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Keywords = photomultiplier tubes (PMT)

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17 pages, 1027 KiB  
Review
Photon Detector Technology for Laser Ranging: A Review of Recent Developments
by Zhihui Li, Xin Jin, Changfu Yuan and Kai Wang
Coatings 2025, 15(7), 798; https://doi.org/10.3390/coatings15070798 - 8 Jul 2025
Viewed by 582
Abstract
Laser ranging technology holds a key position in the military, aerospace, and industrial fields due to its high precision and non-contact measurement characteristics. As a core component, the performance of the photon detector directly determines the ranging accuracy and range. This paper systematically [...] Read more.
Laser ranging technology holds a key position in the military, aerospace, and industrial fields due to its high precision and non-contact measurement characteristics. As a core component, the performance of the photon detector directly determines the ranging accuracy and range. This paper systematically reviews the technological development of photonic detectors for laser ranging, with a focus on analyzing the working principles and performance differences of traditional photodiodes [PN (P-N junction photodiode), PIN (P-intrinsic-N photodiode), and APD (avalanche photodiode)] (such as the high-frequency response characteristics of PIN and the internal gain mechanism of APD), as well as their applications in short- and medium-range scenarios. Additionally, this paper discusses the unique advantages of special structures such as transmitting junction-type and Schottky-type detectors in applications like ultraviolet light detection. This article focuses on photon counting technology, reviewing the technological evolution of photomultiplier tubes (PMTs), single-photon avalanche diodes (SPADs), and superconducting nanowire single-photon detectors (SNSPDs). PMT achieves single-photon detection based on the external photoelectric effect but is limited by volume and anti-interference capability. SPAD achieves sub-decimeter accuracy in 100 km lidars through Geiger mode avalanche doubling, but it faces challenges in dark counting and temperature control. SNSPD, relying on the characteristics of superconducting materials, achieves a detection efficiency of 95% and a dark count rate of less than 1 cps in the 1550 nm band. It has been successfully applied in cutting-edge fields such as 3000 km satellite ranging (with an accuracy of 8 mm) and has broken through the near-infrared bottleneck. This study compares the differences among various detectors in core indicators such as ranging error and spectral response, and looks forward to the future technical paths aimed at improving the resolution of photon numbers and expanding the full-spectrum detection capabilities. It points out that the new generation of detectors represented by SNSPD, through material and process innovations, is promoting laser ranging to leap towards longer distances, higher precision, and wider spectral bands. It has significant application potential in fields such as space debris monitoring. Full article
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33 pages, 5307 KiB  
Article
SiPM Developments for the Time-Of-Propagation Detector of the Belle II Experiment
by Flavio Dal Corso, Jakub Kandra, Roberto Stroili and Ezio Torassa
Sensors 2025, 25(13), 4018; https://doi.org/10.3390/s25134018 - 27 Jun 2025
Viewed by 280
Abstract
Belle II is a particle physics experiment working at an high luminosity collider within a hard irradiation environment. The Time-Of-Propagation detector, aimed at the charged particle identification, surrounds the Belle II tracking detector on the barrel part. This detector is composed by 16 [...] Read more.
