Search Results (2,128)

The plastic pieces of synthetic polymers, which were previously regarded as primary pollutants of the environment, are increasingly being discovered as internal pollutants of the human body. This review provides a comprehensive overview of the available evidence on human exposure, tissue distribution, and associated biological effects of micro- and nanoplastics. Ingesting contaminated food and water is the major exposure pathway, with inhalation and dermal contact being secondary routes. Various organ systems have been identified as containing polymer particles through the use of advanced analytical methods, including blood, liver, lungs, placenta, breast milk, and brain tissue. Experimental animal studies suggest associations with tissue injury, metabolic illness, and neurotoxicity. Polyethylene, polypropylene, polystyrene, and polyethylene terephthalate are the most frequently found polymers in human samples. New clinical findings indicate potential health implications, though current human evidence remains largely associative rather than causal: a cardiovascular study observed more than a two-fold rise in mortality among patients with polymer-containing arterial plaques, and recent evidence demonstrates over-accumulation of polymers in brain tissue, raising questions about neuroinflammatory processes. Detection technologies have advanced substantially, with deep learning-based polymer classification achieving 95–99% accuracy and ultrasensitive electrochemical and surface plasmon resonance biosensors reaching detection limits approaching 10⁻¹¹ M. Despite these advances, critical issues remain, including lack of standardized analytical procedures, absence of chronic exposure models for humans, and insufficient longitudinal epidemiological data. To address these gaps, physiologically relevant experimental systems including organoids and organ-on-chip platforms will be required, in addition to well-designed prospective cohort studies. Full article

In this work, we propose a hyperbolic metamaterials (HMMs)-based coreless fiber surface plasmon resonance (SPR) sensor. Leveraging the absence of a core in coreless fibers, the evanescent waves at the cladding–external solution interface couple more effectively into the solution, enabling surface plasmon resonance without any additional processing. To enhance sensitivity, we adopted a multimode–coreless–multimode (MCM) structure and grew layered hyperbolic metamaterials as the SPR-excitation-sensitive layer within the coreless region. Through finite element simulations, we optimized HMM parameters and fabricated high-performance HMM-SPR sensors. Test results demonstrate that the fabricated HMM-SPR sensor achieves an optimal refractive index sensitivity of 3703.33 nm/RIU, representing a 49.68% improvement over single-layer gold film SPR sensors. It successfully detects glucose solutions at varying concentrations with a sensitivity of 2671.25 nm/RIU. The high-sensitivity, structurally simple HMM-SPR sensor we proposed demonstrates broad application prospects in biosensing, environmental monitoring, food safety, and other fields. Full article

The interaction between light and chiral plasmonic metasurfaces provides a powerful mechanism for controlling polarization states at the nanoscale. Utilizing displacement Talbot lithography for large-area fabrication, we characterized the chiroptical response by measuring the evolution of Stokes parameters to quantify phase retardation between orthogonal polarization components. To elucidate the underlying physical mechanism, we employ a hybrid finite element method and rigorous coupled-wave analysis approach to investigate the behavior of the far-field and local-field configurations. Our results reveal that the phase shift is highly sensitive to symmetry-breaking features, where the interplay between different modes dictates the overall circular dichroism signal. Furthermore, the analysis of local field plots suggests specific contributions of plasmonic modes to the chiroptical response. We conclude that the phase shift effects, characterized via Stokes parameters and modal analysis, provide a robust metric for engineering chiroptical properties in these systems. This work establishes a fundamental framework for developing compact polarization-control elements and enhances the understanding of phase-modulated light-matter interactions in chiral plasmonic metasurfaces. Full article

