Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

Search Results (165)

Search Parameters:
Keywords = ruptured histories

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
14 pages, 327 KiB  
Article
Risk Profiles and Outcomes of Uterine Rupture: A Retrospective and Comparative Single-Center Study of Complete and Partial Ruptures
by Sunhwa Baek, Valeria Froese and Bernd Morgenstern
J. Clin. Med. 2025, 14(14), 4987; https://doi.org/10.3390/jcm14144987 - 15 Jul 2025
Viewed by 339
Abstract
Background: Uterine rupture is a rare but severe obstetric complication with significant maternal and neonatal consequences. While partial uterine ruptures (PURs) are generally associated with less severe outcomes, complete uterine ruptures (CURs) carry a higher risk of serious impact on both mother and [...] Read more.
Background: Uterine rupture is a rare but severe obstetric complication with significant maternal and neonatal consequences. While partial uterine ruptures (PURs) are generally associated with less severe outcomes, complete uterine ruptures (CURs) carry a higher risk of serious impact on both mother and child. The present study aimed to evaluate outcomes and identify risk factors for each type of rupture, and also to define high- and low-risk uterine ruptures based on clinical outcomes. Methods: A retrospective analysis of 112 uterine rupture cases, including 29 CURs and 83 PURs, was conducted at the Women’s Hospital of the University of Cologne from October 2010 to January 2021. Results: Maternal outcomes revealed that CUR was associated with higher risks of prolonged hospitalization (p = 0.003), postpartum hemorrhage (p < 0.001), maternal transfusion (p = 0.003), and ICU transfer (p = 0.004) compared to PUR. Neonatal outcomes showed a significantly higher risk of severe acidosis (p < 0.001), low APGAR scores (p < 0.001), NICU transfers (p = 0.004), and resuscitation needs (p = 0.016) in CUR cases. Factors increasing the risk of CUR included pathological CTG (OR = 1.9, 95% CI: 0.99–7.14, p = 0.05), abdominal pain (OR = 2.63, 95% CI: 1.10–6.25, p = 0.03), previous vaginal birth (OR = 7.14, 95% CI: 0.025–20, p < 0.001), and no uterine contractions (OR = 7, 95% CI: 1.21–40.56, p = 0.03). A previous cesarean section significantly increased the risk of CUR (OR = 4.94, 95% CI: 1.38–17.67, p = 0.014), whereas more than two cesarean sections reduced the risk (OR = 0.66, 95% CI: 0.13–3.22, p = 0.61). A comparison of CUR with maternal and neonatal high-risk rupture groups revealed that low gestational age and a history of previous cesarean sections were significant risk factors for neonatal high-risk rupture. Conclusion: Vaginal birth and abdominal pain were identified as key risk factors for CUR, which lead to severe maternal and neonatal outcomes. Recognizing these risk factors can help clinicians optimize risk stratification and decision-making, and enhance monitoring strategies to prevent adverse outcomes. Full article
(This article belongs to the Section Obstetrics & Gynecology)
Show Figures