Belle II is a particle physics experiment working at an high luminosity collider within a hard irradiation environment. The Time-Of-Propagation detector, aimed at the charged particle identification, surrounds the Belle II tracking detector on the barrel part. This detector is composed by 16 modules, each module contains a finely fused silica bar, coupled to microchannel plate photomultiplier tube (MCP-PMT) photo-detectors and readout by high-speed electronics. The MCP-PMT lifetime at the nominal collider luminosity is about one year, this is due to the high photon background degrading the quantum efficiency of the photocathode. An alternative to these MCP-PMTs is multi-pixel photon counters (MPPC), known as silicon photomultipliers (SiPM). The SiPMs, in comparison to MCP-PMTs, have a lower cost, higher photon detection efficiency and are unaffected by the presence of a magnetic field, but also have a higher dark count rate that rapidly increases with the integrated neutron flux. The dark count rate can be mitigated by annealing the damaged devices and/or operating them at low temperatures. We tested SiPMs, with different dimensions and pixel sizes from different producers, to study their time resolution (the main constraint that has to satisfy the photon detector) and to understand their behavior and tolerance to radiation. For these studies we irradiated the devices to radiation up to 5×10111 MeV neutrons equivalent (neq) per cm2 fluences; we also started studying the effect of annealing on dark count rates. We performed several measurements on these devices, on top of the dark count rate, at different conditions in terms of overvoltage and temperatures. These measurements are: IV-curves, amplitude spectra, time resolution. For the last two measurements we illuminated the devices with a picosecond pulsed laser at very low intensities (with a number of detected photons up to about twenty). We present results mainly on two types of SiPMs. A new SiPM prototype developed in collaboration with FBK with the aim of improving radiation hardness, is expected to be delivered in September 2025. Full article
(This article belongs to the Section Physical Sensors)
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11 pages, 3293 KiB  
Communication
Single-Photon Computational Imaging System Based on Multi-Pixel Photon Counter
by Rui Sun, Jiaye Kuang, Yi Ding, Jingjing Cheng, Jibin Zhang, Yadong Wang, Ryszard Buczynski and Wenzhong Liu
Photonics 2025, 12(6), 542; https://doi.org/10.3390/photonics12060542 - 27 May 2025
Viewed by 462
Abstract
Existing single-photon computational imaging systems always combine single-photon avalanche diode (SPAD)/photomultiplier tube (PMT) and time-correlated single-photon counting (TCSPC) together to collect the signals for imaging. However, the high equipment complexity and cost limit the wide applications of single-photon computational imaging systems. To overcome [...] Read more.
Existing single-photon computational imaging systems always combine single-photon avalanche diode (SPAD)/photomultiplier tube (PMT) and time-correlated single-photon counting (TCSPC) together to collect the signals for imaging. However, the high equipment complexity and cost limit the wide applications of single-photon computational imaging systems. To overcome this problem, in this paper we propose to employ multi-pixel photon counter (MPPC) as the signal receiver to simplify the system. Due to the linearity of the output amplitude of MPPC, the number of received photons can be directly quantized; thus, the TCSPC is not necessary in our proposed imaging system. Experimental results show that the proposed system could obtain the 256 × 256 pixels images through 2000 measurements; the photons per pixel could be reduced to about 0.1. Full article
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21 pages, 9171 KiB  
Review
Progress in Avalanche Photodiodes for Laser Ranging
by Zhenxing Liu, Ning An, Xingwei Han, Natalia Edith Nuñez, Liang Jin and Chengzhi Liu
Sensors 2025, 25(9), 2802; https://doi.org/10.3390/s25092802 - 29 Apr 2025
Viewed by 1107
Abstract
Laser ranging is a high-precision geodetic technique that plays an indispensable role in the field of geodynamics. Avalanche photodiodes (APDs) offer a series of advantages over other photodetector technologies, including photomultiplier tubes (PMTs) and superconducting single-photon detectors (SNSPDs). These advantages include high sensitivity, [...] Read more.
