Search Results (90)

Background: Central precocious puberty (CPP), defined as the onset of secondary sexual characteristics before age 8 in girls, is increasingly prevalent worldwide. CPP is often caused by early activation of the HPG axis, leading to accelerated growth and bone maturation. However, the diagnostic accuracy of standard bone age (BA) methods remains uncertain in this context. Objective: To compare the diagnostic accuracy of the Greulich–Pyle atlas (GPA) and Tanner–Whitehouse 3 (TW3) methods in estimating skeletal age in girls with CPP and to assess the predictive value of serum hormone levels for estimating chronological age (CA). Methods: An observational, cross-sectional diagnostic study was conducted, involving n = 109 girls aged 6–12 years with confirmed CPP (Ethics Committee approval: CHUC_2023_86; 13 July 2023). Left posteroanterior hand–wrist (PA–HW) radiographs were assessed using the GPA and TW3 methods. Anthropometric measurements were recorded, and serum concentrations of estradiol, LH, FSH, DHEA-S, cortisol, TSH, and free T4 were obtained. Comparisons between CA and BA estimates were conducted using repeated-measures ANOVA, and ANCOVA was applied to examine the hormonal predictors of CA. Results: Both GPA and TW3 overestimated CA between 7 and 12 years, with the GPA showing larger deviations (up to 4.8 months). The TW3 method provided more accurate estimations, particularly at advanced pubertal stages. Estradiol (η²_p = 0.188–0.197), LH (η²_p = 0.061–0.068), and FSH (η²_p = 0.008–0.023) emerged as the strongest endocrine predictors of CA, significantly enhancing the explanatory power of both radiological methods. Conclusions: The TW3 method demonstrated superior diagnostic accuracy over GPA in girls with CPP, especially between 7 and 12 years. Integrating estradiol, LH, and FSH into BA assessment significantly improved the accuracy, supporting a more individualized and physiologically grounded diagnostic approach. Full article

This position paper proposes a conceptual framework (CF-BIAI-SXT) for integrating blockchain with AI to enhance ethical governance, transparency, and privacy in high-risk AI applications that ensure societal resilience through the mitigation of sexual exploitation. Sextortion is a growing form of digital sexual exploitation, and the role of AI in its mitigation and the ethical issues that arise provide a good case for this paper. Through a combination of systematic and narrative literature reviews, the paper first explores the ethical shortcomings of existing AI systems in sextortion prevention and assesses the capacity of blockchain operations to mitigate these limitations. It then develops CF-BIAI-SXT, a framework operationalized through BPMN-modeled components and structured into a three-layer implementation strategy composed of technical enablement, governance alignment, and continuous oversight. The framework is then situated within real-world regulatory constraints, including GDPR and the EU AI Act. This position paper concludes that a resilient society needs ethical, privacy-first, and socially resilient digital infrastructures, and integrating two core technologies, such as AI and blockchain, creates a viable pathway towards this desideratum. Mitigating high-risk environments, such as sextortion, may be a fundamental first step in this pathway, with the potential expansion to other forms of online threats. Full article

The complexity for law enforcement and child protection agencies has been exacerbated by the proliferation of child sexual exploitation channels, facilitated by digital platforms and social media. Generative AI’s ability to analyze large datasets, recognize patterns, and generate new content makes it one of the potential solutions for detecting suspicious behavior and indicators of child sexual exploitation. This paper discusses the potential of generative AI to aid in the fight against pedophilic crimes by reviewing current research, methodologies, and challenges, as well as future directions and ethical concerns. Although the potential benefits are significant, applying AI to such a sensitive area presents numerous challenges, including privacy concerns, algorithmic bias, and potential misuse, which must be addressed carefully. Full article

A preservationist Christian sexual ethic affirms heterosexuality as the only normal and natural expression of wholeness in human intimacy, relationships, and lifestyle. However, revisionist critics would maintain that the central problem of the preservationist perspective is the perceived lack of a compelling verifier. A revisionist Christian ethic embraces homosexuality as an alternative form of wholeness in human relationships and lifestyle. Preservationist critics would maintain that the central problem of the revisionist perspective is the perceived lack of a compelling verifier. They would also identify an additional problem for the revisionist position, namely, the perceived problem of self-contradiction. It may seem to some that problems alleged for a particular side cannot be leveraged to the advantage of the opposing side in this debate. Moreover, even the external judgment that a problem exists for a perspective is disputed within that perspective. This may seem to lead to stalemate between the opposing perspectives. However, it may be that a verifier or vindicator exists for one of these perspectives that would commend that perspective as more acceptable than the other. A vindicator for a perspective need only to reinforce that perspective, while a verifier must be an empirically attested ground for the perspective. In this article, I will compare verifiers and vindicators on each side of the debate and inquire whether there is an ace to be found in any of these arenas. I find that a preservationist Christian sexual ethic speaks for itself when its vehicles of verification and vindication are addressed in dialogue with a revisionist perspective. My aim is to increase the possibility of moving the discussion forward in the debate over normative human sexuality. Full article

