Search Results (1,557)

Burrowing crayfish are among the most important keystone species in North American ecosystems, yet they remain poorly understood. The Meadow River Mudbug (Cambarus pauleyi), native to West Virginia, was only recently described and is known from a very limited range in the Central Appalachians. During planning for an interstate pipeline, two large populations of C. pauleyi were found in the proposed right-of-way. As part of environmental compliance, salvage, relocation, and monitoring for the species were conducted from 2018 to 2024. All C. pauleyi were moved to the Meadow River Wildlife Management Area, where artificial starter burrows were created, and exclusion baskets were placed over them to prevent predation, the process of which is described herein. Monitoring showed a two-month survival rate of 74.0% to 85.5%. These results are promising for the future restoration of burrowing crayfish and other species that rely on crayfish burrows for habitat. Full article

Over the past decade the industry has developed technical, contractual and managerial tools for road construction without recognizing their capacity as solutions to land access restrictions. This systematic review analyzes the strategies for executing road projects under such restrictions. Following the PRISMA 2020 protocol, 51 indexed articles (2015–2026) retrieved from Scopus and Web of Science were examined and classified into land access restrictions, execution strategies (four families: technical–constructive, project management, social–institutional and contractual–legal) and impact on performance. Strategies are documented in 64.7% of the studies, but only 25.5% analyze them as an object, which explains why they have not been recognized as available solutions. The four families are not alternatives: they operate at different moments of the cycle, and their effectiveness depends on the type of restriction, the moment of activation and the institutional capacity, a determining variable that the corpus does not measure. Treating the restriction as a planning variable, rather than a contingency, distinguishes the projects with positive impact. Full article

Background: The Forward Lunge is a representative squash-specific footwork movement involving rapid acceleration, braking, postural stabilization, and return propulsion. This study examined whether pre-competition neuromuscular electrical stimulation (NMES) combined with weighted squats was associated with differences in Forward Lunge performance and neuromuscular control in squash athletes. Methods: Thirty-six male squash athletes were randomly assigned to three groups: Weighted Squats, Fake Stimulation, and Real Stimulation, with 12 participants in each group. After the assigned acute intervention, all participants completed the squash-specific star test. Completion time was recorded using a Microgate Witty photocell timing system, while surface electromyographic (sEMG) signals from 14 right-side muscles were collected using a Delsys Trigno wireless electromyography system. High-speed video was used to identify the Forward Lunge movement cycle, and transistor–transistor logic (TTL) synchronization enabled temporal alignment among timing, video, and sEMG signals. Normalized root mean square (RMS), muscle co-activation index (CI), and non-negative matrix factorization (NMF)-based muscle synergy parameters were calculated. Between-group differences were analyzed using one-way analysis of variance (ANOVA) with Bonferroni post hoc comparisons, and false discovery rate (FDR) correction was applied to secondary neuromuscular outcomes. Results: Star test completion time differed significantly among the three groups (F = 28.65, p < 0.001, η² = 0.63). The Real Stimulation group showed a shorter completion time (10.35 ± 0.45 s) than the Weighted Squats group (11.80 ± 0.55 s) and Fake Stimulation group (11.55 ± 0.50 s). During the Forward Lunge movement cycle, normalized RMS values of the rectus abdominis (ABS; F = 18.56, p < 0.001, η² = 0.55) and latissimus dorsi (LD; F = 13.42, p < 0.001, η² = 0.44) were significantly higher in the Real Stimulation group. The gluteus maximus–biceps femoris (GLM–BF) co-activation index also differed significantly among groups (F = 58.42, p < 0.001, η² = 0.78), with higher values in the Real Stimulation group. Muscle synergy analysis showed group differences in selected muscle activation weights and temporal activation parameters. Conclusions: In this parallel-group acute intervention study based on post-intervention measurements, real NMES combined with weighted squats was associated with shorter star test completion time and altered neuromuscular control during the Forward Lunge movement cycle. The integrated use of photocell timing, wireless sEMG, high-speed video, and TTL synchronization provided temporally aligned sensor-based evidence for evaluating acute pre-competition activation strategies. However, due to the absence of baseline measurements, the findings should be interpreted as post-intervention between-group differences rather than definitive evidence of individual improvement. Full article