Figure 1

22 pages, 5786 KiB  
Review
Narrative and Pictorial Review on State-of-the-Art Endovascular Treatment for Focal Non-Infected Lesions of the Abdominal Aorta: Anatomical Challenges, Technical Solutions, and Clinical Outcomes
by Mario D’Oria, Marta Ascione, Paolo Spath, Gabriele Piffaretti, Enrico Gallitto, Wassim Mansour, Antonino Maria Logiacco, Giovanni Badalamenti, Antonio Cappiello, Giulia Moretti, Luca Di Marzo, Gianluca Faggioli, Mauro Gargiulo and Sandro Lepidi
J. Clin. Med. 2025, 14(13), 4798; https://doi.org/10.3390/jcm14134798 - 7 Jul 2025
Viewed by 481
Abstract
The natural history of focal non-infected lesions of the abdominal aorta (fl-AA) remains unclear and largely depends on their aetiology. These lesions often involve a focal “tear” or partial disruption of the arterial wall. Penetrating aortic ulcers (PAUs) and intramural hematomas (IMHs) are [...] Read more.
The natural history of focal non-infected lesions of the abdominal aorta (fl-AA) remains unclear and largely depends on their aetiology. These lesions often involve a focal “tear” or partial disruption of the arterial wall. Penetrating aortic ulcers (PAUs) and intramural hematomas (IMHs) are examples of focal tears in the aortic wall that can either progress to dilatation (saccular aneurysm) or fail to fully propagate through the medial layers, potentially leading to aortic dissection. These conditions typically exhibit a morphology consistent with eccentric saccular aneurysms. The management of focal non-infected pathologies of the abdominal aorta remains a subject of debate. Unlike fusiform abdominal aortic aneurysms, the inconsistent definitions and limited information regarding the natural history of saccular aneurysms (sa-AAAs) have prevented the establishment of universally accepted practice guidelines for their management. As emphasized in the latest 2024 ESVS guidelines, the focal nature of these diseases makes them ideal candidates for endovascular repair (class of evidence IIa—level C). Moreover, the Society for Vascular Surgery just referred to aneurysm diameter as an indication for treatment suggesting using a smaller diameter compared to fusiform aneurysms. Consequently, the management of saccular aneurysms is likely heterogeneous amongst different centres and different operators. Endovascular repair using tube stent grafts offers benefits like reduced recovery times but carries risks of migration and endoleak due to graft rigidity. These complications can influence long-term success. In this context, the use of endovascular bifurcated grafts may provide a more effective solution for treating these focal aortic pathologies. It is essential to achieve optimal sealing regions through anatomical studies of aortic morphology. Additionally, understanding the anatomical characteristics of focal lesions in challenging necks or para-visceral locations is indeed crucial in device choice. Off-the-shelf devices are favoured for their time and cost efficiency, but new endovascular technologies like fenestrated endovascular aneurysm repair (FEVAR) and custom-made devices enhance treatment success and patient safety. These innovations provide stent grafts in various lengths and diameters, accommodating different aortic anatomies and reducing the risk of type III endoleaks. Although complicated PAUs and focal saccular aneurysms rarely arise in the para-visceral aorta, the consequences of rupture in this segment might be extremely severe. Experience borrowed from complex abdominal and thoracoabdominal aneurysm repair demonstrates that fenestrated and branched devices can be deployed safely when anatomical criteria are respected. Elective patients derive the greatest benefit from a fenestrated graft, while urgent cases can be treated confidently with off-the-shelf multibranch systems, reserving other types of repairs for emergent or bail-out cases. While early outcomes of these interventions are promising, it is crucial to acknowledge that limited aortic coverage can still impede effective symptom relief and lead to complications such as aneurysm expansion or rupture. Therefore, further long-term studies are essential to consolidate the technical results and evaluate the durability of various graft options. Full article
(This article belongs to the Special Issue Clinical Advances in Aortic Disease and Revascularization)
Show Figures

Figure 1

28 pages, 17579 KiB  
Article
Modeling the 2023 Türkiye Earthquakes and Strain Accumulation Along the East Anatolian Fault Zone: Insights from InSAR, GNSS, and Small-Magnitude Seismicity, with Implications for the Seismic Potential at Rupture Terminations
by Daniele Cheloni, Nicola Angelo Famiglietti, Aybige Akinci, Riccardo Caputo and Annamaria Vicari
Remote Sens. 2025, 17(13), 2270; https://doi.org/10.3390/rs17132270 - 2 Jul 2025
Viewed by 1475
Abstract
The 6 February 2023 MW 7.8 and MW 7.6 earthquakes in southeastern Türkiye ruptured more than 400 km of the East Anatolian Fault Zone (EAFZ), producing one of the most destructive seismic sequences in recent history. Here, we integrate InSAR data, [...] Read more.
The 6 February 2023 MW 7.8 and MW 7.6 earthquakes in southeastern Türkiye ruptured more than 400 km of the East Anatolian Fault Zone (EAFZ), producing one of the most destructive seismic sequences in recent history. Here, we integrate InSAR data, a new GNSS velocity field, and small-magnitude earthquakes to investigate the coseismic deformation, rupture geometry, and interseismic strain accumulation along the EAFZ. Using elastic dislocation modeling with a variable-strike, multi-segment fault geometry, we constrain the slip distribution of the mainshocks, showing improved fits to the surface displacement compared to the planar fault model. The MW 7.8 event ruptured a number of fault segments over ~300 km, while the MW 7.6 event activated a more localized fault system with a peak slip exceeding 15 m. We also model two moderate events (MW 5.6 in 2020 and MW 5.3 in 2022) along the southwestern part of the Pütürge segment—an area not ruptured during the 2020 or 2023 sequences. GNSS-derived strain-rate and locking depth estimates reveal strong interseismic coupling and significant strain accumulation in this region, suggesting the potential for a future large earthquake (MW 6.6–7.1). Similarly, the Hatay region, at the southwestern termination of the 2023 rupture, shows a persistent strain accumulation and complex fault interactions involving the Dead Sea Fault and the Cyprus Arc. Our results demonstrate the importance of combining remote sensing and geodetic data to constrain fault kinematics, evaluate rupture segmentation, and assess the seismic hazard in tectonically active regions. Targeted monitoring at rupture terminations—such as the Pütürge and Hatay sectors—may be crucial for anticipating future large-magnitude earthquakes. Full article
Show Figures

