Search Results (58)

When lithium-ion batteries experience thermal runaway, a large amount of heat rapidly accumulates inside, causing the internal pressure to rise sharply. Once the pressure exceeds the battery’s safety valve design capacity, the valve activates and releases flammable gas. If ignited in a high-temperature environment, the escaping gas can cause a jet fire containing high-temperature substances. Effectively controlling the internal temperature of the jet fire, especially rapidly cooling the core area of the flame during the jet process, is important to prevent the spread of lithium-ion battery fires. Therefore, this work proposes a strategy of a synergistic effect using microcapsule fire extinguishing agents and fine water mist to achieve an external barrier and an internal attack. The microcapsule fire extinguishing agents are prepared by using melamine–urea–formaldehyde resin as the shell and 1,1,1,2,2,3,3,4,4-nonafluoro-4-methoxybutane (C₅H₃F₉O) and 1,1,2,2,3,3,4-heptafluorocyclopentane (C₅H₃F₇) as the composite core. During the process of lithium-ion battery thermal runaway, the microcapsule fire extinguishing agents can enter the inner area of the jet fire under the protection of the fine water mist. The microcapsule shell ruptures at 100 °C, releasing the highly effective composite fire suppressant core inside the jet fire. The fine water mist significantly blocks the transfer of thermal radiation, inhibiting the spread of the fire. Compared to the suppression with fine water mist only, the time required to reduce the battery temperature from the peak value to a low temperature is reduced by 66 s and the peak temperature of the high-temperature substances above the battery is reduced by 228.2 °C. The propagation of the thermal runaway is suppressed, and no thermal runaway of other batteries around the faulty unit will occur. This synergistic suppression strategy of fine water mist and microcapsule fire extinguishing agent (FWM@M) effectively reduces the adverse effects of jet fires on the propagation of thermal runaway (TR) of lithium-ion batteries, providing a new solution for efficiently extinguishing lithium-ion battery fires. Full article

Radiation-induced intestinal injury (RIII) is a significant concern for cancer patients receiving radiation therapy, as it can lead to complications such as radiation enteropathy. Presently, there are limited options for preventing or treating RIII. Tea polyphenols (TP), found in tea, provide various health benefits, but their antiradiation mechanisms are not fully understood. C57BL/6 mice pre-treated with TP for five days showed a significant improvement in survival rates after being exposed to 10 Gy of ⁶⁰Co radiation. In the same way, abdominal exposure to 15 Gy of ⁶⁰Co radiation effectively mitigated radiation-induced colon shortening, damage to intestinal tissues, oxidative stress, the release of inflammatory factors, and disruptions in intestinal microbial balance. In addition, TP treatment lowered the elevation of reactive oxygen species (ROS), iron imbalance, mitochondrial damage, and ferroptosis in IEC-6 cells post-irradiation. Utilizing network pharmacology, molecular docking, and affinity testing, we identified that TP has the capability to target the Nrf2/HO-1/GPX4 signaling pathway, while EGCG, a principal constituent of TP, interacts with HSP90 and mitigates radiation-induced ferroptosis. These findings suggest that TP may serve as a promising therapeutic agent to alleviate radiation-induced intestinal injury (RII). Full article

The proliferation of toxigenic fungi in food and the subsequent production of mycotoxins constitute a significant concern in the fields of public health and consumer protection. This review highlights recent strategies and emerging methods aimed at preventing fungal growth and mycotoxin contamination in food matrices as opposed to traditional approaches such as chemical fungicides, which may leave toxic residues and pose risks to human and animal health as well as the environment. The novel methodologies discussed include the use of plant-derived compounds such as essential oils, classified as Generally Recognized as Safe (GRAS), polyphenols, lactic acid bacteria, cold plasma technologies, nanoparticles (particularly metal nanoparticles such as silver or zinc nanoparticles), magnetic materials, and ionizing radiation. Among these, essential oils, polyphenols, and lactic acid bacteria offer eco-friendly and non-toxic alternatives to conventional fungicides while demonstrating strong antimicrobial and antifungal properties; essential oils and polyphenols also possess antioxidant activity. Cold plasma and ionizing radiation enable rapid, non-thermal, and chemical-free decontamination processes. Nanoparticles and magnetic materials contribute advantages such as enhanced stability, controlled release, and ease of separation. Furthermore, this review explores recent advancements in the application of artificial intelligence, particularly machine learning methods, for the identification and classification of fungal species as well as for predicting the growth of toxigenic fungi and subsequent mycotoxin production in food products and culture media. Full article

