Search Results (171)

With the advancement of energy market reform, integrated energy systems (IESs) have achieved rapid development. Considering insufficient research on an electricity–heat coupled master–slave game and the local optimum defect of traditional algorithms, this paper proposes a Stackelberg game optimization strategy for IES considering integrated demand response (IDR), with microgrid operator (MGO) as the leader and load aggregator (LA) as the follower. Firstly, an IDR model containing rigid, shiftable electric loads and reducible thermal loads is established, and a bi-level game model is built: the upper MGO optimizes electricity and heat pricing to maximize profit, while the lower LA adjusts flexible loads for maximum consumer surplus. Secondly, an improved snake optimizer (ISO) is constructed via Hammersley sequence initialization, Lévy flight and random perturbation and combined with quadratic programming (QP) to form the ISO-QP hybrid solving method. Benchmark function and CEC2017 tests verify the superior convergence and stability of ISO against multiple classical intelligent algorithms. Case simulation obtains the Stackelberg equilibrium result, and repeated experiments and parameter sensitivity analysis verify model robustness. Results show that the proposed method smooths load fluctuations via price guidance and synchronously improves MGO revenue and LA consumer surplus on the premise of guaranteed user satisfaction. Full article

Higher education institutions, particularly those with teaching and research laboratories, play an important role in transmitting knowledge and attitudes regarding chemical safety to their students. As such, this study aims to assess the knowledge and attitudes of higher education students across different study programs regarding laboratory chemical safety. A cross-sectional study was conducted using a questionnaire adapted and translated into Portuguese. The instrument comprised twenty-seven questions and was distributed to students enrolled in undergraduate and graduate programs that include laboratory practices in their curricula in March and July of 2025. A total of 284 students participated in the study, divided among the different study programs (CTeSP = 4.2%; Bachelor’s = 70.4%; Master’s = 21%; Doctorate = 4.2%). The results showed that, although a large percentage of students have a high level of knowledge, their attitudes are not always the most appropriate, which could jeopardize their safety and that of those around them. Our findings revealed that there is room for curriculum adjustments. Early exposure to chemical and laboratory safety concepts can promote the development of students’ awareness and future professionals’ competence. Integrating safety modules into education may enhance knowledge and skills for making informed decisions that reduce accidents/incidents in laboratory environments. Full article

Background: Artificial intelligence (AI)-supported learning environments are increasingly used in music education; however, evidence regarding their effectiveness in solfège instruction remains limited. This action research study evaluated the effects of AI-supported solfège instruction on undergraduate students’ attitudes and performance. Materials and Methods: This action research study included 36 undergraduate students enrolled in a conservatory program. A 10-week AI-supported solfège training was implemented using the EarMaster intelligent tutoring system. Data were collected through a solfège attitude scale and a performance test administered before and after the intervention, along with a delayed retention test. Results: Following the intervention, significant improvements were observed in both attitude scores (104.6 vs. 117.3, p < 0.001) and performance scores (32.8 vs. 51.52, p < 0.001). However, retention test scores showed a significant decline after a no-practice period (51.5 vs. 48.8, p < 0.001). Qualitative findings indicated increased motivation, engagement, and individualized learning opportunities. Conclusions: AI-supported solfège instruction improved students’ performance and learning attitudes in higher music education. The findings suggest that adaptive feedback, individualized practice, and continuous engagement may contribute positively to auditory skill development and student motivation. However, sustained practice remains necessary for long-term retention. Artificial intelligence-supported systems should therefore be integrated as complementary tools alongside teacher-guided instruction to support more flexible and personalized learning environments. Full article

