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Search Results (47)

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Keywords = perinatal and infant mental health

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24 pages, 7474 KiB  
Review
Perinatal Depression Research Trends in Canada: A Bibliometric Analysis
by Julia E. Wolak, Nicole Letourneau and K. Alix Hayden
Psychiatry Int. 2025, 6(3), 86; https://doi.org/10.3390/psychiatryint6030086 - 15 Jul 2025
Viewed by 336
Abstract
Background: Perinatal depression refers to a major depressive episode that begins during pregnancy or within four weeks after childbirth and persists through the first year postpartum. Perinatal depression is one of the most common complications of pregnancy, with significant adverse maternal and infant [...] Read more.
Background: Perinatal depression refers to a major depressive episode that begins during pregnancy or within four weeks after childbirth and persists through the first year postpartum. Perinatal depression is one of the most common complications of pregnancy, with significant adverse maternal and infant outcomes. Numerous reviews and policy guidelines have emerged from Canada; however, a bibliometric analysis that focuses not only on the international sources for perinatal depression research, but also on Canadian sources, has not been undertaken. Purpose: To provide insight on perinatal depression publications conducted by researchers affiliated with Canadian institutions, within an international context. Methods: A bibliometric analysis was performed using performance analysis and science mapping techniques, with data retrieved from Scopus until 31 December 2022. The analysis focused on original peer-reviewed publications, applying no language restrictions and ensuring at least one author was affiliated with a Canadian institution. VOSviewer version 1.6.20 was used to generate visual networks for analysis. Results: In total, there were 763 publications identified in 160 different journals. Among these publications, there were 123 institutions represented. At least one author was associated with a Canadian institution per publication. The University of Toronto had the highest frequency of affiliations (n = 313). Most publications (79.55%) occurred between 2011 and 2022, with 2021 as the year with the most publications (n = 80). The journal with the most publications was Archives of Women’s Mental Health (n = 57, 35.65%). Canadian institution-affiliated authors with the largest number of publications were Dennis (n = 57), Oberlander (n = 39), Meaney (n = 38), and Letourneau (n = 37). Conclusion: This is the first study mapping publications on perinatal depression research within a Canadian context. This bibliometric analysis provides a valuable reference for future research by identifying key authors, institutions, journals, and research areas that prioritize perinatal mental health. Full article
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14 pages, 389 KiB  
Review
Relationship Between Vitamin D Deficiency and Postpartum Depression
by Ioanna Apostolidou, Marios Baloukas and Ioannis Tsamesidis
J. Pers. Med. 2025, 15(7), 290; https://doi.org/10.3390/jpm15070290 - 4 Jul 2025
Viewed by 628
Abstract
Background/Objectives: Postpartum depression (PPD) affects approximately 10–20% of women during and after pregnancy, posing significant risks to maternal health, infant development, and family dynamics. Identifying modifiable risk factors is essential for prevention. Emerging evidence suggests that vitamin D, a neuroactive steroid hormone involved [...] Read more.
