Search Results (37)

Background: Vaccine hesitancy (VH) is a significant public health challenge, especially during the COVID-19 pandemic. Despite extensive research on the psychological and socio-political determinants of VH, its psychophysiological mechanisms remain unexplored. Grounded in the Somatic Marker Hypothesis, this study aims to investigate the neurophysiological and affective processes underlying VH. Methods: Two experiments will assess sensorimotor resonance and affective processes in VH. In the first experiment, motor-evoked potentials (MEPs) will be recorded from the deltoid and extensor carpi radialis muscles while participants view images of people receiving COVID-19 and influenza vaccines, as well as blood injections (Block 1), and images of vial containing the same substances (Block 2). Facial electromyographic (EMG) activity will measure disgust and fear responses. In the second experiment, skin conductance response (SCR) will be recorded during a virtual reality-based fear conditioning and extinction paradigm. Expected Outcomes: We hypothesize that vaccine-hesitant individuals will exhibit altered sensorimotor resonance, higher affective responses to vaccination stimuli, and impaired fear extinction learning. Psychological traits such as disgust sensitivity, paranoia, anxiety, and dogmatism are expected to be associated with VH. Conclusions: By identifying the psychophysiological mechanisms of VH, this study will contribute to developing effective vaccine promotion strategies to address future public health emergencies. Full article

Background: Synthetic cathinones and cannabinoids have emerged as significant public health concerns, particularly in pediatric populations. Marketed under deceptive names such as “bath salts” and “K2/Spice”, these substances pose unique challenges due to their accessibility, potency, and unpredictable effects. This narrative review synthesizes evidence on the toxicological effects of synthetic cathinones and cannabinoids in pediatric patients, emphasizing clinical presentations, management challenges, and public health implications. Methods: A structured narrative review was conducted using PubMed and Scopus databases to identify peer-reviewed studies published between January 2010 and September 2024. The selected articles focus on neuropsychiatric, systemic, and management outcomes associated with these substances in individuals aged 0–18 years. Results: Five studies demonstrate that synthetic cathinones frequently cause seizures, sympathomimetic toxidrome (tachycardia, hypertension), and neuropsychiatric effects like paranoia and catatonia. Seven studies show synthetic cannabinoids induce psychosis, respiratory depression requiring ventilation in 12% of cases, and cardiovascular complications like myocardial ischemia. One study highlighted severe outcomes in pediatric accidental exposures, emphasizing the unpredictable and life-threatening effects of these substances, often exacerbated by co-ingestion with alcohol or THC. Conclusions: Pediatric exposure to synthetic cathinones and cannabinoids results in severe and unpredictable toxicological effects, necessitating tailored clinical management strategies and enhanced diagnostic capabilities. Public health measures, including stringent regulatory controls, targeted education initiatives, and robust surveillance systems, are critical to mitigating these risks. A multidisciplinary approach is essential to safeguard vulnerable pediatric populations from the escalating dangers posed by synthetic drugs, and future research must address the long-term impacts and mechanisms of toxicity. Full article

Background/Objectives: Artificial Intelligence (AI) in healthcare employs advanced algorithms to analyze complex and large-scale datasets, mimicking aspects of human cognition. By automating decision-making processes based on predefined thresholds, AI enhances the accuracy and reliability of healthcare data analysis, reducing the need for human intervention. Schizophrenia (SZ), a chronic mental health disorder affecting millions globally, is characterized by symptoms such as auditory hallucinations, paranoia, and disruptions in thought, behavior, and perception. The SZ symptoms can significantly impair daily functioning, underscoring the need for advanced diagnostic tools. Methods: This systematic review has been conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines and examines peer-reviewed studies from the last decade (2015–2024) on AI applications in SZ detection as well as classification. The review protocol has been registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number: CRD42024612364. Research has been sourced from multiple databases and screened using predefined inclusion criteria. The review evaluates the use of both Machine Learning (ML) and Deep Learning (DL) methods across multiple modalities, including Electroencephalography (EEG), Structural Magnetic Resonance Imaging (sMRI), and Functional Magnetic Resonance Imaging (fMRI). The key aspects reviewed include datasets, preprocessing techniques, and AI models. Results: The review identifies significant advancements in AI methods for SZ diagnosis, particularly in the efficacy of ML and DL models for feature extraction, classification, and multi-modal data integration. It highlights state-of-the-art AI techniques and synthesizes insights into their potential to improve diagnostic outcomes. Additionally, the analysis underscores common challenges, including dataset limitations, variability in preprocessing approaches, and the need for more interpretable models. Conclusions: This study provides a comprehensive evaluation of AI-based methods in SZ prognosis, emphasizing the strengths and limitations of current approaches. By identifying unresolved gaps, it offers valuable directions for future research in the application of AI for SZ detection and diagnosis. Full article

