full-arch maxillary rehabilitations using the All-on-Four concept. Methodology: A three-dimensional finite element model of an edentulous atrophic maxilla was developed from a digital point cloud. Four implants were placed according to the All-on-Four protocol: two anterior vertical implants and two posterior implants with inclinations of 0°, 15°, 30°, or 45°. Mini-abutments and a titanium bar prosthesis were included. Material properties were assumed as homogeneous, isotropic, and linearly elastic. Immediate loading was simulated using frictional contacts (µ = 0.3), whereas delayed loading assumed complete osseointegration (bonded contacts). The models were meshed using 10-node quadratic tetrahedral elements (SOLID187) in ANSYS®. Maximum von Mises stress in cortical bone, cancellous bone, implants, abutments, and the prosthetic bar was assessed. Results: Posterior implant tilt significantly reduced peri-implant stress. Under immediate loading, the highest stress occurred at 0° inclination in the posterior left implant (82.36 MPa) and decreased progressively with increasing tilt, reaching 33.63 MPa at 45° (≈59% reduction). Delayed loading generally produces lower stress magnitudes, particularly at extreme tilts. Anterior implants experienced lower stress levels across all configurations. Comparative analysis demonstrated that immediate loading increased stress at lower angulations, while differences between loading protocols were minimal at higher inclinations. Conclusions: Posterior implant angulation and loading protocol critically influence peri-implant stress distribution. Increased posterior tilt combined with appropriate loading reduces peak cortical bone stresses, supporting biomechanical optimization in All-on-Four maxillary rehabilitations. Full article
35 pages, 8598 KB  
Article
Mechanical Characteristics Analysis and Structural Optimization of Wheeled Multifunctional Motorized Crossing Frame
by Shuang Wang, Chunxuan Li, Wen Zhong, Kai Li, Hehuai Gui and Bo Tang
Appl. Sci. 2026, 16(6), 3034; https://doi.org/10.3390/app16063034 - 20 Mar 2026
Abstract
Wheeled multifunctional motorized crossing frames represent a new type of crossing equipment for high-voltage transmission line construction. The initial design is too conservative, having a large safety margin and high material redundancy. Therefore, it is necessary to study a lightweight design version. However, [...] Read more.
Wheeled multifunctional motorized crossing frames represent a new type of crossing equipment for high-voltage transmission line construction. The initial design is too conservative, having a large safety margin and high material redundancy. Therefore, it is necessary to study a lightweight design version. However, as the structure constitutes an assembly consisting of multiple components, it also exhibits relatively high complexity. In a lightweight design, optimizing multi-component and multi-size parameters can lead to structural interference and separation, seriously affecting the smooth progress of design optimization. Therefore, an optimization design method of a multi-parameter complex assembly structure is proposed to solve this problem. Firstly, the typical stress conditions of the wheeled multifunctional motorized crossing frame were analyzed using its structural model. Then, a finite element model of the beam was established in ANSYS 2021 R1 Workbench, and the mechanical characteristics were analyzed. The results show that the arm support is the key load-bearing component and has significant optimization potential. Subsequently, functional mapping relationships were established among the 14 dimension parameters of the arm support, reducing the number of design variables to six and successfully avoiding component separation or interference during optimization. Through global sensitivity analysis, the height, thickness, and length of the arm body were screened out as the core optimization parameters from six initial design variables. Then, 29 groups of sample points were generated via central composite design (CCD), and a response surface model reflecting the relationships among the arm body’s dimensional parameters, total mass, maximum stress, and maximum deformation was established using the Kriging method. Leave-one-out cross-validation (LOOCV) was performed, and the coefficients of determination (R2) for model fitting were all higher than 0.995, indicating extremely high prediction accuracy. Taking mass and deformation minimization as the optimization objectives, the MOGA algorithm was adopted to perform multi-objective optimization and determine the optimal engineering parameters. Simulation verification was conducted on the optimized arm support, and an eigenvalue buckling analysis was performed simultaneously to verify structural stability. Finally, the proposed optimization method was experimentally verified through mechanical performance tests of the full-scale prototype under symmetric and eccentric loads. The results show that the mass of the optimized arm support is reduced from 217.73 kg to 189.8 kg, with a weight reduction rate of 12.8%. Under an eccentric load of 70,000 N, the maximum deformation of the arm support is 8.9763 mm, the maximum equivalent stress is 314.86 MPa, and the buckling load factor is 6.08, all of which meet the requirements for structural stiffness, strength, and buckling stability. The maximum error between the experimental and finite element results is only 4.64%, verifying the accuracy and reliability of the proposed method. The proposed optimization methodology, validated on a wheeled multifunctional motorized crossing frame, serves as a transferable paradigm for the lightweight design of complex assemblies with coupled dimensional constraints, thereby offering a general reference for the structural optimization of multi-component transmission line equipment, construction machinery, and other multi-component engineering systems. Full article
19 pages, 1064 KB  
Systematic Review
Automated Discharge Instructions in Medical and Surgical Care: A Systematic Review of Patient Engagement and Clinical Outcomes
by Maissa Trabilsy, Ariana Genovese, Cesar A. Gomez-Cabello, Syed Ali Haider, Srinivasagam Prabha, Bernardo Collaco, Nadia G. Wood, Sanjay Bagaria, James London and Antonio Jorge Forte
Healthcare 2026, 14(6), 798; https://doi.org/10.3390/healthcare14060798 - 20 Mar 2026
Abstract
Background: Automated discharge instructions are increasingly used to support post-discharge communication, patient education, and nursing follow-up, yet the current state remains unidentified. This systematic review explores the types of automated discharge instructions used and their effectiveness in enhancing patient engagement and reducing readmission, [...] Read more.