Figure 1

11 pages, 1917 KiB  
Case Report
Brittle Cornea Syndrome: Molecular Diagnosis and Management
by Marco Zeppieri, Mattia Gentile, Antonio Acquaviva, Davide Scollo, Fabiana D’Esposito, Giuseppe Gagliano, Alessandro Avitabile, Caterina Gagliano and Lucia Lapenna
Diagnostics 2025, 15(13), 1596; https://doi.org/10.3390/diagnostics15131596 - 24 Jun 2025
Viewed by 438
Abstract
Background and Clinical Significance: Brittle cornea syndrome (BCS) is a rare, autosomal recessive connective tissue disorder characterized by extreme corneal thinning, high myopia, and increased risk of spontaneous or trauma-induced ocular rupture. It is primarily caused by mutations in the ZNF469 or PRDM5 [...] Read more.
Background and Clinical Significance: Brittle cornea syndrome (BCS) is a rare, autosomal recessive connective tissue disorder characterized by extreme corneal thinning, high myopia, and increased risk of spontaneous or trauma-induced ocular rupture. It is primarily caused by mutations in the ZNF469 or PRDM5 genes, which regulate extracellular matrix integrity. Early recognition and diagnosis of BCS are crucial to prevent severe visual impairment. This report presents two genetically confirmed cases of BCS in Albanian siblings, emphasizing the diagnostic value of whole-exome sequencing and individualized surgical management strategies. Case Presentation: Two siblings—a 28-year-old male and a 25-year-old female—presented with progressive visual deterioration and marked corneal thinning (<200 µm). Both had a history of spontaneous ocular rupture following minor trauma in the contralateral eye. Detailed ophthalmologic evaluation revealed keratoglobus, high myopia, and irregular astigmatism. Genetic testing identified the homozygous pathogenic variant c.974delG (p.Cys325LeufsX2) in the PRDM5 gene in both cases. The male underwent penetrating keratoplasty (PKP), achieving a best-corrected visual acuity (BCVA) of 20/30. The female initially underwent deep anterior lamellar keratoplasty (DALK), which was converted to PKP intraoperatively due to central endothelial perforation, resulting in a BCVA of 20/25. Both patients remained complication-free over a 7-year follow-up period. Conclusions: These cases highlight the importance of early genetic diagnosis and a tailored surgical approach in managing BCS. Long-term monitoring and protective strategies are essential to prevent complications. Incorporating genetic testing into clinical practice can enhance diagnostic accuracy and guide personalized treatment plans in patients with hereditary corneal dystrophies. Full article
(This article belongs to the Special Issue Eye Disease: Diagnosis, Management, and Prognosis)
Show Figures

Figure 1

11 pages, 2222 KiB  
Case Report
Case Report: Spontaneous Pneumomediastinum and Pneumothorax Complicating Severe Ketoacidosis—An Unexpected Presentation
by Alexandru Cristian Cindrea, Adina Maria Marza, Alexandra Maria Borita, Antonia Armega-Anghelescu and Ovidiu Alexandru Mederle
Reports 2025, 8(2), 95; https://doi.org/10.3390/reports8020095 - 18 Jun 2025
Viewed by 494
Abstract
Background and Clinical Significance: Diabetic ketoacidosis (DKA) is a serious and potentially life-threatening condition, often triggered by infections or undiagnosed diabetes. Spontaneous pneumomediastinum (SPM) and pneumothorax are rare but recognized complications of DKA, possibly due to alveolar rupture from increased respiratory effort or [...] Read more.
Background and Clinical Significance: Diabetic ketoacidosis (DKA) is a serious and potentially life-threatening condition, often triggered by infections or undiagnosed diabetes. Spontaneous pneumomediastinum (SPM) and pneumothorax are rare but recognized complications of DKA, possibly due to alveolar rupture from increased respiratory effort or vomiting. Sometimes, acute pancreatitis (AP) may further complicate DKA, but the co-occurrence of these three conditions remains exceptionally rare. Case Presentation: We describe the case of a 60-year-old woman without a known history of diabetes who arrived at the emergency department with abdominal pain, fatigue, vomiting, and altered mental status. Initial laboratory findings showed metabolic acidosis, hyperglycemia, and elevated anion gap, consistent with DKA. Imaging revealed spontaneous pneumomediastinum and subsequently a left-sided pneumothorax, without evidence of trauma or esophageal rupture. Epigastric pain, along with elevated serum lipase and CT findings, also confirmed acute pancreatitis. Despite the complexity of her condition, the patient responded well to supportive treatment, including oxygen therapy, fluid resuscitation, insulin infusion, and antibiotics. She was discharged in good condition after 28 days, with a confirmed diagnosis of type 2 diabetes, without further complications. Conclusions: This case highlights an unusual combination of DKA complicated by spontaneous pneumomediastinum, pneumothorax and acute pancreatitis in a previously undiagnosed diabetic patient. Because prompt intervention can lead to favorable outcomes even in complex, multisystem cases, early recognition of atypical DKA complications is critical in order to avoid misdiagnosis. Full article
Show Figures