Low carbon dioxide (CO₂) emissions make nuclear energy crucial in decarbonizing the economy. In this context, nuclear safety, and especially the operation of nuclear power plants, remains a critical issue. This article presents a new fractal cluster method of control that improves the quality of assessing fuel element cladding integrity, which is critical for nuclear and environmental safety. The proposed non-destructive testing method allows for detecting defects on the inner and outer cladding surfaces without removing the elements from the nuclear reactor, which ensures prompt response and prevention of radiation leakage. Studies have shown that the fractal dimension of the cladding surface, which varies from 2.1 to 2.5, indicates significant heterogeneity caused by mechanical damage or corrosion, which can affect its integrity. The density analysis of defect clusters allows quantifying their concentration per unit area, which is an important indicator for assessing the risks associated with the operation of nuclear facilities. The data obtained are used to assess the impact of defects on the vessel’s integrity and, in turn, on nuclear safety. The monitoring results are transmitted in real time to the operator’s automated workstation, allowing for timely decision making to prevent radioactive releases and improve environmental safety. The proposed method is a promising tool for ensuring reliable quality control of the fuel element cladding condition and improving nuclear and environmental safety. While the study is based on VVER-1000 reactor data, the flexibility of the proposed methodology suggests its potential applicability to other reactor types, opening avenues for broader implementation in diverse nuclear systems. Full article

Growth hormone-releasing hormone (GHRH) antagonists exert antitumor functions in different experimental cancers. However, their role in combination with radiotherapy in non-small cell lung cancer (NSCLC) remains unknown. Therefore, we investigated the radiosensitizing effect of GHRH antagonists in NSCLC. A549 and H522 NSCLC cell lines were exposed to ionizing radiation (IR) and GHRH antagonists MIA-602 and MIA-690, either individually or in combination. Cell viability and proliferation were evaluated by MTT, BrdU, flow cytofluorimetry, and clonogenic assays; gene and protein expression, signaling pathways, and apoptosis were analyzed by real-time PCR, Western blot, annexin staining, and caspase-3 assay. GHRH antagonists showed antitumor effects alone and potentiated IR-induced inhibition of cell viability and proliferation. The combination of MIA-690 and IR decreased the expression of GHRH receptor, its oncogenic splice variant 1, and IGF1 mRNA levels. Additionally, cell cycle inhibitors and proapoptotic markers were upregulated, whereas cyclins, oncogenic MYC, and the antiapoptotic protein Bcl-2 were downregulated. Radioresistance was prevented by MIA-690, which also blunted epithelial–mesenchymal transition by enhancing E-cadherin and reducing mesenchymal, oxidative, and proangiogenic effectors. Finally, both MIA-602 and MIA-690 enhanced radiosensitivity in primary human NSCLC cells. These findings highlight the potential of GHRH antagonists as radiosensitizers in NSCLC treatment. Full article

The implementation of real-time dynamic monitoring of disaster formation and severity is essential for the timely adoption of disaster prevention and mitigation measures, which in turn minimizes disaster-related losses and safeguards agricultural production safety. This study establishes a low-temperature disaster (LTD) monitoring system based on machine learning algorithms, which primarily consists of a module for identifying types of disasters and a module for simulating the evolution of LTDs. This study firstly employed the KNN model combined with a piecewise function to determine the daily dynamic minimum critical temperature for low-temperature stress (LTS) experienced by winter wheat in the Huang-Huai-Hai (HHH) region after regreening, with the fitting model’s R², RMSE, MAE, NRMSE, and MBE values being 0.95, 0.79, 0.53, 0.13, and 1.716 × 10⁻¹¹, respectively. This model serves as the foundation for determining the process by which winter wheat is subjected to LTS. Subsequently, using the XGBoost algorithm to analyze the differences between spring frost and cold damage patterns, a model for identifying types of spring LTDs was developed. The validation accuracy of the model reached 86.67%. In the development of the module simulating the evolution of LTDs, the XGBoost algorithm was initially employed to construct the Low-Temperature Disaster Index (LTDI), facilitating the daily identification of LTD occurrences. Subsequently, the Low-Temperature Disaster Process Accumulation Index (LDPI) is utilized to quantify the severity of the disaster. Validation results indicate that 79.81% of the test set samples exhibit a severity level consistent with historical records. An analysis of the environmental stress-mitigation mechanisms of LTDs reveals that cooling induced by cold air passage and ground radiation are the primary stress mechanisms in the formation of LTDs. In contrast, the release of latent heat from water vapor upon cooling and the transfer of sensible heat from soil moisture serve as the principal mitigation mechanisms. In summary, the developed monitoring framework for LTDs, based on environmental patterns of LTD formation, demonstrates strong generalization capabilities in the HHH region, enabling daily dynamic assessments of the evolution and severity of LTDs. Full article