Background/Objectives: Postpartum depression (PPD) affects approximately 10–20% of women during and after pregnancy, posing significant risks to maternal health, infant development, and family dynamics. Identifying modifiable risk factors is essential for prevention. Emerging evidence suggests that vitamin D, a neuroactive steroid hormone involved in neurotransmitter synthesis, neuroinflammation regulation, and calcium homeostasis, may play a protective role against mood disorders, including PPD. Methods: The search was conducted through a comprehensive search of the PubMed, Scopus, and Web of Science databases using a combination of Medical Subject Headings (MeSH) and free-text terms including “vitamin D”, “25-hydroxyvitamin D”, “deficiency”, “pregnancy”, “postpartum”, “depression”, “antenatal depression”, “maternal mental health”, and “perinatal mood disorders”. Results: Numerous observational studies and systematic review reports around the world reinforce the potential global relevance of vitamin D insufficiency. This study advances personalized and precision medicine approaches by emphasizing the importance of individualized screening for vitamin D deficiency during pregnancy and postpartum, enabling tailored interventions that could mitigate the risk of postpartum depression. Conclusions: In conclusion, while a definitive causal relationship between vitamin D deficiency and perinatal depression remains unproven, screening for vitamin D levels during pregnancy could serve as a low-risk intervention to support maternal mental health. Future research should focus on well designed, large-scale randomized trials and standardization of diagnostic criteria to clarify vitamin D’s role in preventing perinatal depression. Recognizing vitamin D status as a modifiable biomarker allows for targeted nutritional and pharmacological strategies to optimize maternal mental health. Full article
(This article belongs to the Special Issue Hormone Therapies for Women)
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15 pages, 276 KiB  
Article
Mother–Infant Relational Quality Following a NICU Stay: Investigating the Role of Maternal Childhood Experiences
by Corinna C. Klein, Camila A. Ferrario, Ying Yan and Nicole M. McDonald
Int. J. Environ. Res. Public Health 2025, 22(5), 732; https://doi.org/10.3390/ijerph22050732 - 3 May 2025
Viewed by 721
Abstract
A Neonatal Intensive Care Unit (NICU) stay complicates the transition to parenthood for new mothers. Women respond differently to perinatal stressors, which can impact their mental health and relationship with their new baby. Mothers’ own histories of adverse and benevolent childhood experiences can [...] Read more.
A Neonatal Intensive Care Unit (NICU) stay complicates the transition to parenthood for new mothers. Women respond differently to perinatal stressors, which can impact their mental health and relationship with their new baby. Mothers’ own histories of adverse and benevolent childhood experiences can also shape their early parenting experiences. This study investigated the relationship between mothers’ adverse and benevolent childhood experiences and the observed and reported quality of interactions with their infant at 1 year following a NICU stay. Somewhat unexpectedly, we found that more maternal childhood adversity predicted less intrusive behavior and more responsiveness during a free play interaction at 12 months, while more benevolent childhood experiences predicted higher levels of observed intrusive mothering. Childhood experiences were not related to maternal perceptions of parent–child interaction quality. The length of the NICU stay was positively associated with maternal responsiveness. Findings highlight that childhood risk and protective factors may interact uniquely with a stay in the NICU, with greater adversity and a longer stay predicting more maternal responsiveness and sensitivity. Our study offers evidence that mothers can overcome their own early life challenges, and that overcoming childhood adversity may build resilience that uniquely prepares mothers for the challenge of a NICU stay. Full article
(This article belongs to the Special Issue How Reproductive Life Events Influence Women's Mental Health)
16 pages, 536 KiB  
Article
Vulnerability and Complexity: Wartime Experiences of Arab Women During the Perinatal Period
by Maram Awad-Yasin, Lia Ring, Elad Mijalevich-Soker and Orit Taubman – Ben-Ari
Int. J. Environ. Res. Public Health 2025, 22(4), 588; https://doi.org/10.3390/ijerph22040588 - 9 Apr 2025
Viewed by 570
Abstract
Pregnancy and transition to motherhood are significant experiences accompanied by manifold changes, particularly during times of crisis, such as exposure to traumatic events, which involve further levels of complexity and vulnerability. This is especially true for Arab women in Israel, considering the interactions [...] Read more.