Ribosome-inactivating proteins are a class of toxins that target eukaryotic ribosomes, inhibit protein synthesis, and ultimately induce cell death. Several of these toxins pose significant clinical and public health threats. Among these, ricin, derived from the castor bean plant (Ricinus communis), is a highly potent biotoxin with recognized bioterrorism potential. Other ribosome-inactivating proteins, including Shiga toxin produced by pathogenic Shigella and Escherichia coli, as well as mucoricin from Mucorales fungi, contribute to disease severity and can lead to life-threatening complications. Despite these risks, no approved therapeutics are currently available. The development of effective inhibitors depends on robust and well-defined strategies to identify and validate small molecules that disrupt toxin–ribosome interactions. Efforts to target the catalytic active site have met with limited success, largely due to its broad, shallow, and highly polar architecture, which is not conducive to high-affinity binding by drug-like molecules. In contrast, the ribosome-binding interface represents a more tractable target, as it is essential for toxin recruitment and offers more structurally defined and druggable features. Inhibitors targeting this interface can also exert allosteric effects by disrupting long-range conformational coupling between the ribosome-binding region and the active site, thereby attenuating catalytic activity without directly engaging the catalytic pocket. In this review, we compile and evaluate biophysical and biochemical assays for the discovery and characterization of small-molecule inhibitors that target toxin–ribosome interactions. We examine in vitro binding approaches, including surface plasmon resonance-based fragment screening and fluorescence anisotropy assays for ranking inhibitory activity. We further review biochemical and molecular assays that assess ribosome protection from toxin-mediated depurination, along with complementary cell-based assays that evaluate functional rescue in cellular systems. Collectively, this review consolidates current screening methodologies and highlights opportunities to refine assay strategies, thereby supporting the advancement of targeted therapeutics. Full article

Machine learning (ML)-assisted design of epsilon-negative polymer nanocomposites requires a clear connection between experimentally controllable synthesis parameters, core–shell nanoparticle geometry, and the resulting effective optical response. The targeted optical response is unusual because the polymer film is predicted to exhibit near-zero or negative real effective permittivity in selected visible spectrum regions, arising from Ag core plasmonic polarizability, SiO₂-mediated dielectric spacing, nanoparticle filling factor, and effective medium coupling rather than from the intrinsic polymer matrix. In this study, a two-stage ML-assisted synthesis-to-optics framework is developed for Ag@SiO₂ core–shell nanoparticle/polymer composite films intended for visible spectrum effective permittivity screening. In the first stage, Stöber synthesis parameters, including water volume, ethanol volume, TEOS content, catalyst volume, reaction time, Ag nanoparticle size, and Ag nanoparticle concentration, were used to predict SiO₂ shell thickness. In the second stage, Ag core size, SiO₂ shell thickness, wavelength, and nanoparticle filling factor were used to screen the real effective permittivity of Ag@SiO₂/polymer nanocomposites within an effective medium design space. Using a duplicate-aware validation workflow, Gradient Boosting provided the strongest held-out test performance for shell thickness prediction, with a test R² of 0.8997, MAE of 7.1822 nm, RMSE of 8.8344 nm, and cross-validation R² of 0.5371 ± 0.4648. The relatively large cross-validation variability indicates that the model is useful for interpolation-based synthesis screening but should not be interpreted as fully robust across heterogeneous literature-derived data. For the optical response task, the highest held-out test performance was obtained by a Decision Tree model (test R² = 0.7586), but cross-validation results were unstable, indicating that the epsilon model should be interpreted as a design space screening tool rather than a generalizable predictor. Design window analysis identified candidate negative effective permittivity regions primarily at 400 nm and high nanoparticle filling factor, with predicted $\mathrm{R}\mathrm{e}\left({\epsilon }_{\mathrm{e}\mathrm{f}\mathrm{f}}\right)$ values ranging from −5.4229 to −0.2086 across selected windows. The main contribution of this work is the treatment of SiO₂ shell thickness as a bridge variable between Stöber-derived synthesis control and effective permittivity screening. Experimental validation remains necessary to confirm the predicted design windows, particularly because shell uniformity, Ag core polydispersity, nanoparticle aggregation, polymer dispersion, high-filling-factor feasibility, and effective medium validity can strongly influence the measured optical response. Full article