In 1978, the American hard rock band Blue Öyster Cult released the song “Godzilla” as the first single from the fifth studio album Spectres. Despite not registering on popular charts, it would eventually evolve into an iconic song of its era. “Godzilla” continues to receive airplay on classic rock stations, and it remains a staple of the band’s touring performances. In 2019, a cover of the song, more than forty years after its release, made its film debut in Godzilla: King of the Monsters. Though the song is primarily a tribute to the Japanese monster from which it gets its name, “Godzilla” also reflects the nuclear fear and paranoia of the 1970s Cold War era. “Godzilla’s” cultural impact, the song’s lyrics, the Cold War context in which it was written, and its connection to the kaiju films featuring the famous monster are examined. While this is the most popular and well-known song dedicated to Godzilla, it is not the only one. Other compositions have, but they have failed to achieve the iconic status that Blue Öyster Cult’s version has attained. This song has evolved into an unofficial anthem for the great monster. Full article

The “haunted house formula” is a central component in every Female Gothic narrative from the eighteenth and nineteenth centuries. Typically, it revolves around a heroine trapped in a gloomy mansion, seeking to escape a male villain. This trope, which covertly explores feminine anxieties such as domestic confinement and familial oppression, recurs multiple times in Shirley Jackson’s “house trilogy” as well, namely The Sundial, The Haunting of Hill House, and We Have Always Lived in the Castle. However, as noted by many critics, while Female Gothic narratives usually conclude with the protagonist’s successful escape and her marriage to the male hero, in Jackson’s fiction, there is “no way out”. Her protagonists remain confined within the domestic space. This essay explores Jackson’s reappropriation of the haunted house trope as a symbol of the paranoia experienced by women in 1950s suburban America. The analysis begins by outlining the theme in traditional Female Gothic fiction, followed by an account of the sociohistorical context in which Jackson operated, without dismissing the significancy of her personal life experiences as well. Jackson’s “house trilogy” will then be examined, paying particular attention to the ways in which the haunted house formula is subverted to function not as an escape narrative, but as a metaphor for modern women’s inescapable confinement. Full article

Background: Piperazines, synthetic compounds known for their stimulant and hallucinogenic effects, have gained prominence among novel psychoactive substances (NPS) and are frequently associated with adverse psychiatric outcomes, including psychosis. Methods: A systematic review of the literature available up to 23 May 2024 was conducted, using the PubMed, Scopus, and Web of Science databases, in addition to the related gray literature, utilizing the following search strategy: “piperazines” AND (“psychosis” OR “hallucination” OR “delusion” OR “schizophrenia” OR “delusional” OR “schizoaffective”) NOT review NOT animal. Data collection adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The research methods were registered with PROSPERO (CRD42024549204). Results: Out of a total of 4547 articles identified, 4 met the inclusion criteria. We observed an important relationship between piperazine abuse and the onset of acute psychotic episodes, marked by symptoms such as paranoia, auditory, and visual hallucinations. Conclusion: The complex polyreceptor action mechanism of piperazines may explain these psychopathological effects, similar to those observed with other NPS. Although studies confirm a link between piperazine use and psychosis, data on long-term outcomes are limited. Recovery is common following cessation and treatment. Further research into the effects of piperazine abuse and the development of specific treatment protocols for substance-induced psychosis is necessary. Full article