This study is dedicated to an in−depth analysis of the combustion characteristics of extruded polystyrene (XPS) as a building insulation material with the aim of accurately assessing its fire risk in the built environment. Innovatively, this research employed a cone calorimeter equipped with a self−designed insulating sample holder to conduct a systematic experimental study. Additionally, it performed a comprehensive analysis of the ignition characteristics, heat release rate, fire hazard, smoke release, and toxic gas emission of XPS materials. The experimental results revealed that the combustion behavior of XPS is influenced by multiple factors, including the content of flame retardants and external heat flux, which significantly affect the fire hazard of XPS. When the thermal radiation intensity escalates from 25 kW/m² to 55 kW/m², the peak heat release rate of XPS−B1 rises from 428 kW/m² to 535 kW/m², marking an increase of 25.00%. Conversely, the peak heat release rate of XPS−B2 surges from 348 kW/m² to 579 kW/m², reflecting a substantial increase of 66.38%. This research not only provides a solid theoretical foundation and detailed experimental data for the fire behavior of XPS materials but also holds significant practical importance for enhancing the fire safety of buildings. Overall, this research contributes to the scientific understanding of XPS insulation materials and supports the development of more effective fire prevention measures in construction. Full article

Antimicrobial polymeric coatings rely not only on their surface functionalities but also on nanoparticles (NPs). Antimicrobial coatings gain their properties from the addition of NPs into a polymeric matrix. NPs that have been used include metal-based NPs, metal oxide NPs, carbon-based nanomaterials, and organic NPs. Copper NPs and silver NPs exhibit antibacterial and antifungal properties. So, when present in coatings, they will release metal ions with the combined effect of having bacteriostatic/bactericidal properties, preventing the growth of pathogens on surfaces covered by these nano-enhanced films. In addition, metal oxide NPs such as titanium dioxide NPs (TiO₂ NPs) and zinc oxide NPs (ZnONPs) are used as NPs in antimicrobial polymeric coatings. Under UV irradiation, these NPs show photocatalytic properties that lead to the production of reactive oxygen species (ROS) when exposed to UV radiation. After various forms of nano-carbon materials were successfully developed over the past decade, they and their derivatives from graphite/nanotubes, and composite sheets have been receiving more attention because they share an extremely large surface area, excellent mechanical strength, etc. These NPs not only show the ability to cause oxidative stress but also have the ability to release antimicrobial chemicals under control, resulting in long-lasting antibacterial action. The effectiveness and life spans of the antifouling performance of a variety of polymeric materials have been improved by adding nano-sized particles to those coatings. Full article

A Solar Corrosion Fenton reactor (SCFr) was developed by packing an iron-carbon steel filament inside the reactor to enable the in situ release of Fe²⁺. A Box–Behnken experimental design was used to optimize the effect of HRT (20, 30, and 40 min), the mass ratios of the packed filament inside the reactor with respect to volume (0.1, 0.2, 0.3 w/v), and the peroxide dosage added (500, 1000, and 1500 mg/L), the response variables were the percentage removal of COD, color, and turbidity. The optimum conditions for SCFr were an HRT of 24.5 min, a ratio of 0.16 (0.0032 m²/L), and a peroxide dose of 1006.9 mg/L. The removal was 91.8%, 98.4%, and 87.3% COD, color, and turbidity, respectively. Without solar radiation, the percentage removal was reduced by 16.3%, 47.9%, and 34.0% in terms of COD, color, and turbidity, respectively. The concentration of Fe²⁺ released was 25.4 mg/L of Fe²⁺. Prolonged HRT increases Fe²⁺ concentration and turbidity, which increase COD. The oxidation kinetics were fitted to a Behnajady–Modirshahla–Ghanbery (BMG) model, which indicated a high oxidation rate that is reflective of low treatment times. The w/v ratio was the most significant factor; the release of Fe²⁺ was stimulated by UV radiation and the chloride concentration of wastewater, which prevents the formation of an oxide layer, thus allowing its continuous release, taking advantage of solar radiation and the pH and chloride concentration of the raw sample. Full article