In this study, we present a thermal-aware design of a compact hybrid plasmonic grating (HPG) TE-pass polarizer on X-cut lithium niobate on insulator (LNOI) for fiber-optic gyroscopes (FOGs). In a three-dimensional simulation, the optimization of the trapezoidal sidewall angle (θ = 78°) and the thickness of the Ag grating (13 nm) yield a polarization extinction ratio of 36.2 dB at 1550 nm (with a peak of 41.4 dB at 1548 nm) within a sub-10 μm grating length. This represents a ~3–8 dB improvement over prior LNOI HPG polarizers at the same footprint. A multiphysics thermo-optic analysis over the wide industrial FOG envelope (from −45 to +85 °C) demonstrates that the operating-wavelength polarization extinction ratio remains within the range of 24.7–36.2 dB across the entire 130 K span (worst case 24.7 dB at −25 °C), constrained solely by a modest 10 pm/K Bragg detuning stemming from the pronounced (~5) thermo-optic anisotropy of LN. The insertion loss exhibits a negligible drift of merely 0.73 dB. A fabrication tolerance study identified the Ag thickness as the predominant budgetary constraint (±1 nm tolerance, PER dropping ~10 dB at the resonance edge), while the ridge width and oxide buffer demonstrated comparatively greater flexibility. The device, therefore, fulfills the criteria for FOG-grade polarization suppression across most of the operational temperature range. The −25 °C point is established at the 25 dB threshold, thereby providing concrete design guidelines for ensuring environmentally stable on-chip polarization control on LNOI. Full article

Graphene–plasmonic electro–optic (EO) modulators have attracted significant interest for compact and energy-efficient integrated photonic systems due to their electrically tunable optical response and strong light–matter interaction. In this work, an ultra-thin silicon-on-insulator (SOI) graphene–plasmonic slot modulator (G-PSM) is investigated using a combined semi-analytical and numerical framework. The analysis integrates finite-temperature Kubo conductivity modeling, perturbation-based effective-index analysis, overlap-factor evaluation, eigenmode analysis, and full-wave simulations to study the influence of silicon thickness on the EO performance of the proposed structure. The obtained results demonstrate that geometry engineering strongly affects modal confinement, overlap enhancement, effective-index perturbation, transmission characteristics, extinction ratio (ER), insertion loss (IL), energy-per-bit consumption, and EO bandwidth. Under optimized operating conditions, the proposed G-PSM achieves an effective refractive-index variation of approximately $3.1\times {10}^{-3}$, an ER of approximately 3.5 dB, an IL of 1.5–2 dB, an energy-per-bit consumption of approximately 7.5 fJ/bit, and a 3 dB EO bandwidth approaching 200 GHz. Strong electromagnetic confinement is achieved inside the plasmonic slot region near the graphene-active layer, enabling efficient electro–absorptive and electro–refractive modulation. Excellent agreement between the semi-analytical calculations and numerical simulations validates the developed framework and confirms the suitability of the proposed ultra-thin SOI G-PSM for compact broadband EO modulation in future integrated photonic systems. Full article

Solar-driven interfacial water evaporation has been recognized as an effective measure to address freshwater scarcity. Photothermal materials lie at the core of this process and have been extensively studied. However, conventional carbon-based materials typically suffer from high thermal emissivity, leading to significant heat loss. Here, we report a tungsten carbide/carbon composite polyvinyl alcohol hydrogel evaporator (PWC) for solar-driven interfacial seawater evaporation. Specifically, a tungsten carbide/carbon (WC/C) composite was synthesized via a straightforward one-step molten salt coating method and exhibited a remarkable photothermal conversion efficiency of 67.1%, attributed to the plasmon resonance absorption effect of WC nanoparticles. When incorporated into a polyvinyl alcohol (PVA) hydrogel via a physical-chemical dual-crosslinking strategy, the resulting PWC evaporator achieved a high evaporation rate of 2.99 kg m⁻² h⁻¹ and a conversion efficiency of 90.9% in a 5 wt% NaCl solution under 1 kW m⁻² illumination. In addition, the evaporator can purify seawater and effectively remove a variety of organic dyes. This study provides a viable strategy for a sustainable freshwater supply. Full article

