Search Results (31)

Since the monotonicity of the best approximant is crucial to establish partial ordering methods, in this paper, we, respectively, characterize the best approximants in Banach function spaces and Lorentz spaces ${\Gamma }_{p,w}$, in which we especially focus on the monotonicity characterizations. We first study monotonicity characterizations of the metric projection operator onto sublattices in general Banach function spaces by the property $H_g$. The sufficient and necessary conditions for monotonicity of the metric projection onto cones and sublattices are then, respectively, established in ${\Gamma }_{p,w}$. The Lorentz spaces ${\Gamma }_{p,w}$ are also shown to be reflexive under the condition $R{B}_p$, which is the basis for the existence of the best approximant. As applications, by establishing the partial ordering methods based on the obtained monotonicity characterizations, the solvability and approximation theorems for best proximity points are deduced without imposing any contractive and compact conditions in ${\Gamma }_{p,w}$. Our results extend and improve many previous results in the field of the approximation and partial ordering theory. Full article

Physical challenges such as illness, injury, and disability significantly alter women’s relationships with their bodies, disrupting established notions of functionality and self-worth. This study re-examines the Holistic Model of Positive Body Image and Outdoor Physical Activity through secondary analysis focusing on women with illness, injury, and disability. From the original sample of N = 553 female participants, open-ended survey responses were identified from n = 84 participants (15.2%) who self-disclosed as having illness, injury, or disability to examine how outdoor settings facilitate positive body image. Through reflexive thematic analysis, the study revealed three key mechanisms: (1) personalized redefinition of functionality transcending standardized metrics, (2) therapeutic engagement with natural environments fostering embodied acceptance, and (3) cyclical reinforcement between physical capability and psychological wellbeing. The findings confirm the model’s utility while indicating necessary adaptations to address the fluctuating nature of body functionality. The adapted model emphasizes how outdoor recreational activities create contexts for reimagining body-self relationships across the spectrum of physical experiences—from temporary recovery to ongoing adaptation of persistent conditions—with implications for rehabilitation professionals, outdoor educators, and healthcare providers. Full article

Background/Objectives: The pathological changes preceding the onset of Parkinson’s disease (PD) commence several decades before motor symptoms manifest, offering a potential window for identifying objective biomarkers for early diagnosis and disease monitoring. Among the primary non-motor features of PD is autonomic dysfunction; however, its precise assessment remains challenging, limiting its viability as a reliable biomarker. Both the pupillary light reflex (PLR) and pupillary unrest are regulated by autonomic pathways suggesting their potential as objective non-invasive indicators of the PD prodromal phase. This review systematically evaluates studies that compare PLR and pupillary unrest in individuals with PD and healthy controls to determine their utility as potential biomarkers of the disease. Methods: A systematic search strategy was designed to identify studies reporting PLR and pupillary unrest findings in PD patients. Searches were conducted across three databases (MEDLINE, Embase PsycINFO), supplemented by cross-referencing relevant studies found on Google Scholar. The literature search was last updated on 7 December 2020. Pupillometric parameters that permitted statistical synthesis included maximum constriction velocity (VMax), constriction amplitude (CAmp), and constriction latency (CL). Pooled incidence and effect sizes were determined using a random-effects model with an inverse variance DerSimonian–Laird estimator. The I² statistic was used to assess study heterogeneity. When meta-analysis was not feasible, a qualitative analysis was undertaken. Results: The initial search yielded 219 references. Following deduplication and exclusion of ineligible studies, 31 papers were selected for review. Pupillometric data from 11 studies were incorporated into the meta-analysis. Effect sizes for PD patients were significant for VMax −0.92, (p < 0.01), CAmp −0.58, (p < 0.05), and CL 0.46, (p < 0.05). Measures of pupillary unrest were elevated in PD patients compared to controls, but evidence was limited to two studies. Conclusions: Pupillary constriction in response to light is characterised by reduced speed and amplitude in PD, with effect sizes suggesting potential clinical applicability. However, evidence regarding baseline pupillary variability remains insufficient, underlining the necessity for further research. Pupillary metrics represent a promising avenue for early PD detection, though their clinical utility is constrained by methodological heterogeneity and variations in disease duration among studies. Full article

