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Keywords = stoma care outcomes

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12 pages, 449 KiB  
Article
Acute Left-Side Colonic Diverticulitis: A Historical Cohort Study on the Optimization of Non-Operative Management Outcomes and Anastomosis Rate After Sigmoid Resection
by Ana Isabel Fernández Sánchez, José Manuel Aranda Narváez, Irene Mirón Fernández and Julio Santoyo Santoyo
J. Clin. Med. 2025, 14(13), 4658; https://doi.org/10.3390/jcm14134658 - 1 Jul 2025
Viewed by 375
Abstract
Background: The guidelines proposed by the World Society for Emergency Surgery (WSES) in 2020 for the management of Acute Diverticulitis (AD) emphasize the safety of non-operative management (NOM) in selected patients and recommend sigmoid resection (SR) with primary anastomosis (PA) as the [...] Read more.
Background: The guidelines proposed by the World Society for Emergency Surgery (WSES) in 2020 for the management of Acute Diverticulitis (AD) emphasize the safety of non-operative management (NOM) in selected patients and recommend sigmoid resection (SR) with primary anastomosis (PA) as the surgical technique of choice. Aim: To analyze the clinical outcomes following the implementation of an evidence-based clinical pathway developed by an Acute Care Surgery Unit (ACSu) at a reference center. Methods: For analysis, patients were divided into two groups: pre-guidelines (2018–2019) and post-guidelines (2020–2023), following the May 2020 WSES publication. Patients were classified according to the WSES classification. Results: NOM failure and PA after SR rates by groups were as follows (NOM failure not applicable to III–IV): 0-IA, 2.7% and 94.7%; IB–IIA, 16% and 85.2%; IIB, 7.1% and 50%; III–IV, 75.6%. The global stoma-free rate was 78.8%, with a 15.7% anastomotic leak rate and 14.2% significant morbidity, with an increased rate of anastomosis in unstable patients thanks to Damage Control Surgery (DCS). A logistic regression model was performed to identify factors associated with postoperative morbidity. Patients who underwent primary anastomosis had a lower risk of postoperative morbidity compared to those treated with Hartmann’s procedure (OR = 0.22 (0.04–1.25), p = 0.088). Conclusions: Excellent outcomes in AD healthcare may be achieved if evidence-based recommendations are followed. The ACSu plays a key role in designing and promoting these protocols. Full article
(This article belongs to the Section Emergency Medicine)
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22 pages, 1455 KiB  
Article
Outcomes of a Risk-Stratified Protocol for Preventing Peristomal Skin Complications in Patients with an Ostomy: A Cohort Study
by Francesco Carlo Denti, Eliana Guerra, Francesca Caroppo, Pietro Abruzzese, Fabrizio Alessi, Filippo Barone, Pasqualina Bernardino, Massimiliano Bergamini, Maria Cristina Bernardo, Gloria Bosio, Paula Carp, Manuela Cecconello, Annalinda Cerchier, Francesca Croci, Rita Detti, Mina Milenova Dimitrova, Cristina Di Pasquale, Maria Rosaria D'Ippolito, Simona Ditta, Erica Ducci, Anna Belloni Fortina, Stefano Frascarelli, Marianna Galante, Rita Guarino, Nicola Leggio, Elisabetta Livio, Alessandra Marchetti, Francesca Marelli, Rita Mastropaolo, Viviana Melis, Nicola Palmiero, Arianna Panarelli, Anna Lea Pascali, Francesco Pizzarelli, Laura Precisi, Cinzia Rastello, Silvia Regaglia, Rossana Elvira Rinaldi, Nadia Rumbolo, Claudio Sansone, Angela Santelli, Giovanni Sarritzu, Stefano Sfondrini, Sara Stanzani, Mattia Stella, Margherita Walterova and Rosario Carusoadd Show full author list remove Hide full author list
Nurs. Rep. 2025, 15(5), 179; https://doi.org/10.3390/nursrep15050179 - 20 May 2025
Cited by 5 | Viewed by 802
Abstract
Background/Objectives: Peristomal skin complications (PSCs) are common among patients with ostomies, significantly impacting quality of life and increasing healthcare utilization. This study aimed to evaluate the effects of the Dermamecum protocol, a risk-stratified educational intervention, on the prevention of PSCs, self-care improvements, health-related [...] Read more.