Pregnancy and transition to motherhood are significant experiences accompanied by manifold changes, particularly during times of crisis, such as exposure to traumatic events, which involve further levels of complexity and vulnerability. This is especially true for Arab women in Israel, considering the interactions between their physical, mental, and social environments, and their impact on health during pregnancy and childcare in wartime. This study sought to examine the experience of Arab women in Israel, who experienced intersectional marginalization as women in a traditional patriarchal society who belong to a minority group, during the perinatal period, following the events of 7 October 2023, and the subsequent Israel–Hamas war. Semi-structured in-depth interviews were conducted with ten participants in different stages of pregnancy and young mothers to infants up to a year old. The thematic analysis revealed four main themes: The impact of the war on intrapersonal identity; The impact within the couple’s relationship identity; The impact on family identity; Socio-political identity. Shining a spotlight on the experiences of Arab women in Israel and their daily functioning in the current complex reality reveals unique challenges, encompassing profound feelings of fear, anxiety, and imposed silence. Deepening the understanding of marginalized women’s experiences can help policymakers in the field of women’s health to design tailored adaptations in health policies for Arab women from minority groups, navigating the complexities of transitioning to motherhood during periods of social instability and wartime challenges. Full article
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12 pages, 226 KiB  
Article
Factors Associated with Adverse Birth Outcomes in Women with an Intellectual or Other Developmental Disability
by Kyle Bradford Jones, Isabel K. Taylor, Tyson Schwab, Camille King, Godwin Okoye and Jaewhan Kim
Healthcare 2025, 13(7), 780; https://doi.org/10.3390/healthcare13070780 - 31 Mar 2025
Viewed by 576
Abstract
Objective. Women with intellectual or developmental disabilities (IDDs) experience poorer prenatal care and worse perinatal health and birth outcomes than the general population. The purpose of this study is to describe the maternal characteristics and to identify factors associated with the increased risk [...] Read more.
Objective. Women with intellectual or developmental disabilities (IDDs) experience poorer prenatal care and worse perinatal health and birth outcomes than the general population. The purpose of this study is to describe the maternal characteristics and to identify factors associated with the increased risk of adverse birth outcomes among women with an IDD. Methods. Electronic medical records and the Utah Population Database were used to identify demographic and medical characteristics of pregnant individuals between 14 and 45 years old with an IDD and the related birth outcomes. Random-effects logistic regression was used to identify factors that were associated with adverse birth outcomes. Results. A total of 5147 births by 2250 mothers with an IDD (average births per mother = 2.33) were identified. Multigestational pregnancy (twins or triplets) (OR = 32.85, p < 0.01), fewer prenatal care visits (OR = 3.01, <0.01), gestational hypertension (OR = 2.74, p < 0.01), and the presence of a mental illness (OR = 1.28, p = 0.01) had an increased risk for preterm delivery. Associated low birth weight factors included multigestational pregnancy (OR = 22.82, p < 0.01), gestational hypertension (OR = 3.23, p < 0.01), maternal smoking status (OR = 1.54, p < 0.01), fewer prenatal visits (OR = 2.91, p < 0.01), and maternal mental health disorder (OR = 1.66, p < 0.01). Cesarean deliveries were associated with gestational hypertension (OR = 2.33, p < 0.01), Medicaid coverage (OR = 1.76, p < 0.01), and gestational diabetes (OR = 1.42, p < 0.01). Neonatal intensive care unit (NICU) admission was associated with increasing maternal age, multigestational pregnancy, the number of prenatal care visits, hypertension, and maternal mental disorders. Conclusions. These results suggest that sociodemographic factors and health problems put women with an IDD at a higher risk of adverse pregnancy and infant outcomes. Appropriate clinical care and social supports should be utilized to optimize the health and outcomes of this population. Full article
(This article belongs to the Special Issue Maternal and Child Health: Advances in Translational Research)
14 pages, 280 KiB  
Review
The Influence of Heat on Pediatric and Perinatal Health: Risks, Evidence, and Future Directions
by Nicola Principi, Beatrice Rita Campana, Alberto Argentiero, Valentina Fainardi and Susanna Esposito
J. Clin. Med. 2025, 14(4), 1123; https://doi.org/10.3390/jcm14041123 - 10 Feb 2025
Cited by 1 | Viewed by 2008
Abstract
Children, particularly infants and those with chronic conditions, are highly vulnerable to heat-induced health risks, similarly to the elderly. This narrative review synthesizes current evidence on the impact of heat exposure on pediatric and perinatal health. A systematic literature search was conducted using [...] Read more.