Background/Objectives: Vestibulo-ocular reflex (VOR) function, measured by the video head impulse test (vHIT) gains, plays a crucial role in postural stability and quality of life. Cochlear implant recipients often experience vestibular dysfunction, but its relationship with balance and patient-reported outcomes remains underexplored. This study aimed to (1) evaluate the relationship between vHIT gains and postural stability in cochlear implant recipients; (2) assess the impact of vHIT gains on quality-of-life metrics; and (3) identify key predictors of postural stability, including vHIT gains and demographic/clinical characteristics. Methods: This cross-sectional study was conducted between August 2023 and February 2024 and included 46 participants that comprised cochlear implant recipients and age-matched normal hearers who underwent the vHIT for lateral, anterior, and posterior semicircular canal function. Postural stability was assessed using dynamic posturography, and quality of life was measured using the Short Form-36 (SF-36). Multiple linear regression and correlation analyses were performed. Results: The vHIT gains demonstrated significant positive correlations with postural stability, with the lateral canal showing the strongest association (r = 0.742, p = 0.001), followed by the posterior (r = 0.701, p = 0.003) and anterior canals (r = 0.684, p = 0.005). A multiple regression analysis identified the lateral canal as the most significant predictor of postural stability (β = 0.512, p = 0.001, adjusted R² = 0.47). Quality-of-life metrics were inversely correlated with the vHIT gains, particularly in the posterior canal (r = −0.712, p = 0.002), which explained 43–51% of the variance. Conclusions: This study highlighted the lateral semicircular canal as the primary determinant of postural stability in cochlear implant recipients, underscoring the importance of vestibular assessments in optimizing balance and functional outcomes. Full article

Background: Neurogenic orthostatic hypotension (NOH) is a significant non-motor manifestation of Parkinson’s disease (PD), that substantially affects patient disability and has a powerful impact on the quality of life of PD patients, while also contributing to increased healthcare costs. This narrative review aims to summarize key insights into the diagnosis and management of NOH in individuals with PD. Methods: For diagnosing NOH, a recently introduced and valuable metric is the ΔHr/ΔSBP index. Additional tools, such as autonomic reflex testing and various blood tests, also can be used to help distinguish orthostatic hypotension (OH) from NOH. Results: Treatment strategies for NOH involve both non-pharmacological and pharmacological approaches. As NOH frequently coexists with other abnormal blood pressure patterns (supine hypertension, nocturnal hypertension, and non-dipping hypertension), its treatment can be a challenge for the clinician. Droxidopa and midodrine are the primary pharmacological agents for NOH, though emerging therapies, such as norepinephrine transporter inhibitors, are being investigated. Conclusions: Despite these advancements, further research is needed to better understand the underlying pathophysiology of NOH, enabling more tailored and effective treatment options for individuals with PD. Full article

This article aims to adopt some notions for mapping $\mathfrak{f}:{\mathfrak{X}}^k\to \mathfrak{X}$, (where integer k is positive) and to prove the nonlinear-Prešić-type results on metric spaces employing a $\mathfrak{f}$-reflexive and locally finitely $\mathfrak{f}$-transitive binary relation (not necessarily partial order). The outcomes proven herewith are extended and generalized to several fixed point findings of literature. Lastly, examples are provided to support the applicability of these outcomes. Full article

This article deals with a few outcomes ensuring the fixed points of a weak $(G,\psi )$-contraction map of metric spaces comprised with a reflexive and transitive digraph G. To validate our findings, we furnish several examples. The findings we obtain enable us to seek out the unique solution of a nonlinear integral equation. The outcomes presented herewith sharpen, subsume, unify, improve, enrich, and compile a number of existing theorems. Full article

The aim of this study is to assess the effectiveness of a 12-week doxycycline treatment for thyroid eye disease (TED), an autoimmune condition associated with thyroid dysfunction. In this randomized controlled clinical trial, 82 patients were randomly assigned at a 1:1 ratio to receive doxycycline (50 mg) or to undergo no treatment. Various metrics, including margin reflex distance (MRD1 and MRD2), eyelid aperture, levator muscle function, lagophthalmos, proptosis, ocular motility, diplopia, and Graves’ ophthalmopathy-specific quality-of-life (GO-QOL) scale scoring were assessed. Exclusion criteria were uncontrolled systemic diseases, tetracycline allergies, pregnancy, lactation, or age below 18. The mean age was 51.6 years (SD), 87.8% of participants were female, and all were Caucasians. By week 12, the doxycycline group exhibited a significant improvement rate based on MRD2 (from 4 to 15 participants with physiological findings), clinical activity score (from 7 to 35 participants with non-active disease), and GO-QOL (from 51.22% to 70.73% of participants with a good life quality). Doxycycline showcased anti-inflammatory and immunomodulatory effects in treating TED, suggesting its potential efficacy for TED and other orbit inflammatory conditions. However, these results warrant further validation through future research involving extended follow-up periods and larger cohorts. Full article