Background/Objectives: Peristomal skin complications (PSCs) are common among patients with ostomies, significantly impacting quality of life and increasing healthcare utilization. This study aimed to evaluate the effects of the Dermamecum protocol, a risk-stratified educational intervention, on the prevention of PSCs, self-care improvements, health-related quality of life (HRQoL), and patient satisfaction over a 90-day follow-up period. Methods: This prospective cohort study included 305 patients stratified into three risk-based groups (green, yellow, and red paths) according to the Dermamecum protocol. Primary outcomes included PSC rates at 30, 60, and 90 days. Secondary outcomes included self-care scores, HRQoL, and patient satisfaction. Comparative analyses and trend assessments were performed across groups and time points. Temporal trends in PSCs were analyzed using Poisson regression. Results: Early PSC rates were 8.5% at 30 days, with late complications at 7.9% and 6.2% at 60 and 90 days, respectively. No significant differences in PSC rates were observed between paths. Self-care scores improved over time, with stability across groups and domains. HRQoL remained stable, with minor fluctuations in physical and mental components. Patient satisfaction was high across all paths. Poisson regression identified significant temporal trends in PSC rates, with higher risks at 30, 60, and 90 days compared to baseline. Age, BMI, and path assignment (lower risk for the green path) were significant predictors of PSCs. Conclusions: The Dermamecum protocol effectively maintained low PSC rates, supported self-care, and sustained HRQoL and patient satisfaction. These findings highlight the value of risk-stratified, patient-centered interventions in ostomy care. Further studies are needed to validate these results and explore long-term outcomes. Full article
(This article belongs to the Special Issue Research Innovations in Skin and Wound Care)
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11 pages, 432 KiB  
Article
Defunctioning Ileostomy After Low Anterior Resection of Rectum: Morbidity Related to Fashioning and Closure
by Nikolaos Gouvas, Dimitrios Manatakis, Christos Agalianos, Nikoletta Dimitriou, Ioannis Baloyiannis, George Tzovaras and Evangelos Xynos
Medicina 2024, 60(11), 1864; https://doi.org/10.3390/medicina60111864 - 14 Nov 2024
Cited by 1 | Viewed by 1197
Abstract
Background and Objectives: The aim of this study was to assess any predisposing factors to the morbidity of fashioning and reversal of diverting ileostomy in a prospective cohort of patients who have undergone TME and low colo-rectal or colo-anal anastomosis for rectal [...] Read more.
Background and Objectives: The aim of this study was to assess any predisposing factors to the morbidity of fashioning and reversal of diverting ileostomy in a prospective cohort of patients who have undergone TME and low colo-rectal or colo-anal anastomosis for rectal cancer. Materials and Methods: Consecutive patients with rectal cancer undergoing low anterior resection and a defunctioning loop ileostomy in three surgical units from 2016 to 2020 were included in the study and retrospectively analyzed. Results: One hundred eighty-two patients from three centres were included. Ileostomy-related mortality was 0.5%, attributed to renal failure.. Ileostomy-related morbidity was 46%. Postoperative ileus was seen in 37.4%, and dehydration in 18.8% of the patients. The readmission rate for ileostomy-related reasons was 15.4%. Stoma care was problematic in 15.7% or poor in 7% of the cases. Advanced age, male gender and obesity were independent risk factors for ileostomy-related morbidity. Ileostomy was reversed in 165 patients. The morbidity in 165 patients was 16%. Ileus was seen in 10.3%, anastomotic leak in 4.8% and wound infection in 12.7% of the cases. One patient died because of an anastomotic leak. No predisposing factors that affect the outcomes of ileostomy closure were identified. Conclusions: Diverting ileostomy-related morbidity is high. Life threatening dehydration and renal failure from ileus is more commonly seen in elderly, male and obese patients and should be anticipated. Ileostomy closure-related morbidity is low. Full article
(This article belongs to the Special Issue Recent Advances and Future Challenges in Colorectal Surgery)
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12 pages, 2493 KiB  
Article
Evaluating the Effect of a Novel Digital Ostomy Device on Leakage Incidents, Quality of Life, Mental Well-Being, and Patient Self-Care: An Interventional, Multicentre Clinical Trial
by Richard R. W. Brady, Diane Sheard, Mandie Alty, Martin Vestergaard, Esben Bo Boisen, Rachel Ainsworth, Helle Doré Hansen and Teresa Adeltoft Ajslev
J. Clin. Med. 2024, 13(19), 5673; https://doi.org/10.3390/jcm13195673 - 24 Sep 2024
Cited by 5 | Viewed by 2783
Abstract
Background: Most people with a stoma worry about leakage, and a quarter experience leakage of stomal effluent outside the baseplate on a monthly basis. Leakage has additional physical and psychosocial consequences, for instance, peristomal skin complications, feeling unable to cope, and self-isolation. Method: [...] Read more.