Background: The purpose of this in vitro study was to evaluate and compare the fracture resistance of 3D-printed partial veneers with finish lines at three different locations and conventional full veneers with finish lines at the gingival level. All restorations were digitally designed and 3D printed using a nanoceramic filled resin specifically developed for veneer restorations. Methods: Four maxillary right central incisor typodont teeth were prepared for labial veneers with finish lines at different locations: incisal third (InT), middle portion of the middle third (MmT), lower portion of the middle third (LmT), and conventional veneer with the finish line at the gingival level (CoV). Each preparation was scanned, and 15 casts were 3D printed from each scan. A total of 60 3D-printed veneers were fabricated (n = 15 per group) using a nanoceramic-filled resin designed for veneer restorations. The restorations were cemented to the 3D-printed dies using the manufacturer’s adhesive and resin cement. The specimens were artificially aged with 10,000 thermal cycles between 5 °C and 55 °C, with a dwell time of 30 s, and then loaded to failure using a universal testing machine. Fracture load values were analyzed using one-way ANOVA and the Tukey honestly significant difference post hoc test (α = 0.05). In addition, fracture patterns were evaluated using scanning electron microscopy images for descriptive purposes. Results: The mean fracture resistance of the 3D-printed partial and conventional labial veneers differed significantly depending on restoration design (p < 0.05). Among the partial veneers, the LmT group showed the highest fracture resistance (279.86 N), followed by the MmT group (266.92 N), while the InT group showed the lowest value (179.22 N). The conventional veneer group (CoV) demonstrated higher fracture resistance (404.07 N) than all partial veneer groups. Conclusions: The fracture resistance of 3D-printed partial and conventional labial veneers fabricated with nanoceramic-filled resins differed according to finish line location. Conventional veneers demonstrated higher fracture resistance than all partial veneer designs. The smallest partial veneer, with the margin located in the incisal third, showed lower fracture resistance than the partial veneer designs with finish lines in the middle third. Full article

Background: Cardiovascular disease (CVD) is the leading cause of global mortality, necessitating its early detection. Carotid intima-media thickness (CIMT) is a validated biomarker of CVD. In Saudi Arabia (SA), population-specific CIMT data for young adults are lacking. This pilot study aimed to generate single-institution preliminary CIMT data using the Butterfly iQ+ handheld ultrasound device (HHUD) and identify CVD risks. Methods: A cross-sectional observational study was conducted on 63 medical students. CIMT was measured bilaterally on common carotid artery (CCA), using the Butterfly iQ+ HHUD. Data on sex, age, ethnicity, BMI, mean arterial pressure (MAP), family history, and dietary habits were collected and analysed using t-tests, one-way ANOVA, Chi-square tests, Spearman’s rho (ρ) correlation, and stepwise multiple linear regression. Results: Mean age was 19.19 ± 1.89 years, and mean BMI was 24.93 ± 4.72 kg/m². Mean CIMT was 0.053 ± 0.006 cm. Males demonstrated thicker right CIMT (0.055 cm; 95% CI: 0.053–0.058 cm) than females (0.051 cm; 95% CI: 0.048–0.053 cm; mean difference: 0.005 cm, 95% CI: 0.001–0.008 cm; p = 0.012) and higher mean CIMT (0.0548 vs. 0.0513 cm; mean difference: 0.004 cm, 95% CI: 0.000–0.007 cm; p = 0.031). Height (ρ = 0.266; p = 0.035) and weight (ρ = 0.320; p = 0.011) correlated with right CIMT. Stepwise regression identified sex as the sole independent predictor (R² = 0.105; F = 6.541; p = 0.013). Conclusions: This pilot study establishes preliminary single-institution CIMT data for young healthy medical students at a single university in Riyadh, Saudi Arabia. Sex, height, and body weight are key early determinants of carotid wall thickness. The Butterfly iQ+ HHUD is a feasible point-of-care tool for CIMT measurement, supporting community-based CVD screening in the region. Full article