Children, particularly infants and those with chronic conditions, are highly vulnerable to heat-induced health risks, similarly to the elderly. This narrative review synthesizes current evidence on the impact of heat exposure on pediatric and perinatal health. A systematic literature search was conducted using PubMed/MEDLINE and manual reference checks, focusing on studies from 2000 to 2024. Findings indicate that maternal heat exposure is associated with adverse pregnancy outcomes, including pre-eclampsia, gestational diabetes, hypertension, and increased hospital admissions. Additionally, prenatal heat stress correlates with preterm birth, low birth weight, birth defects, and stillbirth. In childhood, heat-related health consequences range from heatstroke and dehydration to renal impairment, respiratory diseases, and gastrointestinal infections. Psychosocial effects, including cognitive impairment, sleep disturbances, and mental health issues, have also been reported in school-age children and adolescents. Despite strong epidemiological evidence, critical knowledge gaps remain, including the exact temperature thresholds that increase disease risk and how these thresholds vary by age and underlying health conditions. Urgent public health measures are required to mitigate these risks, while further research is needed to define exposure–response relationships and effective interventions. Addressing the rising burden of heat-related pediatric illness is essential in the context of climate change and increasing global temperatures. Full article
(This article belongs to the Section Intensive Care)
16 pages, 524 KiB  
Systematic Review
The Connection Between Stress and Women’s Smoking During the Perinatal Period: A Systematic Review
by M. Carmen Míguez, Yara Queiro, Cristina M. Posse and Alba Val
Brain Sci. 2025, 15(1), 13; https://doi.org/10.3390/brainsci15010013 - 26 Dec 2024
Viewed by 1138
Abstract
Introduction. In women, smoking during pregnancy and the postpartum period has important consequences for maternal and infant health, and interventions to assist smoking cessation during this period are essential. Although smoking has been associated with the presence of mental health problems, few studies [...] Read more.
Introduction. In women, smoking during pregnancy and the postpartum period has important consequences for maternal and infant health, and interventions to assist smoking cessation during this period are essential. Although smoking has been associated with the presence of mental health problems, few studies addressing the factors associated with perinatal smoking have examined the role of stress. The aim of this review was to identify the relationships between the presence of stress and smoking during pregnancy and the postpartum period. Method. A literature search of the PsycInfo, Pubmed and Web of Science databases was carried out to identify relevant articles published between January 2013 and June 2024. A total of 15 studies that met the inclusion criteria were selected for review. Results. Twelve of the studies analysed the relationship between stress and smoking during pregnancy, two studies involved the postpartum period, and one study included both periods. Diverse instruments were used to assess stress, although the PSS-14 was the most commonly used. Eleven of the studies found a relationship between stress and smoking in the perinatal period, with stress being a predictor of smoking. Conclusions. The findings highlight the need to consider stress management when developing effective interventions to help women quit smoking during pregnancy and maintain abstinence in the postpartum period. Full article
(This article belongs to the Special Issue Hot Topics in Stress-Related Mental Health Disorders)
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8 pages, 197 KiB  
Perspective
Treatment Advances in Perinatal Depression: Innovations and Promising Approaches
by Kathleen Kendall-Tackett
J. Clin. Med. 2024, 13(24), 7744; https://doi.org/10.3390/jcm13247744 - 18 Dec 2024
Cited by 1 | Viewed by 1842
Abstract
Background/Objectives: Psychotherapy and antidepressants are the standard treatment for depression during pregnancy or postpartum. However, several new treatments for depression represent major advances and paradigm changes. This commentary highlights some innovative treatment options that are on the horizon. Most of these modalities [...] Read more.