Background: Concussion examination is based primarily on clinical evaluation and symptomatic reporting. Pupillary light reflex (PLR) metrics may provide an objective physiological marker to inform concussion diagnosis and recovery, but few studies have assessed PLR, and normative data are lacking, particularly for adolescents. Aim: To capture PLR data in adolescent rugby players and examine the effects of concussion history and biological sex. Design: Cross-sectional. Methods: Male and female adolescent rugby union players aged 16 to 18 years were recruited at the start of the 2022–2023 playing season. PLR was recorded using a handheld pupillometer which provided seven different metrics relating to pupil diameter, constriction/dilation latency, and velocity. Data were analysed using a series of 2 × 2 ANOVAs to examine the main effects of independent variables: biological sex, concussion history, and their interactions, using adjusted p-values (p < 0.05). Results: 149 participants (75% male) were included. A total of 42% reported at least one previous concussion. Most metrics were unaffected by the independent variables. There were however significant main effects for concussion history (F = 4.11 (1); p = 0.05) and sex (F = 5.42 (1); p = 0.02) in end pupil diameters, and a main effect for sex in initial pupil diameters (F = 4.45 (1); p = 0.04). Although no significant interaction effects were found, on average, females with a concussion history presented with greater pupillary diameters and velocity metrics, with many pairwise comparisons showing large effects (SMD > 0.8). Conclusions: Pupillary diameters in adolescent athletes were significantly affected by concussion history and sex. The most extreme PLR metrics were recorded in females with a history of concussion (higher pupillary diameters and velocities). This highlights the importance of establishing baseline PLR metrics prior to interpretation of the PLR post-concussion. Long-standing PLR abnormalities post-concussion may reflect ongoing autonomic nervous system dysfunction. This warrants further investigation in longitudinal studies. Full article

Roughly speaking, Ekeland’s Variational Principle (EkVP) (J. Math. Anal. Appl. 47 (1974), 324–353) asserts the existence of strict minima of some perturbed versions of lower semicontinuous functions defined on a complete metric space. Later, Pando Georgiev (J. Math. Anal. Appl. 131 (1988), no. 1, 1–21) and Tomonari Suzuki (J. Math. Anal. Appl. 320 (2006), no. 2, 787–794 and Nonlinear Anal. 72 (2010), no. 5, 2204–2209)) proved a Strong Ekeland Variational Principle, meaning the existence of strong minima for such perturbations. Please note that Suzuki also considered the case of functions defined on Banach spaces, emphasizing the key role played by reflexivity. In recent years, an increasing interest was manifested by many researchers to extend EkVP to the asymmetric case, i.e., to quasi-metric spaces (see references). Applications to optimization, behavioral sciences, and others were obtained. The aim of the present paper is to extend the strong Ekeland principle, both Georgiev’s and Suzuki’s versions, to the quasi-pseudometric case. At the end, we ask for the possibility of extending it to asymmetric normed spaces (i.e., the extension of Suzuki’s results). Full article

In this paper, we initiate a concept of graph-proximal functions. Furthermore, we give a notion of being generalized Geraghty dominating for a pair of mappings. This permits us to establish the existence of and unique results for a common best proximity point of complete metric space. Additionally, we give a concrete example and corollaries related to the main theorem. In particular, we apply our main results to the case of metric spaces equipped with a reflexive binary relation. Finally, we demonstrate the existence of a solution to boundary value problems of particular second-order differential equations. Full article

Food neophobia is standard behaviour in child development. It is a complex process and occurs to varying degrees. The symptoms of neophobia can be variable depending on the individual. Food neophobia is a fear of new foods, whereby difficulties in eating and trying unfamiliar foods follow. It is one of the more vital determinants of the number of meals consumed at a young age. Such a process is not a disorder in itself but can lead to one. The highest severity of neophobia occurs between the ages of two and six, but in some children, it lasts beyond age 6. This study aimed to assess the prevalence of food neophobia among children aged 2–7 years, taking into account the method of complementary feeding, the length of breastfeeding, exclusive breastfeeding, the period of introduction of complementary foods, and the use of the BLW method during the period of dietary expansion. Materials and methods: The study used an anonymous survey questionnaire consisting of five parts as the research tool. The first part of the questionnaire was a metric and concerned the socio-demographic data of the parent/guardian and their child. A standardised questionnaire assessing food neophobia among children was used to assess food neophobia: the Food Neophobia Scale—Children (FNSC). Results: In the study group, 171 children (29.23%) had a low risk of food neophobia according to the FNSC, 182 children (31.11%) had a medium risk of neophobia, and 232 children (39.66%) had a high risk of neophobia. A correlation was observed between the age and the risk of food neophobia (p = 0.0002). Statistically significant differences were found between children aged 2 and 4 (p = 0.003) and children aged 2 and 5 years (p = 0.049). We observed no correlation between gagging (p = 0.88557), choking (p = 0.17597), and needing medical intervention (p = 0.61427) and the risk of associated neophobia. Conclusion: In the study group of children, the highest risk of food neophobia was characterized by children aged 4, 5, and 7 years. The length of breastfeeding and exclusive breastfeeding did not affect the risk of food neophobia. In the month in which complementary feeding (CF) was introduced, the children were fed using the baby-led weaning method (BLW method), and introducing puree and puree with lump food into the children’s diet also did not affect the risk of food neophobia. It was shown, however, that children whose mothers observed difficulties during CF and whose children had a vomiting reflex and spat food out of their mouths during CF were more likely to develop food neophobia at the preschool age. Full article