People with schizophrenia have died at disproportionately higher rates during recent extreme heat events (EHEs) in Canada, including the deadly 2021 Heat Dome in British Columbia (B.C.). However, to date, little research has qualitatively focused on how people with schizophrenia experience and respond to EHEs. This study aimed to (i) explore how people with schizophrenia experienced and were impacted by the 2021 Heat Dome physically, cognitively, and emotionally and (ii) understand their level of awareness and health-protective actions taken in response to the EHE. Between October 2023 and February 2024, interviews were conducted with 35 people with schizophrenia who experienced the 2021 Heat Dome in a community setting within B.C., Canada. The semi-structured interviews were guided by pre-defined questions to explore the participant’s background, living situation, social network, awareness and access to heat-mitigation measures. The transcripts were analyzed using a descriptive form of thematic analysis. Participants shared critical insights on how the EHE impacted them, including descriptions of mild to severe physical manifestations of heat stress (e.g., fainting, heat rashes), the triggering of schizophrenia-related symptoms (e.g., paranoia, hallucinations), and the detrimental effects on their energy levels and emotional stability, which further caused disruptions to their everyday life. Participants also illustrated gaps in knowledge and challenges experienced with accessing information, which hindered their ability to manage the heat exposure effectively and, for some, resulted in no actions (or counter-intuitive actions) being taken to mitigate the heat. These findings demonstrate the complex ways that individuals with schizophrenia experienced and responded to the 2021 Heat Dome and revealed various situational and contextual factors that further compounded the challenge of heat mitigation. These findings can support the development of tailored individual and community-level heat response and communication initiatives and strategies for people with schizophrenia. Full article

This case report focuses on what patients and family members may experience when a neurological trauma transpires and resultant intensive care (ICU) delirium occurs. It is the personal account of the patient (A.B.) and spouse’s (R.G.B.) perspectives when the patient (A.B) suffered a vertebral artery aneurysm and hemorrhage and experienced intensive care unit (ICU) delirium after being in the ICU for 22 days. This case report provides the patient’s and spouse’s perspectives regarding delirium, i.e., A.B.’s inability to discern reality, loss of memory, paranoia and hallucinations, agency and recovery, post-ICU syndrome, and post-traumatic stress disorder (PTSD). Clinical diagnosis by the neurosurgeon indicated delirium, with treatment consisting of sleep sedation and uninterrupted sleep. A.B. was able to regain consciousness yet experienced post-traumatic stress disorder up to one year afterward. Consistent family participation in the patient’s delirium care is crucial. Family member care and family-centered strategies are provided with implications for future research and health care. Full article

The Hindu law tradition grounds its social ethics on an ideological hierarchy of class or caste known as varṇa. The positive inculcation of this hierarchy is bolstered by a fear of social inversion, known as pratiloma, in every area of law and society. Through an examination of the concept of pratiloma, this article contends first that the central Hindu law principle of dharma, religious and legal duty, depends upon knowing and abiding by one’s place in society. From this Hindu articulation of social rank as the foundation of ethics, the article then draws a comparison between classical Anglo-American conservatism and Hindu law to suggest that conservative traditions in general base moral action on social station and the fear of breaking social rank. Ethics in Hindu law, therefore, are derived from an acceptance of social station within the varṇa hierarchy and the constant cultivation of local expectations of proper behavior according to social position. Full article

The enantioselective separation of synthetic cathinones via capillary electrophoresis with ultraviolet detection (CE-UV) was successfully achieved using an acidic formate buffer with the ionic liquid tetrabutylammonium chloride (TBAC) and beta-cyclodextrin (β-CD) as co-additives. Synthetic cathinones (also known as “bath salts”) belong to a class of unregulated drugs labeled new psychoactive substances (NPS). These drugs are readily available and can cause paranoia, confusion, violence, and suicidal thoughts. The stereochemistry of synthetic cathinones, as with other drugs, can influence their potency, toxicity, metabolism, and interaction with other molecules. Thus, it is important to be able to effectively separate different types of synthetic cathinone as well as to resolve enantiomers of each. A study of buffer additives, pH, and counter ions was conducted to identify a system yielding complete enantioselective separation of synthetic cathinones by capillary electrophoresis. Buffer additives TBAC and β-CD, when used separately, did not afford the desired separation; however, when employed as co-additives, enantiomers of each of six different bath salt standards (pentylone, 4-MEC, methylone, MDPBP, MDPV, and naphyrone) were resolved. Achieving this separation of a complex mixture of closely related illicit drugs by CE using an ionic liquid and cyclodextrin together, as buffer co-additives, may provide a new starting point from which to approach the enantiomeric analysis of other drug samples as syntheses of NPS continue to rapidly evolve to evade regulation and law enforcement. Full article

