Search Results (158)

Introduction: Asthma is a chronic respiratory disease affecting approximately 5 million children in the US, but little is known about whether asthma alters children’s attention and memory functions. Most studies on this topic focus on psychiatric and QoL outcomes rather than cognitive functions, leaving a gap in the literature. We aimed to conduct a systematic review and meta-analysis to evaluate the attention deficit and memory function outcomes in children with bronchial asthma. Methods: A systematic search was conducted in PubMed, Web of Science, and Cochrane Library from inception to 28 February 2025 for studies evaluating attention deficit and memory function in children with bronchial asthma. Outcomes of interest included attention deficit and memory function. Statistical analysis was performed with R 4.3.1. Heterogeneity was accessed using the I² statistics and Cochrane Q test. The standardized mean difference (SMD) with restricted maximum-likelihood estimator random-effects method was computed for all outcomes. Results: A total of seven studies were included in the final meta-analysis, comprising 104,975 patients, of whom 10,200 (9.7%) had bronchial asthma (mean age ± 8.98 years, mean 45% females). In the pooled analysis, children with asthma had a worsened attention deficit compared to the healthy group (SMD 0.29; 95% CI [0.07; 0.51]; p = 0.01; I² = 92%). However, no statistically significant difference was found in memory function between groups (SMD −0.24; 95% CI [−1.81; 1.33]; p = 0.77; I² = 96%). Conclusions: Children with asthma showed significantly higher attention deficit scores compared to healthy children. No statistically significant differences were observed in memory function between the groups. These findings may have implications for early cognitive screening in pediatric asthma management. Full article

Background: Cognitive impairment (CI) is a common and disabling symptom in patients with relapsing–remitting multiple sclerosis (RRMS), potentially emerging at any stage, including preclinical phases. Despite its impact on quality of life, CI often goes unrecognized, as clinical follow-up typically focuses on motor and sensory symptoms. Validated tools, such as the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and patient-reported outcomes (PROs), should be integrated into routine evaluations beyond the Expanded Disability Status Scale (EDSS). Objective: The objective of this study was to evaluate cognitive impairment and quality of life in patients with RRMS using the BICAMS and PROs. Methods: This cross-sectional, descriptive study included patients with RRMS under follow-up at a tertiary hospital in San Luis Potosí, Mexico. Participants underwent cognitive screening with the BICAMS battery and completed the MSQoL-54 (quality of life), FSMC (fatigue), and MSIS-29 (functional impact) scales. Statistical analyses included ANOVA, the Kruskal–Wallis test, and Pearson correlations. Results: Nineteen patients were evaluated (73.7% female, mean age 36.5 ± 8.9 years). BICAMS results showed variable cognitive performance, with no significant differences across treatment groups for processing speed (p = 0.222), verbal memory (p = 0.082), or visuospatial memory (p = 0.311). A significant correlation was found between verbal and visuospatial memory (r = 0.668, p = 0.002). Total quality of life differed significantly across treatments (F = 8.007, p = 0.029), with a strong correlation between overall quality of life and general health perception (r = 0.793, p < 0.001). Fatigue and MSIS scores showed no association with treatment. Conclusions: Cognitive impairment is common in RRMS and can be detected using brief assessment tools, such as the BICAMS. Incorporating cognitive screening and PROs into clinical practice is essential to guide comprehensive management. Full article

Background/Objectives: Neuropsychological assessment tools adapted for digital formats are crucial to expanding access and improving cognitive evaluation in post-stroke patients. This study aimed to examine the reliability, convergent validity, and criterion-related validity (concurrent and known-groups) of TRIACOG-Online, a computerized cognitive screening tool designed to assess multiple domains in post-stroke adults in person or remotely. Methods: 98 participants (47 neurologically healthy adults and 51 post-stroke patients) completed a sociodemographic questionnaire, the Mini-Mental State Examination—MMSE, G-38—Nonverbal Intelligence Test, and the TRIACOG-Online assessment. Evaluations were conducted in person, computer mediated. Results: TRIACOG-Online demonstrated high internal consistency (Cronbach’s α = 0.872; McDonald’s ω = 0.923). Statistically significant differences were found between groups in episodic memory, attention, executive functions, and numerical processing, with healthy individuals outperforming post-stroke participants. Effect sizes were medium to large in several domains, especially for visual memory. Validity evidence based on the relationship with external variables was supported by negative correlations with age and positive correlations with education and reading and writing habits, particularly in the clinical group. Educational level showed stronger associations with verbal memory and language, suggesting a protective role in post-stroke cognitive performance. TRIACOG-Online scores demonstrated evidence of convergent validity with MMSE and G-38. Conclusions: TRIACOG-Online shows strong psychometric properties for the cognitive assessment of post-stroke adults. Its computerized format represents a promising tool for clinical and research use in neuropsychology, especially for bedside applications. Full article