Laser ranging is a high-precision geodetic technique that plays an indispensable role in the field of geodynamics. Avalanche photodiodes (APDs) offer a series of advantages over other photodetector technologies, including photomultiplier tubes (PMTs) and superconducting single-photon detectors (SNSPDs). These advantages include high sensitivity, small size, high integration, and low power consumption, which have contributed to the widespread use of APDs in laser ranging applications. This paper analyses the key role of APDs in enhancing the accuracy and stability of laser ranging through the examination of application examples, including Si-APD and InGaAs/InP APD. Finally, based on the technological needs of laser ranging, the future development directions of APDs are envisioned, aiming to provide a reference for the research of photodetectors in high-precision and high-frequency laser ranging applications. Full article
(This article belongs to the Section Electronic Sensors)
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16 pages, 7837 KiB  
Article
Light Output Response of a Barium Fluoride (BaF2) Inorganic Scintillator Under X-Ray Radiation
by Vasileios Ntoupis, Christos Michail, Nektarios Kalyvas, Athanasios Bakas, Ioannis Kandarakis, George Fountos and Ioannis Valais
Inorganics 2025, 13(3), 83; https://doi.org/10.3390/inorganics13030083 - 13 Mar 2025
Viewed by 826
Abstract
In this study, the luminescence efficiency of a crystal-form barium fluoride (BaF2) inorganic scintillator was assessed for medical imaging applications. For the experiments, we used a typical medical X-ray tube (50–140 kVp) for estimating the absolute luminescence efficiency (AE). Furthermore, we [...] Read more.
In this study, the luminescence efficiency of a crystal-form barium fluoride (BaF2) inorganic scintillator was assessed for medical imaging applications. For the experiments, we used a typical medical X-ray tube (50–140 kVp) for estimating the absolute luminescence efficiency (AE). Furthermore, we examined the spectral matching of the inorganic scintillator with a series of optical detectors. BaF2 showed a higher AE than cerium fluoride (CeF3), comparable to that of commercially available bismuth germanate (Bi4Ge3O12-BGO), but lower than that of the gadolinium orthosilicate (Gd2SiO5:Ce-GSO:Ce) inorganic scintillator. The maximum AE of BaF2 was 2.36 efficiency units (EU is the S.I. equivalent μWm−2/(mR/s) at 140 kVp, which is higher than that of the corresponding fluoride-based CeF3 (0.8334 EU)) at the same X-ray energy. GSO:Ce and BGO crystals, which are often integrated in commercial positron emission tomography (PET) scanners, had AE values of 7.76 and 3.41, respectively. The emission maximum (~310 nm) of BaF2 is adequate for coupling with flat-panel position-sensitive (PS) photomultipliers (PMTs) and various photocathodes. The luminescence efficiency results of BaF2 were comparable to those of BGO; thus, it could possibly be used in medical imaging modalities, considering its significantly lower cost. Full article
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18 pages, 3699 KiB  
Article
A Systematic Investigation of Beam Losses and Position-Reconstruction Techniques Measured with a Novel oBLM at CLEAR
by Montague King, Sara Benitez, Alexander Christie, Ewald Effinger, Jose Esteban, Wilfrid Farabolini, Antonio Gilardi, Pierre Korysko, Jean Michel Meyer, Belen Salvachua, Carsten P. Welsch and Joseph Wolfenden
Instruments 2025, 9(1), 4; https://doi.org/10.3390/instruments9010004 - 28 Feb 2025
Viewed by 1178
Abstract
Optical Beam-Loss Monitors (oBLMs) allow for cost-efficient and spatially continuous measurements of beam losses at accelerator facilities. A standard oBLM consists of several tens of metres of optical fibre aligned parallel to a beamline, coupled to photosensors at either or both ends. Using [...] Read more.
Optical Beam-Loss Monitors (oBLMs) allow for cost-efficient and spatially continuous measurements of beam losses at accelerator facilities. A standard oBLM consists of several tens of metres of optical fibre aligned parallel to a beamline, coupled to photosensors at either or both ends. Using the timing information from loss signals, the loss positions can be reconstructed. This paper presents a novel oBLM system recently deployed at the CERN Linear Electron Accelerator for Research (CLEAR). Multiple methods of extracting timing and position information from measured waveforms with silicon photomultipliers (SiPM) and photomultiplier tubes (PMT) are investigated. For this installation, the optimal approach is determined to be applying a constant fraction discrimination (CFD) on the upstream readout. The position resolution is found to be similar for the tested SiPM and PMT. This work has resulted in the development of a user interface to aid operations by visualising the beam losses and their positions in real time. Full article
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17 pages, 5985 KiB  
Article
A Highly Spatiotemporal Resolved Pyrometry for Combustion Temperature Measurement of Single Microparticles Applied in Powder-Fueled Ramjets
by Zhangtao Wang, Xunjie Lin, Xuefeng Huang, Houye Huang, Minqi Zhang, Qinnan Yu, Chao Cui and Shengji Li
Nanomaterials 2025, 15(3), 223; https://doi.org/10.3390/nano15030223 - 30 Jan 2025
Cited by 1 | Viewed by 1018
Abstract
It is vital to measure combustion temperature to define combustion models accurately. For single fuel particles in powder-fueled ramjets, their size distribution ranges from submicron to submillimeter, and their burn time is short to millisecond order. Moreover, the radiation intensity of different types [...] Read more.