Figure 1

13 pages, 489 KiB  
Article
Over Two Decades of Experience in Aortic Arch Reoperations: Long-Term Outcomes and Mortality Risk Factors
by Nikoleta Bozini, Nicole Piber, Keti Vitanova, Konstantinos Sideris, Ulf Herold, Ralf Guenzinger, Andrea Amabile, Teodora Georgescu, Markus Krane and Anatol Prinzing
J. Clin. Med. 2025, 14(12), 4087; https://doi.org/10.3390/jcm14124087 - 10 Jun 2025
Viewed by 361
Abstract
Background/Objectives: After years of work in the field of aortic arch surgery, the technique has evolved, making this procedure relatively safe, with lasting results. Due to the increasing long-term survival and overall aging of the patient population, more patients require aortic arch reoperation. [...] Read more.
Background/Objectives: After years of work in the field of aortic arch surgery, the technique has evolved, making this procedure relatively safe, with lasting results. Due to the increasing long-term survival and overall aging of the patient population, more patients require aortic arch reoperation. In the present study, the safety of aortic arch reoperations was analyzed in the long term, focusing on risk factors for mortality. Methods: Between 1999 and 2023, 108 patients were included in our study who underwent reoperation on aortic arch after prior operation on the aorta, the aortic valve, or a combination of both. The exclusion criteria were being aged under 18 years and transcatheter aortic valve implantation as a previous intervention. The principal outcome was the incidence of mortality, and additional outcomes of interest included cardiac re-reoperation, bleeding, a new aortic type B dissection, infective endocarditis, readmission due to a cardiac cause, coronary intervention and neurovascular complications, pacemaker implantation, and temporary mechanical circulatory support. Results: The mean age was 56 ± 14 years, and 75% (81/108) of patients were male. In our study, we found age (p ≤ 0.01) and history of coronary artery disease (p = 0.01) to be preoperative risk factors for adverse outcomes. The mean time between the index operation and reoperation was 6.84 years (1.61–14.94). Indications for reoperation included dilatation (HR = 0.49, p = 0.05), rupture or false aneurysm (HR = 2.08, p= 0.08), dissection (HR = 1.41, p = 0.30), and endocarditis (HR = 1.49, p = 0.41). A main risk factor was the need for a salvage reoperation (p ≤ 0.01). Also, a longer operation (p = 0.04), cardiopulmonary bypass (p ≤ 0.01), and ventilation time (p ≤ 0.01), bleeding complications (p ≤ 0.01), and requiring temporary mechanical circulatory support (p = 0.04) were linked to higher mortality. The overall survival was 82% after 1 year, 73% after 5 years, and 56% after 10 years. In the multivariate Cox regression analysis, age (HR = 1.04, p ≤ 0.01), the need for a salvage operation (HR = 5.38, p = 0.01), a prolonged ventilation time (HR = 1.08, p = 0.04), and bleeding complications (HR = 3.76, p = 0.03) were associated with higher mortality. In the ROC analysis, an age over 57.5 years was associated with significantly lower overall survival (p ≤ 0.01). Conclusions: Aortic arch reoperations can be performed with acceptable long-term outcomes, but perioperative factors significantly influence early mortality. Salvage operations, bleeding complications, and prolonged ventilation were strong predictors of adverse outcomes. Older age, particularly >57.5 years, was independently associated with increased mortality risk. Full article
(This article belongs to the Special Issue Clinical Advances in Vascular and Endovascular Surgery)
Show Figures

Graphical abstract

5 pages, 729 KiB  
Case Report
A Rare Case of Paired Congenital Cervical Aneurysms in a Communicating Vein: Clinical and Imaging Findings in a Pediatric Patient
by Grigol Keshelava, Zurab Robakidze and Igor Mikadze
Pathophysiology 2025, 32(2), 25; https://doi.org/10.3390/pathophysiology32020025 - 6 Jun 2025
Viewed by 671
Abstract
A four-year-old female patient was admitted for evaluation after a mass on the right side of her neck was noticed during straining (Valsalva maneuver). The family first observed the mass when the patient was one year old, and noted that it gradually increased [...] Read more.
A four-year-old female patient was admitted for evaluation after a mass on the right side of her neck was noticed during straining (Valsalva maneuver). The family first observed the mass when the patient was one year old, and noted that it gradually increased in size over time. A family history assessment revealed no known genetic disorders. The patient underwent neck ultrasonography and computed tomography angiography (CTA), which revealed two aneurysms in a right-sided communicating vein. One aneurysm was located above the jugular notch, and the other was located in the retro-parotid region. The presence of two venous aneurysms in a right-sided communicating vein—one above the jugular notch and the other in the retro-parotid region—suggests a rare and apparently benign congenital anomaly. The progressive enlargement of these malformations warrants close monitoring and surgical intervention, and long-term follow-up may be necessary to prevent complications such as thrombosis, rupture, or compression of adjacent structures. Full article
Show Figures