Background: Gender-based violence has serious health impacts on survivors and is perpetuated by cultural norms, patriarchy, and traditional values. This study explored women’s (survivors) views, attitudes and the impact of gender-based violence on their health in a selected rural village within the Collins Chabane Municipality, Vhembe District, Limpopo Province. Methods: A qualitative descriptive design was used, involving 20 women aged 18 to 59. Semi-structured in-depth interviews were conducted, and data were analysed thematically using ATLAS.ti 8, based on Braun and Clarke’s six-step framework. Ethical considerations were prioritised due to the sensitive nature of the research. Results: The results revealed that women in the Collins Chabane Municipality experience multiple forms of GBV, including physical, sexual, emotional, and financial abuse, which severely impacts their mental and physical health. Additionally, socioeconomic factors like unemployment and financial dependence exacerbate their vulnerability, making it difficult to escape abusive relationships. Conclusions: Cultural norms, patriarchal beliefs, and limited community support intersect to shape women’s experiences and responses to abuse. Full article

Background/Objectives: The Y chromosome is a crucial tool in forensic genetics due to its unique characteristics, such as its haploid inheritance and lack of recombination. Y-STRs (short tandem repeats on the Y chromosome) are widely used for identifying male genetic profiles in DNA mixtures, especially in sexual assault cases where high levels of female DNA hinder autosomal analysis. This study evaluates the applicability of Y-STRs in forensic investigations, addressing their limitations and the impact of advanced technologies, such as rapidly mutating Y-STRs (RM Y-STRs). Methods: A comprehensive literature review was conducted to analyze existing knowledge on the application of Y-STRs in sexual crimes. The study also examines the role of population databases, such as YHRD, in estimating haplotype frequencies and enhancing forensic reliability. Results: Y-STR analysis proves essential for male DNA identification in complex mixtures, with RM Y-STRs enhancing discriminatory power. However, limitations persist, particularly in cases involving closely related male lineages. The population database coverage remains insufficient in regions like Cape Verde, affecting forensic reliability. Case studies demonstrate Y-STR effectiveness in solving cold cases and sexual crimes, reinforcing the need for expanded databases and methodological advancements. Conclusions: Y-STRs play a fundamental role in forensic genetics, particularly in sexual assault investigations. Their integration with advanced sequencing technologies and expanded databases is critical for improving forensic accuracy. Ethical considerations regarding genetic data privacy and potential discrimination must be addressed through clear regulations and forensic best practices. Full article

Bystander intervention and sexual assault research typically rely on self-reported intent to intervene. However, predicted behaviour can be considerably different from actual behaviour. Hypothetical scenarios are often utilised to remove extenuating circumstances, limiting insight into actual behaviour where those circumstances impact intervention. This paper discusses the development and evaluation of an innovative methodology to measure actual bystander behaviour when witnessing signs of an impending sexual assault. With careful attention paid to ethical considerations and participant safety, 13 participants were directly deceived about the true aim of the research. Utilising observational data and a funnelling debrief, the findings demonstrated varied reactions to sexual assault cues, from not noticing and therefore not intervening, to noticing and (in)directly intervening. Participants’ responses indicated they remained unaware of the deception until it was formally revealed, suggesting the methodology effectively realised the study’s aims. The funnelling debrief mitigated the adverse effects of the deception, with some participants reporting more confidence and motivation to intervene in the future. Further development of this methodology could create more interactive bystander intervention programmes that teach people to identify signs of a sexual assault, develop skills to safely intervene, and raise awareness about sexual violence. Full article

The decision to neuter pet dogs remains a significant and ongoing debate from ethical, animal health, and animal welfare perspectives. Millions of dogs worldwide are considered integral family members, and their behavior, as well as the bond they form with their owners, play a key role in the decision to keep them as pets. When behavioral problems arise, neutering is often viewed as a potential solution. However, by removing the source of sexual hormones, neutering creates the potential for both beneficial and harmful effects on a dog’s health and behavior. It is crucial for society to rely on professionals to provide informed advice about whether and when the procedure should be performed on a pet, taking into account the unique risks and benefits of each individual case. Instead, the conclusions drawn from existing research—both in terms of behavior and health aspects—remain inconclusive and sometimes conflicting. Studies have reported higher risks for developing reproductive, urinary, metabolic, and musculoskeletal disorders in neutered dogs. Additionally, some studies suggest increases in stress, fear, anxiety, and even certain types of aggression following neutering. The limitations of current research, the subjectivity of pet owners’ evaluations of their dogs’ behaviors, the influence of various demographic factors, and the complex relationships between sex hormones and other hormones or neurotransmitters all contribute to the challenges in this field of study. Despite these complexities, they also offer promising avenues for future research. This review aims to provide a comprehensive overview of the various effects of neutering on dogs, with a particular focus on behavioral outcomes. Full article