Background: Automated discharge instructions are increasingly used to support post-discharge communication, patient education, and nursing follow-up, yet the current state remains unidentified. This systematic review explores the types of automated discharge instructions used and their effectiveness in enhancing patient engagement and reducing readmission, emergency department visits and reoperation rates. Methods: A systematic search was conducted on 15 April 2025, using Embase, PubMed, Scopus, Web of Science, and CINAHL, following PRISMA guidelines. Inclusion criteria required peer-reviewed original research evaluating the utilization of automated patient discharge instructions following hospital admission or surgical stay. Exclusion criteria included correspondence, reviews, educational materials, not peer-reviewed, retracted reports, not retrievable, and no English translation. Risk of bias was assessed independently using NIH, JBI, ROB-2, and ROBINS-I tools. Two investigators independently conducted the screening, extraction, and synthesis of results using Endnote and Microsoft Excel. Results: Of the 1252 records identified, 13 studies were selected for analysis. There was a total of 34,386 patients across a diverse range of healthcare settings and clinical contexts. The average sample size per study was approximately 4912, with study samples ranging from 16 to 13,188 patients. The modalities of discharge instructions included automated phone calls (23.1%) and/or text messages (53.8%), as well as printed out auto-generated summaries (15.4%). Patient engagement was generally high, with automated phone calls showing the most consistent interaction, with completion rates ranging from 44% to 56%, often prompting clinical follow-up. SMS tools demonstrated strong scalability and response rates up to 87%. Two studies reported on hospital readmission outcomes and only a single study reported on emergency department revisit rates, while none assessed reoperation outcomes. Among those reporting readmission, automated phone calls and SMS were associated with lower or proxy-reduced readmission rates. Included studies had low to moderate levels of bias. Conclusions: While evidence on clinical outcomes such as readmissions, emergency department revisits, and reoperations remains limited and inconclusive, automated discharge tools—particularly phone calls and SMS—consistently demonstrated high patient engagement. Automated discharge tools show promise for supporting transitional care, discharge education, and post-discharge monitoring, highlighting the future role of automated tools in nursing workflows to support follow-up, escalation, and continuity of care. Full article
13 pages, 1485 KB  
Article
Temporal Wettability Dynamics in Sustainable Olive Pomace Biochar Composites: A Signal-Driven and Bat Algorithm Framework
by Mehmet Ali Biberci
Processes 2026, 14(6), 999; https://doi.org/10.3390/pr14060999 - 20 Mar 2026
Abstract
Olive pomace biochar, obtained through the pyrolysis of lignocellulosic biomass, has emerged as a sustainable and multifunctional additive for polymer composites. Its physicochemical properties, including porosity, surface area, and electrical conductivity, can be tailored by controlling feedstock type and pyrolysis conditions. Although mechanical [...] Read more.