Parkinson’s disease is one of the neurodegenerative conditions that has seen a significant increase in prevalence in recent decades. The lack of specific screening tests and notable disease biomarkers, combined with the strain on healthcare systems, leads to delayed detection of the disease, which worsens its progression. The development of diagnostic support tools can support early detection and facilitate timely intervention. The ability of Deep Learning algorithms to identify complex features from clinical data has proven to be a promising approach in various medical domains as support tools. In this study, we present an investigation of different architectures based on Gated Recurrent Neural Networks to assess their effectiveness in identifying subjects with Parkinson’s disease from gait records. Models with Long-Short term Memory (LSTM) and Gated Recurrent Unit (GRU) layers were evaluated. Performance results reach competitive effectiveness values with the current state-of-the-art accuracy (up to 93.75% (average ± SD: 86 ± 5%)), simplifying computational complexity, which represents an advance in the implementation of executable screening and diagnostic support tools in systems with few computational resources in wearable devices. Full article

Kawasaki disease (KD) is a rare yet potentially life-threatening pediatric vasculitis that, if left undiagnosed or untreated, can result in serious cardiovascular complications. Its heterogeneous clinical presentation poses diagnostic challenges, often failing to meet classical criteria and increasing the risk of oversight. Leveraging routine laboratory tests with AI offers a promising strategy for enhancing early detection. However, due to the extremely low prevalence of KD, conventional models often struggle with severe class imbalance, limiting their ability to achieve both high sensitivity and specificity in practice. To address this issue, we propose a multi-stage AI-based predictive framework that incorporates clustering-based undersampling, data augmentation, and stacking ensemble learning. The model was trained and internally tested on clinical blood and urine test data from Chang Gung Memorial Hospital (CGMH, n = 74,641; 2010–2019), and externally validated using an independent dataset from Kaohsiung Medical University Hospital (KMUH, n = 1582; 2012–2020), thereby supporting cross-institutional generalizability. At a fixed recall rate of 95%, the model achieved a specificity of 97.5% and an F1-score of 53.6% on the CGMH test set, and a specificity of 74.7% with an F1-score of 23.4% on the KMUH validation set. These results underscore the model’s ability to maintain high specificity even under sensitivity-focused constraints, while still delivering clinically meaningful predictive performance. This balance of sensitivity and specificity highlights the framework’s practical utility for real-world KD screening. Full article

Cognitive problems are associated with impaired learning ability and memory dysfunction. Neuroinflammation has been identified as an important factor in the progression of anxiety and depressive disorders. Zingerone is a phenolic alkanone derived from ginger (Zingiber officinale Roscoe), which is known for its antioxidant and anti-inflammatory properties. A number of studies have investigated the effect of zingerone on neuroinflammation and cognitive impairment. However, this evidence has not been systematically reviewed. This study sought to systematically review the effect of zingerone on neuroinflammation and neurobehavioural changes associated with memory and learning impairment and anxiety-like and depressive-like behaviours. A systematic review was conducted using pre-defined search criteria on Google Scholar, Scopus and Web of Science. The records obtained were screened based on inclusion criteria, and data was extracted from the included studies. Out of the 482 studies that were identified, only 9 studies met the inclusion criteria. Neuroinflammatory markers such as interleukin 1β (IL-1β), interleukin 6 (IL-6), tumour necrosis factor-alpha (TNF-α) and ionized calcium binding adaptor molecule (IBA-1), as well as behavioural parameters including Morris water maze, Y-Maze, recognition test, passive avoidance test, elevated plus maze, sucrose preference test and forced swimming test were measured. Zingerone exhibited anti-neuroinflammatory effects by improving IL-1β, IL-6 and TNF-α levels. However, zingerone did not show any significant changes on activated microglia. The anti-neuroinflammatory mechanisms of zingerone were linked to the inhibition of nuclear factor kappa B (NF-kB) activation and the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome, as well as the reduction in neuronal nitric oxide synthase (nNOS). The anxiolytic and anti-depressive effects of zingerone were also associated with an improvement in cortical cholinergic transmission, the mitigation of oxidative stress and the upregulation of neurotransmitters such as serotonin and dopamine. This review provides scientific evidence on the cognitive enhancing and neuroprotective mechanisms of zingerone, which may be beneficial for future experimental investigations. Full article

