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Keywords = psychiatric dog

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20 pages, 1780 KB  
Article
Psychiatric Assistance Dogs for Adults with Mental Health Conditions: Use, Perceived Effectiveness and Challenges
by Yuxuan Zhang, Amanda J. Salmon and Nancy A. Pachana
Behav. Sci. 2026, 16(7), 1178; https://doi.org/10.3390/bs16071178 - 13 Jul 2026
Viewed by 1031
Abstract
Psychiatric assistance dogs (PADs) are increasingly recognised as complementary supports for individuals with mental health conditions, yet their role in everyday functioning as well as handler and animal welfare remains underexplored. This study explored how PADs are used by individuals with a range [...] Read more.
Psychiatric assistance dogs (PADs) are increasingly recognised as complementary supports for individuals with mental health conditions, yet their role in everyday functioning as well as handler and animal welfare remains underexplored. This study explored how PADs are used by individuals with a range of mental health conditions, the benefits they provide, and any challenges experienced in terms of both handler and animal well-being. An online mixed-methods survey was conducted, yielding 85 valid responses. Quantitative data were analysed descriptively; qualitative responses were examined using Leximancer. Findings suggest that PADs provide benefits beyond specific trained tasks, offering ongoing support that helps handlers feel safer and more able to engage in activities of daily living and mental health treatment. At the same time, participants reported challenges such as stigma, public misunderstanding of public access rights, and financial costs, which can limit the effectiveness of PAD support. Many participants also reported relying heavily on their PAD, which may have detrimental consequences for the well-being of both handler and animal. These findings highlight the importance of improving public awareness, access, and support systems to maximise the benefits of PADs and help ensure the well-being and safety of both PADs and their handlers. Future research should consider both human and animal perspectives in greater depth to better understand these partnerships. Full article
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26 pages, 12460 KB  
Article
A Pilot Randomized Controlled Trial Examining the Impact of Therapy Dog Visitation on Mood, Anxiety, and Depression in Patients Hospitalized for the Treatment of Mental Illness
by Nancy R. Gee, Lisa Townsend, Erika Friedmann, Sandra B. Barker, Tushar P. Thakre and Megan K. Mueller
Healthcare 2026, 14(10), 1420; https://doi.org/10.3390/healthcare14101420 - 21 May 2026
Viewed by 834
Abstract
Background/Objectives: Evidence suggests that AAIs may be useful to support the mental health of individuals with psychiatric diagnoses, but there is limited research on the efficacy of AAIs for patients hospitalized for the treatment of acute mental illness. Methods: A randomized [...] Read more.
Background/Objectives: Evidence suggests that AAIs may be useful to support the mental health of individuals with psychiatric diagnoses, but there is limited research on the efficacy of AAIs for patients hospitalized for the treatment of acute mental illness. Methods: A randomized controlled trial (RCT) design, where patients hospitalized for the treatment of mental illness (N = 60) were randomized into to one of three conditions: dog + handler intervention (AAI), handler only conversational control (CC), or usual care (UC), for 20 min per day for three days. Mood (Smiley Face Assessment Scale), Anxiety (State Trait Anxiety Scales) and Depression (Center for Epidemiological Studies) were the outcome measures. Linear Mixed Models with random intercepts were applied to compare changes in anxiety and mood between conditions pre/post daily intervention session and pre/post three-day intervention phase (days 2–4), and anxiety and depression were assessed from baseline to the day after intervention (days 1–5) (p < 0.01). Results: Mood and anxiety improved more for the AAI than for the CC or UC conditions. Females and people who did not live with a dog experienced similar improvements in mood in the AAI and CC conditions relative to UC, while males and people who live with a dog experienced greater improvement in the AAI condition. Depression decreased similarly in the AAI and CC conditions and both were significantly better than the UC condition. Conclusions: These results indicate that a dog + handler interaction is effective for reducing anxiety and depression and improving mood in adults hospitalized for the treatment of mental illness. Human handler-only visits did not consistently result in similar findings, indicating that there may be something unique and beneficial about the presence of the dog. Full article
(This article belongs to the Section Mental Health and Psychosocial Well-being)
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17 pages, 3331 KB  
Article
Service Dog Training Interventions for Veterans with Post-Traumatic Stress: Examining Gender-Based Differences in Psychosocial Outcomes
by Shahar Almog, Cheryl A. Krause-Parello, Alejandra Quintero, Deborah Taber and Erika Friedmann
Healthcare 2026, 14(9), 1253; https://doi.org/10.3390/healthcare14091253 - 6 May 2026
Viewed by 827
Abstract
Background: Poor mental health is prevalent among veterans who suffer from post-traumatic stress disorder (PTSD) and other psychiatric conditions. Canine-assisted interventions may improve psychological and social health in veterans. The parent study, a randomized controlled trial, revealed improvements in PTSD following both a [...] Read more.
