Search Results (17)

Cannabidiol (CBD) has gained popularity in veterinary medicine for its potential to alleviate stress, pain, and inflammation in dogs. However, its oral administration is limited by hydrophobicity, variable absorption, and extensive first-pass metabolism, which requires optimized delivery methods to enhance efficacy. This study investigated the effects of daily oral supplementation of CBD oil and CBD gel (each at 4 mg/kg), compared to a placebo, over 14 days in shelter dogs subjected to solitary confinement-induced stress. Both CBD formulations appeared safe under the study conditions, with no adverse effects on hematological and biochemical parameters. Post-stress cortisol levels were significantly lower in CBD-treated groups compared to controls, with CBD-infused gel showing a pattern toward greater attenuation. Multivariate analysis revealed distinct blood profile shifts in CBD-treated dogs, with PCA loadings indicating associations between CBD supplementation and lymphocyte percentages and IgG levels. These findings support gel-based CBD as a promising strategy for stress modulation in dogs. Further studies should explore its pharmacokinetics and long-term immune effects to optimize veterinary applications. Full article

The goal of this research is to utilize some ansatz forms of solutions to obtain novel forms of soliton solutions for the Benney–Luke equation. It is a mathematically valid approximation that describes the propagation of two-way water waves in the presence of surface tension. By using ansatz forms of solutions, with an appropriate set of parameters, the lump soliton, periodic cross-kink waves, multi-waves, breather waves, Ma-breather, Kuznetsov–Ma-breather, periodic waves and rogue waves solutions can be obtained. Breather waves are confined, periodic, nonlinear wave solutions that preserve their amplitude and shape despite alternating between compression and expansion. For some integrable nonlinear partial differential equations, a lump soliton is a confined, stable solitary wave solution. Rogue waves are unusually powerful and sharp ocean surface waves that deviate significantly from the surrounding wave pattern. They pose a threat to maritime safety. They typically show up in solitary, seemingly random circumstances. Periodic cross-kink waves are a particular type of wave pattern that has frequent bends or oscillations that cross at right angles. These waves provide insights into complicated wave dynamics and arise spontaneously in a variety of settings. In order to predict the wave dynamics, certain 2D, 3D and contour profiles are also analyzed. Since these recently discovered solutions contain certain arbitrary constants, they can be used to describe the variation in the qualitative characteristics of wave phenomena. Full article

Along with the familiar Rossby–Haurwitz waves, two-dimensional flows on the surface of a rotating sphere in the regime of zonostrophic turbulence harbor another class of waves known as zonons. Zonons are wave packets produced by energetic large-scale Rossby–Haurwitz wave modes ‘enslaving’ other wave modes. They propagate westward with the phase speed of the enslaving modes. Zonons can be visualized as enslaving modes’ ‘ringing’ in the enslaved ones with the frequencies of the former, the property that renders zonons non-dispersive. Zonons reside in high-shear regions confined between the opposing zonal jets yet they are mainly attached to westward jets and sustained by the ensuing barotropic instability. They exchange energy with the mean flow while preserving their identity in a fully turbulent environment, a feature characteristic of solitary waves. The goal of this study is to deepen our understanding of zonons’ physics using direct numerical simulations, a weakly non-linear theory, and asymptotic analysis, and ascertain that zonons are indeed isomorphic to solitary waves in the Korteweg–de Vries framework. Having this isomorphism established, the analysis is extended to eddies detected in the atmospheres of Jupiter and Saturn based upon the observed mean zonal velocity profiles and earlier findings that circulations on both planets obey the regime of zonostrophic macroturbulence. Not only the analysis confirms that many eddies and eddy trains on both giant planets indeed possess properties of zonons, but the theory also correctly predicts latitudinal bands that confine zonal trajectories of the eddies. Full article

This article aims to examine the nonlinear excitations in a coupled Hirota system described by the fractal fractional order derivative. By using the Laplace transform with Adomian decomposition (LADM), the numerical solution for the considered system is derived. It has been shown that the suggested technique offers a systematic and effective method to solve complex nonlinear systems. Employing the Banach contraction theorem, it is confirmed that the LADM leads to a convergent solution. The numerical analysis of the solutions demonstrates the confinement of the carrier wave and the presence of confined wave packets. The dispersion nonlinear parameter reduction equally influences the wave amplitude and spatial width. The localized internal oscillations in the solitary waves decreased the wave collapsing effect at comparatively small dispersion. Furthermore, it is also shown that the amplitude of the solitary wave solution increases by reducing the fractal derivative. It is evident that decreasing the order $\alpha$ modifies the nature of the solitary wave solutions and marginally decreases the amplitude. The numerical and approximation solutions correspond effectively for specific values of time (t). However, when the fractal or fractional derivative is set to one by increasing time, the wave amplitude increases. The absolute error analysis between the obtained series solutions and the accurate solutions are also presented. Full article