Spain is the world’s leading producer and exporter of olive oil, with Andalusia being the autonomous community with the largest cultivated area. In recent decades, agricultural practices have followed a trend toward maximizing production without adequately considering ecosystem contamination. Olive groves are, in fact, complex agroecosystems in which thousands of plant species and numerous plant communities have been documented, supporting a rich diversity of vertebrate and invertebrate fauna. Intensive and unsustainable practices have led to a decline in floral diversity and, consequently, in faunal diversity. The aim of this research is to demonstrate the loss of floristic diversity associated with herbicide use. To this end, a comparative analysis of floristic diversity was conducted across 117 plots, contrasting data collected in 2007 with that from the same plots in 2021. From a methodological perspective, an inquiry-based approach was implemented involving students from the Master’s program in Olive Growing, Olive Oil, and Health. Abundance–dominance indices were compared, and the Importance Value Index (IVI) was calculated to assess changes in plant community composition. For instance, Hordeum leporinum exhibited an IVI > 70 in 2007, decreasing in 2021 to values ranging between 11 and 31.58. Similarly, Sinapis alba subsp. mairei showed a decline in IVI from 81.06 to 26.35. A notable result is the greater floristic change observed in plots located on basic substrates where herbicides were applied, compared to plots on siliceous substrates designated for grazing. This issue clearly highlights a lack of knowledge regarding appropriate cultivation techniques that promote sustainable development and social awareness. It underscores the need for educational interventions that foster learning at all levels about agricultural practices, sustainability, and ecosystem services. Full article

Background: Knee osteoarthritis (KOA) is one of the leading causes of chronic pain and long-term disability worldwide. Despite its high prevalence, KOA remains underrepresented in repetitive peripheral magnetic stimulation (rPMS) research. While total knee arthroplasty remains the definitive treatment, there is a growing need for non-invasive approaches to reduce symptoms in patients seeking conservative alternatives or awaiting surgery. Methods: Thirty patients with KOA underwent a non-invasive treatment program consisting of eight sessions of double-coil repetitive peripheral magnetic stimulation (rPMS) over three weeks. Outcome measures included pain intensity assessed by the Visual Analog Scale (VAS), functional ability evaluated by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Timed Up and Go test (TUG), and joint mobility measured as knee flexion and extension. Clinical relevance was evaluated using the Minimal Clinically Important Difference (MCID), and subgroup analyses were performed according to Kellgren-Lawrence (KL) grade. Results: Double-coil rPMS was associated with statistically and clinically significant improvements in all outcomes. MCID responder rates exceeded 80% for VAS and TUG, exceeded 70% for WOMAC, and approached 50% for joint mobility outcomes. Subgroup analysis indicated that patients with lower KL grades experienced greater pain reduction, whereas those with higher grades showed greater functional gains. Conclusions: Double-coil rPMS provided preliminary evidence of potential clinical benefit as a non-invasive approach in patients with KOA. Given the single-arm pilot design, the findings should be interpreted cautiously and require confirmation in adequately powered randomized controlled trials with longer follow-up. Full article

Background: Fibromyalgia (FM) and eating disorders (ED) represent distinct clinical entities traditionally managed within separate medical specialties, yet emerging evidence suggests significant comorbidity and potential shared pathophysiological mechanisms. Both conditions disproportionately affect women, involve complex multifactorial etiologies and substantially impair quality of life. Despite documented clinical overlaps, the mechanistic connections linking these conditions remain poorly characterized, and integrated treatment approaches are lacking. Objective: This narrative review examines the role of oxidative stress and nuclear factor erythroid 2-related factor 2 (Nrf2) pathway dysfunction as a unifying molecular mechanism connecting fibromyalgia and eating disorders, with emphasis on implications for integrated rehabilitation strategies. Methods: We synthesized current evidence on oxidative stress pathophysiology in fibromyalgia and eating disorders, focusing on Nrf2-Keap1 pathway function, clinical comorbidity patterns and rehabilitation interventions targeting antioxidant defense mechanisms. In PubMed, representative search strings included “(fibromyalgia [MeSH] OR fibromyalgia [Title/Abstract]) AND (“eating disorders” [MeSH] OR “anorexia nervosa” [MeSH] OR “bulimia nervosa” [MeSH])” and “fibromyalgia AND (“oxidative stress” OR Nrf2 OR “redox”)”. Articles in English published through December 2025 were considered, with additional records identified by manually screening reference lists. Results: Fibromyalgia patients exhibit elevated oxidative stress markers, impaired antioxidant enzyme function and compromised Nrf2 activity correlating with disease severity, with studies reporting approximately 30–50% reductions in coenzyme Q10 levels compared with healthy controls. Similarly, eating disorders demonstrate mitochondrial dysfunction and oxidative stress dysregulation, though patterns differ across eating disorder phenotypes. Nrf2 serves as the master regulator of cellular antioxidant defense, coordinating expression of over 500 genes involved in detoxification, cytoprotection, inflammation modulation and metabolic regulation. Evidence suggests Nrf2 activity is regulated by energy balance, potentially linking nutritional status with cellular stress responses. Rehabilitation interventions, including graduated exercise and nutritional optimization with Nrf2-activating foods (cruciferous vegetables, polyphenols, omega-3 fatty acids), offer mechanism-based therapeutic approaches through hormetic Nrf2 activation and direct Keap1 modification. Conclusions: Multidisciplinary rehabilitation programs integrating physical therapy, exercise prescription and nutritional strategies targeting Nrf2 activation offer evidence-based, mechanism-driven approaches to address shared oxidative stress pathophysiology. Nrf2 pathway dysfunction represents a promising and biologically plausible molecular target that may help to unify our understanding of fibromyalgia and eating disorders pending confirmation from prospective clinical studies in comorbid populations. Future research should prioritize prospective clinical trials testing Nrf2-targeted interventions in comorbid populations and collaborative patient-centered care models. Full article

