Search Results (339)

To contrast the COVID-19 pandemic brought by the corona virus SARS-CoV-2, two mRNA-based anti-COVID-19 vaccines (by Pfizer-BioNTech and Moderna) were made available relatively quickly and deployed worldwide based on an emergency approval. Being considered vulnerable and at risk of infection, cancer patients have been prioritized for COVID-19 vaccination and vaccinated repeatedly because of the short time protection provided by these vaccines. Recently, a surge in the incidence and rapid progression of cancers has been observed in many countries, which could (at least partially) represent cancers undiagnosed or untreated during the pandemic. It has also been suggested that the SARS-CoV-2 itself or even the anti-COVID-19 mRNA vaccines could have contributed to the recurrence and worse clinical outcome in cancer patients, given the high incidence of COVID-19 in hospitalized patients and that these patients have been vaccinated with priority several times and in a short period. Although it appears extremely unlikely that SARS-CoV-2 and anti-COVID-19 mRNA vaccines elicit genotoxic events and cause neo-cancerogenesis in a short time, they could still cause non-genotoxic pro-carcinogenic effects by triggering an exaggerated inflammatory reaction, compromising immune homeostasis, stimulating cell proliferation, and negatively affecting cellular stress response and damage repair machinery. This could result in the promotion of regrowth of dormant micrometastases or relapses of stable minimal residual disease. Such a harmful outcome may likely result from a synergy between the virus and the vaccine, especially in multi-vaccinated and multi-infected individuals. Here, I bring the cell pathologist’s point of view and discuss the multiple possible mechanisms by which the virus and the anti-COVID-19 mRNA vaccine might favor tumorigenesis. While a causal link cannot be established at this stage, knowledge of potential carcinogenic risks could help doctors and health policymakers take the best actions to protect vulnerable patients and convince the vaccine developer to design a vaccine free from such harm. Full article

Background: The COVID-19 pandemic, declared to be over by the World Health Organization (WHO) on 5 May 2023, significantly impacted global physical, mental, economic, social, and political conditions. Since the onset of the pandemic, conspiracy theories have surged globally, facilitated by the Internet and social media. Conspiracy thinking is associated with mistrust in traditional sources of information, such as newspapers and news/TV programs, and lower adherence to public health guidance. However, there is limited understanding of how these beliefs are reflected in specific health-related behaviors and the mediating variables involved. Objective: The study aims to analyze the relationship between the belief in conspiracy theories, perceived personal control, and psychological well-being during the COVID-19 pandemic in Italy to understand how belief in conspiracy theories may contribute to less adherence to government guidelines and the role of factors such as personal control, trust in social media, and traditional sources of information in this relationship. Methods: In total, 437 Italian adults (296 women, 140 men, 1 non-binary; M_age = 31.41, SD = 13.32) completed measures of well-being, perceived control, use/trust of traditional vs. social-media sources, conspiracy beliefs, and adherence. Results: Well-being correlated positively with perceived control and social-media trust. Perceived control correlated positively with social-media trust and negatively with traditional-source trust. Adherence correlated positively with traditional-source trust and negatively with all conspiracy measures. Mediation showed an indirect effect of conspiracy beliefs on lower adherence only via reduced trust in traditional sources. In contrast, no indirect effects were found via social-media trust or perceived control. Conclusions: Conspiracy beliefs undermine adherence primarily by eroding trust in traditional information. Risk communication should rebuild institutional trust and tailor messaging across both social and traditional channels, taking into account psychological factors. Full article

Previous research on financial contagion has mostly looked at volatility spillovers using static or fixed parameter models. These models don’t always take into account how inter-market links change and depend on frequency during big crises. This study fills in that gap by looking at how changes in volatility in the G20 equity markets affected four big global events: the global financial crisis of 2008, the European debt crisis, the COVID-19 pandemic, and the Russia-Ukraine war. The study uses a Time-Varying Parameter Vector Autoregression (TVP VAR) framework along with the Baruník-Křehlík frequency domain spillover measure to look at how connectedness changes over short-term (1–5 days) and long-term (5–Inf days) time periods. The results show that systemic connectedness changes a lot during crises. For example, the Total Connectedness Index (TCI) was 24–25 percent during the GFC and EDC, 34 percent during COVID-19, and a huge jump to 60 percent during the Russia-Ukraine war. During the global financial crisis and the war between Russia and Ukraine, the US constantly emerged as the largest transmitter. During the European debt crisis, on the other hand, emerging markets like Turkey, South Africa, and Japan acted as net transmitters. During all crisis times, short-term spillovers are the most common. This shows how important high-frequency volatility transmission is. This study is different from others because it uses both time-varying and frequency domain views. This gives us a better idea of how crises change the way global finances are linked. The results are very important for policymakers and investors because they show how important it is to coordinate risk management, improve market safety, and make systemic stress testing better in a global financial world. Full article