Background/Objectives: Psychotherapy and antidepressants are the standard treatment for depression during pregnancy or postpartum. However, several new treatments for depression represent major advances and paradigm changes. This commentary highlights some innovative treatment options that are on the horizon. Most of these modalities are promising, and most are non-invasive. Many of these modalities have been used in the general population, where evidence supports their use. The methods have only recently been used for pregnant and postpartum women. Other modalities are specifically for perinatal women but do not have an established track record. Methods: This commentary describes some promising approaches to treatment, while acknowledging that the literature is preliminary. The goal is to highlight some interesting approaches drawn from a recent comprehensive review of the entire literature on treatment for perinatal mental illness. Results: Integrative treatments include vitamin D, infant massage, mindfulness-based cognitive therapy, acupuncture, and repetitive transcranial magnetic stimulation (rTMS). Many studies in the general population have found that these methods are effective, and they also show promise for perinatal women without side effects associated with medications. Some of these treatments can also be adjuncts to what is considered standard care. Two new medications, brexanolone and esketamine, quickly and effectively treat severe depression and work on GABA and glutamate receptors rather than serotonin or norepinephrine. These medications become less effective after 30 days but can be combined with selective serotonin reuptake inhibitors (SSRIs). Conclusions: Pregnant and postpartum women seeking care for depression and other mental health conditions have many options beyond psychotherapy and SSRI/SNRI antidepressants. These modalities can also be added to their care. Full article
(This article belongs to the Section Clinical Pediatrics)
16 pages, 1724 KiB  
Article
New Materialist Mapping the Lived Experiencing of Trauma in Perinatal and Infant Mental Health
by Emma van Daal and Ariel Moy
Soc. Sci. 2024, 13(12), 682; https://doi.org/10.3390/socsci13120682 - 16 Dec 2024
Viewed by 1849
Abstract
Contemporary therapeutic trauma practice privileges symptom-based models that overlook the potential of materiality and space in trauma healing. The responsibility for recovery is situated in the individual (i.e., the parent). We suggest that trauma and lived experiencing produce and are produced by the [...] Read more.
Contemporary therapeutic trauma practice privileges symptom-based models that overlook the potential of materiality and space in trauma healing. The responsibility for recovery is situated in the individual (i.e., the parent). We suggest that trauma and lived experiencing produce and are produced by the complex relational entanglings of parent, infant, and the dyad with the world. Employing a new materialist orientation to perinatal and infant mental health and trauma, we propose multimodal mapping as an approach that can move with the multisensorial, multidimensional rhythms of trauma and trauma healing as they unfold in a series of now moments; moments that emerge within the context of the parent–infant relationship. This article re-presents the conceptual material and multimodal maps that emerged from our presentation and experiential invitation at the Big Trauma, Big Change Forum, 2024. Organised into two interconnected parts, we begin by emphasising the capacity of multimodal mapping to enable a nuanced translation of lived experiencing for parents and infants, in research and practice, that can transform trauma and potentiate healing. The second part brings focus to a new mapping experiment whereby the audience engaged in a multimodal process of re-configuring the lived experiencing of parent–infant night-time spaces using collage, images, and group process. We include three illustrations of night-time spaces common to parents and infants, exploring the power of materiality, the arts, and objects in transforming the affective, sensory, and embodied affordances that shape mental health. Arts-based mapping interventions can profoundly shape how we understand and respond to trauma, moving us towards a “more-than” conceptualisation of lived experiencing that is sensed and animated in everyday and every “thing” moments. Our hope is to inspire the audience in adopting a relational orientation that innovates new processes of discovery by mapping the human and more-than-human elements involved in parent–infant well-being and the unravelling of trauma. Full article
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18 pages, 2883 KiB  
Systematic Review
Bibliometric Analysis on of the Impact of Screening to Minimize Maternal Mental Health on Neonatal Outcomes: A Systematic Review
by Maria Tzitiridou-Chatzopoulou and Georgia Zournatzidou
J. Clin. Med. 2024, 13(19), 6013; https://doi.org/10.3390/jcm13196013 - 9 Oct 2024
Cited by 2 | Viewed by 2438
Abstract
(1) Background: Prenatal depression, maternal anxiety, puerperal psychosis, and suicidal thoughts affect child welfare and development and maternal health and mortality. Women in low-income countries suffer maternal mental health issues in 25% of cases during pregnancy and 20% of cases thereafter. However, [...] Read more.