Antibiotic resistance and biofilm-associated infections require sustainable antimicrobial platforms that combine efficacy with biocompatibility. Fermented matrices are attractive for green nanomaterial production because they provide reducing metabolites and surface-active capping compounds. Rooibos kombucha is a polyphenol-rich fermentation system with potential to serve as a biosynthetic matrix for silver nanoparticles (AgNPs). The present work aimed to develop a rooibos kombucha-enabled platform for the green biosynthesis of phytochemical-capped silver nanoparticles, AgNPs-K, and evaluate their antibacterial, antibiofilm, and in vivo activity. Rooibos kombucha was fermented for 14 days and profiled by liquid chromatography–tandem mass spectrometry (LC–MS/MS). AgNPs-K were generated using kombucha extract and AgNO₃, purified, and characterized by ultraviolet–visible spectroscopy (UV–Vis), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), and nanoparticle tracking analysis. Antibacterial activity against eight Gram-positive and Gram-negative reference pathogens was assessed by EUCAST-based microdilution and time-kill assays. Biofilm inhibition was measured by the crystal violet assay. In vivo toxicity and therapeutic efficacy were evaluated in Galleria mellonella larvae. AgNP formation was confirmed by a surface plasmon resonance (SPR) peak at 415 nm. TEM showed predominantly spherical nanoparticles with a main size range of 20–30 nm, a hydrodynamic diameter of 98 nm, and a zeta potential of −14.62 ± 0.04 mV. AgNPs-K showed overlapping minimum inhibitory concentration and minimum bactericidal concentration values of 1.14 µg/mL for Gram-positive species and 1.33 µg/mL for Gram-negative species. Time-kill assays showed rapid bactericidal activity after threshold concentrations were reached, with sustained suppression at 24 h. Biofilm formation was abolished at 40 µg/mL and strongly reduced at lower concentrations. AgNPs-K were non-toxic up to 400 µg/mL and improved survival in six of seven infection models. Fermented rooibos kombucha functions as an effective biosynthetic matrix for the green production of phytochemical-capped AgNPs. The resulting nanoparticles combine low-dose antibacterial and antibiofilm activity with favorable in vivo tolerability and efficacy, supporting fermentation-enabled nanobiotechnology strategies against biofilm-associated infection. Full article

Background/Objectives: Wound infections represent a major clinical challenge due to their polymicrobial nature, biofilm formation, and increasing antimicrobial resistance, which compromise conventional treatments. This study aimed to develop and evaluate ligand-stabilized silver nanoparticles (AgNPs) with improved antimicrobial activity and cytocompatibility, and to investigate their incorporation into electrospun nanofibers for wound management. Methods: Four AgNP formulations stabilized with citrate, cysteine, ketorolac, and diclofenac were synthesized via chemical reduction. Physicochemical characterization included surface plasmon resonance and zeta potential measurements. Antimicrobial activity was assessed through minimum inhibitory concentration (MIC) and bactericidal assays against Gram-positive, Gram-negative, and fungal strains. Toxicity was evaluated using the HET-CAM assay, while cytocompatibility was determined in fibroblasts, MG-63 cells, and mesenchymal stem cells. Diclofenac-stabilized AgNPs were incorporated into electrospun PCL/PEO nanofibers to generate a functional nanocomposite system. Results: All AgNPs exhibited a characteristic SPR at ~400 nm and high colloidal stability. Diclofenac-stabilized AgNPs (dc-AgNPs) showed the highest antimicrobial activity, with MIC values of 18.8 mg/L against Staphylococcus aureus and Pseudomonas aeruginosa, and 4.7 mg/L against Candida albicans, along with strong bactericidal effects. HET-CAM assays indicated negligible irritation at concentrations up to 75 mg/L. Cytocompatibility results revealed a dose-dependent response, with fibroblasts being more sensitive. Electrospun nanofibers loaded with dc-AgNPs achieved a 2.6 log reduction against Streptococcus mutans and moderate reductions (0.4–0.7 log) against other pathogens. Conclusions: Ligand engineering critically influences the antimicrobial efficacy and biocompatibility of AgNPs. The incorporation of dc-AgNPs into electrospun nanofibers represents a promising approach for treating biofilm-associated wound infections. Full article