Introduction: Previous studies have shown those with a history of a traumatic brain injury (TBI) have altered pupillary light responses compared with those without a history of TBI. Those with a history of TBI are also more likely to have accommodative deficits. We investigated the relationship between light-evoked pupil dynamics and accommodative function in individuals who have previously experienced a TBI. Methods: A total of 17 participants with a history of mild TBI were recruited. Pupil metrics were measured using a commercial pupillometer and included baseline diameter, latency, constriction amplitude, average constriction velocity, peak constriction velocity and peak dilation velocity. Accommodative function was assessed using clinical measurements of facility and amplitude. Pupil metrics were compared among those with versus without accommodative dysfunction. Results: One-way ANCOVA testing (controlling for age and time since most recent TBI) comparing groups with and without accommodative dysfunction showed that those with accommodative dysfunction had significantly larger light-evoked pupil constriction amplitudes (p = 0.037) and significantly faster average constriction velocity (p = 0.007) compared with those without accommodative dysfunction. No significant differences were observed for other pupil metrics (p > 0.05 for all). ANCOVA testing (controlling for age and time since TBI) to determine whether decreased amplitude of accommodation or facility was more strongly related to the differences in pupil metrics observed between those with versus without accommodative dysfunction, showed significantly larger light-evoked pupil constriction amplitudes (p = 0.007) and significantly faster average constriction velocity (p = 0.002) among those with reduced accommodative facility compared with those with normal accommodative facility. No statistically significant differences were observed between those with reduced versus normal accommodative amplitude (p ≥ 0.07). Among all participants, monocular accommodative facility measures were significantly correlated with greater pupil constriction amplitude (right eye: rho = −0.721, p = 0.001; left eye: rho = −0.65, p = 0.005), and greater average constriction velocity (right eye: rho = −0.58, p = 0.015; left eye: rho = −0.57, p = 0.016). Conclusions: The results of this small-sample study suggest that accommodative function and light-evoked pupillary dynamics are correlated in individuals with a history of TBI. Those with accommodative dysfunction showed greater pupil constriction amplitudes and velocities and this relationship may reflect shared autonomic or oculomotor mechanisms. Full article

Background/Objectives: Medication discrepancies at hospital discharge are common and may contribute to adverse drug events and avoidable healthcare use. Patients with mental health conditions may be at increased risk because of greater clinical complexity, polypharmacy, and fragmented care, but comparative evidence during general hospital admissions is limited. Our primary objective was to determine whether adults with mental health conditions were more likely than those without such conditions to experience unintended medication discrepancies at hospital discharge. Secondary objectives were to examine discrepancy subtypes, assess whether associations differed for serious mental illness versus other mental health conditions, and explore whether associations varied by reconciliation arm. Methods: We conducted a retrospective cohort study using linked data from the RightRx cluster-randomized trial at the McGill University Health Centre (2014–2016) and Quebec administrative databases. Adults with continuous provincial drug coverage for at least 12 months before admission who met study eligibility criteria were included. The primary exposure was any documented mental health condition; secondary analyses distinguished serious mental illness (SMI) from other mental health conditions. The primary outcome was any unintended medication discrepancy at discharge; subtype analyses examined omissions, therapeutic duplications, and unintended dose changes. Results: Among 3567 patients, 877 (24.6%) had a mental health condition. Crude discrepancy prevalence was similar between groups. In the prespecified primary analysis, mental health condition status was associated with lower observed odds of any unintended discrepancy at discharge. This unexpected inverse association should not be interpreted as evidence of a protective effect and may reflect differences in documentation, residual confounding, selection, or other unmeasured processes. Secondary and supplementary analyses, including omission and SMI subgroup comparisons, did not remain statistically significant after Holm correction. Conclusions: These findings suggest that documentation-based discrepancy measures may relate to mental health status in heterogeneous ways, but they require confirmation in independent settings. Full article

In this article, I show how discourses of African tradition, human rights, and African indigeneity circumscribe and curtail the emancipatory potential of discussions of same-sex relations in Africa. The terms of the debate on both sides—those who claim that same-sex relations are ‘un-African’ and the critics who rightly challenge this view—are circumscribed by what I call the religious-secular divide. This divide continues to entrap discussions of African humanity and agency within racial-colonial strictures of tradition/religion and secularity/modernity. Instead, by engaging with the work of Amilcar Cabral and Aimé Césaire, I develop a notion of decolonial or emancipatory African agency and a way of understanding African humanity as an alternative basis for engaging with the question of same-sex relations in Africa, African traditions, and African indigeneity, and with questions of African humanity and decolonial agency more generally. Full article

The Itaewon tragedy in South Korea highlighted the severe risks associated with ultra-high-density pedestrian environments. In this study, pedestrian safety in narrow urban alleys was quantitatively evaluated using a FLEXSIM-based Multi-Agent System (MAS) simulation that models individual pedestrian interactions under extremely crowded conditions. Two simulation scenarios were established: a typical alley configuration and a bottleneck condition caused by illegal construction. In addition, three pedestrian control strategies (i.e., bidirectional flow, right-side walking enforcement, and one-way traffic control) were comparatively analyzed. Evacuation time, pedestrian collision frequency, and associated risk levels (Level 0–Level 4) were evaluated according to pedestrian density and movement direction. The simulation results show that bottleneck conditions significantly increase pedestrian collision frequency and evacuation time under high-density conditions. Among the examined strategies, one-way traffic control most effectively reduced pedestrian interactions and evacuation delays, whereas the bottleneck scenario under bidirectional pedestrian flow showed the highest risk level. These findings highlight the importance of pedestrian flow control and bottleneck management in reducing crowd risk in ultra-high-density pedestrian environments and provide quantitative data for pedestrian safety assessment and crowd management planning. Furthermore, the present study provides a quantitative simulation-based approach for analyzing pedestrian collision risk and evacuation safety under ultra-high-density bottleneck conditions in narrow urban alley environments. Full article