Figure 1

18 pages, 19607 KiB  
Article
Identifying the Latest Displacement and Long-Term Strong Earthquake Activity of the Haiyuan Fault Using High-Precision UAV Data, NE Tibetan Plateau
by Xin Sun, Wenjun Zheng, Dongli Zhang, Haoyu Zhou, Haiyun Bi, Zijian Feng and Bingxu Liu
Remote Sens. 2025, 17(11), 1895; https://doi.org/10.3390/rs17111895 - 29 May 2025
Viewed by 568
Abstract
Strong earthquake activity along fault zones can lead to the displacement of geomorphic units such as gullies and terraces while preserving earthquake event data through changes in sedimentary records near faults. The quantitative analysis of these characteristics facilitates the reconstruction of significant earthquake [...] Read more.
Strong earthquake activity along fault zones can lead to the displacement of geomorphic units such as gullies and terraces while preserving earthquake event data through changes in sedimentary records near faults. The quantitative analysis of these characteristics facilitates the reconstruction of significant earthquake activity history along the fault zone. Recent advancements in acquisition technology for high-precision and high-resolution topographic data have enabled more precise identification of displacements caused by fault activity, allowing for a quantitative assessment of the characteristics of strong earthquakes on faults. The 1920 Haiyuan earthquake, which occurred on the Haiyuan fault in the northeastern Tibetan Plateau, resulted in a surface rupture zone extending nearly 240 km. Although clear traces of surface rupture have been well preserved along the fault, debate regarding the maximum displacement is ongoing. In this study, we focused on two typical offset geomorphic sites along the middle segment of the Haiyuan fault that were previously identified as having experienced the maximum displacement during the Haiyuan earthquake. High-precision geomorphologic images of the two sites were obtained through unmanned aerial vehicle (UAV) surveys, which were combined with light detection and ranging (LiDAR) data along the fault zone. Our findings revealed that the maximum horizontal displacement of the Haiyuan earthquake at the Shikaguan site was approximately 5 m, whereas, at the Tangjiapo site, it was approximately 6 m. A cumulative offset probability distribution (COPD) analysis of high-density fault displacement measurements along the ruptures indicated that the smallest offset clusters on either side of the Ganyanchi Basin were 4.5 and 5.1 m long. This analysis further indicated that the average horizontal displacements of the Haiyuan earthquake were approximately 4–6 m. Further examination of multiple gullies and geomorphic unit displacements at the Shikatougou site, along with a detailed COPD analysis of dense displacement measurements within a specified range on both sides, demonstrated that the cumulative displacement within 30 m of this section of the Haiyuan fault exhibited at least five distinct displacement clusters. These dates may represent the results of five strong earthquake events in this fault segment over the past 10,000–13,000 years. The estimated magnitude, derived from the relationship between displacement and magnitude, ranged from Mw 7.4 to 7.6, with an uneven recurrence interval of approximately 2500–3200 years. Full article
Show Figures

Figure 1

27 pages, 15985 KiB  
Article
Representation of Suffering, Destruction, and Disillusion in the Art of Marcel Janco
by Alexandru Bar
Arts 2025, 14(3), 61; https://doi.org/10.3390/arts14030061 - 29 May 2025
Viewed by 712
Abstract
This article examines Marcel Janco’s Holocaust drawings, positioning them within the broader discourse of Holocaust representation, trauma, and avant-garde aesthetics. Created in response to the Bucharest Pogrom of January 1941, these works resist both forensic realism and pure abstraction, instead embodying rupture, instability, [...] Read more.
This article examines Marcel Janco’s Holocaust drawings, positioning them within the broader discourse of Holocaust representation, trauma, and avant-garde aesthetics. Created in response to the Bucharest Pogrom of January 1941, these works resist both forensic realism and pure abstraction, instead embodying rupture, instability, and fragmentation. Janco’s grotesque distortions neither document events with the precision of testimony nor dissolve into conceptual erasure; rather, they enact the instability of Holocaust memory itself. This essay argues that Janco’s Holocaust works, long overshadowed by his modernist and Dadaist contributions, challenge dominant frameworks of remembrance. Through comparative analysis with artists, such as David Olère, Anselm Kiefer, and George Grosz, it situates Janco’s approach at the limits of witnessing, exploring how his figures embody violence rather than merely depict it. While Olère reconstructs genocide through forensic detail and Kiefer engages with the material traces of memory, Janco’s grotesque forms share an affinity with Grosz’s politically charged distortions—though here, fragmentation serves not as critique but as testimony. Furthermore, the study interrogates the institutional and critical neglect of these works, particularly within Israeli art history, where they clashed with the forward-looking ethos of abstraction. By foregrounding Janco’s Holocaust drawings as both aesthetic interventions and acts of historical witnessing, this article repositions them as crucial yet overlooked contributions to Holocaust visual culture—demanding recognition for their capacity to unsettle, resist closure, and insist on the incompleteness of memory. Full article
Show Figures