The COVID-19 pandemic has inflicted unprecedented pressure on communities and healthcare systems around the world. An outstandingly broad and intensive investigation of possible therapeutic interventions is currently taking place to prevent similar future threats to the global population. Investigating the related mechanisms of action is often complex and time consuming. Moreover, research on biochemical interactions of new drugs involves a considerable amount of effort, consequently bearing inherent financial and operational risks for pharmaceutical companies. An interesting approach to counteract colonization and infection is the concept of antiseptic treatment in vivo. Antiseptics are cost-effective and globally accessible, due to their ease of production, transportation and handling. A broad spectrum of active agents with different properties is readily available. One of these substances is hypochlorous acid (HOCl), which is also a naturally occurring biocidal agent and as such part of the innate immune system. Its successful history of medical use in wound treatment, combined with low cytotoxicity and documented efficacy against various pathogens, suggests that HOCl might be an effective agent for treating the respiratory mucosa. This could potentially enable therapeutic inhalation for combating bacterial infections and viral pathogens such as human respiratory syncytial, influenza, and SARS-CoV-2 viruses, which will be discussed in the present article. Full article

This study examines the long-term financial sustainability of commercial banks, emphasizing the crucial role of credit risk management. Given that the core function of credit creation inherently exposes banks to credit risk, this analysis evaluates how five key bank-specific risk variables, namely expected credit losses (ECL_BS), impairment gains or losses (ECL_IS), non-performing loans (NPLs), common equity tier 1 capital (CET1), and leverage (LEV) affect long-term financial sustainability. Applying a panel error correction model on data from listed South African banks spanning 2006 to 2023, the study reveals a stable long-term relationship, with approximately 74% of short-term deviations corrected over time, indicating convergence towards equilibrium. By taking into account the significance of major exogeneous shocks such as the 2009–2010 global financial crisis and the COVID-19 pandemic, as well as regulatory framework changes, the results reveal persistent relationships between credit risk factors and banks’ long-term financial sustainability in both short and long horizons. Notably, expected credit losses, and impairment gains and losses exert significant negative influence on long-term financial sustainability, while higher CET1 and NPLs exhibit positive effects. The study findings are framed within four complementary theoretical perspectives—the resource-based view, institutional theory, industrial organisation, and the dynamic capabilities framework—highlighting the multidimensional drivers of financial resilience. Thus, the study’s originality lies in its integrated approach to assessing credit risk, offering a holistic model for evaluating its influence on long-term financial sustainability. This integrated framework provides valuable, actionable insights for financial regulators, bank executives, policymakers, and banking practitioners committed to strengthening credit risk frameworks and aligning banking sector stability with broader sustainable development goals. Full article

Canada’s national surveillance shows an 11% year-over-year decline in deaths from opioid and other unregulated drug poisonings, and a 10% drop in related hospitalisations in 2024. In stark contrast, Québec, home to more than nine million residents, and Montréal, the country’s second-largest city, experienced a continued rise in suspected drug-poisoning mortality through 2024, with fentanyl or analogues detected in almost two-thirds of opioid deaths. We conducted a narrative synthesis of provincial coroner and public-health surveillance tables, Health Canada dashboards, and the 2022–2025 Québec Strategy on Psychoactive-Substance Overdose Prevention. Results indicate a 40% increase in opioid-related mortality since 2018, a parallel uptick in stimulant toxicity, and a five-fold rise in overdose reversals at Montréal supervised-consumption services during the COVID-19 pandemic recovery. We aim to summarise the key problems underlying this epidemic and offer province-specific public-health strategies while also sending a call to action for first-line clinicians and psychiatrists to integrate overdose-risk screening, take-home naloxone, and stimulant-use-disorder treatments into routine care. We further urge Québec healthcare professionals to deepen their knowledge of provincial services such as supervised-injection sites and stay up to date with the rapidly evolving substance-use-prevention literature. Québec’s divergent trajectory underscores the need for region-tailored harm-reduction investments and stronger policy-to-clinic feedback loops to reduce preventable deaths. Full article

In recent years, supply chain risks and stability have become a focal point of public attention. However, there is no consensus on how exogenous shocks affect the sustainability of supply chain relationships, nor a clear mechanism of influence. This study uses data from all A-share listed companies in China from Q2 2018 to Q4 2021, constructing a “supplier–quarter–customer” relationship dataset, with the COVID-19 pandemic serving as an exogenous shock. The results show that after experiencing exogenous shocks, the sustainability of supply chain relationships actually strengthens. This suggests that companies may take measures to enhance supply chain stability and maintain existing relationships to ensure sustainability. Channel analysis reveal that trade credit serves as a channel for the impact of exogenous shocks on the sustainability of supply chain relationships, with companies adjusting trade credit supply to downstream customers to maintain and strengthen stability. Additionally, the impact of exogenous shocks on the sustainability of supply chain relationships varies with market concentration, product input heterogeneity, and firms’ ownership type. Therefore, companies should enhance supply chain relationship management, utilize trade credit as a risk buffer, and optimize the supply chain structure to reduce risk transmission and maintain sustainability. Full article