Indigenous Peoples continue to steward their Lands through their traditional ecological knowledge (TEK), their Laws, and their kinship-driven processes as they have for millennia. There are various factors, including climate change, that threaten Indigenous TEK, Lands, and other processes including intergenerational knowledge transfer. Our team carried out a qualitative research study with Indigenous community members to increase understanding of Dene Peoples’ connections with Land, community TEK protection and stewardship, as well as changes in local environments. Semi-structured interviews were conducted with ten participants from the Northwest Territories (NWT), Canada, from December 2024 to February 2025. Coding and reflexive thematic analysis were carried out using qualitative software. Six themes were characterized from the interview data including: (1) intergenerational TEK are central to our ways of life; (2) despite various factors, our communities continue to share TEK across generations; (3) our collective health and healing are tied to our TEK as well as our values; (4) climate change-related threats and damages are impacting our People and the Land; (5) protecting and governing our own data is crucial for preserving our stories and knowledge; and (6) we need to protect Mother Earth for future generations. This study further demonstrates that the protection of Indigenous TEK is deeply important for the overall health and wellbeing of Indigenous Peoples. Additionally, the honouring of Indigenous sovereignty and Land rights is essential to transform current climate change approaches. Full article

As the “fifth major factor of production,” data plays a crucial role in fostering China’s tourism industry, advancing high-quality economic development, and gaining competitive market advantages. Serving as institutional infrastructure for data factor rights confirmation, pricing, trading, and value conversion, data trading platforms are central to the market-based allocation of data factors. The efficient flow and value realization of data elements have paved the way for the rapid development of digital tourism; new forms of digital tourism represent a profound transformation of the industry resulting from integration and innovation with other sectors. Based on the platform ecosystem theory, we select the panel data of 297 Chinese cities from 2012 to 2024 and innovatively use the Double/Debiased Machine Learning (DDML) model to empirically test the impact of data trading platforms on the new forms of digital tourism and its mechanisms. It is found that the construction of data trading platforms effectively empowers the development of new forms of digital tourism, and this conclusion still holds after a series of robustness tests, such as changing the sample split ratio, replacing the machine learning algorithm, and the instrumental variables method. Mechanism analysis indicates that data trading platforms significantly promote new forms of digital tourism through dual pathways of talent agglomeration and technological innovation, an effect further strengthened by increased government support. Heterogeneity analysis found that the empowerment effect is more significant in cities with lower resource endowment and common administrative level and historical cities, which can be effectively transformed into an employment support effect. Spatial effect analysis reveals that the establishment of data trading platforms exerts a positive pull effect on new forms of tourism in surrounding cities within a 30 km core zone. However, this effect gradually weakens with increasing distance, turning into a significant negative siphon effect beyond 60 km. The findings provide theoretical basis and empirical support for regionally differentiated digital tourism development policies. Full article

Animal growth involves changes in size with age and is associated with environmental factors. The aim was to conduct a study of a representative group of the Santandereana Creole goat breed to evaluate morphometric allometry according to sex. A sample of 23 males and 76 females, ranged 8–72 and 8–84 months of age respectively, was studied. Morphometric allometry was evaluated using 30 linear characters. A Mann–Whitney test assessed right- and left-side differences in horns (length and perimeter) and ears (length and width). A one-way PERMANOVA, using Gower distances, assessed sex differences. Principal component analysis (PCA) using a var-covar matrix identified the most discriminating traits. A one-way ANCOVA, using loadings at PC1, was performed to compare allometric trends between sexes. Differences between sexes were observed in linear traits (p = 0.0101) and indices (p = 0.0364). No differences were observed between the right and left sides in horns and ears. Differences were observed in size, with body weight, body length, thoracic perimeter, and horn length (right/left) being the most discriminating values reflecting sexual dimorphism of size. The indexes corroborated the larger size of males, especially in relation to skull width, rump length, chest depth, and body weight. Detected differences may reflect variations in the development of skeletal maturity. The indexes confirm that the Santandereana Creole goat is an animal with a tendency for meat production, with larger males and brachycephalic features due to the shape of the head. Discriminatory measures can be considered as parameters of interest for preserving the breed and establishing genetic improvement programs. Full article