Background: Poor mental health is prevalent among veterans who suffer from post-traumatic stress disorder (PTSD) and other psychiatric conditions. Canine-assisted interventions may improve psychological and social health in veterans. The parent study, a randomized controlled trial, revealed improvements in PTSD following both a service dog training program and an active control condition consisting of virtual dog training lessons. Thus, in the present post hoc secondary analysis, we analyzed both groups together (pooled arms) to examine gender-based differences in the effects of the altruistic service dog training programs on psychosocial outcomes. Methods: Veterans (N = 59) participated either in hands-on (with a dog and trainer) or virtual (no dog present) dog training programs over eight weeks and completed self-reported psychosocial measures before and after the program. Mixed-effect linear models were used to assess the interaction between time and gender on a series of psychosocial outcomes in the pooled sample. Results: The findings supported greater psychosocial improvements for female participants compared to male participants, including significant improvements in PTSD, perceived stress, and perceived physical health, and feeling greater closeness and lower avoidance in close relationships (ps < 0.05). The results revealed moderate to large effect sizes among female participants, suggesting meaningful clinical effects of the interventions (ds = 0.47–0.70). Conclusions: While the secondary analysis and small sample size limit causal inferences, the exploratory evidence suggests greater improvements in psychosocial health in female veterans after participating in the service dog training programs. Future research should tailor interventions to optimize the therapeutic effects for male and female veterans and identify other individual characteristics involved, such as combat exposure or post-traumatic stress symptom severity. Full article
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16 pages, 694 KB  
Article
Feasibility of Recruiting Psychiatrically Hospitalized Adults for a Randomized Controlled Trial of an Animal-Assisted Intervention
by Lisa Townsend, Nancy R. Gee, Erika Friedmann, Megan K. Mueller, Tushar P. Thakre and Sandra B. Barker
Healthcare 2026, 14(2), 154; https://doi.org/10.3390/healthcare14020154 - 7 Jan 2026
Cited by 1 | Viewed by 838
Abstract
Background/Objectives: Evaluating the feasibility of randomized controlled trials (RCTs) represents a critical next step for advancing human–animal interaction (HAI) science and rigorously exploring the role of animal-assisted interventions (AAIs) in psychiatric acute care. This study presents strategies for conducting a pilot RCT [...] Read more.
Background/Objectives: Evaluating the feasibility of randomized controlled trials (RCTs) represents a critical next step for advancing human–animal interaction (HAI) science and rigorously exploring the role of animal-assisted interventions (AAIs) in psychiatric acute care. This study presents strategies for conducting a pilot RCT comparing an animal-assisted intervention involving dogs (AAI) with an active conversational control (CC), which incorporated conversation with a human volunteer, and treatment as usual (TU) for improving mental health outcomes in psychiatrically hospitalized adults. Methods: We recruited participants from an acute-care psychiatric unit at an academic medical center. AAI and CC were delivered by volunteer handlers with and without their registered therapy dogs. Feasibility data included number of recruitment contacts, recruitment rate, and reasons for non-enrollment. We describe recruitment challenges encountered and mitigating strategies for successful study completion. Results: Recruitment occurred over 23 months with a goal of 60 participants participating in at least one intervention day. A total of 264 patients were referred to the study and 72 enrolled. The additional 12 people were recruited to replace participants who did not complete any intervention days and did not provide any intervention data. Study recruitment goals were met with a recruitment rate of 27.30%. Conclusions: Research to improve the lives of patients in acute psychiatric care is a vital public health goal, yet RCTs are difficult to conduct in acute care settings. Studies like this strengthen HAI and psychiatric science by providing a roadmap for implementing successful AAI RCT designs. Full article
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18 pages, 682 KB  
Review
Trilostane: Beyond Cushing’s Syndrome
by Ali R. Olaimat, Parastoo Jafarzadehbalagafsheh, Mohammad Gol, Anna-Maria Costa, Giuseppe Biagini and Chiara Lucchi
Animals 2025, 15(3), 415; https://doi.org/10.3390/ani15030415 - 2 Feb 2025
Cited by 6 | Viewed by 8101
Abstract
Trilostane is a drug able to block the synthesis of progesterone from pregnenolone, dependent on the enzyme 3β-hydroxysteroid dehydrogenase/Δ5−4 isomerase. As a consequence of this effect, it is used to treat endocrinological diseases such as Cushing’s syndrome, especially in dogs. Because of [...] Read more.