Background/Objectives: Q-VAX vaccine, approved in Australia, prevents Q fever. However, individuals with prior Coxiella burnetii (Cb) infection have an increased risk of adverse reactions, requiring pre-vaccination screening by an intradermal hypersensitivity skin test for cell-mediated immune memory and a serological assay for anti-Cb antibodies. The week-long interval for skin test assessment limits efficient vaccination. This study evaluated a standardized interferon-γ release assay (IGRA) as a potential skin test alternative. Methods: Immune assays were compared in Australian populations with different incidences of prior Cb exposure. Cell-mediated immunity was assessed by the Q-VAX skin test and IGRA. Serological status was evaluated with established diagnostic assays. Hypothetical vaccine eligibility decisions using combined IGRA and serology results were compared with actual clinical decisions made using current guidelines. Results: All tests performed better in detecting prior infection than in detecting prior vaccination. Only the IGRA identified all individuals with a known history of Q fever. Agreement between the skin test and IGRA was limited. Moderate agreement was observed between hypothetical vaccine eligibility determinations based on IGRA plus serology results and actual clinical decisions. IGRA-positive but serology- and skin test-negative individuals received Q-VAX without clinically significant side effects, suggesting that elevated IGRA responses alone are not predictive of susceptibility to vaccine reactogenicity. Conclusions: The IGRA is not yet a suitable skin test replacement when assessing eligibility for Q fever vaccination, despite the significant limitations of the latter. We offer recommendations for designing future studies that might allow the development of appropriate guidelines for IGRA use in vaccine eligibility screening. Full article

In order to explore the correlation between meteorological factors and power load changes, as well as the role of these factors in load forecasting, a hybrid load forecasting modeling framework based on quantile Granger causality test and bidirectional long short-term memory (QGCT-BiLSTM) is proposed. The Augmented Dickey–Fuller test (ADF) is used to test the smoothness of the influencing factor series and the load series, and the variables that passed the smoothness test are subjected to QGCT for identification of the characteristic variables with significant causal associations. Furthermore, the BiLSTM model is then constructed using the selected factors to generate load forecasts. Using real data from Fujian, China, we demonstrate that QGCT-based feature screening reduces forecasting errors by an average of 34.96%, where the RMSE, MAE and MAPE are 29.19%, 30.06% and 45.63%, respectively, thereby validating the necessity of causal factor selection. Additionally, single-factor perturbation analysis at seasonal scales quantifies load sensitivity to environmental changes, while geographic–climatic coupling mechanisms explain observed load variation patterns. The results confirm that QGCT-BiLSTM effectively isolates critical meteorological drivers and significantly enhances prediction accuracy compared to conventional approaches, achieving 20.3% lower RMSE and 16.8% lower MAE than LSTM. Full article

In this cohort study, we evaluated the cognitive and learning difficulties of school-age children perinatally infected with Chikungunya virus (CHIKV) on Reunion Island using the Evaluation of Cognitive Functions and Learning in Children (EDA) battery screening test compared to the healthy children cohort used for EDA development. Of the 19 infected children, 11 (57.9%) exhibited subnormal or abnormal scores, of whom 3 were classified as high risk, and 8 were classified as at risk for cognitive and learning difficulties. Children who had encephalopathy were at higher risk for displaying at least one difficulty than non-encephalopathic children (relative risk 2.13; 95% CI 1.05–4.33). The difficulties observed affected verbal functions, non-verbal functions, and learning abilities, such as phonology, lexical evocation and comprehension, graphism, selective visual attention, planning, visual–spatial reasoning, dictation and mathematics, as well as core executive functions, such as inhibitory control, shifting, and working memory. Neurocognitive dysfunctions could be linked to severe brain damage, as evidenced by severe white matter reduction mainly in the frontal lobes and corpus callosum and potentially in all functional networks involved in difficulties. These results should motivate further investigation of intellectual and adaptive functioning to diagnose intellectual deficiency and severe maladaptive behaviour in children perinatally infected with Chikungunya virus. Full article