Figure 1

17 pages, 961 KiB  
Article
Association Between the COL5A1 rs12722 Genotype and the Prevalence of Anterior Cruciate Ligament Rupture in Professional Football Players
by Manuel Manchón-Davó, Juan Del Coso, Francisco J. Vera-Garcia, Joaquín González-Rodenas, Aarón Miralles-Iborra, Gil Rodas, Roberto López-Del Campo and Víctor Moreno-Pérez
Genes 2025, 16(6), 649; https://doi.org/10.3390/genes16060649 - 28 May 2025
Viewed by 853
Abstract
Background: Previous studies have tested the association between the COL5A1 rs12722 polymorphism and the risk of anterior cruciate ligament (ACL) injury. Overall, their results are contradictory because most studies used relatively small samples and data from ACL ruptures during sport activities have been [...] Read more.
Background: Previous studies have tested the association between the COL5A1 rs12722 polymorphism and the risk of anterior cruciate ligament (ACL) injury. Overall, their results are contradictory because most studies used relatively small samples and data from ACL ruptures during sport activities have been mixed with ruptures suffered in non-sporting contexts. Objective: To examine the association between the COL5A1 rs12722 polymorphism and the prevalence of ACL rupture in a homogeneous sample of professional male football players. Methods: A total of 268 professional male football players participated in this study. The COL5A1 rs12722 genotype (CC, CT and TT) was obtained from each player using genomic DNA samples obtained from a buccal swab and measured with PCR RFLP. Players with history of ACL rupture during their professional career were identified by the medical staff of each team. Only ACL injuries obtained during football exposure were considered for this investigation. In this process, we identified 49 ACL ruptures pertaining to 43 players suffered between 2013 and 2024. The situational pattern (i.e., attacking or defending, type of football action, moment of the season, match/training exposure, etc.) was also obtained for each injury. A sub-analysis of non-contact ACL ruptures was conducted, as these injuries are more likely to be influenced by genetic factors. Results: The distribution of genotypes was similar in players with history of ACL rupture (n = 43; CC/CT/TT, 24.4/48.9/26.7%) and with no history of ACL rupture (n = 225; 25.3/49.8/24.9%; p = 0.973). Overall, the prevalence of players with history of ACL injury was 16.2% for the whole group of CC players (11 out of 68 players), 16.4% for whole group of CT (22 out of 135 players) and 15.2% for the group of TT players (10 out of 66 players; p = 0.973). However, the COL5A1 rs12722 genotype affected the dominance of the injured leg (p = 0.012), the type of action that originated the injury (p = 0.047), and the distribution of non-contact ACL injuries depending on the time of the match (p = 0.020). Specifically, CC players suffered ruptures predominantly in the dominant leg, when landing or reaching (offensive actions) and in the last 15 min of the match (all p < 0.050). On the contrary, TT players had ACL ruptures predominantly in their non-dominant leg, when pressing the opponent (defensive actions) and in the first 15 min of the match (all p < 0.050). Conclusion: There was no association between any of the COL5A1 rs12722 genotypes and the overall prevalence of ACL rupture in professional football players. However, the COL5A1 rs12722 polymorphism appeared to influence specific characteristics of the injury, such as the type of action leading to the rupture and the timing within the match, suggesting a potential genetic contribution to injury susceptibility. Full article
(This article belongs to the Section Molecular Genetics and Genomics)
Show Figures