(1) Background: Prenatal depression, maternal anxiety, puerperal psychosis, and suicidal thoughts affect child welfare and development and maternal health and mortality. Women in low-income countries suffer maternal mental health issues in 25% of cases during pregnancy and 20% of cases thereafter. However, MMH screening, diagnosis, and reporting are lacking. The primary goals of the present study are twofold, as follows: firstly, to evaluate the importance of screening maternal mental health to alleviate perinatal depression and maternal anxiety, and, secondly, to analyze research patterns and propose novel approaches and procedures to bridge the current research gap and aid practitioners in enhancing the quality of care offered to women exhibiting symptoms of perinatal depression. (2) Methods: We conducted a bibliometric analysis to analyze the research topic, using the bibliometric tools Biblioshiny and VOSviewer, as well as the R statistical programming language. To accomplish our goal, we obtained a total of 243 documents from the Scopus and PubMed databases and conducted an analysis utilizing network, co-occurrence, and multiple correlation approaches. (3) Results: Most of the publications in the field were published between the years 2021 and 2024. The results of this study highlight the significance of shifting from conventional screening methods to digital ones for healthcare professionals to effectively manage the symptoms of maternal mental health associated with postpartum depression. Furthermore, the results of the present study suggest that digital screening can prevent maternal physical morbidity, contribute to psychosocial functioning, and enhance infant physical and cognitive health. (4) Conclusions: The research indicates that it is crucial to adopt and include a computerized screening practice to efficiently and immediately detect and clarify the signs of prenatal to neonatal depression. The introduction of digital screening has led to a decrease in scoring errors, an improvement in screening effectiveness, a decrease in administration times, the creation of clinical and patient reports, and the initiation of referrals for anxiety and depression therapy. Full article
(This article belongs to the Special Issue Clinical Risks and Perinatal Outcomes in Pregnancy and Childbirth)
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13 pages, 804 KiB  
Article
Maternal Stress Mediates Association of Infant Socioemotional Development with Perinatal Mental Health in Socioeconomically Vulnerable Peruvian Settings
by Magaly Nóblega, Olenka Retiz, Juan Nuñez del Prado and Ramón Bartra
Int. J. Environ. Res. Public Health 2024, 21(7), 844; https://doi.org/10.3390/ijerph21070844 - 28 Jun 2024
Viewed by 2226
Abstract
Increased maternal mental health during the perinatal period has been widely associated with a variety of positive outcomes for both mothers and infants. However, no studies in Peru have yet focused on studying maternal mental health and related psychological variables during this stage. [...] Read more.
Increased maternal mental health during the perinatal period has been widely associated with a variety of positive outcomes for both mothers and infants. However, no studies in Peru have yet focused on studying maternal mental health and related psychological variables during this stage. Thus, the aim of this study was to test a model to associate a mother’s parental stress with infant socioemotional difficulties and maternal mental health. The sample included 988 mothers of infants aged 6 to 18 months from Peru, all from socioeconomically vulnerable settings. The findings showed that infant socioemotional difficulties were associated with poorer maternal mental health through the mother’s parental stress (χ2(7) = 28.89, p < 0.001, CFI = 0.98, RMSEA = 0.06, SRMR = 0.03). These results provide a better understanding of the key elements associated with maternal mental health during the perinatal period in Peru and offer valuable insights for developing interventions and support strategies for socioeconomically vulnerable mothers and their young children. Full article
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22 pages, 1009 KiB  
Article
Motherhood, Human Trafficking, and Asylum Seeking: The Experiences and Needs of Survivor Mothers in Birthing and Postnatal Care
by Lois Bosatta, Mariana Crespi de Valldaura, Kevin Bales, Helen Spiby and Laoise Ni Bhriain
Societies 2024, 14(5), 69; https://doi.org/10.3390/soc14050069 - 16 May 2024
Viewed by 2071
Abstract
This article aims to illuminate the little-studied phenomenon of asylum-seeking child-bearing women in the UK, survivors of violence and human trafficking. This is a significant issue in terms of the proportion of women affected and the paucity of care and support currently available [...] Read more.