Aim: Our aim was to survey people with dementia and their carers with respect to their propensity to join a randomized trial of community singing in dementia, in the context of uncertainty following the COVID-19 pandemic. Method: We employed an online anonymous questionnaire, comparing activities before and after lockdown, worries about COVID-19, whether people would attend a singing group and what measures might make this more likely. With a target sample of 100, the survey was distributed to the general population of people with dementia and carers in the UK between June and August 2022. Results: We had a total of 168 respondents, of whom 30% were people living with dementia and 70% were carers. Those who were not worried (roughly 62%) were more likely to go out to groups. Worries about COVID-19 affected 38% of respondents but some judged the risk of going out to be worthwhile. Most felt able to take adequate precautions against infection. However, COVID-19 transmission was not the main impediment to attending a singing group and 19% of respondents were simply not interested in doing so, while mobility and shyness deterred others. Conclusions: Given recruitment problems, quantitative studies of singing in dementia need to take account of individual preferences as well as contextual barriers, including fear of virus transmission, individual perceptions of the intervention and logistical obstacles to participation. Full article

This study investigates the relationship between ownership structure (foreign and domestic) and bank risk-taking over the period 2014–2022. The analysis includes 66 banks operating in the GCC, divided into 44 domestically owned, and 22 foreign-owned banks. The research examines the relationship across two distinct periods: the pre-pandemic and the COVID-19 pandemic era, using the two-stage least squares (2SLS) method, and panel data techniques for robust analysis. The findings reveal that, in both periods, foreign-owned banks exhibited lower credit risk, greater cost efficiency, and less risk-taking compared to domestic counterparts. Domestic banks, while maintaining profitability, relied heavily on capital absorbency, which resulted in elevated credit risk and operational inefficiencies. These inefficiencies, observed among domestic banks, stem from inadequate monitoring of borrowers’ information and the occurrence of moral hazard. Foreign banks played a crucial role in supporting banking sector stability, as their presence enhanced the GDP growth. The results are in line with the “global advantage hypothesis”. Full article

Events of recent years, such as the COVID-19 pandemic and the war in Ukraine, have caused significant fluctuations in financial markets, including energy and precious metals markets. Many investors see commodity investments as a way to diversify portfolio risk. The article’s main aim was to evaluate the performance of Polish commodity funds and analyze how external factors influenced their investment results from 2020 to 2023. Using popular investment fund performance metrics, it was determined that precious metals funds could not be considered effective during the 2020–2023 period, whereas the opposite conclusion applied to energy commodity funds. Additionally, mixed linear regression models showed that the average performance of precious metals funds was significantly positively influenced by the price of gold. Meanwhile, the performance of the average energy commodity fund was significantly positively impacted by the CRB Commodity Index value. The conducted analysis demonstrates that mixed linear regression models can be successfully applied in evaluating the external factors influencing the efficiency of commodity funds, taking into account their capital allocation policies. The obtained results can be utilized by current and potential participants of commodity funds, investors seeking portfolio diversification opportunities, and commodity fund managers to maximize investment performance. Full article

During the COVID-19, Muslim entrepreneurs had to adapt to remain resilient. These Muslim entrepreneurs can rely on entrepreneurial personality and skill traits to survive a crisis. This paper aims to expand the analysis of the several contributing factors to the resiliency of small- and medium-sized enterprises (SMEs) managed by Muslim entrepreneurs, as identified in various scholarly publications. Additionally, this study emphasises the significance of entrepreneurial personality and skill traits, investigates the mediating role of entrepreneurial orientation on the link between entrepreneurial traits and SME resilience, and explores the moderating effects of Muslim religiosity. Furthermore, it delves into specific Islamic principles such as “ikhtiar” (effort) and “tawakkal” (reliance on God), which contribute to the resilience of Muslim entrepreneurs. This study centres on Muslim business owners of small- and medium-sized enterprises (SMEs) in West Sumatra. The final sample obtained was 452 Muslim entrepreneurs. This research was conducted in 2021, at the peak of the COVID-19 pandemic. The findings indicate that entrepreneurial traits influence the resiliency of Muslim entrepreneurs in two distinct ways: directly and indirectly via entrepreneurial orientation. This research advances the entrepreneurial literature in three ways. First, research on entrepreneurial resilience is extended, considering the different dimensions of entrepreneurial personality and traits (negotiation skills, risk-taking, optimism, locus of control, and need for achievement). Second, this study explores the mediating role of entrepreneurial orientation on the relationship between entrepreneurial personality and skill traits toward entrepreneurial resilience. Finally, this study specifically discusses Muslim entrepreneurs as research respondents. Full article