Cutaneous syncytial myoepithelioma (CSM) is a rare type of cutaneous neoplasm that typically presents as a solitary and well-circumscribed nodule on the skin. It predominantly occurs on the upper and lower extremities of adult patients. Immunohistochemically, CSM is characterized by the co-expression of smooth muscle and epithelial markers. Fluorescence in situ hybridization (FISH) targeting the EWSR1 gene rearrangement is an important diagnostic tool for CSM. In our case report, we found the focal positivity for CD34, which has never been previously observed; this was mostly confined to a central area of the neoplasm. Full article

In French Grandes Écoles, heavy alcohol consumption seems to be generalized and largely tolerated, leading to particular concerns about Alcohol Use Disorder and harmful alcohol practices among students. The COVID-19 pandemic led to increased psychological difficulties, and two coexisting scenarios seemed to emerge regarding alcohol consumption: A decrease in alcohol consumption linked to the absence of festive events, and an increase in solitary alcohol consumption to cope with lockdowns. The aim of this exploratory study is to investigate the evolution of alcohol consumption, consumption motives and the relationship of these factors to the anxiety and the depression of French Grandes Écoles students during the COVID-19 pandemic, depending on their residential status. After the last lockdown, 353 students completed a questionnaire measuring alcohol consumption, motivation to drink, anxiety and depression during and after the COVID-19 period. Although students confined to campus were more likely to increase their alcohol use, they also presented higher well-being scores than those who lived off campus. A significant proportion of students were aware of their increased alcohol use due to the COVID-19 pandemic, and the motives attributed to their increased consumption highlight the need for vigilance and specialized support facilities. Full article

Introduction: The prevalence of psychiatric morbidity is high among incarcerated individuals. Severe mental disorder is five to ten times higher among prisoners compared to the general population. Several factors are held to be responsible for the high prevalence of depression in prison: mainly poor living conditions (narrow room, loss of privacy), limited interpersonal relationships, and lack of mental health access. Inmates are at increased risk of all-cause mortality, suicide, self-harm, violence, and victimization while those with mental disorders are involved in conflicts and are more likely to be charged with prison rules. Purpose: To explore depression among male inmates. Methods and material: In the study, 101 male inmates were enrolled. Data were collected by the completion of a “self-rating depression scale (SDS)-Zung” which included participants’ characteristics. The statistical significance level was p < 0.05. Results: Of the 101 participants, 51.4% of inmates were under 40 years old, 54.5% were married, 45.6% had been convicted of homicide and 38.6% had a life sentence. Normal depression levels were experienced by 62.4% of the participants, while 21.8% were mildly depressed, 14.9% were moderately depressed and 1.0% severely depressed. Foreign prisoners had statistically significant higher scores of depression compared to Greeks (median 48 vs. 45, p = 0.012); those suffering from a chronic disease compared to those who did not (median 48 vs. 45, p = 0.038); those who had spent time in solitary confinement compared to those who had not (median 46 vs. 43.5, p = 0.038) as well as those who had not considered harming themselves compared to those who had thought of it (median 46 vs. 44, p = 0.017). Conclusion: Given that prison populations are marginalized and deprived of the rights that people in the community benefit from, establishing the prevalence of depression in male inmates and its associated characteristics may help to formulate recommendations for future prison health care services. Clinical, research, and policy efforts are needed to improve prison mental health. Full article