Background: Most people with a stoma worry about leakage, and a quarter experience leakage of stomal effluent outside the baseplate on a monthly basis. Leakage has additional physical and psychosocial consequences, for instance, peristomal skin complications, feeling unable to cope, and self-isolation. Method: An interventional, single-arm, multi-centre study was undertaken in the United Kingdom to evaluate a novel digital leakage notification system for ostomy care, including a support service (=test product) for 12 weeks in patients with a recent stoma formation (≤9 months). Patients completed questionnaires at baseline and after 4, 6, 8, 10, and 12 weeks, evaluating leakage episodes, Ostomy Leak Impact (tool containing three domains), and patient self-management (by PAM-13). Additionally, mental well-being (by WHO-5) and health-related quality of life (QoL) (by EQ-5D-5L) were assessed. Outcomes between baseline and final evaluation were compared by generalised linear and linear mixed models. Results: 92 patients (ITT population) with a mean age of 49.4 years (range 18–81 years) were recruited. Of these, 80% had an ileostomy, and 53% were female. After 12 weeks of using the test product, a significant decrease in mean episodes of leakage outside the baseplate (1.57 versus 0.93, p < 0.046) was observed. Ostomy Leak Impact scores improved across all three domains (p < 0.001), indicating less embarrassment, increased engagement in social activities, and increased control. Patient self-management also improved significantly (PAM-13 score: ∆6.6, p < 0.001), as did the WHO-5 well-being index (∆8.0, p < 0.001). Lastly, EQ-5D-5L profile scores tended to improve (p = 0.075). Conclusions: A new digital leakage notification system demonstrated strong improvements to patients’ stoma self-care, mental well-being, and QoL. Registration number on ClinicalTrials.gov: NCT05135754. Full article
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
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18 pages, 1186 KiB  
Article
Exploring the Impact of a Structured Educational Approach on Peristomal Skin Complications: An Interim Analysis
by Francesco Carlo Denti, Eliana Guerra, Francesca Caroppo, Pietro Abruzzese, Fabrizio Alessi, Filippo Barone, Pasqualina Bernardino, Massimiliano Bergamini, Cristina Bernardo, Gloria Bosio, Paula Carp, Manuela Cecconello, Annalinda Cerchier, Francesca Croci, Rita Detti, Cristina Di Pasquale, Maria Rosaria D’Ippolito, Simona Ditta, Erica Ducci, Anna Belloni Fortina, Stefano Frascarelli, Marianna Galante, Rita Guarino, Nicola Leggio, Elisabetta Livio, Alessandra Marchetti, Francesca Marelli, Rita Mastropaolo, Viviana Melis, Nicola Palmiero, Arianna Panarelli, Anna Lea Pascali, Francesco Pizzarelli, Laura Precisi, Cinzia Rastello, Silvia Regaglia, Rossana Elvira Rinaldi, Nadia Rumbolo, Claudio Sansone, Angela Santelli, Giovanni Sarritzu, Stefano Sfondrini, Sara Stanzani, Mattia Stella, Margherita Walterova and Rosario Carusoadd Show full author list remove Hide full author list
Healthcare 2024, 12(18), 1805; https://doi.org/10.3390/healthcare12181805 - 10 Sep 2024
Cited by 2 | Viewed by 1685
Abstract
This study, employing an interim analysis, investigates the effects of the Dermamecum protocol, a structured educational and tailored approach that stratifies ostomy patients into risk paths (green, yellow, red) based on pre-operative and post-operative characteristics. The green path indicates a low risk of [...] Read more.