This study examined how pedagogical strategies can support student-coaches’ (SCs) empowerment and promote preservice teachers’ (PSTs) professional learning within Sport Education (SE) seasons. Sixty-seven tenth-grade students (aged 15–18) participated in SE units taught by three PSTs (two males, one female, aged 22–25) enrolled in a master’s degree program in Teaching of Physical Education in Primary and Secondary Education in northern Portugal. Data were collected through participant observation, informal and focus group interviews, and PSTs’ reflective diaries within a Collaborative Action Research (CAR) framework and analyzed thematically. Three CAR cycles addressed key challenges: (1) encouraging SCs to assume responsibility for their role, (2) fostering inclusive and supportive team interactions, (3) strengthening SCs’ sport-specific and instructional knowledge. Guided by a facilitator, PSTs implemented strategies including pre-lesson meetings, structured communication routines, task-modification and feedback cards, accountability systems, and visual identification of SCs. Findings suggest that SCs’ empowerment was progressively constructed through interconnected psychological, relational and pedagogical processes, supported by structured mediation and iterative reflection. Simultaneously, engagement in CAR cycles enabled PSTs to develop adaptive instructional decision-making and mediation strategies. The study highlights how empowerment in SE is shaped through relational and pedagogical conditions and illustrates how CAR can foster reciprocal learning between SCs and PSTs in authentic teacher education contexts. Full article

Mitochondria are a key organelle in maintaining metabolic homeostasis. It not only generates most of the cell’s energy through oxidative phosphorylation but also acts as a complex sensor of the redox state and oxygen in the cell. This review thoroughly analyzes the interactions among mitochondrial iron metabolism, mitochondrial reactive oxygen species (mtROS), and lipid peroxidation (LPO), the triggering factors of ferroptosis, an iron-dependent form of programmed cell death. We point out research showing that intrinsic mitochondrial machinery, such as iron–sulfur (Fe-S) cluster assembly and heme metabolism, is both an important cofactor and a master regulator. If these processes are disrupted, they can lead to ferroptosis. Unlike views that focus on the cytosol, we explain that the stability of Fe-S clusters in complexes such as aconitase and respiratory Complex I is crucial for preventing electron leakage and excessive mtROS formation. The Fenton reaction and its direct effect on cardiolipin (CL) oxidation in the inner membrane of mitochondria is a central event in cardiometabolic diseases. Its peroxidation and breakdown make the organelle very unstable and lead to cell death though Ca²⁺ overload and a significantly decreased reduced/oxidized glutathione ratio. Additionally, the functions of essential iron transporters and glutathione homeostasis are examined, and their dysregulation is correlated with ferroptosis-associated progression of cardiometabolic and neurodegenerative disorders, such as obesity and Alzheimer’s disease. This review focused on the need to revisit the classic bioenergetic core of the mitochondria as a key player in the pathophysiology of metabolic and neurodegenerative diseases. Full article