The zebrafish model is an emerging model for the study of the complex behavioural patterns noted in depression and neurological disorders. Confinement and memory loss are linked with cognition and mental health impairment, where confinement paradigms are assessed using other behavioural responses based on novel tanks or T tanks. Since zebrafish are exploratory animals, the impact during confinement cannot be evaluated using a novel tank or T tank. The present study investigates the response of the zebrafish to acute confinement and assesses its memory-based learning behaviour through parameters such as movement, swimming speed, and time spent inside the confined space. The movement and swimming speed of the fishes in confinement showed no significant difference. When confined inside a space, the fish showed their anxiety with erratic movements or bouts of freezing, which declined by 83%, during the six days of confinement and the escape time from the confinement space also decreased by 58%. The impact of anxiety, resulting in clockwise and counter-clockwise movement, also reduced after three days. Our results summarise that the decrease in anxiety can help the fish in habituating itself to a forced condition. This experiment on zebrafish behavioural biology is used to assess the cognitive behaviour against confinement, and it emphasizes the learning of behavioural adaptions under both crowded and solitary conditions. Full article

Resulting in pervasive feelings of despair, the culture of incarceration in the U.S. relies on punitive correctional strategies such as solitary confinement to control the behavior of incarcerated individuals. Inevitably, correctional culture which focuses primarily on punishment is dysfunctional, rife with gang violence, drug use, suicide, and violence perpetuated by and against staff. Our dialogic essay is voiced by (a) a currently incarcerated, Native American person who has survived solitary confinement and the spiritual drain of castigating correctional culture; and (b) a music educator who founded a prison choir for both non-incarcerated and incarcerated individuals in an effort to erode and transform some of the revengeful structures of US incarceration. We draw from Indigenous educator, language specialist, and member of the Lil’wat First Nation, Dr. Lorna Williams’ research on Indigenous Knowledge in our efforts to understand the relationships among group singing, spirituality, and our experiences in the Oakdale prison choir. Our dialogue charts a search for spiritual healing in the unsympathetic atmosphere of prison and offers an experience-based account of ways in which group singing can function as a medium of spiritual healing and growth in environments of conflict. Full article

Incarceration, along with its most restrictive iteration, solitary confinement, is an increasingly common experience in America. More than two million Americans are currently incarcerated, and at least one-fifth of incarcerated people will experience solitary confinement. Understanding the barriers to care people experience in prison, and especially in solitary confinement, is key to improving their access to care during and after incarceration. Drawing on in-depth qualitative interviews with a random sample of 106 people living in solitary confinement and a convenience sample of 77 people working in solitary confinement in Washington State, we identify two key barriers to care that people in solitary confinement face: cultural barriers (assumptions that incarcerated people do not need or do not deserve care) and structural barriers (physical spaces and policies that make contacting a healthcare provider difficult). While scholarship has documented both the negative health consequences of solitary confinement and correctional healthcare providers’ challenges navigating between the “dual loyalty” of patient care and security missions, especially within solitary confinement, few have documented the specific mechanisms by which people in solitary confinement are repeatedly triaged out of healthcare access. Understanding these barriers to care is critical not only to improving correctional healthcare delivery but also to improving healthcare access for millions of formerly incarcerated people who have likely had negative experiences seeking healthcare in prison, especially if they were in solitary confinement. Full article

Sociality can be broadly defined as the ability and tendency of individuals to reside in social groups with either conspecifics and/or other species. More specifically, sociability relates to the ability and tendency of individuals to display affiliative behaviours in such contexts. The domestic cat is one of the most globally popular companion animals and occupies a diverse range of lifestyles. Despite an arguably short period of domestication from an asocial progenitor, the domestic cat demonstrates an impressive capacity for both intra- and interspecific sociality and sociability. At the same time, however, large populations of domestic cats maintain various degrees of behavioural and reproductive autonomy and are capable of occupying solitary lifestyles away from humans and/or conspecifics. Within social groups, individuals can also vary in their tendency to engage in both affiliative and agonistic interactions, and this interindividual variation is present within free-living populations as well as those managed in confined environments by humans. Considerable scientific enquiry has focused on cats’ social behaviour towards humans (and conspecifics to a much lesser extent) in this latter context. Ontogeny and human selection, in addition to a range of proximate factors including social and environmental parameters and individual cat and human characteristics, have been highlighted as important moderators of cats’ sociability. Such factors may have important consequences regarding individuals’ adaptability to the diverse range of lifestyles that they may occupy. Where limitations to individuals’ social capacities do not enable sufficient adaption, compromises to their wellbeing may occur. This is most pertinent for cats managed by humans, given that the physical and social parameters of the cats’ environment are primarily dictated by people, but that positive human-selection for traits that enhance cats’ adaptability to such lifestyles appears to be limited. However, limitations in the availability and quality of evidence and equivocal findings may impede the current understanding of the role of certain factors in relation to cat sociability and associations with cat wellbeing, although such literature gaps also present important opportunities for further study. This review aims to summarise what is currently known about the various factors that may influence domestic cats’ sociality and sociability towards both humans and conspecifics, with a predominant focus on cats managed by humans in confined environments. Current limitations, knowledge gaps, and implications for cat wellbeing are also discussed. Full article