Trilostane is a drug able to block the synthesis of progesterone from pregnenolone, dependent on the enzyme 3β-hydroxysteroid dehydrogenase/Δ5−4 isomerase. As a consequence of this effect, it is used to treat endocrinological diseases such as Cushing’s syndrome, especially in dogs. Because of the modulatory effects of trilostane on the hypothalamic–pituitary–adrenal axis, trilostane administration causes an increase in brain levels of neurosteroids with anticonvulsant properties, as in the case of allopregnanolone. Allopregnanolone is also of interest in curing depression, suggesting that trilostane might represent a tool to address neurological and psychiatric disorders. In this review, we investigated the historical development of this drug and its current use, mechanisms, and possible developments. By searching the literature from 1978 to 2025, we identified 101 papers describing studies with trilostane. Precisely, 55 were about dogs and trilostane, 3 were on cats, and 23 were with other animals. Some studies (15) were also designed with human patients. The main disease treatment with trilostane was hyperadrenocorticism. However, we also found two preclinical papers on trilostane’s potential use in psychiatric diseases and three on trilostane’s potential use in neurological disorders. Moreover, few clinical and preclinical studies suggested the involvement of neurosteroids modulated by trilostane in different neurological disorders, thus opening a possible new perspective for the use of this drug. Full article
(This article belongs to the Section Animal Welfare)
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17 pages, 274 KB  
Case Report
Witnessing Self-Affirming Moments in Persons with Dementia While Interacting with Therapy Dogs: A Case Report
by Carolyn Brooks, Colleen A. Dell, Darlene Chalmers and Ben D. B. Carey
Animals 2024, 14(24), 3620; https://doi.org/10.3390/ani14243620 - 15 Dec 2024
Cited by 1 | Viewed by 2742
Abstract
Individuals, families, and communities are impacted by Alzheimer’s disease and other dementias worldwide. In Canada and elsewhere, family members commonly see loved ones living with dementia experience difficult moments, including anxiety, stress, and fear. Struggling health care systems strive to apply the latest [...] Read more.
Individuals, families, and communities are impacted by Alzheimer’s disease and other dementias worldwide. In Canada and elsewhere, family members commonly see loved ones living with dementia experience difficult moments, including anxiety, stress, and fear. Struggling health care systems strive to apply the latest evidence-based interventions. In this case report, we explore how individuals who care for people with dementia can help redirect difficult personal and interpersonal moments towards hopeful moments in the presence of therapy dogs. The cases of four individuals diagnosed with dementia and interacting with therapy dog intervention in one of three environments—at a family home, in a hospital awaiting placement to a long-term care facility, and in a psychiatric centre—are reviewed from the perspectives of two attending therapy dog handlers. In addition to being researchers in the therapy dog field and authors on this case report, both handlers were guided in a 110 min focused conversational method by a third author, from which self-affirmation theory surfaced as a guiding framework for explaining their observations and experiences. Therapy dog visiting appears to facilitate positive social interactions that can help redirect difficult moments to moments defined by self-affirmation or experiencing a positive sense of self. This is an under-recognized association in the dementia literature. Self-affirmation is demonstrated through four themes during therapy dog visits: (a) physical movement, (b) psychological shift, (c) a transition in the experience of time, and (d) connective interactions. Therapy dogs are identified here as a promising self-affirming psychosocial intervention for individuals with dementia and their caregivers worthy of further research and practice attention. Full article
(This article belongs to the Section Human-Animal Interactions, Animal Behaviour and Emotion)
20 pages, 299 KB  
Review
Psychological Sequelae of Dog Bites in Children: A Review
by Laura Monti, Georgios D. Kotzalidis, Valentina Arcangeli, Camilla Brozzi, Rossella Iacovino, Cristina Giansanti, Daniela Belella, Elisa Marconi, Silvia Maria Pulitanò, Marianna Mazza, Giuseppe Marano, Giorgio Conti, Delfina Janiri, Gabriele Sani and Daniela Pia Rosaria Chieffo
Children 2024, 11(10), 1218; https://doi.org/10.3390/children11101218 - 7 Oct 2024
Cited by 11 | Viewed by 6702
Abstract
Background/Objectives: Although rare in the Western world, dog bites may be lethal or lead to physically severe outcomes. However, little attention is given to their psychological consequences. We aimed to review their psychological consequences in children 1–14 years of age, focusing on the [...] Read more.