This study, employing an interim analysis, investigates the effects of the Dermamecum protocol, a structured educational and tailored approach that stratifies ostomy patients into risk paths (green, yellow, red) based on pre-operative and post-operative characteristics. The green path indicates a low risk of peristomal skin complications (PSCs), focusing on sustaining healthy behaviours and basic stoma care. The yellow path represents a moderate risk, emphasizing the need for patients to self-monitor and recognize early signs of complications. The red path corresponds to high risk, requiring stringent monitoring and immediate access to healthcare support. The study aims to reduce PSCs and improve patient outcomes. Methods include the stratification of 226 patients, with significant differences in gender distribution, BMI categories, and stoma types across the paths. Results show an occurrence rate of PSCs of 5.9% in all risk paths (5.7% green path, 4.7% yellow path, and 7.9% red path, p = 0.685), significantly lower than the median rate of 35% reported in the literature. Multiple correspondence analysis validated the stratification, with distinct clusters for each path. Poisson regression models in the exploratory framework of an interim analysis identified male gender as the only significant predictor of PSCs, indicating the need for gender-specific interventions. The findings suggest that the Dermamecum protocol effectively reduces early PSCs, providing a foundation for further research. Full article
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20 pages, 4316 KiB  
Systematic Review
Diagnosis and Management of Simple and Complicated Meconium Ileus in Cystic Fibrosis, a Systematic Review
by Mădălina Andreea Donos, Gabriela Ghiga, Laura Mihaela Trandafir, Elena Cojocaru, Viorel Țarcă, Lăcrămioara Ionela Butnariu, Valentin Bernic, Eugenia Moroșan, Iulia Cristina Roca, Dana Elena Mîndru and Elena Țarcă
Diagnostics 2024, 14(11), 1179; https://doi.org/10.3390/diagnostics14111179 - 4 Jun 2024
Cited by 4 | Viewed by 4354
Abstract
The early management of neonates with meconium ileus (MI) and cystic fibrosis (CF) is highly variable across countries and is not standardized. We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. The protocol was registered [...] Read more.
The early management of neonates with meconium ileus (MI) and cystic fibrosis (CF) is highly variable across countries and is not standardized. We conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. The protocol was registered in PROSPERO (CRD42024522838). Studies from three providers of academic search engines were checked for inclusion criteria, using the following search terms: meconium ileus AND cystic fibrosis OR mucoviscidosis. Regarding the patient population studied, the inclusion criteria were defined using our predefined PICOT framework: studies on neonates with simple or complicated meconium which were confirmed to have cystic fibrosis and were conservatively managed or surgically treated. Results: A total of 566 publications from the last 10 years were verified by the authors of this review to find the most recent and relevant data, and only 8 met the inclusion criteria. Prenatally diagnosed meconium pseudocysts, bowel dilation, and ascites on ultrasound are predictors of neonatal surgery and risk factor for negative 12-month clinical outcomes in MI-CF newborns. For simple MI, conservative treatment with hypertonic solutions enemas can be effective in more than 25% of cases. If repeated enemas fail to disimpact the bowels, the Bishop–Koop stoma is a safe option. No comprehensive research has been conducted so far to determine the ideal surgical protocol for complicated MI. We only found three studies that reported the types of stomas performed and another study comparing the outcomes of patients depending on the surgical management; the conclusions are contradictory especially since the number of cases analyzed in each study was small. Between 18% and 38% of patients with complicated MI will require reoperation for various complications and the mortality rate varies between 0% and 8%. Conclusion: This study reveals a lack of strong data to support management decisions, unequivocally shows that the care of infants with MI is not standardized, and suggests a great need for international collaborative studies. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Management of Pediatric Diseases)
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13 pages, 239 KiB  
Article
Malignant Bowel Obstruction: A Retrospective Multicenter Cohort Study
by Maria-Evanthia Sotirianakou, Maximos Frountzas, Athina Sotirianakou, Haridimos Markogiannakis, George E. Theodoropoulos, Sotirios Sotirianakos and Konstantinos G. Toutouzas
J. Clin. Med. 2024, 13(1), 263; https://doi.org/10.3390/jcm13010263 - 2 Jan 2024
Cited by 1 | Viewed by 2082
Abstract
Background: Malignant bowel obstruction (MBO) is a serious clinical entity that requires surgical intervention in almost 50% of cases. However, overall survival remains low even for operable cases. The aim of the present study was to investigate the correlation between patients’ characteristics, perioperative [...] Read more.