Innovative pedagogies that nurture higher-order competencies such as autonomy and problem-solving are critical in graduate STEM contexts. This study conceptualizes Thinking Classrooms as a pedagogical framework for graduate engineering education and examines how classroom practices associated with this approach support the development of autonomous learning and complex problem-solving. Drawing on classroom-based evidence collected over multiple academic cohorts in a master’s program in mechanical engineering, we describe patterns of student engagement, instructor adaptations, and evolving learning behaviors. Our findings highlight the potential of Thinking Classroom principles to inform instructional design, foster learner agency, and strengthen disciplinary problem-solving practices in postgraduate engineering education. We discuss implications for curriculum development and future research directions in STEM education. Full article

Cities play a central role in shaping opportunities for physical activity, health, and social well-being. However, municipalities often lack operational methodologies capable of translating active living and healthy urban environment strategies into coordinated, implementable, and evaluable local action. This study addresses this gap by proposing a methodology for creating Active City Master Plans, an integrative planning and governance framework designed to support municipalities in the systematic creation, implementation, and monitoring of local active living strategies. This structured approach integrates urban planning, public health, sport policy, and social development via a multi-phase planning process combining political anchoring, evidence-based diagnosis, participatory prioritization, project programming, and indicator-based monitoring. Emphasis is placed on intersectoral governance, institutional coordination, and the use of spatially locatable indicators to support decision-making and resource allocation. The methodology was developed through the synthesis of international active living and healthy urban planning frameworks. It is currently in the second stage of development, following refinement through pilot application in the medium-sized Spanish municipality of Torrelodones, which served as a methodological testing environment. While early results demonstrate feasibility and policy integration potential, further research is required to evaluate long-term population-level outcomes and transferability across diverse urban contexts. By providing a transferable methodology rather than a predefined plan model, municipalities—particularly small and medium-sized cities—can develop context-adapted Active City Master Plans aligned with sustainability, equity, and public health objectives. Full article

Training the public health workforce is a critical component of health system strengthening. In Mexico, postgraduate education operates under a national accreditation framework intended to ensure academic quality and social relevance, yet comprehensive information about the scope and distribution of training programs is limited. This study characterizes public health and related academic programs available in 2024, examining the institutional sector, delivery modality, geographic distribution, and accreditation status. A systematic institutional mapping was conducted through structured searches of the official websites of public and private higher education institutions. Eligible programs included bachelor’s degrees, specializations, master’s degrees, and PhDs that were active between March and November 2024. Searches used predefined keyword combinations, repeated at multiple timepoints, and were restricted to official institutional domains. Data were extracted on academic level, institutional sector, delivery format, duration, geographic region, and inclusion in the National Postgraduate System. Descriptive statistics and logistic regression were used to analyze accreditation patterns; geospatial analysis assessed regional distribution. A total of 175 programs were identified across 30 of Mexico’s 32 states. Professional master’s degrees represented the largest category, followed by research-oriented master’s and PhD programs. Public institutions offered nearly two-thirds of all programs. Among postgraduate programs, fewer than half were accredited, with accreditation concentrated in master’s degrees in science (84.6%) and PhDs (55.6%). Only 23.0% of professional master’s degree were accredited. Most programs were delivered fully in person; online offerings were limited and more common in private institutions. Research-oriented programs were geographically concentrated in a small number of states, whereas professional programs exhibited broader but uneven national distribution. Public health education in Mexico shows growth in professionally oriented training but also reveals persistent gaps in accreditation, geographic equity, and flexible delivery modalities. The disproportionate expansion of professional programs without corresponding integration into accreditation frameworks raises concerns for workforce planning and educational equity. Strengthening national information systems, improving institutional reporting standards, and aligning accreditation criteria with workforce needs are essential to ensure that public health training supports progress towards universal health coverage and the Sustainable Development Goals. Full article