The skin, being the largest organ of the human body, serves as the primary barrier against external insults, including UV radiation, pollutants, and microbial pathogens. However, prolonged exposure to these environmental stressors can lead to the generation of reactive oxygen species (ROS), causing oxidative stress, inflammation, and ultimately, skin aging and diseases. Antioxidants play a crucial role in neutralizing ROS and preserving skin health by preventing oxidative damage. In recent years, nanotechnology has emerged as a powerful tool for enhancing the delivery of antioxidants onto the skin. In particular, liposomal formulations have offered unique advantages such as improved stability, controlled release, and enhanced penetration through the skin barrier. This has led to a surge in research focused on developing liposomal-based antioxidant delivery systems tailored for skin health applications. Through a comprehensive analysis of the literature from the 2019–2024 period, this review provides an overview of emerging trends in the use of liposomal delivery systems developed for antioxidants aimed at improving skin health. It explores the latest advancements in liposomal formulation strategies, vesicle characterization, and their applications in delivering antioxidants to combat oxidative stress-induced skin damage and other associated skin pathologies. A comparison of various delivery systems is conducted for the most common antioxidants. Finally, a brief analysis of lipid nanovesicles used in the cosmeceutical industry is provided. Full article

Melanoma is one of the most malignant forms of skin cancer, characterised by the highest mortality rate among affected patients. This study aims to analyse and compare the effects of lipid extracts from the microalgae Nannochloropsis oceanica (N.o.) and Chlorococcum amblystomatis (C.a.) on the intra and extracellular proteome of UVA-irradiated melanoma cells using a three-dimensional model. Proteomic analysis revealed that UVA radiation significantly increases the levels of pro-inflammatory proteins in melanoma cells. Treatment with algae extracts reduced these protein levels in both non-irradiated and irradiated cells. Furthermore, untreated cells released proteins responsible for cell growth and proliferation into the medium, a process hindered by UVA radiation through the promotion of pro-inflammatory molecules secretion. The treatment with algae extracts effectively mitigated UVA-induced alterations. Notably, UVA radiation significantly induced the formation of 4-HNE and 15-PGJ2 protein adducts in both cells and the medium, while treatment with algae extracts stimulated the formation of 4-HNE-protein adducts and reduced the level of 15-PGJ2-protein adducts. However, both algae extracts successfully prevented these UVA-induced modifications. In conclusion, lipid extracts from N.o. and C.a. appear to be promising agents in supporting anti-melanoma therapy. However, their potent protective capacity may limit their applicability, particularly following cells exposure to UVA. Full article

Basal Stem Rot (BSR), caused by Ganoderma spp., is one of the most important emerging diseases of oil palm in Colombia and is so far restricted to only two producing areas in the country. However, despite the controls established to prevent its spread to new areas, containment has not been possible. This study aimed to understand BSR’s propagation mechanisms and related environmental conditions by measuring Ganoderma basidiospores’ concentrations at various heights using four 7-day Burkard volumetric samplers in a heavily affected plantation. Meteorological data, including solar radiation, temperature, humidity, precipitation, and wind speed, were also recorded. Analysis revealed higher basidiospore concentrations below 4 m, peaking at 02:00 h, with increased levels towards the study’s end. Spore concentrations were not directly influenced by temperature, humidity, or precipitation, but showed higher releases during drier periods. A significant correlation was found between wind speed and spore concentration, particularly below 1.5 m/s, though higher speeds might aid long-distance pathogen spread. This study highlights the complexity of BSR propagation and the need for continued monitoring and research to manage its impact on Colombia’s oil palm industry. Full article