Background: Malignant bowel obstruction (MBO) is a serious clinical entity that requires surgical intervention in almost 50% of cases. However, overall survival remains low even for operable cases. The aim of the present study was to investigate the correlation between patients’ characteristics, perioperative details, histopathological results and postoperative outcomes of patients who were operated on due to MBO. Methods: A retrospective search of patients who were operated on due to MBO in a university and a rural hospital was conducted. Patients’ characteristics, perioperative details, histopathological results and postoperative outcomes were reported. Univariable and multivariable analysis was performed. Results: Seventy patients were included with a mean age of 76.1 ± 10.6 years. The 30-day mortality rate was 18.6%, the Intensive Care Unit (ICU) admission rate was 17.1% and the mean length of stay (LOS) was 12.4 ± 5.7 days. Postoperative 30-day mortality was associated with increased age, known malignant recurrence, microscopically visible metastatic foci and defunctioning stoma creation. Colorectal malignancy type, sigmoid obstruction and primary anastomosis were correlated with decreased 30-day mortality. In addition, operation at the university hospital led to increased LOS, while stoma creation led to decreased LOS. Finally, ICU admission rates were increased for operations at university hospitals, at least one comorbidity, known malignant recurrence and longer preoperative waiting interval, whereas they were decreased for colorectal primary malignancy type. Conclusions: Surgery due to MBO leads to increased morbidity and mortality. Therefore, prospective studies are needed to highlight inter-patient differences regarding the best individualized therapeutic strategy. Full article
12 pages, 3437 KiB  
Review
Evidence-Based Analysis of the Critical Steps of Radical Cystectomy for Bladder Cancer
by Vincent D. D’Andrea, Kevin Melnick, Kendrick Yim, John Ernandez, Nnamdi Onochie, Timothy N. Clinton, Graeme S. Steele, Mark A. Preston, Adam S. Kibel and Matthew Mossanen
J. Clin. Med. 2023, 12(21), 6845; https://doi.org/10.3390/jcm12216845 - 30 Oct 2023
Cited by 4 | Viewed by 3015
Abstract
Radical cystectomy (RC) is an integral part of the management of patients with advanced-stage bladder cancer. This major oncologic operation is prone to complications resulting in morbidity and mortality. We analyzed the critical steps of open RC, performed an evidence-based review of these [...] Read more.