Background/Objectives: Although rare in the Western world, dog bites may be lethal or lead to physically severe outcomes. However, little attention is given to their psychological consequences. We aimed to review their psychological consequences in children 1–14 years of age, focusing on the prevalence and nature of psychological disorders, evaluating the impact on future mental health of children and their families, and assessing the effectiveness of preventive interventions and measures. Methods: On 23 May 2024, we investigated the PubMed, CINAHL, and PsycINFO/PsycARTICLES databases using (“dog bite” OR animal-induced OR animal-caused) AND (psychol* OR mental OR psychiatr* OR anxiety OR anxious OR depress* OR obsess* OR trauma* OR psychosis OR psychotic OR schizophren* OR schizoaffect*) filtered for ages 0–18 years. This resulted in 311 records, of which 50 were eligible. These included original research, case reports, patient surveys, and reviews/meta-analyses. Results: Findings indicate that younger children are particularly vulnerable, often suffering head/neck bites, leading to severe injuries and psychological distress, with post-traumatic stress disorder (PTSD) being a common outcome. Symptoms such as nightmares, flashbacks, anxiety, and social withdrawal were frequently reported. Positive parental support and timely psychological interventions were found to mitigate these effects. Conclusions: Interdisciplinary approaches integrating education, cognitive restructuring, and behaviour modification are needed to effectively prevent and address the psychological impacts of dog bites. Summarising, dog bites in children result in substantial psychological sequelae, necessitating robust prevention and intervention strategies to improve their quality of life and reduce the risk of chronic mental conditions. Full article
10 pages, 275 KB  
Article
Human–Animal Bond Generated in a Brief Animal-Assisted Therapy Intervention in Adolescents with Mental Health Disorders
by Maylos Rodrigo-Claverol, Marta Manuel-Canals, Luis Lucio Lobato-Rincón, Natalia Rodriguez-Criado, Maite Roman-Casenave, Elisabet Musull-Dulcet, Esther Rodrigo-Claverol, Josep Pifarré and Yvette Miró-Bernaus
Animals 2023, 13(3), 358; https://doi.org/10.3390/ani13030358 - 20 Jan 2023
Cited by 14 | Viewed by 14431
Abstract
Background: The human–animal bond is crucial for the proper development of animal-assisted therapy (AAT) sessions. However, in specific cases such as in AAT focused on psychiatric patients who are admitted to acute units, there is only a short period of time available to [...] Read more.
Background: The human–animal bond is crucial for the proper development of animal-assisted therapy (AAT) sessions. However, in specific cases such as in AAT focused on psychiatric patients who are admitted to acute units, there is only a short period of time available to establish this bond. Objectives: To assess the degree of HAB generated after two AAT sessions in adolescents admitted to acute psychiatry units. Methods: A prospective multicenter cohort study aimed at adolescents aged 13 to 17 years admitted to the acute child and adolescent psychiatry unit of three hospitals. Intervention: Two weekly 1 h group sessions of AAT with therapy dogs. Main outcome: The Center for the Study of Animal Wellness Pet Bonding Scale Survey (CSAWPB). Results: One hundred and fourteen adolescents participated. A positive perception of the dog was generated, achieving a good level of bonding and attachment. Conclusions: The results obtained make it possible to affirm that a short period of time is enough to establish a good HAB between patients and therapy dogs. This study aims to contribute to the study of non-pharmacological interventions as a complement to pharmacological treatments in adolescents with mental health disorders. Full article
20 pages, 379 KB  
Review
Current Perspectives on the Challenges of Implementing Assistance Dogs in Human Mental Health Care
by Sandra Foltin and Lisa Maria Glenk
Vet. Sci. 2023, 10(1), 62; https://doi.org/10.3390/vetsci10010062 - 15 Jan 2023
Cited by 11 | Viewed by 13013
Abstract
The prevalence of mental health disorders, driven by current global crises, is notably high. During the past decades, the popularity of dogs assisting humans with a wide spectrum of mental health disorders has significantly increased. Notwithstanding these dogs’ doubtless value, research on their [...] Read more.