It is vital to measure combustion temperature to define combustion models accurately. For single fuel particles in powder-fueled ramjets, their size distribution ranges from submicron to submillimeter, and their burn time is short to millisecond order. Moreover, the radiation intensity of different types of fuel particles significantly oscillated with several orders of magnitude. Current temperature measurement technology is facing this challenge. This paper proposes a highly spatiotemporal resolved pyrometry to measure the combustion temperature of fuel particles by coupling single-point photomultiplier tube (PMT)-based and two-dimensional complementary metal oxide semiconductor (CMOS)-based photoelectric devices. Both the offline calibration by blackbody furnace and online calibration by standard lamp confirmed the measurement accuracy of the pyrometry. Then, the pyrometry was used to measure the combustion temperature of fuel particles including micro-Al, nano-Al, micro-Mg, nano-B, and micro-B4C. The temperature evolution and distribution of burning fuel particles were complementarily obtained, especially the interfacial flame temperature near the particle surface. Based on the obtained combustion temperature, the combustion characteristics and the energy release efficiencies among these fuels were evaluated and compared in detail, which are helpful to recognize, in depth, the combustion behavior and reveal the combustion mechanism of fuel particles in powder-fueled ramjets. Full article
(This article belongs to the Special Issue Advances in Nano-Enhanced Thermal Functional Materials)
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13 pages, 4543 KiB  
Article
The Development of a Large-Area Microchannel Plate Photomultiplier Tube with a Gate Function
by Ziyu Liu, Hulin Liu, Ping Chen, Kuinian Li, Yonglin Wei, Luanxuan He, Xinnan Zhao, Wei Zhao and Jinshou Tian
Photonics 2025, 12(1), 46; https://doi.org/10.3390/photonics12010046 - 7 Jan 2025
Viewed by 903
Abstract
To meet the application requirements of neutron detectors, a novel large-area microchannel plate photomultiplier tube with a gate function (G-MCP-PMT) was developed in this study. A kind of regular hexagonal mesh electrode as the gated electrode was designed to achieve excellent gating functions [...] Read more.
To meet the application requirements of neutron detectors, a novel large-area microchannel plate photomultiplier tube with a gate function (G-MCP-PMT) was developed in this study. A kind of regular hexagonal mesh electrode as the gated electrode was designed to achieve excellent gating functions for target pulse signals. The photoelectron transmittances for different mesh electrode sizes and voltages were studied via numerical simulations. To increase the effective detection area of the photocathode, an electrostatic-focusing electrode was designed in the G-MCP-PMT. By optimizing the structure of the focusing electrode, an effective photocathode detection surface diameter of 80 mm was achieved based on commercially available MCPs with a diameter of 56 mm. By adjusting the channel diameter configurations of the dual MCPs, the output pulse peak and time response of the large-area G-MCP-PMT can be flexibly adjusted. The experimental results indicate that when the large-area G-MCP-PMT is operated at −2700 V, the gate establishment time is approximately 50 ns. The extinction ratio of the large-area G-MCP-PMT is higher than 3000:1, and the maximum linear output current is greater than 300 mA at 250 ns FWHM, meeting application needs in various fields such as white neutron detection and laser radar. Full article
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9 pages, 2029 KiB  
Article
Pulse Shape Discrimination of n/γ in Liquid Scintillator at PMT Nonlinear Region Using Artificial Neural Network Technique
by Eungyu Yun, Ji Young Choi, Sang Yong Kim and Kyung Kwang Joo
Sensors 2024, 24(24), 8060; https://doi.org/10.3390/s24248060 - 18 Dec 2024
Viewed by 1228
Abstract
Reactor-emitted electron antineutrinos can be detected via the inverse beta decay reaction, which produces a characteristic signal: a two-fold coincidence between a prompt positron event and a delayed neutron capture event within a specific time frame. While liquid scintillators are widely used for [...] Read more.