Early post-Vatican Catholic moral theologians made significant global proposals for renewed theological ethics in their own time and culture. However, after the culmination of the work of these great scholars in the 1980s and 1990s, Catholic moral theology became anchored in contingent polemic and polarized debates. It ceased to offer integral proposals of fundamental Christian ethics for the new challenges in the personal, intersubjective, and social scenarios. Subsequent studies often focused on bioethics, sexuality, family, and social justice but rarely attempted to renew a public fundamental morality for the 21st century. The essential features of this article are the proposal of new categories and debates for fundamental moral theology, grounded on the conviction that promoting this discipline as a humanization proposal builds on the profound potential human beings are called to fulfill. Humanity understood in all its complexity requires a theological ethics capable of incorporating this human condition and its categories, such as vulnerability, corporality, and recognition from a transdisciplinary point of view. These challenges underscore the urgent need for a renewed ethical framework articulated in a significant language for our time. Drawing on extensive literature and analytical research methods, it examines the interplay between these multifaceted issues. Full article

This study addresses the biases in artificial intelligence (AI) when generating creative content, a growing challenge due to the widespread adoption of these technologies in creating automated narratives. Biases in AI reflect and amplify social inequalities. They perpetuate stereotypes and limit diverse representation in the generated outputs. Through an experimental approach with ChatGPT-4, biases related to age, gender, sexual orientation, ethnicity, religion, physical appearance, and socio-economic status, are analyzed in AI-generated stories about successful individuals in the context of Spain. The results reveal an overrepresentation of young, heterosexual, and Hispanic characters, alongside a marked underrepresentation of diverse groups such as older individuals, ethnic minorities, and characters with varied socio-economic backgrounds. These findings validate the hypothesis that AI systems replicate and amplify the biases present in their training data. This process reinforces social inequalities. To mitigate these effects, the study suggests solutions such as diversifying training datasets and conducting regular ethical audits, with the aim of fostering more inclusive AI systems. These measures seek to ensure that AI technologies fairly represent human diversity and contribute to a more equitable society. Full article

The Fourth Industrial Revolution (4IR) has significantly impacted healthcare, including sexually transmitted infection (STI) management in Sub-Saharan Africa (SSA), particularly among key populations (KPs) with limited access to health services. This review investigates 4IR technologies, including artificial intelligence (AI) and machine learning (ML), that assist in diagnosing, treating, and managing STIs across SSA. By leveraging affordable and accessible solutions, 4IR tools support KPs who are disproportionately affected by STIs. Following systematic review guidelines using Covidence, this study examined 20 relevant studies conducted across 20 SSA countries, with Ethiopia, South Africa, and Zimbabwe emerging as the most researched nations. All the studies reviewed used secondary data and favored supervised ML models, with random forest and XGBoost frequently demonstrating high performance. These tools assist in tracking access to services, predicting risks of STI/HIV, and developing models for community HIV clusters. While AI has enhanced the accuracy of diagnostics and the efficiency of management, several challenges persist, including ethical concerns, issues with data quality, and a lack of expertise in implementation. There are few real-world applications or pilot projects in SSA. Notably, most of the studies primarily focus on the development, validation, or technical evaluation of the ML methods rather than their practical application or implementation. As a result, the actual impact of these approaches on the point of care remains unclear. This review highlights the effectiveness of various AI and ML methods in managing HIV and STIs through detection, diagnosis, treatment, and monitoring. The study strengthens knowledge on the practical application of 4IR technologies in diagnosing, treating, and managing STIs across SSA. Understanding this has potential to improve sexual health outcomes, address gaps in STI diagnosis, and surpass the limitations of traditional syndromic management approaches. Full article