Thomas Jefferson, the Author of the Declaration of Independence and the Father of the University of Virginia, considered it a self-evident truth that our rights must be secured through government and that the people themselves are the only safe guardians of their liberty in a republican form of government. The civic education of the people is, therefore, imperative, in his view, if they are to be informed citizens. This article examines the ways that the first States sought to institute public universities, through both constitutional and legislative means, and highlights Jefferson’s vision for civic education against the activity of the States in establishing education. Surveying early State constitutions and university charters reveals, for those States instituting public education, a wide range of approaches, particularly with respect to three aspects: authorizing mode (constitutional or legislative mandates); civic rhetoric; and scope (tiered system or single institution). While several of the States recognize education as important to republican government, their commitments to public civic education vary. Against this backdrop, Jefferson’s views on education appear both comprehensive and constant, from his reform Bill for the More General Diffusion of Knowledge and Notes on the State of Virginia, which envision a three-tiered public system, to his efforts in retirement to pass education reform and establish a new university, with his purpose being explicitly civic. While his State never adopted his full system, Jefferson continued to advocate for ward republics and public instruction throughout his life. The founding of the University of Virginia in 1819 partially fulfilled this pursuit, embodying the keystone in his educational architecture. Yet Jefferson’s broader system—grounded in local participation and universal civic instruction—remained unrealized. This survey further reveals that statesmen in early America did not always agree with Jefferson that States must have an enduring institutional commitment to public civic education, as the best means to inform the people and to secure republican self-government. Full article

This study focuses on a large rubber-tired gantry crane (RTGC) operating in a nomadic prefabricated beam yard and develops a Digital Twin-driven dynamic feasible route planning method for the path planning problem under the combined effects of a discrete topological road network, dynamic road occupation, time-window constraints, and right-of-way priority rules. By integrating the existing digitalized yard management system with field-acquired data, an operational-stage updating mechanism for dynamic topology and time windows is established. On this basis, long-vehicle occupancy, time-window constraints, and right-of-way priority rules are embedded into the A* search and rolling replanning process, forming a Digital Twin-based dynamic A* (TD-A*) feasible route planning algorithm under evolving operational constraints. Results from a representative operational case show that, under long-path conditions with significant dynamic constraints, TD-A* reduces transportation distance by 16.8% and operation time by 18.9%. For the full-process results, the transportation distance is reduced by 16.4%, the operation time by 12.8%, and the number of turning maneuvers by 50.0%. The results demonstrate that the proposed method can improve the adaptability of feasible route planning to dynamic road occupation and traffic conflicts in a real nomadic beam yard with a single RTGC, and demonstrate the engineering feasibility of embedding Digital Twin-driven dynamic constraints into the route planning process. Full article

Objectives: In this in vitro study, we aimed to evaluate the effect of bur wear during grinding on the marginal gap of Zirconia Lithium Silicate (ZLS) single crowns. Methods: A single maxillary right canine typodont tooth, pre-prepared for a full ceramic crown, was scanned using an intra-oral scanner. A total of 32 ZLS crowns were ground using a four-axis grinding unit and divided into four equal groups (n = 8) based on the grinding sequence to represent progressive bur wear: Group 1 (crowns 1–8), Group 2 (crowns 9–16), Group 3 (crowns 17–24), and Group 4 (crowns 25–32). All crowns were ground consecutively using the same set of diamond burs. Each crown was temporarily cemented to the typodont tooth, and the marginal gap was measured at four reference points (buccal, palatal, mesial, distal) using scanning electron microscopy (SEM) at ×250 magnification. A Kolmogorov–Smirnov test performed on the study variables indicated a normal distribution (p > 0.05). Results: One-way ANOVA revealed no significant differences in the mean total marginal gap between the groups (p = 0.117), with values of 47.20 ± 5.16, 44.62 ± 7.23, 54.14 ± 10.02, and 48.53 ± 7.87 μm for Groups 1, 2, 3, and 4, respectively. Furthermore, no significant differences were found regarding a specific surface (distal, mesial, palatal, buccal) (p > 0.05). Conclusions: The cumulative wear of diamond burs after the consecutive grinding of 32 ZLS crowns did not significantly affect the marginal adaptation. All recorded marginal gaps were well within the clinically acceptable range (<120 μm). Full article