Reactor-emitted electron antineutrinos can be detected via the inverse beta decay reaction, which produces a characteristic signal: a two-fold coincidence between a prompt positron event and a delayed neutron capture event within a specific time frame. While liquid scintillators are widely used for detecting neutrinos reacting with matter, detection is difficult because of the low interaction of neutrinos. In particular, it is important to distinguish between neutron (n) and gamma (γ) signals. The principle of the interaction of neutrons with matter differs from that of gamma rays with matter, and hence the detection signal’s waveform is different. Conventionally, pulse shape discrimination (PSD) is used for n/γ separation. This study developed a machine learning method to see if it is more efficient than the traditional PSD method. The possibility of n/γ discrimination in the region beyond the linear response limits was also examined, by using 10- and 2-inch photomultiplier tubes (PMTs) simultaneously. To the best of our knowledge, no study has attempted PSD in a PMT nonlinear region using artificial neural networks. Our results indicate that the proposed method has the potential to distinguish between n and γ signals in a nonlinear region. Full article
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11 pages, 1847 KiB  
Article
Development of an Integrating Sphere-Based Wide-Range Light Source System for the Linearity Evaluation of a Photodetector Used in Radiation Detection and Bioanalysis Instruments
by Tetsuro Matsumoto, Akihiko Masuda, Minoru Tanabe, Seiya Manabe, Hideki Harano and Kazuki Niwa
Sensors 2024, 24(23), 7544; https://doi.org/10.3390/s24237544 - 26 Nov 2024
Viewed by 5951
Abstract
We developed a compact wide-range light source system for evaluating the linearity of photomultiplier tube (PMT) output. This system utilizes two integrating spheres equipped with a continuously variable slit and output aperture to modulate a stabilized light-emitting diode light source, producing an output [...] Read more.
We developed a compact wide-range light source system for evaluating the linearity of photomultiplier tube (PMT) output. This system utilizes two integrating spheres equipped with a continuously variable slit and output aperture to modulate a stabilized light-emitting diode light source, producing an output light range as wide as seven orders of magnitude. To verify the wide linearity range of the integrating sphere system, three silicon photodiodes coupled with electric current readers monitored the light intensity and simultaneously confirmed each other’s linearity. Using this system, we evaluated the linearity of the PMT used in a neutron detector we are currently developing and found it to have a linear range of more than four orders of magnitude. Non-linearity characteristics were also successfully measured in detail at a higher output range. Neutron detector operation requires both calibration of the detection efficiency and evaluation of the linearity between the neutron dose and its output. These results indicate that this system is a simple and useful method to evaluate the linearity of photodetectors used in radiation detectors and other applications. Full article
(This article belongs to the Section Optical Sensors)
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11 pages, 2024 KiB  
Article
The Development of an Electron Pulse Dilation Photomultiplier Tube Diagnostic Instrument
by Wenyong Fu, Chenman Hu, Ping Chen, Rongyan Zhou and Ling Li
Sensors 2024, 24(23), 7497; https://doi.org/10.3390/s24237497 - 24 Nov 2024
Cited by 1 | Viewed by 1092
Abstract
A new pulse-dilated photomultiplier tube (PD-PMT) with sub-20 ps temporal resolution and associated drivers have been developed for use detection and signal amplification in the inertial confinement fusion (ICF) community. The PD-PMT is coupled to a transmission line output in order to provide [...] Read more.