Radical cystectomy (RC) is an integral part of the management of patients with advanced-stage bladder cancer. This major oncologic operation is prone to complications resulting in morbidity and mortality. We analyzed the critical steps of open RC, performed an evidence-based review of these steps, and discussed our experience and approach. We conducted a literature review of the open RC technique, identified the critical steps that consistently appeared across different sources, and organized these steps into a framework. PubMed was queried with the critical steps as keywords for relevant articles published from 1 January 2013 to 1 August 2023. We utilized this query to conduct a systematic review of the literature using the outcomes of overall survival and 90-day complication rate. We developed the “Summary for the 10 Critical Operative Steps of Radical Cystectomy”, a concise guide to the approach to open RC. When available, an evidence-based analysis of each critical step was performed. We also included additional components of cystectomy optimization such as pre-habilitation in the preoperative phase, standard versus extended lymphadenectomy, the vaginal-sparing approach to female radical cystectomy, patient-reported outcomes following urinary diversion, the use of a mesh for stoma formation, and the use of the ERAS protocol for postoperative care. An evidence-based assessment of RC may help provide valuable information to optimize surgical techniques and patient outcomes. Full article
(This article belongs to the Special Issue Bladder Cancer: Surgical Treatment and Prognosis)
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10 pages, 813 KiB  
Article
Achieving a Textbook Outcome in Colon Cancer Surgery Is Associated with Improved Long-Term Survival
by Dimitrios K. Manatakis, Maria Tzardi, John Souglakos, John Tsiaoussis, Christos Agalianos, Ioannis D. Kyriazanos, George Pechlivanides, Athanasios Kordelas, Nikolaos Tasis, Nikolaos Gouvas and Evaghelos Xynos
Curr. Oncol. 2023, 30(3), 2879-2888; https://doi.org/10.3390/curroncol30030220 - 28 Feb 2023
Cited by 13 | Viewed by 2775
Abstract
Background: Colon cancer surgery is a complex clinical pathway and traditional quality metrics may exhibit significant variability between hospitals and healthcare providers. The Textbook Outcome (TO) is a composite quality marker capturing the fraction of patients, in whom all desired short-term outcomes of [...] Read more.
Background: Colon cancer surgery is a complex clinical pathway and traditional quality metrics may exhibit significant variability between hospitals and healthcare providers. The Textbook Outcome (TO) is a composite quality marker capturing the fraction of patients, in whom all desired short-term outcomes of care are realised. The aim of the present study was to assess the TO in a series of non-metastatic colon cancer patients treated with curative intent, with emphasis on long-term survival. Methods: Stage I–III colon cancer patients, who underwent curative colectomy following the Complete Mesocolic Excision principles, were retrospectively identified from the institutional database. TO was defined as (i) hospital survival, (ii) radical resection, (iii) no major complications, (iv) no reintervention, (v) no unplanned stoma and (vi) no prolonged hospital stay or readmission. Results: In total, 128 patients (male 61%, female 39%, mean age 70.7 ± 11.4 years) were included in the final analysis. Overall, 60.2% achieved a TO. The highest rates were observed for “hospital survival” and “no unplanned stoma” (96.9% and 97.7%), while the lowest rates were for “no major complications” and “no prolonged hospital stay” (69.5% and 75%). Older age, left-sided resections and pT4 tumours were factors limiting the chances of a TO. The 5-year overall and 5-year cancer-specific survival were significantly better in the TO versus non-TO subgroup (81% vs. 59%, p = 0.009, and 86% vs. 65%, p = 0.02, respectively). Conclusions: Outcomes in colon cancer surgery may be affected by patient-, doctor- and hospital-related factors. TO represents those patients who achieve the optimal perioperative results, and is furthermore associated with improved long-term cancer survival. Full article
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12 pages, 520 KiB  
Review
Obstetric Considerations in Pregnant Women with Crohn’s Disease
by Konstantina Rosiou and Christian P. Selinger
J. Clin. Med. 2023, 12(2), 684; https://doi.org/10.3390/jcm12020684 - 15 Jan 2023
Cited by 3 | Viewed by 5397
Abstract
Crohn’s disease affects many women of childbearing age. Fecundity rates are often lower than in the general population due to reduced fertility during active inflammation, effects of pelvic surgery or voluntary childlessness. Many women have concerns regarding the effects of pregnancy on their [...] Read more.