This article aims to illuminate the little-studied phenomenon of asylum-seeking child-bearing women in the UK, survivors of violence and human trafficking. This is a significant issue in terms of the proportion of women affected and the paucity of care and support currently available to them as mother survivors. This study looked to examine the frontline support services of one project to survivor mothers through two collaborating organisations, Happy Baby Community and Hestia, and how their services support mothers’ experiences of perinatal mental health, infant feeding, and the general experiences of migrant women and trafficking survivors in maternity care in the UK. Using evidence collected from semi-structured service-users’ interviews and focus groups, and an anonymous online staff survey, this article shows the types of care and support that are required to address not only the challenges faced by any new mother, but also the additional challenges experienced with trafficking and seeking asylum such as mental health, housing, and legal and access to other support. This article illustrates the many complex and inter-related challenges these women face, and the way the project meets practical, informational, emotional, appraisal, and social needs. It concludes by identifying several implications of the support provided and/or needed, which could be considered by other services or policymakers looking to meet the fundamental needs and rights of this cohort. Full article
(This article belongs to the Special Issue Human Trafficking and Human Rights)
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22 pages, 690 KiB  
Review
Adults with Perinatally Acquired HIV; Emerging Clinical Outcomes and Data Gaps
by Merle Henderson, Sarah Fidler and Caroline Foster
Trop. Med. Infect. Dis. 2024, 9(4), 74; https://doi.org/10.3390/tropicalmed9040074 - 3 Apr 2024
Cited by 13 | Viewed by 3922
Abstract
In resourced settings, adults living with perinatally acquired HIV are approaching the 5th decade of life. Their clinical and psychological outcomes highlight potential future issues for the much larger number of adolescents growing up with HIV in sub–Saharan Africa, and will inform the [...] Read more.
In resourced settings, adults living with perinatally acquired HIV are approaching the 5th decade of life. Their clinical and psychological outcomes highlight potential future issues for the much larger number of adolescents growing up with HIV in sub–Saharan Africa, and will inform the development of appropriate healthcare services. Lifelong exposure to HIV, and increasingly to antiretroviral therapy throughout growth and development, contrasts with adults acquiring HIV in later life. This review describes the clinical outcomes for adults living with perinatally acquired HIV including post transition mortality, morbidity and retention in care. Rates of viral suppression, drug resistance and immunological function are explored. Co-morbidities focus on metabolic, cardiovascular, respiratory and bone health with quality-of-life data including neurocognitive functioning and mental health. Sexual and reproductive health including vaccine-preventable disease and the prevention of onward transmission to partners and infants are considered. The data gaps and future research questions to optimise outcomes for this emerging adult cohort are highlighted. Full article
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12 pages, 261 KiB  
Review
Neurobiological and Behavioral Underpinnings of Perinatal Mood and Anxiety Disorders (PMADs): A Selective Narrative Review
by Mihaela Oancea, Ștefan Strilciuc, Dan Boitor Borza, Răzvan Ciortea, Doru Diculescu and Dan Mihu
J. Clin. Med. 2024, 13(7), 2088; https://doi.org/10.3390/jcm13072088 - 3 Apr 2024
Cited by 2 | Viewed by 2336
Abstract
Perinatal mood and anxiety disorders (PMADs) profoundly impact maternal and infant health, affecting women worldwide during pregnancy and postpartum. This review synthesizes current research on the neurobiological effects of PMADs, particularly their influence on brain structure, function, and corresponding cognitive, behavioral, and mental [...] Read more.