Introduction: Epilepsy is a chronic neurological disorder, with cognitive impairment being one of its most significant comorbidities. While the majority of individuals with epilepsy maintain regular intellectual abilities, they are more likely to experience cognitive impairment compared to a healthy control group of the same age and educational level. Aim: This study aimed to assess cognitive impairment during epilepsy, particularly temporal lobe epilepsy, and to evaluate the effectiveness of using the Montreal Cognitive Assessment (MoCA) test for cognitive screening in individuals with epilepsy. Materials and methods: One hundred and fifty subjects were included between 2022 and 2023, which were divided into 50 people diagnosed with temporal lobe epilepsy (TLE), 50 people with other types of epilepsy according to the International League Against Epilepsy (ILAE), and 50 healthy controls without epilepsy (HC). Results: Significant differences were found in the total mean scores of the MoCA between TLE, other types of epilepsy, and healthy control groups (p = 0.000), particularly in visuospatial orientation, concentration, memory recall, abstraction, and language skills. Conclusions: Evaluating cognitive impairment in epilepsy involves comprehensive neuropsychological assessments, which have significantly advanced in recent years. Nevertheless, we consider the Montreal Cognitive Assessment (MoCA) test to be an appropriate initial screening tool for assessing cognitive impairment in epilepsy. Full article

Background/Objectives: Neuropsychological testing is key in defining cognitive profiles at early stages of dementia. More importantly, the detection of subtle cognitive changes, such as subjective cognitive complaints (SCCs), an understudied phenomenon, is critical for early detection and preventive interventions. Methods: This systematic review analyzes the empirical data on the cognitive domains and neuropsychological tests used in studies addressing SCC in the last 15 years (2009–2024). Results: A selection of 15 papers with exploratory, cross-sectional, and prospective scope in this field was obtained from PubMed and Embase databases. They used screening tests (17%) and a broad spectrum of neurocognitive domains. Yet, we identified three main targeted cognitive domains: executive functions (28%), language (17%), and memory (17%). Myriad assessment tools were also applied, but the most commonly used was a set of eight tests: Mini-mental Scale Examination (MMSE), Trail Making Test (A-B), Stroop test, Digit span test (DST), Semantic and Phonological fluency test, Rey Auditory Verbal Learning Test (RAVLT), Weschler Memory Scale (WMS), and Boston Naming Test (BNT). New approaches involved including the Geriatric Depression Scale (GDS) and self/informant reports. Conclusions: Despite scarce agreement in the assessment protocols, the identification of early neurocognitive symptoms to objectivate the SCC phenomenon envisions a broad field of research. Full article

The physical inactivity of adolescents and their sedentary lifestyle with profuse usage of screens has been a growing issue for the last few years. In contrast, there is some evidence that videogame-based exercising improves cognitive abilities and psychological well-being during growth and maturation. Therefore, there is a need for the wider exploration of innovation tools in physical education (PE) and extracurricular activities for schoolchildren. The aim of this study was to determine the change in psychological well-being and cognitive skills of adolescents when exercising is supplemented with videogame-based activity. The short-term physical activity (PA) program, initiated by in-service PE teachers (n = 3), involved 13–15-year-old adolescents (n = 63, of them 20 were boys) from one of biggest cities in Lithuania. The research subjects were participants of extracurricular exercise groups on a regular basis, attending their respective three-times-a-week sessions for 1 month. The first intervention group engaged in a 60 min functional training program (FT group, n = 31). The second group had 30 min of FT followed by 30 min of video-based dance class (FT + Just Dance group, n = 32). The Trail-Making test (part A and B), the Visual Digit Span test, and the Stroop test were performed to investigate students’ cognitive abilities. In addition, the WHO-5 questionnaire was used to analyse the respondents’ psychological well-being. When comparing pre- and post-intervention results, no changes were observed in the psychological state, visual–executive skills, and short-term visual memory in both groups. Reaction time improved significantly in both groups (p < 0.05). The working memory significantly improved in the FT + Just Dance group (p < 0.05). The implementation of videogame-based training, Just Dance, improved adolescents’ working memory, but had no effect on subjectively perceived psychological well-being. Full article