Optical nonreciprocity (ONR) plays an important role in laser technique, optical communications, quantum information, etc. Realizing ONR at the quantum level of few photons or single photons is also essential for quantum communications or quantum networks. In this work, we propose a hybrid configuration composed of a quantum dot–metallic nanoparticle (QD-MNP) composite in a ring cavity to achieve ONR at the few-photon level via optical bistability. With the surface plasmon effect of the MNP, the bistable property and regime of photons producing ONR in an asymmetric ring cavity including a QD and an MNP inside can be significantly improved in comparison with the case of a single QD. By using the bistability effect, giant ONR can be achieved in an optimal window of numbers of input photons. The detuning and the coupling strength coefficients of the hybrid system can be adjusted and utilized to optimize the performance of the quantum nonreciprocity. This work may find promising applications in quantum nonreciprocal devices and photonic quantum circuits. Full article

This study presents a comprehensive first-principles investigation of the structural, elastic, electronic, and optical behavior of cubic CsCaF₃ under hydrostatic pressure. The material is confirmed to be a stable Pm-3m fluoride perovskite, with a lattice constant of $4.496 \AA$ and a tolerance factor of $0.902$. At ambient conditions, CsCaF₃ exhibits high intrinsic stiffness ($C_{11}=107.88 \mathrm{G}\mathrm{P}\mathrm{a}$, $B=53.07 \mathrm{G}\mathrm{P}\mathrm{a}$, $G=29.16 \mathrm{G}\mathrm{P}\mathrm{a}$, $E=73.94 \mathrm{G}\mathrm{P}\mathrm{a}$) and maintains mechanical stability while becoming progressively stiffer under compression. The electronic structure reveals a wide indirect band gap of $7.1 \mathrm{e}\mathrm{V}$ that broadens to $8.43 \mathrm{e}\mathrm{V}$ and transforms into a direct gap at elevated pressures. Optical calculations show strong transparency in the visible range, with a low refractive index ($1.58$) and reflectivity ($~5\%$), and a deep-UV absorption edge near $6 \mathrm{e}\mathrm{V}$. Pressure enhances these features, increasing the refractive index to 1.66 and the maximum reflectivity to 45.87% at $24 \mathrm{G}\mathrm{P}\mathrm{a}$. The plasmon resonance also displays pronounced tunability, blue-shifting from $29.56$ to $30.79 \mathrm{e}\mathrm{V}$ with a fourfold rise in intensity. Analysis of the effective-electron number further indicates pressure-driven redistribution of spectral weight within the UV region. Together, these findings demonstrate that CsCaF₃ combines robust structural stability with highly pressure-tunable optical and plasmonic responses, positioning it as a promising candidate for deep-UV optoelectronics, photonic coatings, and pressure-responsive optical technologies. Full article