Perinatal mood and anxiety disorders (PMADs) profoundly impact maternal and infant health, affecting women worldwide during pregnancy and postpartum. This review synthesizes current research on the neurobiological effects of PMADs, particularly their influence on brain structure, function, and corresponding cognitive, behavioral, and mental health outcomes in mothers. A literature search across PubMed, PsycINFO, and Google Scholar yielded studies utilizing neuroimaging (MRI, fMRI) and cognitive assessments to explore brain changes in PMADs. The key findings indicate significant neurobiological alterations in PMADs, such as glutamatergic dysfunction, neuronal damage, and altered neural connectivity, particularly in postpartum depression (PPD). Functional MRI studies reveal distinct patterns of brain function alteration, including amygdala non-responsivity in PPD, differing from traditional major depressive disorder (MDD). These neurobiological changes are connected with cognitive impairments and behavioral modifications, impacting maternal caregiving. Understanding these alterations is fundamental for developing effective treatments. The findings emphasize the importance of focusing on maternal mental health, advocating for early detection, and personalized treatment strategies to improve maternal and child outcomes. Full article
(This article belongs to the Section Mental Health)
17 pages, 1637 KiB  
Article
Maternal Wellbeing Five Years after a Very Preterm Delivery: Prevalence and Influencing Factors in a European Cohort
by Lena Wohlers, Rolf F. Maier, Marina Cuttini, Emilija Wilson, Valérie Benhammou, Jo Lebeer, Sabine Laroche, Iemke Sarrechia, Stavros Petrou, Nicole Thiele, Jennifer Zeitlin and Adrien M. Aubert
Children 2024, 11(1), 61; https://doi.org/10.3390/children11010061 - 31 Dec 2023
Viewed by 2292
Abstract
(1) Background: Mothers of very preterm (VPT) infants may experience psychological symptoms compromising long-term emotional wellbeing. This study describes the emotional wellbeing of mothers of five-year-old children born VPT. We assess the association between sociodemographic, perinatal and neonatal characteristics, and the child’s health [...] Read more.
(1) Background: Mothers of very preterm (VPT) infants may experience psychological symptoms compromising long-term emotional wellbeing. This study describes the emotional wellbeing of mothers of five-year-old children born VPT. We assess the association between sociodemographic, perinatal and neonatal characteristics, and the child’s health and development at five years old and maternal emotional wellbeing. (2) Methods: Data are from the prospective European “Effective Perinatal Intensive Care in Europe” (EPICE) and subsequent “Screening for Health In very Preterm infantS in Europe” (SHIPS) projects including births <32 weeks’ gestational age in 11 countries in 2011/12. Data were abstracted from obstetric and neonatal records. At five years old, 2605 mothers answered a parental questionnaire including the Mental Health Inventory-5 (MHI-5). Associations between sociodemographic and health characteristics and the mother’s MHI-5 score were investigated using multilevel multivariate linear regression analysis with the country modelled as a random effect and inverse probability weighting to correct for attrition bias. (3) Results: The mean MHI-5 score was 71.3 (SD 16.7) out of 100 (highest emotional wellbeing) with a variation among countries from 63.5 (SD 16.8; Poland) to 82.3 (SD 15.8; the Netherlands). MHI-5 scores were significantly lower for mothers whose child had a severe health problem, developmental, or speech delay, for multiparous and single mothers, and when at least one of the parents was unemployed. (4) Conclusions: The emotional wellbeing of mothers of VPT infants differs between European countries. Identifying sociodemographic characteristics and child’s health and developmental conditions that affect maternal emotional wellbeing may help to identify groups of mothers who need special assistance to cope with consequences of the delivery of a VPT child. Full article
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