Background/Objectives: Previous research suggests that social media use can have immediate cognitive effects, raising concerns about its impact on adolescent cognition. This study aimed to examine the short-term cognitive effects of acute social media exposure and screen time habits by comparing cognitive performance in adolescents (13–15 years old) following 30 min of social media interaction versus face-to-face conversation, according to their screen time habits (more or less time spent in front of a screen). Methods: A total of 66 participants were divided into four groups: a social media group who used to spend less than 540 min per week in front of a screen (n = 19, a social media group with a habit of more than 540 min per week of screen time (n = 14), a face-to-face conversation group with a habit of less screen time per week (n = 15), and a face-to-face conversation group who used to spend more time per week in front of a screen (n = 18). Cognitive performance was assessed through attention (D2 Test), working memory (Corsi Blocks), abstract reasoning (Abstract Reasoning Test Battery), and inhibitory control (Go/No-Go Task). Additionally, mental effort was measured using a Visual Analogue Scale. Results: Contrary to our hypothesis, no significant differences emerged between groups in any cognitive domain or mental effort, with interaction modality and screen time showing no impact on response variables. Also, we found no significant interaction effect between factors. This suggests that a single 30-min session of social media use does not immediately impair cognition, nor does face-to-face interaction enhance it, despite screen time spent per week (when it varies from 135 to 540 min and from more than 540 to 1320 min). Conclusions: The absence of cognitive effects may be explained by excessive screen time as a key factor in cognitive impact and by the cultural integration of social media, creating a “ceiling effect” that minimizes the impact of short-term exposure and resembles addictive behavior. These findings emphasize the importance of a holistic approach involving families, schools, and governments to address both acute and cumulative social media use in adolescents. Full article

Objective: Cognitive impairments are one of the most common and disabling symptoms associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Here, we address the possibility of a specific cognitive profile inherent to ME/CFS. Due to the occurrence of cognitive deficits, fatigue, and pain in both pathologies, multiple sclerosis (MS) is a relevant comparison model. For this purpose, we carried out a comparative study between cognitive profiles of patients with ME/CFS and patients suffering from MS. Methods: In total, 40 ME/CFS and 40 MS patients were included. A complete screening of all cognitive functions was carried out through an extensive battery of tests routinely used in clinical practice. Results: ME/CFS and MS patients showed deficits in episodic memory retrieval, visual selective attention and reading speed. ME/CFS patients also elicited a lower level of performance than MS patients regarding consolidation. For both groups, levels of performance on these cognitive tests did not correlate with levels of fatigue, pain, and depression. Conclusions: This study highlighted both similarities and differences in the cognitive profiles of ME/CFS and MS patients. While both groups exhibited deficits in episodic memory retrieval, visual selective attention, and reading speed, ME/CFS patients showed distinct impairment in consolidation processes. These cognitive deficits were not correlated with fatigue, pain, or depression, reinforcing the hypothesis of intrinsic cognitive dysfunction in ME/CFS. These findings define a specific cognitive phenotype for ME/CFS, which could improve diagnostic accuracy and therapeutic strategies. Future research, particularly in functional imaging, may elucidate the neurobiological mechanisms underlying these impairments. Full article

Speech and language deficits often occur in preschool children, and empirical studies have indicated an association between language impairments and challenges in different cognitive domains. The primary aim of the current study was to evaluate the associations between speech and language deficits, executive function (EF) impairments, Attention Deficit/Hyperactivity Disorder (ADHD), and aspects of giftedness in Greek preschoolers based on assessments from their teachers. Investigating the associations between aspects of EFs, ADHD, and giftedness was another objective of the current study. Finally, we examined on a sample of Greek preschool children the convergent validity of the LAMP screening test in relation to the following questionnaires: the Childhood Executive Functioning Inventory (CHEXI), the ADHD-IV Questionnaire, the Gifted Rating Scales-Preschool/Kindergarten Form (GRS-P), and the Scales for Rating the Behavioral Characteristics of Superior Students (SRBCSS). For the purpose of the present study, 20 kindergarten teachers and 71 Greek preschoolers (41 boys and 30 girls) were included in the sample. Data analysis revealed that according to teachers’ estimations, speech and language deficits are positively associated to a statistically significant degree with ADHD and with deficits in working memory (WM) and inhibition. On the other hand, aspects of preschool-aged creativity and giftedness were significantly correlated negatively with speech and language deficits. Additionally, the findings demonstrated a negative correlation between aspects of giftedness and ADHD symptoms as well as poor achievement on working memory (WM) and inhibition assessment tests. Furthermore, there was no association between hyperactivity/inhibition deficit and creativity, which is an aspect of giftedness. The moderate positive associations of the LAMP screening test with the psychometric tools of measurement of ADHD and executive function (EF) deficits, and the negative associations with the scales of giftedness showed the good convergent and distinct validity of the LAMP assessment test. Full article