The study of impacts on and risks to citizens generated by climatic or environmental phenomena in urban settlements is made complex by the coexistence of events that can affect the risk assessment. In this work, a model for the assessment of impacts on and risks to the population generated by heatwaves in urban settlements in the presence of pandemic periods is proposed. The presence of epidemics is treated as a stressor that contributes to altering exposure. To assess the prevalence of this stressor, a fuzzy-based emotion detection method is utilized, which uses the FREDoC framework to categorize the subzones that comprise the urban study area according to the relevance of the pleasant and unpleasant emotions of the citizens, identified based on the examination of posts that have been published on social networks. The proposed model was tested on the urban area of study of the city of Naples in Italy, taking into consideration a heatwave scenario that occurred in the summer of 2021 during the COVID-19 pandemic and analyzing the variation in exposure in the thirty districts into which the city is partitioned. The findings demonstrate that the model can accurately represent the range of impacts and hazards associated with the heatwave brought on by the COVID-19 pandemic. Full article

The COVID-19 pandemic offers an opportunity for the revitalisation of empty Spain and the development of new sustainable business models in a healthier environment, taking the competitive advantages of digitalisation and the benefits of contact with nature. This study presents a positive analysis of the situation after three months of confinement with the research objective of evaluating the potential for development a sustainable social economy in empty Spain based on the hypotheses presented. In order to demonstrate the six hypotheses put forward in the research, a review of the existing literature was conducted, socio-economic and environmental indicators from official sources were consulted, and descriptive statistics methods have been applied. Digitalisation, the social economy, the bio-economy, and the revitalisation of heritage seem to be the drivers for achieving the challenges proposed. By perceiving reality through a lens that values nature and creative intelligence, a new avenue of opportunities may be opened up, leading to an improvement in quality of life and well-being, and potentially retaining the rural population. Following this study, which assesses the opportunities, risks, and challenges and establishes a plan of measures, players, and resources for future implementation in vacant Spain, new lines of work will become available. Full article

The world has gone through the COVID-19 pandemic and has now returned to normalcy. We reviewed the strategies and public health actions conducted in Hong Kong during the COVID-19 pandemic, and reflected on the lessons learned, which are potentially useful in the fight against antimicrobial resistance (AMR). We recommended extending wastewater surveillance for AMR, apart from SARS-CoV2. We suggested exploring the use of rapid tests in outpatients to aid clinical diagnosis and reduce antibiotic use for viral infections. Stringent infection control measures are crucial to prevent nosocomial transmission of resistant microorganisms, such as vancomycin-resistant enterococci and carbapenemase-producing Enterobacterales in hospitals and in elderly homes. Taking COVID-19 experiences as a reference, transparent data, the prompt dissemination of information, and strategic risk communication should be adopted to maintain sustained behavioral changes in AMR. We also encouraged the adoption of information technology, artificial intelligence, and machine learning in antimicrobial stewardship programs. We also discussed the potential merits and limitations of these strategies. The lessons learned from the COVID-19 pandemic may provide insights into the long battle against AMR. Full article

The COVID-19 pandemic highlighted the urgent need for effective surface disinfection solutions, which has led to the use of mobile robots equipped with ultraviolet (UVC) lamps as a promising technology. This study aims to optimize the navigation of differential mobile robots equipped with UVC lamps to ensure maximum efficiency in disinfecting complex environments. Bio-inspired metaheuristic algorithms such as the gazelle optimization algorithm, whale optimization algorithm, bat optimization algorithm, and particle swarm optimization are applied. These algorithms mimic behaviors of biological beings such as the evasive maneuvers of gazelles, the spiral hunting patterns of whales, the echolocation of bats, and the collective behavior of flocks of birds or schools of fish to optimize the robot’s trajectory. The optimization process adjusts the robot’s coordinates and the time it takes to stops at key points to ensure complete disinfection coverage and minimize the risk of excessive UVC exposure. Experimental results show that the proposed algorithms effectively adapt the robot’s trajectory to various environments, avoiding obstacles and providing sufficient UVC radiation exposure to deactivate target microorganisms. This approach demonstrates the flexibility and robustness of these solutions, with potential applications extending beyond COVID-19 to other pathogens such as influenza or bacterial contaminants, by tuning the algorithm parameters. The results highlight the potential of bio-inspired metaheuristic algorithms to improve automatic disinfection and achieve safer and healthier environments. Full article