Olive pomace biochar, obtained through the pyrolysis of lignocellulosic biomass, has emerged as a sustainable and multifunctional additive for polymer composites. Its physicochemical properties, including porosity, surface area, and electrical conductivity, can be tailored by controlling feedstock type and pyrolysis conditions. Although mechanical reinforcement and thermal stability improvements are well documented, the influence of biochar on surface-related properties such as wettability and contact angle remains insufficiently explored for environmentally relevant composite systems. In this study, epoxy-based composites containing biochar synthesized at 750 °C were evaluated in terms of their water interaction behavior by monitoring the evaporation dynamics of ultra-pure water droplets (10 μL, 0.055 mS/cm conductivity) at eight time intervals between 20 and 580 s using high-resolution digital microscopy. Image enhancement and segmentation were performed prior to Discrete Cosine Transform (DCT) analysis to describe droplet geometry in the frequency domain. Time-dependent variations in the standard deviations of DCT coefficients were optimized using the Bat Algorithm, resulting in mathematical models capable of accurately representing droplet evolution and surface–fluid interactions. The primary novelty of this study lies in the development of a hybrid experimental–computational framework that integrates droplet-based wettability measurements with signal-domain analysis and metaheuristic optimization. Unlike conventional studies focusing solely on material characterization, this approach establishes quantitative relationships between surface behavior and numerical descriptors derived from DCT and the Bat Algorithm. The proposed methodology provides a data-driven tool for predicting wettability trends in biochar-reinforced composites and supports the development of moisture-resistant materials for coatings, packaging, and thermal insulation applications within the context of sustainable composite design. Full article
(This article belongs to the Section Materials Processes)
15 pages, 533 KB  
Article
Scaling Surface-Guided Radiation Therapy to Larger Lung Cancer Cohorts: Frameless Immobilization and Enhanced Setup Accuracy
by Jang Bo Shim, Jeongeun Hwang, Sun Myung Kim, Yeong Cheol Lee, Eun Hee Jeon and Hakyoung Kim
Life 2026, 16(3), 517; https://doi.org/10.3390/life16030517 - 20 Mar 2026
Abstract
Objectives: This study aimed to evaluate the setup accuracy and intrafractional geometric stability of surface-guided radiation therapy (SGRT) under frameless immobilization in lung cancer radiotherapy and to assess its clinical utility in a relatively large patient cohort. Materials and Methods: A total of [...] Read more.
Objectives: This study aimed to evaluate the setup accuracy and intrafractional geometric stability of surface-guided radiation therapy (SGRT) under frameless immobilization in lung cancer radiotherapy and to assess its clinical utility in a relatively large patient cohort. Materials and Methods: A total of 678 treatment fractions from 52 patients with primary non-small cell lung cancer (NSCLC), treated between October 2024 and November 2025, were retrospectively analyzed. Patient setup was performed using SGRT with the Identify system, and cone-beam computed tomography (CBCT) served as the reference for internal target localization Intrafractional setup displacements, center-of-mass (COM) shifts, residual setup errors, and intrafractional clinical target volume (CTV) variations were evaluated. Spatial agreement between planned and intrafractional tumor volumes was quantified using the Dice Similarity Coefficient (DSC). Results: The mean CBCT-based intrafractional shifts were −0.01 mm (vertical), 0.03 mm (longitudinal), and 0.01 mm (lateral), indicating negligible systematic errors. The greatest variability was observed in the longitudinal direction (standard deviation, 1.32 mm), with a maximum displacement of 4.58 mm. COM-based analysis demonstrated near-zero mean displacements in all directions, with standard deviations ranging from 0.01 to 0.02 mm. DSC values ranged from 0.91 to 0.98, with a mean of 0.96, indicating excellent spatial agreement between planned and intrafractional tumor volumes. Residual setup errors were predominantly within ±1 mm, and the mean intrafractional CTV volume change was minimal (0.27 cm3). Conclusions: SGRT-based frameless lung cancer radiotherapy demonstrated high setup accuracy and robust intrafractional geometric stability. Although slightly greater variability was observed in the longitudinal direction, overall positional deviations and volumetric changes remained within clinically acceptable limits. These findings support the feasibility of integrating SGRT with CBCT-guided radiotherapy and suggest potential benefits for workflow efficiency and planning target volume margin optimization. Full article
(This article belongs to the Special Issue Pathology, Diagnosis, and Treatments of Airway Diseases)
41 pages, 1814 KB  
Review
Hydrogel Development, Processing and Applications in Agriculture: A Review
by Carmen Mª. Granados-Carrera, Victor M. Perez-Puyana, Mercedes Jiménez-Rosado and Alberto Romero
Gels 2026, 12(3), 259; https://doi.org/10.3390/gels12030259 (registering DOI) - 20 Mar 2026
Abstract
Hydrogels have emerged as promising functional materials for improving water management and nutrient delivery in agriculture, particularly under conditions of increasing water scarcity and declining soil fertility. However, most commercially available superabsorbent hydrogels are based on petroleum-derived polymers, raising concerns regarding their persistence [...] Read more.