The prevalence of mental health disorders, driven by current global crises, is notably high. During the past decades, the popularity of dogs assisting humans with a wide spectrum of mental health disorders has significantly increased. Notwithstanding these dogs’ doubtless value, research on their legal status, certification processes, training and management practices, as well as their welfare status, has been scarce. This scoping review highlights that in contrast to other assistance dogs such as guide dogs, there exists no consistent terminology to mark dogs that assist humans with impaired mental health. Legal authorities monitoring the accreditation process, training and tracking of mental health supporting dogs are broadly lacking, with only few exceptions. This review emphasizes the need to address several topics in the promotion of progress in legal and welfare issues related to assistance dogs as well as emotional support dogs for humans with a mental health disorder. The current body of knowledge was assessed in three different areas of focus: (1) the legal dimension including definitions and certification processes; (2) the dimension of performed tasks; and (3) the dog welfare dimension including aspects of the relationship with the handler and risks associated with children recipients. Considering the challenges associated with a mental health diagnosis, collaborations of dog provider organizations and health care professionals would be desirable to continuously assess the efficiency of the human-dog dyad regarding their overall compatibility, general satisfaction and mutual well-being. Full article
(This article belongs to the Special Issue Veterinary Medical Education: Challenges and Perspectives)
12 pages, 924 KB  
Article
The Benefits of Dog-Assisted Therapy as Complementary Treatment in a Children’s Mental Health Day Hospital
by Elías Guillen Guzmán, Laia Sastre Rodríguez, Pilar Santamarina-Perez, Laura Hermida Barros, Marta García Giralt, Eva Domenec Elizalde, Fransesc Ristol Ubach, Miguel Romero Gonzalez, Yeray Pastor Yuste, Cristina Diaz Téllez, Soledad Romero Cela, Laura Real Gisbert, Miquel Salmeron Medina, Anna Ballesteros-Urpi and Astrid Morer Liñan
Animals 2022, 12(20), 2841; https://doi.org/10.3390/ani12202841 - 19 Oct 2022
Cited by 18 | Viewed by 11454
Abstract
Dog-assisted therapy (DAT) has shown benefits in people with mental health disorders. A child psychiatric day hospital would be a suitable setting to implement DAT and evaluate the benefits in a pediatric population. Methods: Mixed methods research in a naturalistic setting was considered [...] Read more.
Dog-assisted therapy (DAT) has shown benefits in people with mental health disorders. A child psychiatric day hospital would be a suitable setting to implement DAT and evaluate the benefits in a pediatric population. Methods: Mixed methods research in a naturalistic setting was considered in this pre-post quantitative study including 23 children under 13 treated in a day hospital over 2 years. Quantitative analysis included the number of emotional and behavioral outbursts and attendance rate and self-control and social impairment questionnaires completed by family members and therapists. In the qualitative study, the experiences of 12 mental health professionals involved in DAT were documented through semi-structured interviews. Results: On DAT days, there were fewer emotional and behavioral outbursts and higher attendance. Significant differences were obtained between pre- and post-test scores on the SCRS and the SRS-2 completed by the therapists, while no significant differences were obtained on the questionnaires completed by the parents. Observations based on the qualitative study were as follows: (1) DAT improves emotional self-regulation; (2) DAT could facilitate the work of therapists in day hospitals; (3) health professionals displayed uncertainty due to a lack of familiarity with DAT. Conclusions: DAT improved emotional self-regulation, attendance rate and self-control and social response in children with mental disorders attending a day hospital. Full article
(This article belongs to the Section Human-Animal Interactions, Animal Behaviour and Emotion)
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19 pages, 1368 KB  
Article
Evaluating ADHD Assessment for Dogs: A Replication Study
by Barbara Csibra, Nóra Bunford and Márta Gácsi
Animals 2022, 12(7), 807; https://doi.org/10.3390/ani12070807 - 22 Mar 2022
Cited by 17 | Viewed by 7078
Abstract
The family dog, in its natural environment, exhibits neuropsychological deficits redolent of human psychiatric disorders, including behaviours similar to human Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms. For dogs, Vas and colleagues developed a 13-item questionnaire to measure inattention and hyperactivity/impulsivity (Dog ARS; 2007). We re-assessed, [...] Read more.