A paradigm for high buffering performance with an essential fulfillment for sensing and modulation was set forth. Through substituting the fundamental two rows of air holes in an elongated hexagonal photonic crystal (E-PhC) by one row of the triangular gaps, the EPCW is molded to form an irregular waveguide. By properly adjusting the triangle dimension solitary, we fulfilled the lowest favorable value of the physical-size of each stored bit by about μ$5.5510\mathsf{\mu }\mathrm{m}.$ Besides, the EPCW is highly sensitive to refractive index (RI) perturbation attributed to the medium through infiltrating the triangular gaps inside the EPCW by microfluid with high RI sensitivity of about 379.87 nm/RIU. Furthermore, dynamic modulation can be achieved by applying external voltage and high electro-optical (EO) sensitivity is obtained of about 748.407 nm/RIU. The higher sensitivity is attributable to strong optical confinement in the waveguide region and enhanced light-matter interaction in the region of the microfluid triangular gaps inside the EPCW and conventional gaps (air holes). The EPCW structure enhances the interaction between the light and the sensing medium. Full article

Receptors form the crux for any biochemical signaling. Receptor-like kinases (RLKs) are conserved protein kinases in eukaryotes that establish signaling circuits to transduce information from outer plant cell membrane to the nucleus of plant cells, eventually activating processes directing growth, development, stress responses, and disease resistance. Plant RLKs share considerable homology with the receptor tyrosine kinases (RTKs) of the animal system, differing at the site of phosphorylation. Typically, RLKs have a membrane-localization signal in the amino-terminal, followed by an extracellular ligand-binding domain, a solitary membrane-spanning domain, and a cytoplasmic kinase domain. The functional characterization of ligand-binding domains of the various RLKs has demonstrated their essential role in the perception of extracellular stimuli, while its cytosolic kinase domain is usually confined to the phosphorylation of their substrates to control downstream regulatory machinery. Identification of the several ligands of RLKs, as well as a few of its immediate substrates have predominantly contributed to a better understanding of the fundamental signaling mechanisms. In the model plant Arabidopsis, several studies have indicated that multiple RLKs are involved in modulating various types of physiological roles via diverse signaling routes. Here, we summarize recent advances and provide an updated overview of transmembrane RLKs in Arabidopsis. Full article

The proliferation of jails and prisons as places of institutionalization for persons with serious mental illness (SMI) has resulted in many of these patients receiving jail-based punishments, including solitary confinement. Starting in 2013, the New York City (NYC) jail system developed a new treatment unit for persons with SMI who were judged to have violated jail rules (and previously would have been punished with solitary confinement) called the Clinical Alternative to Punitive Segregation (CAPS) unit. CAPS is designed to offer a full range of therapeutic activities and interventions for these patients, including individual and group therapy, art therapy, medication counseling and community meetings. Each CAPS unit requires approximately $1.5 million more investment per year, largely in additional staff as compared to existing mental health units, and can house approximately 30 patients. Patients with less serious mental illness who received infractions were housed on units that combined solitary confinement with some clinical programming, called Restrictive Housing Units (RHU). Between 1 December 2013 and 31 March 2015, a total of 195 and 1433 patients passed through the CAPS and RHU units, respectively. A small cohort of patients experienced both CAPS and RHU (n = 90). For these patients, their rates of self-harm and injury were significantly lower while on the CAPS unit than when on the RHU units. Improvements in clinical outcomes are possible for incarcerated patients with mental illness with investment in new alternatives to solitary confinement. We have started to adapt the CAPS approach to existing mental health units as a means to promote better clinical outcomes and also help prevent jail-based infractions. The cost of these programs and the dramatic differences in length of stay for patients who earn these jail-based infractions highlight the need for alternatives to incarceration, some of which have recently been announced in NYC. Full article

USP Marion is the first supermax federal penitentiary. Marionization refers to the experimental control program used at this prison. The prisoners speaking in this article suffered many years of solitary confinement. This research brief discusses some of what they experienced in their own words. These are the recollections of a few Marion prisoners that have summoned the courage to speak out and share their darkest memories. Full article