Hydrogels have emerged as promising functional materials for improving water management and nutrient delivery in agriculture, particularly under conditions of increasing water scarcity and declining soil fertility. However, most commercially available superabsorbent hydrogels are based on petroleum-derived polymers, raising concerns regarding their persistence in soils, potential microplastic formation and long-term environmental impact. In response, significant research efforts are being directed toward the development of biodegradable hydrogels derived from renewable biopolymers. This review provides a critical overview of recent advances in hydrogel systems designed for agricultural applications, with a particular focus on biopolymer-based materials. First, the current landscape of hydrogel technologies used as soil conditioners and controlled-release systems for agrochemicals is contextualized, highlighting the limitations of conventional synthetic hydrogels. Subsequently, the main classes of natural polymers explored for hydrogel fabrication, including polysaccharides (e.g., chitosan, alginate, cellulose and starch) and proteins (e.g., gelatin, keratin and soy protein), are analyzed in terms of raw material sources, gelation mechanisms and structure–property relationships. Their performance in key agricultural functions, such as water retention, controlled nutrient release, soil conditioning and enhancement of plant growth, is also discussed. Finally, the review identifies major challenges that currently hinder large-scale implementation, including mechanical stability, degradation behavior in complex soil environments, nutrient release control and economic scalability. By integrating recent progress and outlining emerging research directions, this work aims to support the rational design of next-generation biodegradable hydrogels capable of contributing to sustainable agriculture and circular bioeconomy strategies. Full article
(This article belongs to the Special Issue Innovative Gels: Structure, Properties, and Emerging Applications)
16 pages, 2570 KB  
Article
Tunable Bandpass Filtering in Coupled Nanodrums Enabled by 1:1 Internal Resonance
by Yikun Liu, Jiaxin Miao, Haoran Wang, Jinghong Tang, Cao Xia and Xiaoyu Liu
Micromachines 2026, 17(3), 379; https://doi.org/10.3390/mi17030379 (registering DOI) - 20 Mar 2026
Abstract
In recent years, microelectromechanical systems (MEMS) filters exploiting structural nonlinearity and coupled resonance have enabled programmable passband shaping beyond traditional single-peak designs, yet they still face low operating frequencies and limited electrical tuning range. Here, leveraging 1:1 internal resonance, we propose a gate-programmable [...] Read more.
In recent years, microelectromechanical systems (MEMS) filters exploiting structural nonlinearity and coupled resonance have enabled programmable passband shaping beyond traditional single-peak designs, yet they still face low operating frequencies and limited electrical tuning range. Here, leveraging 1:1 internal resonance, we propose a gate-programmable tuning strategy for two-dimensional (2D) material-based nanoelectromechanical systems (NEMS), enabling high-frequency operation and wide-range reconfigurability. Benefiting from the high resonant frequency and wide electrostatic tunability of 2D materials such as MoS2, our theoretical analysis indicates wide-range programmability up to f/f0200%. Sweeping Vg1=Vg2 from 9 to 16 V while maintaining 1:1 frequency matching shifts the passband upward quasi-linearly at 4.4~MHz/V. In contrast, with the coupling strength nearly unchanged, mV-level bias mismatch perturbs the frequency ratio by 105, enabling highly sensitive bandwidth trimming from 3.18 to 5.20 kHz, supporting a two-step strategy of coarse center-frequency tuning followed by fine bandwidth control. To broaden the bandwidth, we further analyze a three-drum case: with Vg1=Vg2=Vg3=16 V, the bandwidth reaches 21.79 kHz with a 5056.05 dB/MHz transition slope and 0.95 dB ripple, which is nearly 4 times wider than the two drum case with the same gate voltage. This study shows that 1:1 internal resonance can be used to tune the bandpass response of NEMS resonators. All results are obtained from theoretical modeling and numerical simulations. Full article
(This article belongs to the Special Issue Novel RF Nano- and Microsystems)
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25 pages, 2248 KB  
Article
Polymorph II Cellulose Nanocrystals Derived from Oil Palm Empty Fruit Bunches for High-Efficiency COD Removal in Industrial Wastewater
by Jemina Pomalaya-Velasco, Yéssica Bendezú-Roca, Yamerson Canchanya-Huaman and Juan A. Ramos-Guivar
Nanomaterials 2026, 16(6), 374; https://doi.org/10.3390/nano16060374 (registering DOI) - 20 Mar 2026
Abstract
This study reports the valorization of oil palm empty fruit bunches into cellulose nanocrystals (CNCs) for the removal of the chemical oxygen demand (COD) from industrial wastewater generated by the same processing sector. Cellulose Iβ was first isolated through sequential bleaching, delignification, [...] Read more.