The family dog, in its natural environment, exhibits neuropsychological deficits redolent of human psychiatric disorders, including behaviours similar to human Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms. For dogs, Vas and colleagues developed a 13-item questionnaire to measure inattention and hyperactivity/impulsivity (Dog ARS; 2007). We re-assessed, in a large sample of dogs (N = 319), psychometric properties of the Dog ARS, to identify possible limitations as a basis for further development. We examined the cross-study stability of factor structure and 40-day temporal stability of item and subscale scores and compared owner-report with expert (dog trainer)-report (n = 86), paralleling human parent/teacher assessments. To identify ambiguous items, we administered a modified version (including “I don’t know” options, N = 520) to a different sample. We could replicate the factor structure with evidence of good internal consistency and test–retest reliability of both subscales. Agreement between owner and trainer ratings was fair (inattention) and moderate (hyperactivity/impulsivity). Three ambiguous items were identified. Overall, we claim that the Dog ARS is a reliable tool to assess ADHD-like behaviour in dogs, but in its current form, it is not suitable to detect diagnosable individuals, as it does not comprise items assessing functional impairment, and also, the inclusion of owner-expert ratings in the evaluation process would be necessary. Full article
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12 pages, 3487 KB  
Commentary
Psycho-Behavioural Changes in Dogs Treated with Corticosteroids: A Clinical Behaviour Perspective
by Lorella Notari, Roxane Kirton and Daniel S. Mills
Animals 2022, 12(5), 592; https://doi.org/10.3390/ani12050592 - 26 Feb 2022
Cited by 16 | Viewed by 18431
Abstract
Arousal and distress are often important factors in problematic behaviours, and endogenous corticosteroids are important mediators in the associated stress responses. Exogenous corticosteroid treatments have been reported to change behaviour in human patients and laboratory animals, with similar changes also noted in pet [...] Read more.
Arousal and distress are often important factors in problematic behaviours, and endogenous corticosteroids are important mediators in the associated stress responses. Exogenous corticosteroid treatments have been reported to change behaviour in human patients and laboratory animals, with similar changes also noted in pet dogs. These behaviours not only potentially adversely impact the welfare of the dogs, but also the quality of life of their owners. Indeed, corticosteroids can bias sensitivity towards aversion in dogs. A decrease in behaviours associated with positive affective states, such as play and exploratory behaviours, together with an increase in aggression and barking have also been described in dogs. According to the available literature, human patients with pre-existing psychiatric disorders are more at risk of developing behavioural side effects due to corticosteroid treatments. It is reasonable to consider that the same may happen in dogs with pre-existing behavioural problems. In this paper, the possible behavioural side effects of exogenous corticosteroids are summarised to help inform and support veterinarians prescribing these drugs. Full article
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10 pages, 1413 KB  
Article
Genetic Dissection of Temperament Personality Traits in Italian Isolates
by Maria Pina Concas, Alessandra Minelli, Susanna Aere, Anna Morgan, Paola Tesolin, Paolo Gasparini, Massimo Gennarelli and Giorgia Girotto
Genes 2022, 13(1), 4; https://doi.org/10.3390/genes13010004 - 21 Dec 2021
Cited by 3 | Viewed by 6937
Abstract
Human personality (i.e., temperament and character) is a complex trait related to mental health, influenced by genetic and environmental factors. Despite the efforts performed during the past decades, its genetic background is only just beginning to be identified. With the aim of dissecting [...] Read more.
Human personality (i.e., temperament and character) is a complex trait related to mental health, influenced by genetic and environmental factors. Despite the efforts performed during the past decades, its genetic background is only just beginning to be identified. With the aim of dissecting the genetic basis of temperament, we performed a Genome-Wide Association Study (GWAS) on Cloninger’s Temperament and Character Inventory in 587 individuals belonging to different Italian genetic isolates. Data analysis led to the identification of four new genes associated with different temperament scales, such as Novelty Seeking (NS), Harm Avoidance (HA), and Reward Dependence (RD). In detail, we identified suggestive and significant associations between: MAGI2 (highest p-value = 9.14 × 10−8), a gene already associated with schizophrenia and depressive disorder, and the NS–Extravagance scale; CALCB (highest p-value = 4.34 × 10−6), a gene likely involved in the behavioral evolution from wild wolf to domestic dog, and the NS–Disorderliness scale; BTBD3 (highest p-value = 2.152 × 10−8), a gene already linked to obsessive–compulsive disorder, and the HA–Fatigability scale; PRKN (highest p-value = 8.27 × 10−9), a gene described for early onset Parkinson’s disease, and the RD scale. Our work provides new relevant insights into the genetics of temperament, helping to elucidate the molecular basis of psychiatric disorders. Full article
(This article belongs to the Special Issue Genetics of Psychiatric Disease and the Basics of Neurobiology)
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