Figure 1

12 pages, 439 KiB  
Article
Maternal Vitamin D Deficiency and the Risk of Placental Abruption: A Cross-Sectional Study in a Greek Obstetric Population
by Artemisia Kokkinari, Evangelia Antoniou, Eirini Orovou, Maria Dagla, Maria Tzitiridou-Chatzopoulou, Antigoni Sarantaki, Kleanthi Gourounti and Georgios Iatrakis
Clin. Pract. 2025, 15(6), 102; https://doi.org/10.3390/clinpract15060102 - 26 May 2025
Viewed by 454
Abstract
Background: Vitamin D deficiency (VDD) during pregnancy has been associated with various obstetric complications, including preeclampsia, gestational diabetes, and premature rupture of membranes. However, its potential link to placental abruption remains underexplored. The aim of this study was to investigate whether low maternal [...] Read more.
Background: Vitamin D deficiency (VDD) during pregnancy has been associated with various obstetric complications, including preeclampsia, gestational diabetes, and premature rupture of membranes. However, its potential link to placental abruption remains underexplored. The aim of this study was to investigate whether low maternal vitamin D levels are associated with an increased risk of placental abruption in pregnancies considered otherwise low-risk. Methods: We conducted a cross-sectional study involving 248 pregnant women who were admitted for delivery at a public hospital in Athens, Greece. Serum levels of 25-hydroxyvitamin D [25(OH)D] were measured upon admission. Levels below 30 ng/mL were classified as insufficient. Although this threshold corresponds to insufficiency according to the Endocrine Society, for the purposes of this study, levels < 30 ng/mL were treated as indicative of vitamin D deficiency in order to capture broader physiological implications. Cases of placental abruption were identified based on obstetric history and clinical documentation at the time of delivery. A Chi-square test was used to assess the association between vitamin D status and placental abruption, and a multivariate logistic regression model was applied to control for potential confounders, including hypertensive disorders of pregnancy, smoking, and preterm birth. The potential role of vitamin D supplementation during pregnancy was also explored as part of the analysis. Results: Our analysis revealed that women with VDD had a significantly higher incidence of placental abruption (p < 0.05). In the multivariate model, VDD remained an independent risk factor (adjusted OR: 3.2, 95% CI: 1.1–9.6). Additional risk factors that showed significant associations with placental abruption included pregnancy-induced hypertension and maternal smoking. Conclusions: These findings support the hypothesis that insufficient maternal vitamin D levels may contribute to adverse pregnancy outcomes, including placental abruption. Further prospective studies are warranted to clarify the causal mechanisms and to evaluate whether early detection and correction of vitamin D deficiency could serve as a preventive strategy in prenatal care. Full article
Show Figures

Figure 1

26 pages, 6288 KiB  
Article
Earthquake History and Rupture Extents from Morphology of Fault Scarps Along the Valley Fault System (Philippines)
by Rolly E. Rimando and Peter L. K. Knuepfer
GeoHazards 2025, 6(2), 23; https://doi.org/10.3390/geohazards6020023 - 25 May 2025
Viewed by 1388
Abstract
The morphologic dating of single-event fault scarps along the dextral strike-slip Valley Fault System (VFS) yielded distinct clusters of relative ages (kt), which we interpret as evidence of independent surface ruptures. The boundaries between structural and geometric segments of the East Valley Fault [...] Read more.
The morphologic dating of single-event fault scarps along the dextral strike-slip Valley Fault System (VFS) yielded distinct clusters of relative ages (kt), which we interpret as evidence of independent surface ruptures. The boundaries between structural and geometric segments of the East Valley Fault (EVF) appear to have been nonpersistent during the recent rupture cycle. We associate the youngest cluster with the largest historical earthquake (M > 7 in 1863) felt in Manila, which is believed to have come from three segments of the EVF. Thus, future multiple-segment events, M > 7, could occur on the EVF. Our results do not support rupturing of the entire length of the West Valley Fault (WVF), but its northern segment (segment I) is capable of generating an M > 7 earthquake. This is the first time that diffusivity and relative ages of fault scarps are determined from this part of the world and is one of the few studies applying analysis of recent fault scarps to rupture segmentation studies. The recent scarps along the WVF’s segment II are due to aseismic creep and occur along pre-existing tectonic structures. Continued groundwater overextraction within the creeping zone could induce seismicity and modulate the natural timing of future earthquakes along the WVF. Full article
Show Figures

Figure 1

12 pages, 8236 KiB  
Article
Unusual Iridescent Clouds Observed Prior to the 2008 Wenchuan Earthquake and Their Possible Relation to Preseismic Disturbance in the Ionosphere
by Yuji Enomoto, Kosuke Heki, Tsuneaki Yamabe and Hitoshi Kondo
Atmosphere 2025, 16(5), 549; https://doi.org/10.3390/atmos16050549 - 6 May 2025
Viewed by 1037
Abstract
The Wenchuan earthquake (Ms8.0), which struck Sichuan Province, China, on 12 May 2008, was one of the most devastating seismic events in recent Chinese history. It resulted in the deaths of nearly 90,000 people, left millions homeless, and caused widespread destruction of infrastructure [...] Read more.
The Wenchuan earthquake (Ms8.0), which struck Sichuan Province, China, on 12 May 2008, was one of the most devastating seismic events in recent Chinese history. It resulted in the deaths of nearly 90,000 people, left millions homeless, and caused widespread destruction of infrastructure across a vast area. In addition to the severe ground shaking and surface rupture, a variety of unusual atmospheric/ionospheric and geophysical phenomena were reported in the days and hours leading up to the earthquake. Notably, iridescent clouds were observed just before the earthquake at three distinct locations approximately 450–550 km northeast of the epicenter. These clouds appeared as fragmented rainbows located beneath the sun and were characterized by their short lifespan, lasting only 1–10 min. Moreover, they exhibited striped patterns within the iridescent regions, suggesting the influence of an external electric field. These features cannot be adequately explained by the well-known meteorological phenomenon of circumhorizontal arcs, raising the possibility of a different origin. The formation mechanism of these clouds remains unclear. In this study, we explore the hypothesis that the iridescent clouds were precursory phenomena associated with the impending earthquake. Specifically, we examine a potential causal relationship between the appearance of these clouds and the geological environment of the earthquake source. We propose a novel model in which electrical disturbances generated along the fault system immediately before the mainshock propagated upward and interacted with the ionosphere, resulting in the creation of a localized electric field. This electric field, in turn, induced electro-optic effects that altered the scattering of sunlight and projected iridescent patterns onto cirrus clouds, leading to the observed phenomena. Full article
Show Figures