Crohn’s disease affects many women of childbearing age. Fecundity rates are often lower than in the general population due to reduced fertility during active inflammation, effects of pelvic surgery or voluntary childlessness. Many women have concerns regarding the effects of pregnancy on their Crohn’s, any potential effect of medication on the fetus, and passing on Crohn’s disease to the offspring. International guidelines on reproduction for women with Crohn’s disease provide evidence-based advice to patients and health care professionals. There is an increasing literature on the safety of advanced medication for Crohn’s disease during pregnancy. This review article therefore focuses on obstetric considerations beyond medication safety. We provide information on fertility, factors affecting pregnancy and fetal outcomes, obstetric complications, factors influencing mode of delivery, management of intestinal stomas during pregnancy and general considerations around breast feeding. Full article
(This article belongs to the Special Issue Current Status, Challenges and Future Directions in Crohn's Disease)
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17 pages, 1985 KiB  
Article
Stratification of Length of Stay Prediction following Surgical Cytoreduction in Advanced High-Grade Serous Ovarian Cancer Patients Using Artificial Intelligence; the Leeds L-AI-OS Score
by Alexandros Laios, Daniel Lucas Dantas De Freitas, Gwendolyn Saalmink, Yong Sheng Tan, Racheal Johnson, Albina Zubayraeva, Sarika Munot, Richard Hutson, Amudha Thangavelu, Tim Broadhead, David Nugent, Evangelos Kalampokis, Kassio Michell Gomes de Lima, Georgios Theophilou and Diederick De Jong
Curr. Oncol. 2022, 29(12), 9088-9104; https://doi.org/10.3390/curroncol29120711 - 23 Nov 2022
Cited by 8 | Viewed by 3078
Abstract
(1) Background: Length of stay (LOS) has been suggested as a marker of the effectiveness of short-term care. Artificial Intelligence (AI) technologies could help monitor hospital stays. We developed an AI-based novel predictive LOS score for advanced-stage high-grade serous ovarian cancer (HGSOC) patients [...] Read more.
(1) Background: Length of stay (LOS) has been suggested as a marker of the effectiveness of short-term care. Artificial Intelligence (AI) technologies could help monitor hospital stays. We developed an AI-based novel predictive LOS score for advanced-stage high-grade serous ovarian cancer (HGSOC) patients following cytoreductive surgery and refined factors significantly affecting LOS. (2) Methods: Machine learning and deep learning methods using artificial neural networks (ANN) were used together with conventional logistic regression to predict continuous and binary LOS outcomes for HGSOC patients. The models were evaluated in a post-hoc internal validation set and a Graphical User Interface (GUI) was developed to demonstrate the clinical feasibility of sophisticated LOS predictions. (3) Results: For binary LOS predictions at differential time points, the accuracy ranged between 70–98%. Feature selection identified surgical complexity, pre-surgery albumin, blood loss, operative time, bowel resection with stoma formation, and severe postoperative complications (CD3–5) as independent LOS predictors. For the GUI numerical LOS score, the ANN model was a good estimator for the standard deviation of the LOS distribution by ± two days. (4) Conclusions: We demonstrated the development and application of both quantitative and qualitative AI models to predict LOS in advanced-stage EOC patients following their cytoreduction. Accurate identification of potentially modifiable factors delaying hospital discharge can further inform services performing root cause analysis of LOS. Full article
(This article belongs to the Section Gynecologic Oncology)
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17 pages, 375 KiB  
Review
Neobladder “Function”: Tips and Tricks for Surgery and Postoperative Management
by Daniela Fasanella, Michele Marchioni, Luigi Domanico, Claudia Franzini, Antonino Inferrera, Luigi Schips and Francesco Greco
Life 2022, 12(8), 1193; https://doi.org/10.3390/life12081193 - 4 Aug 2022
Cited by 8 | Viewed by 5219
Abstract
Orthotopic neobladder (ONB) reconstruction is a continent urinary diversion procedure increasingly used in patients with muscle-invasive bladder cancer following radical cystectomy (RC). It represents a valid alternative to the ileal duct in suitable patients who do not prefer a stoma and are motivated [...] Read more.
Orthotopic neobladder (ONB) reconstruction is a continent urinary diversion procedure increasingly used in patients with muscle-invasive bladder cancer following radical cystectomy (RC). It represents a valid alternative to the ileal duct in suitable patients who do not prefer a stoma and are motivated to undergo adequate training of the neobladder. Careful patient selection, taking into account the absolute and relative contraindications for ONB as well as an adequate recovery protocol after surgery are integral to the success of this procedure and the oncological and functional outcomes. The objective of this review is to summarize the current data on RC with ONB in terms of patient selection, preoperative preparation, surgical techniques and functional (continence and sexual activity) and oncological outcomes, with particular attention to the management of complications and the impact on quality of life (QoL). Full article
(This article belongs to the Special Issue Urological Dysfunction: State of the Art)
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