This study proposes a novel anti-resonant fiber sensing structure based on a composite “egg-shaped” configuration with surface plasmon resonance (SPR) effect. By designing a novel anti-resonant structure consisting of a semicircle and a semi-ellipse and coating its inner surface with a gold film, the optimal structural parameters are determined through three sets of simulation experiments using temperature sensitivity as the criterion. The optimal sensing structure was applied to the simulated detection and analysis of cancer cells, aiming to provide value and reference for the application of high-sensitivity optical fiber sensor in the field of cancer cell detection. Simulation results show that the proposed sensing structure achieves a maximum temperature sensitivity (TS) of 3.86 nm/°C. For the detection of six different types of cancer cells, the maximum wavelength sensitivity (WS), optimal resolution (R), maximum figure of merit (FOM), maximum signal-to-noise ratio (SNR), and best limit of detection (LOD) reach 12,142.86 nm/RIU, 8.24 × 10⁻⁶, 3035.72 RIU⁻¹, 65.50, and 0.94 nm, respectively. Owing to its unique detection mechanism, the proposed sensing structure exhibits label-free characteristics and demonstrates balanced and excellent performance across all metrics for both temperature and cancer cell detection, showing broad application prospects and great potential in the fields of environmental monitoring and medical prevention and treatment. Full article

Existing ground-slotted coplanar waveguide (CPW) spoof surface plasmon polariton (SSPP) low-pass filters (LPFs) remain constrained by the difficulty of achieving a wide stopband while maintaining a compact size, as well as by undesired radiation leakage arising from their open-aperture slot configuration. To address these issues, a grounded coplanar waveguide spoof surface plasmon polariton (GCPW-SSPP) low-pass filter based on a multi-arm star-shaped slot (MASS) loading topology is proposed. An equivalent-circuit interpretation and full-wave dispersion analysis show that the multi-arm slots introduce enhanced distributed reactive loading, thereby lowering the asymptotic frequency and enabling compact SSPP implementations. The near-field characteristics further demonstrate tighter electromagnetic confinement, as reflected by an approximately 48% reduction in the electric-field confinement width along the z-direction. To alleviate the trade-off between miniaturization and wide-stopband performance in cascaded SSPP LPFs, the single-cell S-parameters of the proposed topology are investigated. A single MASS unit exhibits a sharp cutoff and a deep transmission notch, allowing a wide stopband to be obtained with fewer cascaded cells. Radiation characteristics are subsequently quantified by a loss-decomposition method, and the MASS topology is found to suppress the radiation leakage of open-aperture ground-slotted structures, yielding a maximum radiation-loss reduction of approximately 75%. To validate the design methodology, a MASS-loaded GCPW-SSPP LPF is designed, fabricated, and measured. The measured results are in good agreement with the simulated ones, confirming the effectiveness of the proposed scheme. By simultaneously achieving a wide stopband, compact size, and suppressed radiation leakage, the proposed filter offers a promising low-interference filtering solution for highly integrated microwave and RF front-end systems. Full article

This work presents an intrinsic optical fiber sensor based on plasmonic phenomena in modified plastic optical fibers (POFs). The sensing area is achieved by replacing the polymethyl methacrylate (PMMA) core with a molecularly imprinted polymer (MIP) containing gold nanorods (GNRs). Thus, in the sensing area, the MIP acts as both a selective recognition element and an optically sensitive guiding medium where plasmonic phenomena occur. This optical–chemical configuration has been developed as a proof-of-concept for the detection of furfural in aqueous solution. The proposed sensor achieves a limit of detection (LOD) of 27 pM, demonstrates high selectivity for the analyte of interest, and is applicable even in real-world scenarios, as demonstrated by experimental results (a commercially available infant milk). The proposed sensor presents a significant enhancement of the sensor response, of about six orders of magnitude, compared to a conventional configuration where the same (or a similar) mixture of MIP/GNRs is spun over the exposed PMMA of a D-shaped POF area for comparison. Notably, even if this study has been carried out via a proof-of-concept in furfural detection, this substantial improvement is achieved while preserving a simple, portable, and cost-effective optical setup, highlighting the potential of this sensing strategy for the development of highly selective sensors by changing the MIP template. Full article