A new pulse-dilated photomultiplier tube (PD-PMT) with sub-20 ps temporal resolution and associated drivers have been developed for use detection and signal amplification in the inertial confinement fusion (ICF) community. The PD-PMT is coupled to a transmission line output in order to provide a continuous time history of the input signal. Electron pulse dilation provides high-speed detection capabilities by converting incoming signals into a free-electron cloud and manipulating the electron signal with electric and magnetic fields. This velocity dispersion is translated into temporal separation after the electrons transit into a drift space. The free electrons are then detected by using conventional time-resolved methods and the effective temporal resolution is improved about 12 times. In order to accurately obtain the actual device input signal, we experimentally investigated the relationship between microchannel plate (MCP) gain and electron energy during the first collision. We report the measurements with the PD-PMT, and the error source of the amplitude of the compressed signal is analyzed, which provides a reference for subsequent accurate construction. Full article
(This article belongs to the Section Optical Sensors)
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13 pages, 9309 KiB  
Article
Research on Rate Adaptation of Underwater Optical Communication with Joint Control of Photoelectric Domain
by Yu Chen, Hongbing Qiu and Yanlong Li
Photonics 2024, 11(11), 1004; https://doi.org/10.3390/photonics11111004 - 25 Oct 2024
Cited by 1 | Viewed by 1277
Abstract
As the communication distance changes, the received signal strength of an underwater optical communication system will change, and the range of its variation may not only exceed the dynamic range of the photoelectric detection device but also cause the reliability of communication to [...] Read more.
As the communication distance changes, the received signal strength of an underwater optical communication system will change, and the range of its variation may not only exceed the dynamic range of the photoelectric detection device but also cause the reliability of communication to change due to the change in the received signal-to-noise ratio. In order to maintain better communication over a longer distance, this paper proposes a rate-adaptive method for underwater optical communication with joint control in the photoelectric domain. In the optical domain, the incident light’s power is adaptively adjusted by controlling the transmittance of the liquid crystal light valve to reduce saturation distortion. In the electrical domain, the constellation distribution is optimized according to the desired probability mass function, and the modulation order is adjusted in real time by estimating the received signal-to-noise ratio of the link. The simulation results show that under the forward error correction (FEC) threshold, the proposed method increases the dynamic range of the photomultiplier tube (PMT) by about 10 dB and expands the dynamic range of the system’s communication distance. Full article
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18 pages, 2273 KiB  
Article
Optimization of the Pixel Design for Large Gamma Cameras Based on Silicon Photomultipliers
by Carolin Wunderlich, Riccardo Paoletti and Daniel Guberman
Sensors 2024, 24(18), 6052; https://doi.org/10.3390/s24186052 - 19 Sep 2024
Viewed by 1274
Abstract
Most single-photon emission computed tomography (SPECT) scanners employ a gamma camera with a large scintillator crystal and 50–100 large photomultiplier tubes (PMTs). In the past, we proposed that the weight, size and cost of a scanner could be reduced by replacing the PMTs [...] Read more.