Figure 1

14 pages, 1102 KiB  
Review
Beyond Size: Advanced MRI Breakthroughs in Predicting Intracranial Aneurysm Rupture Risk
by Jose E. Leon-Rojas
J. Clin. Med. 2025, 14(9), 3158; https://doi.org/10.3390/jcm14093158 - 2 May 2025
Viewed by 781
Abstract
Intracranial aneurysms (IAs) are present in approximately 3–5% of the global population and carry a significant risk of rupture, leading to subarachnoid haemorrhage (SAH), a condition associated with high morbidity and mortality. Even with developments in neuroimaging, fundamental clinical difficulty remains in precisely [...] Read more.
Intracranial aneurysms (IAs) are present in approximately 3–5% of the global population and carry a significant risk of rupture, leading to subarachnoid haemorrhage (SAH), a condition associated with high morbidity and mortality. Even with developments in neuroimaging, fundamental clinical difficulty remains in precisely predicting which aneurysms will rupture. Although aneurysm size, location, and patient history define traditional risk assessment, these elements by themselves have insufficient predictive ability. Key elements in rupture risk are aneurysm wall biology, haemodynamics, and inflammation; recent developments in magnetic resonance imaging (MRI) including high-resolution vascular wall imaging (VWI), 4D flow MRI, and quantitative susceptibility mapping (QSM) provide fresh insights on these aspects. The present evidence on these sophisticated MRI techniques is synthesised in this review of the literature, which also analyses their clinical relevance and addresses newly developed computational methods like machine learning for better risk stratification. I underline important studies showing the diagnostic and prognostic worth of MRI-based biomarkers, discuss present constraints, and suggest future lines of research. Personalised aneurysm care could benefit from the combination of multiparametric MRI data with artificial intelligence (AI), hence improving patient outcomes. Full article
(This article belongs to the Special Issue Personalized Diagnosis and Treatment for Intracranial Aneurysm)
Show Figures

Graphical abstract

4 pages, 1284 KiB  
Interesting Images
Visualizing Aortic Inflammation by Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS)
by Asuka Suzuki, Koji Hayashi, Mamiko Sato, Yuka Nakaya, Toyoaki Miura, Naoko Takaku, Toshiko Iwasaki and Yasutaka Kobayashi
Diagnostics 2025, 15(9), 1151; https://doi.org/10.3390/diagnostics15091151 - 30 Apr 2025
Cited by 1 | Viewed by 498
Abstract
A 75-year-old man, with a history of descending thoracic aortic rupture and dissection treated with aortic stenting at 73 years old, was admitted for rehabilitation following recurrent cerebral ischemic attacks. Upon admission, blood tests revealed elevated inflammatory markers, including a C-reactive protein (CRP) [...] Read more.
A 75-year-old man, with a history of descending thoracic aortic rupture and dissection treated with aortic stenting at 73 years old, was admitted for rehabilitation following recurrent cerebral ischemic attacks. Upon admission, blood tests revealed elevated inflammatory markers, including a C-reactive protein (CRP) level of 10.75 mg/dL and a D-dimer level of 4.2 µg/mL, alongside microcytic anemia. Despite thorough evaluations using computed tomography (CT) and ultrasound, the origin of these abnormalities remained unidentified. Two months later, MRI using diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) revealed hyperintensities in the thoracic aorta. He remained asymptomatic and progressed well during rehabilitation, prompting continued observation. However, three months after admission, he developed hemoptysis. Contrast-enhanced CT showed pneumonia, as well as enhanced lesions in the aortic wall, confirming aortic inflammation. Due to concerns about aortic stent ulceration, an emergency stent graft insertion extending to the superior mesenteric artery was performed. He recovered uneventfully and was discharged. DWIBS is an MRI-based tool that avoids exposure to radiation or contrast agents and is cost-effective. MRI using DWIBS demonstrated high signal accumulations in the aortic wall, indicative of inflammation. These findings suggest that DWIBS holds significant potential as a powerful imaging tool for detecting and assessing inflammation, particularly in the aorta. Full article
(This article belongs to the Special Issue New Trends in Cardiovascular Imaging)
Show Figures

Figure 1

Back to TopTop