Horticultural significance in Hoya hybrids stems from their distinctive foliage and flowers. Morphological characterization of hybrids aids in understanding genetic diversity and in forming the basis for breeding new varieties that meet market demands and enhance sustainable horticultural practices through a diversity of attributes. In this study, two first-generation offspring, GTX-021 (H. deleoniorum × H. peninsularis), GTX-067 (H. deleoniorum × H. subquintuplinervis), and their respective parents underwent phenetic examination. This encompassed the assessment of 13 vegetative traits, including aspects of leaf shape, size, and indumentum, as well as 23 reproductive traits, which included features related to inflorescence, corolla, and corona. The traits were analyzed using the UPGMA clustering method, employing the Jaccard similarity coefficient for qualitative traits and the Euclidean distances for quantitative traits. Polymorphism appeared in 14 out of 24 qualitative traits, with significant variations in all quantitative metrics except corona height (p < 0.05). Cluster analysis revealed that GTX-021 exhibited an intermediate overall morphology, comprising both qualitative and quantitative traits, falling between its parents. Notable traits include shared corolla pubescence with H. peninsularis and a distinct corona column similar to H. deleoniorum. Furthermore, GTX-067 resembled its pollen father, H. subquintuplinervis, exhibiting less twinning, horizontal stem growth, and reflexed corolla lobes. Morphometrically, it clustered close to the seed parent, with corona measurements distinguishing it from the pollen parent. This characterization emphasizes the hybrids’ distinctiveness, suggesting their potential as ornamental plants. Additionally, their contribution to enhanced genetic diversity is crucial for developing future varieties, benefiting the horticultural industry with more robust and diverse plant options. Full article

Background and Objectives: Patients recovering from mild coronavirus disease (COVID-19) reportedly have dysphagia or difficulty in swallowing. We compared the prevalence of dysphagia between patients diagnosed with mild COVID-19 and those diagnosed with aspiration pneumonia alone. Materials and Methods: A retrospective study was conducted from January 2020 to June 2023 in 160 patients referred for a videofluoroscopic swallowing study (VFSS) to assess for dysphagia. The cohort included 24 patients with mild COVID-19 and aspiration pneumonia, 30 with mild COVID-19 without aspiration pneumonia, and 106 with aspiration pneumonia alone. We reviewed the demographic data, comorbidities, and VFSS results using the penetration–aspiration scale (PAS) and functional dysphagia scale (FDS). Results: In a study comparing patients with mild COVID-19 (Group A) and those with aspiration pneumonia alone (Group B), no significant differences were observed in the baseline characteristics, including the prevalence of dysphagia-related comorbidities between the groups. Group A showed milder dysphagia, as evidenced by lower PAS and FDS scores, shorter oral and pharyngeal transit times (p = 0.001 and p = 0.003, respectively), and fewer residues in the vallecula and pyriform sinuses (p < 0.001 and p < 0.03, respectively). When Group A was subdivided into those with COVID-19 with (Group A1) and without aspiration pneumonia (Group A2), both subgroups outperformed Group B in terms of specific VFSS metrics, such as oral transit time (p = 0.01), pharyngeal transit time (p = 0.04 and p = 0.02, respectively), and residue in the vallecula (p = 0.04 and p = 0.02, respectively). However, Group B showed improved triggering of the pharyngeal swallowing reflex compared with Group A2 (p = 0.02). Conclusion: Mild COVID-19 patients showed less severe dysphagia than those with aspiration pneumonia alone. This finding was consistent across VFSS parameters, even when the COVID-19 group was subdivided based on the status of aspiration pneumonia. Full article