Timber is the most widely used material for furniture in view of its characteristics of light mass, high strength, easy processing, coloring, and decorative appearance. However, the flammability of wood has been frequently associated with increased fire intensity and the rapid spread of fire in buildings. In this paper, the combustion performance of six kinds of common furniture timber was investigated based on thermogravimetric analysis at 25–500 °C, cone calorimetry with 50 kW/m² thermal radiation intensity, and flame spread experiments with 3 kW/m² thermal radiation intensity. The ignition, weight loss, thermogenesis, smoke, and flame spread characteristics of these timbers were obtained. Subsequently, a comprehensive index system including thermal stability, heat release ability, smoke production capacity, and flame spreading speed was constructed to evaluate the combustion performance of the selected timbers. In addition, a grey correlation method relying on the game theory to assign weight was proposed for the quantitative analysis of the relevant evaluation indexes. As a result, the combustion performance of the six kinds of timber, which was defined as a specific value from poor to good, was as follows: pine (0.8696) > Chinese fir (0.8568) > Oriented Strandboard (OSB) (0.8425) > density board (0.8122) > plywood (0.8087) > elm (0.7909). Timber with poor combustion performance contributes to the reduction in fire risk in buildings. Our suggestions are of great significance for selecting furniture timber from the perspective of the prevention and control of building fires. Full article

From grape cultivation to ripening and harvest timing to processing, each step of the winemaking process can be a critical point when it comes to wine quality and phenolic composition. In this study, the influence of winemaking technology on resveratrol and quercetin content, as well as other polyphenolic compounds, was investigated. Resveratrol is a non-flavonoid polyphenolic stilbene synthesized by grape skin when damaged by infectious diseases or ionizing radiation. Quercetin is a phenol found in grape skins and stems and is produced to protect grapes from UV light damage. Trans-resveratrol and quercetin are known to act as antioxidants, reduce the risk of atherosclerosis and type 2 diabetes, inhibit the growth of cancer cells, and prevent the release of allergic and inflammatory molecules. However, the question was whether red wine could be enriched with these phenols using a co-inoculation winemaking technology. The main new idea was to completely replace the cold maceration process with maceration with the addition of wild yeast (Torulaspora delbrueckii, Td). Maceration with the addition of wild yeast (Td) offers the following advantages over traditional cold maceration: (1) higher concentrations of trans-resveratrol (>35–40%) and quercetin (>35–40%) in the final wine, (2) the new wine has a higher potential for human health, (3) the wine has better aroma and stability due to the higher mannoprotein content, and (4) better energy efficiency in the production process. The study of stability during storage and aging also included derivatives of benzoic acid and hydroxycinnamic acid, piceid, catechin, naringenin, rutin, kaempherol, hesperetin, and anthocyanins. This study found that younger wines had higher phenolic content, while storage of the wine resulted in a decrease in total phenolic content, especially monomeric stilbenes and quercetin. This study represents a small part of the investigation of the influence of non-Saccharomyces yeasts on the phenolic profile of wine, which still requires extensive research with practical application. In addition, non-Saccharomyces yeasts such as Kluyveromyces thermotolerans, Candida stellata, and Metschnikowia pulcherrima could also be used in future studies. Full article

Human activities, global warming, frequent extreme weather events, and changes in atmospheric composition affect the solar radiation reaching the Earth’s surface, affect mass and heat transfer at the air–water interface, and induce oscillations in wind-driven internal waves. This leads to changes in the spatiotemporal characteristics of thermal stratification in lakes, altering lake circulation patterns and vertical mass transfer. However, thermal stratification structures are often overlooked. The intensification of lake thermal stratification due to warming may lead to increased release of bottom pollutants, spreading through the dynamic behavior of the thermocline to the epilimnion. Moreover, the increased heat storage is beneficial for the growth and development of certain phytoplankton, resulting in rapid transitions of the original steady state of lakes. Consequently, water quality deterioration, ecological degradation, and declining biodiversity may occur. Conventional surface water monitoring may not provide comprehensive, accurate, and timely assessments. Model simulations can better predict future thermal stratification behaviors, reducing financial burdens, providing more refined assessments, and thus preventing subsequent environmental issues. Full article