More than three decades ago, the Supreme Court of the United States (SCOTUS) ruled that individuals who are not competent (alternatively referred to by the Court as insane) at the time of their scheduled execution cannot be put to death. Despite the years that have passed since the Court’s decision and the literal life-or-death stakes involved, competency for execution (CFE) remains underexplored in the psychological, psychiatric, and legal literature. A number of important legal and ethical issues that arise when a person on death row maintains they are not competent to be executed are still unresolved even after the landmark Supreme Court cases such as Ford v. Wainwright (1986), Panetti v. Quarterman (2007), and Madison v. Alabama (2019). In this first-of-its-kind descriptive study, we analyzed the demographic and case characteristics of the 28 successful Ford claimants—individuals in the United States who have been found to be incompetent to be executed and compared them to the general death row population and homicide cases nationwide. Our findings reveal some similarities but also some differences between these claimants and the general death row population and homicide cases: the successful Ford claimants are exclusively male (in keeping with the general prison population on death row), relatively older, and underrepresented among White and Latinx inmates (i.e., Black claimants are more successful than their White and Latinx counterparts at evading execution). Nearly all (96%) suffer from schizophrenia, with 79% experiencing psychiatric comorbidity, yet only 54% received any significant treatment before or after the criminal offense. The claimants’ cases also involve a higher proportion of child victims, male family members, and female non-family member victims, as well as more multiple-victim cases (not indiscriminate) and fewer intraracial homicides. Fewer victims are male, and more are female. However, the cases do not align with typical male-on-male violent crimes or femicide patterns, such as those involving sexual or domestic violence. Additionally, systematic psycho-legal deficiencies are prevalent, including a low rate of mental health evidence (61%) presented at trials and some cases lacking psychiatric involvement in CFE evaluations. Temporal influence and drastic state variations on CFE evaluation are also noted. Although the small sample size limits generalizability, this small-scale descriptive study offers a number of important insights into the complexities of CFE decisions and lays the groundwork for future research and policy development. Full article

Chlamydia trachomatis (Ct) is a leading cause of sexually transmitted infections globally, often resulting in inflammatory disorders, ectopic pregnancies, and infertility. Studying Ct’s pathogenesis remains challenging due to its unique life cycle and host-specific interactions, which require diverse experimental models. Animal studies using mouse, guinea pig, pig, and non-human primate models provide valuable insights into immune responses, hormonal influences, and disease progression. However, they face limitations in terms of translational relevance due to physiological differences, as well as ethical concerns. Complementing these, in vitro systems, ranging from simple monolayer to advanced three-dimensional models, exhibit improved physiological relevance by replicating the human tissue architecture. This includes the detailed investigation of epithelial barrier disruptions, epithelium–stroma interactions, and immune responses at a cellular level. Nonetheless, in vitro models fall short in mimicking the intricate tissue structures found in vivo and, therefore, cannot faithfully replicate the host–pathogen interactions or infection dynamics observed in living organisms. This review presents a comprehensive overview of the in vivo and in vitro models employed over the past few decades to investigate Ct and its pathogenesis, addressing their strengths and limitations. Furthermore, we explore emerging technologies, including organ-on-chip and in silico models, as promising tools to overcome the existing challenges and refine our understanding of Ct infections. Full article

This paper examines a recent shift in Catholic moral teaching, characterized by the emergence of a ‘new moral absolutism’, in which certain acts traditionally subject to prudential judgment—such as the death penalty, ecological harm, and restrictive migration policies—are increasingly portrayed as universally and gravely wrong in our age. Simultaneously, traditional moral absolutes, especially in sexual and life ethics, have experienced cautious relativization. Drawing on the framework of Veritatis Splendor (1993), the paper critiques the approach of this new moral absolutism, arguing that it undermines the proper role of individual conscience and situational discernment while failing to provide coherent guidance on complex moral dilemmas. It links its emergence to proportionalist ethics: when traditional moral absolutes are relativized, new types of wrongs take their place. The paper proposes a return to the principles of Veritatis Splendor, advocating for a nuanced approach that preserves the constant and limited set of absolute negative norms and encourages the formation and use of conscience for all other matters. Full article

Walking Miracles, a dance/theater project, was created from the stories of six adult survivors of child sexual abuse and completed due to the conscientious work of many collaborators. A psychotherapy group of fourteen sessions was audiotaped and attended by the six survivors, three dancer/choreographers, and one psychotherapist. Our goals were to provide positive psychotherapeutic experiences for the survivors and the foundation for a dance/theater piece that would then be presented to the public at the conclusion of the group sessions. Our hope was that audiences would gain a deeper empathetic understanding of child sexual abuse and would become stronger allies for the survivors and stronger advocates for child abuse prevention. Empathetic abilities were critical for this project—in the psychotherapy process, in the care taken to protect the trust and confidentiality of the survivors, and in the creation of the script, choreography, music, and poetry. I will examine the nature of empathy and the processes for creating specific movements from such dark experiences. How does one approach a work about issues so intensely personal? What care do we need to provide for the participants during the progression of the work? What are the ethical aspects of such projects that use the personal narratives of hidden communities? Full article