Background: This systematic review aims to identify modifiable and non-modifiable predictors of exercise capacity (VO₂peak level or change) in stroke survivors. These insights may further optimize rehabilitation treatment and improve long-term health outcomes. Methods: PubMed (PubMed.gov), EMBASE (Elsevier), CINAHL (EBSCO), and Web of Science (Clarivate) were searched (last search on 7 October 2025). Inclusion criteria were: (1) adults (>18 years) who survived a stroke (ischemic and hemorrhagic), (2) outcome was a measurement of maximum exercise capacity (VO₂peak) measured with CPET (or equivalent), (3) predictors of exercise capacity were measured (e.g., personal factors, disease-related factors, components of rehabilitation), (4) predictors of exercise capacity were analyzed in multivariate regression models, (5) primary research, and (6) full-text available. During the data extraction phase, predictors were categorized into modifiable and non-modifiable predictors. Risk of bias was assessed with the McMaster Critical Review Form for Quantitative Studies. Results: Of 919 unique articles, seventeen were included. Modifiable factors such as BMI (4/8 articles) and fat mass (1/1), lower limb strength (3/3), cardiorespiratory fitness (e.g., baseline VO₂peak (2/4)), training intensity (2/2) and perceived fatigue (1/1) significantly predicted VO₂peak (level or change). Significant non-modifiable predictors were age (3/11), sex (1/8), diabetes (1/2), and stroke-specific (4/8) factors. Conclusions: This systematic review highlights the significant role of modifiable and non-modifiable predictors in optimizing exercise capacity (VO₂peak) for stroke survivors. In addition, considering modifiable and non-modifiable predictors allows for more personalized treatment planning. The findings can guide healthcare professionals in tailoring rehabilitation programs, though further research is needed to develop a comprehensive prediction model. Full article

This paper analyzes the implementation of the Geoportal SIG FESBAL–UPM, a Participatory Geographic Information System (PGIS) developed within the Master’s and Doctorate programs in Rural Development Project Planning and Sustainable Management at UPM. The study introduces a model integrated with Project-Based Learning (PBL), the Working With People (WWP) framework, and the CFS-RAI principles to address challenges in responsible food systems. The geoportal designed to be applied at the Food Bank–UPM Chair–FESBAL, acts as an innovative instrument for participation among the different stakeholders enabling the spatialization and analysis of data across social, environmental, and governance dimensions. Functionally, it offers a robust foundation for evidence-based decision-making, systematizes geographic information, and visualizes data via the web, supporting research, training, and community engagement actions. Furthermore, this study details the specific projects and activities developed under the three involved action lines: research, training, and community engagement, identifying strengths and weaknesses in each. The findings affirm that this participatory approach ensures that the proposed solutions are aligned with local needs and priorities, increasing the sustainability and long-term success of the projects implemented through the geoportal. Full article

Recent research has documented both questionable and responsible research practices in published psychology research, but it is unclear which research practices psychology students engage in when graduating from their master’s program. In this study, we documented the prevalence of responsible and questionable research practices in 300 psychology master’s theses from Tilburg University, the Netherlands, and associated these practices with supervisor’s grading of the theses. Compared to authors of published scientific manuscripts, master’s students seemed to engage more in responsible research practices, conducted more power analyses, used larger sample sizes, reported fewer statistically significant results, and provided more detailed reporting of their results. However, statistical reporting errors were almost as common in master’s theses as they are in the published literature. We found no relationship between thesis grades and any of the responsible or questionable research practices. We also found no relationships among practices, suggesting that there is no unidimensional construct of “responsible scientific behavior”. Full article

This paper examines the 14-year journey of the Mongolian National University of Medical Sciences (MNUMS) in achieving and sustaining international accreditation for its undergraduate medical program. Beginning in 2010, MNUMS undertook a series of institutional reforms that culminated in full accreditation in 2016 and re-accreditation in 2024 by an international agency recognized by the European Network for Quality Assurance in Higher Education (ENQA). Drawing on institutional self-assessment reports, evaluator feedback, and stakeholder consultations, this case study explores how the accreditation process functioned as a catalyst for educational reform and quality enhancement. The findings reveal major transformations in curriculum design, assessment systems, and institutional governance. MNUMS adopted the European Credit Transfer and Accumulation System (ECTS), introduced outcome-based education and Entrustable Professional Activities (EPAs), expanded its Clinical Skills Center, and implemented a compulsory undergraduate research project. Additionally, the creation of an integrated Bachelor–Master pathway and strengthened international partnerships further advanced the university’s alignment with global medical education standards. This case illustrates how international accreditation can drive systemic improvement in medical education within developing-country contexts. The MNUMS experience highlights the value of sustained institutional commitment, responsiveness to external evaluation, and the strategic use of accreditation as a framework for continuous innovation and global integration. Full article