Objective: A study was conducted to investigate the effects of different levels of physical activity and circadian rhythm differences on the nine factors of obsessive-compulsive disorder, interpersonal sensitivity, depression, anxiety, hostility, phobia, paranoia, and psychoticism on the SCL-90 scale. Methods: A questionnaire and mathematical and statistical methods were used to conduct the study. Data were collected through a web-based cross-sectional survey of college students from three universities in Anhui. A statistical analysis of the collected data was conducted using mathematical and statistical methods. Results: A total of 1248 students were included in the statistics of this study. Binary logistic regression analysis revealed that low physical activity levels were associated with somatization (OR = 1.36, 95% CI = 0.95–1.94), obsessive-compulsive disorder (OR = 1.85, 95% CI = 1.25–2.75), interpersonal sensitivity (OR = 1.94, 95% CI = 1.30–2.88), depression (OR = 2.03, 95% CI = 1.31–3.16), anxiety (OR = 1.67, 95% CI = 1.03–2.69), hostility (OR = 1.80, 95% CI = 1.12–2.89), phobia (OR = 1.88, 95% CI = 1.20–2.94), and paranoia (OR = 2.23, 95% CI = 1.43–3.46). Circadian rhythm differences were associated with somatization (OR = 0.91, 95% CI = 0.87–0.96), obsessive-compulsive disorder (OR = 0.93, p < 0.01, 95% CI = 0.89–0.98), interpersonal sensitivity (OR = 0.90, 95% CI = 0.85–0.94), depression (OR = 0.92, 95% CI = 0.87–0.97), anxiety (OR = 0.89, 95% CI = 0.83–0.95), hostility (OR = 0.91, 95% CI = 0.86–0.97), phobia (OR = 0.87, 95% CI = 0.82–0.93), and paranoia (OR = 0.90, 95% CI = 0.85–0.95) were all negatively associated. In addition, gender was associated with somatization and obsessive-compulsive disorder (OR = 0.75, 95% CI = 0.57–0.98), depression (OR = 0.92, 95% CI = 0.87–0.97), and paranoia (OR = 0.55, 95% CI = 0.40–0.76). Conclusions: Low-intensity physical activity was more likely to be associated with somatization, obsessive-compulsive disorder, relationship sensitivity, depression, anxiety, hostility, terror, and paranoia than high-intensity and moderate-intensity physical activity, and circadian rhythm differences showed that people who slept later (known as nocturnal) were more likely to have these problems. Full article

Aggressive behaviors of people with dementia pose a significant challenge to employees in nursing homes and aged care facilities. Aggressive behavior is a result of psychomotor agitation in dementia (BPSD). Globally, psychotropic interventions are the preferred treatment for BPSD. However, it is still unclear which psychotropic should be prescribed. The purpose of this systematic review is to compare pharmacological interventions for psychomotor agitation and psychosis symptoms. Method: The studies were extracted from databases, such as PubMed, OVID, and Cochrane, with a date restriction from 2000 to present, and in English. PRISMA steps were used to refine the extracted data. The RCTs extracted for this systematic review compared active ingredient medications to one another or to a placebo. Results: PRISMA was used to assess all selected trials comprehensively. Four trials are being conducted on quetiapine, two on haloperidol, one on olanzapine, three on risperidone, one on brexpiprazole, one on pimavanserin, and two on aripiprazole. Compared to typical antipsychotics, quetiapine showed tolerable adverse effects and did not worsen parkinsonism. Psychosis symptoms and behavioral improvements can be improved with haloperidol. Among elderly patients with psychosis, risperidone reduces angriness, paranoia, and aggression, as well as improves global functioning. As compared with other antipsychotics, aripiprazole provides a lower risk of adverse effects and demonstrated improvement in agitation, anxiety, and depression associated with psychosis. While olanzapine improves hostile suspiciousness, hallucinations, aggression, mistrust, and uncooperativeness, it worsens depression symptoms. Psychosis was treated effectively with pimavanserin without adverse effects on motor functions. Psychosis symptoms are well tolerated by brexpiprazole, but insomnia, headache, and urinary tract infections are common side effects. Conclusions: In this systematic review, we provide an overview of how to choose the correct antipsychotics and dosages for the management of BPSD and emphasize the importance of safe and conservative use of these drugs. Full article