This study reports the valorization of oil palm empty fruit bunches into cellulose nanocrystals (CNCs) for the removal of the chemical oxygen demand (COD) from industrial wastewater generated by the same processing sector. Cellulose Iβ was first isolated through sequential bleaching, delignification, and mercerization, and two hydrolysis routes were evaluated to obtain CNCs: a concentrated acid route (60% v/v H2SO4, 50 °C, 60 min) for CNCs-1 and a low-acid, long-duration route (1% v/v H2SO4, 80 °C, 12 h) for CNCs-2. Rietveld refinement of the X-ray diffractograms confirmed the polymorphic transition, assigning cellulose Iβ to the intermediate materials and cellulose II to the CNC samples, with crystallite sizes of 4.99 nm for CNCs-1 and 5.43 nm for CNCs-2. attenuated total reflectance–Fourier transform infrared (ATR-FTIR) spectroscopy analysis showed the progressive removal of lignin and hemicellulose and supported the cellulose Iβ to II transition through changes in hydroxyl bonding and crystallinity-related bands. Preliminary adsorption tests showed better COD removal with CNCs-2, which were therefore selected for optimization using a Box–Behnken design with the adsorbent mass, pH, and contact time as variables. The quadratic model was significant (R2 = 0.9675; predicted R2 = 0.8908), and the maximum COD removal reached 91.47%, decreasing the COD concentration from 2459.0 to 209.85 mg L−1 under the optimum conditions of 0.09 g CNCs-2, pH 3, and 20 min. These results highlight cellulose II nanocrystals derived from oil palm waste as a promising and scalable adsorbent for industrial wastewater treatment. Full article
21 pages, 3595 KB  
Article
Machine Learning Predicts Drivers of Biochar-Diazotrophic Bacteria in Enhancing Brachiaria Growth and Soil Quality
by Thallyta das Graças Espíndola da Silva, Diogo Paes da Costa, Rafaela Félix da França, Argemiro Pereira Martins Filho, Maria Renaí Ferreira Barbosa, Jamilly Alves de Barros, Gustavo Pereira Duda, Claude Hammecker, José Romualdo de Sousa Lima, Ademir Sérgio Ferreira de Araújo and Erika Valente de Medeiros
AgriEngineering 2026, 8(3), 118; https://doi.org/10.3390/agriengineering8030118 - 20 Mar 2026
Abstract
Data-driven approaches are increasingly required to optimize biofertilization strategies in forage systems. Machine learning (ML) provides an efficient tool for identifying functional drivers in complex plant–soil–microbe systems, offering important perspectives for precision data-driven agriculture. However, despite its potential, ML remains data-driven in studies [...] Read more.
Data-driven approaches are increasingly required to optimize biofertilization strategies in forage systems. Machine learning (ML) provides an efficient tool for identifying functional drivers in complex plant–soil–microbe systems, offering important perspectives for precision data-driven agriculture. However, despite its potential, ML remains data-driven in studies involving diazotrophic inoculation using biochar as a pelletizing material, particularly in forage grasses. This study applied ML to predict the key drivers controlling Brachiaria brizantha performance and soil quality under biochar-pelletized diazotrophic bacteria (DB). Five isolates were inoculated with or without biochar, and plant traits and soil attributes, including pH, potassium, phosphorus, sodium, and urease activity were evaluated. These data were integrated into multivariate analyses and ML algorithms, including Linear Discriminant Analysis, Random Forest, and Support Vector Machine, to identify the functional drivers that best discriminate treatment performance and uncover mechanistic functional drivers. All isolates increased soil potassium content, with the highest values in the biochar amended treatments, and a 39% increase. Soil pH and urease activity were significantly modulated by isolate identity, while biomass allocation patterns differed among treatments. Overall, the results highlight that biochar pelletization can enhance the effectiveness of DB inoculants. ML revealed that dry foliar biomass, soil pH, and fresh root weight were the most predictive variables, highlighting consistent signatures explaining plant–soil responses to biochar-pelletized DB. These findings demonstrate that interpretable ML can disentangle complex plant–soil–microbe interactions, support precision biofertilization design, and serve as an efficient decision-support tool for sustainable pasture management. Beyond the present system, this study establishes a transferable and scalable analytical framework for precision biofertilization strategies in forage systems and other biochar-mediated agroecosystems, advancing predictive and data-driven approaches in sustainable agricultural engineering. Full article
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