Most single-photon emission computed tomography (SPECT) scanners employ a gamma camera with a large scintillator crystal and 50–100 large photomultiplier tubes (PMTs). In the past, we proposed that the weight, size and cost of a scanner could be reduced by replacing the PMTs with large-area silicon photomultiplier (SiPM) pixels in which commercial SiPMs are summed to reduce the number of readout channels. We studied the feasibility of that solution with a small homemade camera, but the question on how it could be implemented in a large camera remained open. In this work, we try to answer this question by performing Geant4 simulations of a full-body SPECT camera. We studied how the pixel size, shape and noise could affect its energy and spatial resolution. Our results suggest that it would be possible to obtain an intrinsic spatial resolution of a few mm FWHM and an energy resolution at 140 keV close to 10%, even if using pixels more than 20 times larger than standard commercial SiPMs of 6 × 6 mm2. We have also found that if SiPMs are distributed following a honeycomb structure, the spatial resolution is significantly better than if using square pixels distributed in a square grid. Full article
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14 pages, 5233 KiB  
Article
Experiments of Ultrasonic Positioning System with Symmetrical Array Used in Jiangmen Underground Neutrino Observatory
by Guolei Zhu, Wenxin Yang, Duo Teng, Qi Wang, Jiaqi Hui and Jie Lian
Symmetry 2024, 16(9), 1218; https://doi.org/10.3390/sym16091218 - 17 Sep 2024
Viewed by 880
Abstract
The experimental environment of the JUNO is a spherical container filled with a liquid scintillator (alkylbenzene) with a diameter of about 35 m. To observe neutrino interactions in alkylbenzene with photomultiplier tubes (PMTs) and to precisely measure the neutrino properties in this environment, [...] Read more.
The experimental environment of the JUNO is a spherical container filled with a liquid scintillator (alkylbenzene) with a diameter of about 35 m. To observe neutrino interactions in alkylbenzene with photomultiplier tubes (PMTs) and to precisely measure the neutrino properties in this environment, it is necessary to design a high-precision localization system for the PMT device. In this paper, we report the design of an ultrasonic localization system with a symmetrical receiving array, based on the construction of an experimental setup that reproduces the configuration of JUNO’s environment. We show through positioning consistency and accuracy measurements that the ultrasonic localization system has a high localization accuracy and can perform effective localization in an alkylbenzene solution with 98% purity. Full article
(This article belongs to the Special Issue Symmetry and Its Application in Wireless Communication)
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40 pages, 3495 KiB  
Review
Optical Image Sensors for Smart Analytical Chemiluminescence Biosensors
by Reza Abbasi, Xinyue Hu, Alain Zhang, Isabelle Dummer and Sebastian Wachsmann-Hogiu
Bioengineering 2024, 11(9), 912; https://doi.org/10.3390/bioengineering11090912 - 12 Sep 2024
Cited by 6 | Viewed by 3336
Abstract
Optical biosensors have emerged as a powerful tool in analytical biochemistry, offering high sensitivity and specificity in the detection of various biomolecules. This article explores the advancements in the integration of optical biosensors with microfluidic technologies, creating lab-on-a-chip (LOC) platforms that enable rapid, [...] Read more.
Optical biosensors have emerged as a powerful tool in analytical biochemistry, offering high sensitivity and specificity in the detection of various biomolecules. This article explores the advancements in the integration of optical biosensors with microfluidic technologies, creating lab-on-a-chip (LOC) platforms that enable rapid, efficient, and miniaturized analysis at the point of need. These LOC platforms leverage optical phenomena such as chemiluminescence and electrochemiluminescence to achieve real-time detection and quantification of analytes, making them ideal for applications in medical diagnostics, environmental monitoring, and food safety. Various optical detectors used for detecting chemiluminescence are reviewed, including single-point detectors such as photomultiplier tubes (PMT) and avalanche photodiodes (APD), and pixelated detectors such as charge-coupled devices (CCD) and complementary metal–oxide–semiconductor (CMOS) sensors. A significant advancement discussed in this review is the integration of optical biosensors with pixelated image sensors, particularly CMOS image sensors. These sensors provide numerous advantages over traditional single-point detectors, including high-resolution imaging, spatially resolved measurements, and the ability to simultaneously detect multiple analytes. Their compact size, low power consumption, and cost-effectiveness further enhance their suitability for portable and point-of-care diagnostic devices. In the future, the integration of machine learning algorithms with these technologies promises to enhance data analysis and interpretation, driving the development of more sophisticated, efficient, and accessible diagnostic tools for diverse applications. Full article
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