The COVID-19 pandemic has presented those with experience of psychosis with a number of additional challenges. In the present study, we extend previous literature on this subject to explore experiences of COVID-19 vaccination in those with psychosis or schizophrenia. We analysed 38 posts from three popular Reddit sites for individuals with experiences of psychosis and schizophrenia. We employed reflexive, inductive thematic analysis and identified the following two themes: (i) facilitators for COVID-19 vaccination uptake, and (ii) barriers to COVID-19 vaccination uptake. The facilitators consisted of (i) trust in science/fact-checking, (ii) fear of the virus/vulnerable status/personal experience, (iii) help from trusted people, (iv) others becoming vaccinated, (v) rationalising fears/paranoia, and (vi) moral decision/contact with vulnerable people. The barriers consisted of (i) lack of trust (in doctors, government, science), (ii) psychosis about things inserted into the body/fear of adverse reactions, and (iii) and increased paranoia because of the coercive tone of discussions around the vaccination. It is clear that public health guidance can be problematic for individuals who have lived experience of psychosis. We recommend employing experts by experience in the design of public health campaigns that aim to reduce the fear around COVID-19 vaccinations. Full article

Methodological approaches to assess the human cognitive status are constantly evolving. At the same time, the creation of new assessment methods is accompanied by traditional research. This paper discusses the direction of research on the search for markers of stress resilience. The basis for the formation of the research algorithm was the assessment of activation factors of emotional states, including preceding stress–sensory (cognitive and informational) and psycho-emotional factors. This was determined using methodological techniques, stress factors, working conditions in professional teams, etc. For an express analysis (25–40 min) of diagnosing stress resistance, a research algorithm was justified, consisting of clinical and psychological testing, as well as EEG with traditional tests and analysis of indicators and spectra. Therefore, this research was aimed at the psychological and neurophysiological substantiation of approaches to express algorithms for assessing cognitive functions and resilience to stress under time deficit. A study on 102 healthy subjects and 38 outpatients of a neuropsychiatric clinic was performed. Basic outcomes: the integrative indicator SCL-90-R—”general index of severity” has a high statistical significance (p < 0.05) in both healthy subjects and neuropsychiatric outpatients. The effectiveness of the Mini-Mult test in conditions of time deficit is determined by the results of the scales of hypochondria, depression, hysteria, paranoia, psychasthenia, schizoid and hypomania (p < 0.05). Furthermore, we used a line of logical thinking techniques. A line of four logical methods is highly informative in assessing the mental status in conditions of time deficit. EEG power indices and spectra in theta, delta and alpha frequency ranges are an effective reflection of cognitive status. In this article, a testing algorithm as a variant for assessing neurocognitive status in screening studies of large groups is discussed. Full article

BACKGROUND: Cyberbullying has become an essential public health psychological issue affecting people’s lives in the online ecology. However, previous studies have rarely examined adolescent paranoia, moral cognition, and cyberbullying in association. Therefore, this study was based on cognitive-behavioral theory to investigate the relationship between child-like paranoid tendencies, cyberbullying, and moral disengagement. METHODS: This study used the Paranoia Scale, Cyberbullying Scale, and Moral Disengagement Scale to conduct an anonymous online survey of 1519 adolescents in China. RESULTS: (1) Paranoid tendencies, moral disengagement, and cyberbullying were all significantly and positively correlated. Boys showed higher rates of moral disengagement, while girls showed higher rates of paranoid tendencies. (2) The direct effect of paranoid tendency on cyberbullying was significant (β = 0.31, p < 0.01). (3) There was a mediating effect of moral disengagement in the influence of paranoid tendencies on cyberbullying, with an effect proportion of 20.5%. CONCLUSION: Adolescent cyberbullying should be regulated at the family and social levels to enhance juvenile mental health issues and help them establish proper moral standards. Full article