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Keywords = rosmarinosin A

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12 pages, 1315 KB  
Article
Rosmarinosin A Inhibits Inflammatory Response in Lipopolysaccharide-Induced RAW 264.7 Macrophages via Suppressing NF-κB and MAPK Signaling Pathway
by Hanui Lee, Gyeong Han Jeong, Seung Sik Lee, Kyung-Bon Lee, Sanghwa Park, Tae Hoon Kim, Hyoung-Woo Bai and Byung Yeoup Chung
Molecules 2025, 30(18), 3752; https://doi.org/10.3390/molecules30183752 - 15 Sep 2025
Cited by 3 | Viewed by 1696
Abstract
In the present study, we investigated the mechanisms underlying the anti-inflammatory effects of rosmarinosin A in (LPS)-stimulated RAW 264.7 macrophages. The cells were pretreated with various concentrations of rosmarinosin A, and then stimulated with LPS. Rosmarinosin A reduced the production of nitric oxide [...] Read more.
In the present study, we investigated the mechanisms underlying the anti-inflammatory effects of rosmarinosin A in (LPS)-stimulated RAW 264.7 macrophages. The cells were pretreated with various concentrations of rosmarinosin A, and then stimulated with LPS. Rosmarinosin A reduced the production of nitric oxide (NO) and prostaglandin E2 (PGE2), possibly through the modulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, respectively. Additionally, it inhibited the production of pro-inflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukin (IL) 1β, and IL-6. The molecular mechanisms of rosmarinosin A involved the suppression of nuclear factor κB (NF-κB) p65 translocation into the nucleus. Furthermore, rosmarinosin A exhibited anti-inflammatory properties by suppressing the mitogen-activated protein kinase (MAPK) signaling pathway. These findings suggest that rosmarinosin A may exert its anti-inflammatory effects, at least in part, through the modulation of NF-κB and MAPK pathways in LPS-activated macrophages, offering the potential for therapeutic development. Full article
(This article belongs to the Special Issue Anti-inflammatory Activities of Natural Products—Third Edition)
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10 pages, 788 KB  
Article
Phytochemical Investigation of Tradescantia Albiflora and Anti-Inflammatory Butenolide Derivatives
by Ping-Chen Tu, Han-Chun Tseng, Yu-Chia Liang, Guan-Jhong Huang, Te-Ling Lu, Tzong-Fu Kuo and Yueh-Hsiung Kuo
Molecules 2019, 24(18), 3336; https://doi.org/10.3390/molecules24183336 - 13 Sep 2019
Cited by 10 | Viewed by 4181
Abstract
Phytochemical investigation of the whole plant of Tradescantia albiflora Kunth led to the isolation and characterization of a butanolide, rosmarinosin B (1), that was isolated from natural sources for the first time, a new butenolide, 5-O-acetyl bracteanolide A ( [...] Read more.
Phytochemical investigation of the whole plant of Tradescantia albiflora Kunth led to the isolation and characterization of a butanolide, rosmarinosin B (1), that was isolated from natural sources for the first time, a new butenolide, 5-O-acetyl bracteanolide A (2), and a new apocarotenoid, 2β-hydroxyisololiolide (11), together with 25 known compounds (compounds 310 and 1228). The structures of the new compounds were elucidated by analysis of their spectroscopic data, including MS, 1D, and 2D NMR experiments, and comparison with literature data of known compounds. Furthermore, four butenolides 4a4d were synthesized as novel derivatives of bracteanolide A. The isolates and the synthesized derivatives were evaluated for their preliminary anti-inflammatory activity against lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production in RAW 264.7 cells. Among them, the synthesized butenolide derivative n-butyl bracteanolide A (4d) showed enhanced NO inhibitory activity compared to the original compound, with an IC50 value of 4.32 ± 0.09 μg/mL. Full article
(This article belongs to the Special Issue Anti-Inflammatory Activity of Natural Products)
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